HGNC approved symbol | OGT |
HGNC ID | HGNC:8127 |
HGNC approved name | O-linked N-acetylglucosamine (GlcNAc) transferase |
Entrez gene ID | GeneID:8473 (SSTAR profile) |
UniProt AC (human) | O15294 |
UniProt ID (human) | OGT1_HUMAN |
Pfam domains | TPR_11 PF13414 (90-144, 363-410, 429-471) TPR_8 PF13181 (157-190, 225-258) TPR_1 PF00515 (191-224, 259-292) TPR_12 PF13424 (293-360) Glyco_transf_41 PF13844 (477-1016) |
MGI symbol | Ogt |
MGI ID | MGI:1339639 |
UniProt AC (mouse) | Q8CGY8 |
UniProt ID (mouse) | OGT1_MOUSE |
HGNC gene family tag | TTC |
HGNC gene family description | Tetratricopeptide (TTC) repeat domain containing |
Function | Histone modification write |
Modification | Histone GlcNAcylation |
PMID for information on function | PMID:22121020 |
Protein complex | NSL |
Target molecule | histone |
Target entity | H2BS112 |
Product | H2BS112GlcNa |
PMID for information on target | PMID:22121020 |
Comment | Histone H2B is GlcNAcylated at residue S112 by OGT in vitro and in living cells. Histone GlcNAcylation fluctuated in response to extracellular glucose through the hexosamine biosynthesis pathway (HBP). |
Status of entry | # |
Expression range: | 6.28 to 1542.04 |
Mean expression: | 106.48 ± 91.54 |
Median expression: | 82.7 |