| HGNC approved symbol | MBD4 |
| HGNC ID | HGNC:6919 |
| HGNC approved name | methyl-CpG binding domain protein 4 |
| Entrez gene ID | GeneID:8930 (SSTAR profile) |
| UniProt AC (human) | O95243 |
| UniProt ID (human) | MBD4_HUMAN |
| Pfam domains | MBD PF01429 (81-149) domain PF00730 (463-560) |
| MGI symbol | Mbd4 |
| MGI ID | MGI:1333850 |
| UniProt AC (mouse) | Q9Z2D7 |
| UniProt ID (mouse) | MBD4_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | DNA modification |
| Modification | # |
| PMID for information on function | PMID:10930409 |
| Protein complex | # |
| Target molecule | DNA |
| Target entity | G:T, G:U |
| Product | # |
| PMID for information on target | PMID:10930409 |
| Comment | MED1 functions as a mismatch-specific DNA repair enzyme. MED1 lacks uracil glycosylase activity on single-strand DNA and abasic site lyase activity. The glycosylase activity of MED1 prefers substrates containing a G:T mismatch within methylated or unmethylated CpG sites; since G:T mismatches can originate via deamination of 5-methylcytosine to thymine, MED1 may act as a caretaker of genomic fidelity at CpG sites. |
| Status of entry | # |
| Expression range: | 1.4 to 241.16 |
| Mean expression: | 32.02 ± 23.21 |
| Median expression: | 26.3 |