| HGNC approved symbol | PRDM6 |
| HGNC ID | HGNC:9350 |
| HGNC approved name | PR domain containing 6 |
| Entrez gene ID | GeneID:93166 (SSTAR profile) |
| UniProt AC (human) | Q9NQX0 |
| UniProt ID (human) | PRDM6_HUMAN |
| Pfam domains | PRDM2_PR PF21549 (255-374) zf-C2H2 PF00096 (501-523, 529-551, 557-577) |
| MGI symbol | Prdm6 |
| MGI ID | MGI:2684938 |
| UniProt AC (mouse) | Q3UZD5 |
| UniProt ID (mouse) | PRDM6_MOUSE |
| HGNC gene family tag | ZNF |
| HGNC gene family description | Zinc fingers, C2H2-type |
| Function | Histone modification write |
| Modification | Histone methylation |
| PMID for information on function | PMID:17898714, PMID:16537907 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H3R2, H4K20 |
| Product | H3R2me1, H3R2me2, H4K20me1 |
| PMID for information on target | PMID:17898714, PMID:18057026 |
| Comment | The arginine methyltransferase PRMT6 catalyses H3R2 di-methylation in vitro and controls global levels of H3R2me2a in vivo. H3R2 methylation by PRMT6 was prevented by the presence of H3K4me3 on the H3 tail. PRISM =PRDM6 acts as a transcriptional repressor by interacting with class I histone deacetylases and the G9a histone methyltransferase, thereby identifying PRISM as a novel SMC-restricted epigenetic regulator. |
| Status of entry | # |
| Expression range: | 0.0 to 74.52 |
| Mean expression: | 0.69 ± 3.97 |
| Median expression: | 0.0 |