| HGNC approved symbol | BRE |
| HGNC ID | HGNC:1106 |
| HGNC approved name | brain and reproductive organ-expressed (TNFRSF1A modulator) |
| Entrez gene ID | GeneID:9577
(SSTAR profile) |
| UniProt AC (human) | Q9NXR7 |
| UniProt ID (human) | BRE_HUMAN |
| Pfam domains | BRE PF06113 (9-334) |
| MGI symbol | Bre |
| MGI ID | MGI:1333875 |
| UniProt AC (mouse) | Q8K3W0 |
| UniProt ID (mouse) | BRE_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Histone modification write cofactor |
| Modification | Histone ubiquitination |
| PMID for information on function | PMID:14636569 |
| Protein complex | BRISC, BRCC, BRCA1-A |
| Target molecule | histone |
| Target entity | # |
| Product | # |
| PMID for information on target | PMID:14636569 |
| Comment | BRCC36 and BRCC45 are novel components of the complex with sequence homology to a subunit of the signalosome and proteasome complexes. Reconstitution of a recombinant four-subunit complex containing BRCA1/BARD1/BRCC45/BRCC36 revealed an enhanced E3 ligase activity compared to that of BRCA1/BARD1 heterodimer. Furthermore, a recent report describes the ability of BRCA1-BARD1 heterodimer to autoubiquitinate BRCA1 and BARD1 and transubiquitinate the histone H2A(X). |
| Status of entry | # |