HGNC approved symbol | USP3 |
HGNC ID | HGNC:12626 |
HGNC approved name | ubiquitin specific peptidase 3 |
Entrez gene ID | GeneID:9960 (SSTAR profile) |
UniProt AC (human) | Q9Y6I4 |
UniProt ID (human) | UBP3_HUMAN |
Pfam domains | zf-UBP PF02148 (29-107) UCH PF00443 (160-508) |
MGI symbol | Usp3 |
MGI ID | MGI:2152450 |
UniProt AC (mouse) | Q91W36 |
UniProt ID (mouse) | UBP3_MOUSE |
HGNC gene family tag | USP |
HGNC gene family description | Ubiquitin-specific peptidases |
Function | Histone modification write |
Modification | Histone ubiquitination |
PMID for information on function | PMID:17980597 |
Protein complex | # |
Target molecule | histone |
Target entity | H2Aub, H2Bub |
Product | H2A, H2B |
PMID for information on target | PMID:17980597 |
Comment | The ubiquitin-specific protease 3 USP3 is a deubiquitinating enzyme for uH2A and uH2B. USP3 dynamically associates with chromatin and deubiquitinates H2A/H2B in vivo. |
Status of entry | # |
Expression range: | 3.42 to 285.37 |
Mean expression: | 45.64 ± 45.81 |
Median expression: | 30.27 |