Protein complex info
Complex group nameHAT
Complex nameHBO1
Status of entry#
Genes in complexMEAF6#353, (ING4#280|ING5#281), (JADE1#287|JADE2#288|JADE3#289)+, KAT7#303
Alternative names#
Proteins involvedING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3
Uniprot IDs of involved proteins
EAF6_HUMAN, (ING4_HUMAN|ING5_HUMAN), (JADE1_HUMAN|JADE2_HUMAN|JADE3_HUMAN)+, KAT7_HUMAN
PMID for reference on complex composition16387653
Functionhistone acetylation complex
PMID for reference on function10438470
Target molecule typehistone
Specific targetH3, H4
ProductH3ac, H4ac
Target UniProt IDH31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN, H4_HUMAN
PMID for reference on targets and products10438470
CommentHas a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription.