Protein complex info
Complex group namePcG and PcG-like
Complex namePRC2
Genes in complexAEBP2#11, (JARID2#291|PHF1#432|MTF2#375|PHF19#437)?, EED#181, (EZH1#212|EZH2#213), SUZ12#600, (RBBP4#497|RBBP7#499)
Alternative names#
Proteins involvedEED, EZH1, SUZ12, RBBP4, RBBP7, JARID2 or PHF1 or PCL and AEBP2
Uniprot IDs of involved proteins
AEBP2_HUMAN, (JARD2_HUMAN|PHF1_HUMAN|MTF2_HUMAN|PHF19_HUMAN)?, EED_HUMAN, (EZH1_HUMAN|EZH2_HUMAN), SUZ12_HUMAN, (RBBP4_HUMAN|RBBP7_HUMAN)
PMID for reference on complex compositionPMID:20075857, PMID:23104054, PMID:23273982, PMID:22325352, PMID:24217316
FunctionPolycomb group complex
PMID for reference on functionPMID:15225548, PMID:20075857
Target molecule typehistone
Specific targetH3K9, H3K27
ProductH3K9me1, H3K9me2, H3K9me3, H3K27me1, H3K27me2, H3K27me3
Target UniProt IDH31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN
PMID for reference on targets and productsPMID:15225548, PMID:20075857
CommentMethylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, EZH1 is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH1 is less abundant than the PRC2/EED-EZH2 complex, has weak methyltransferase activity and compacts chromatin in the absence of the methyltransferase cofactor S-adenosyl-L-methionine (SAM). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
Status of entryUpdated