HGNC approved symbol |
HGNC ID |
HGNC approved name |
Entrez gene ID |
UniProt AC (human)
| UniProt ID (human)
| Pfam domains |
MGI symbol |
MGI ID |
UniProt AC (mouse)
| UniProt ID (mouse)
| HGNC gene family tag |
HGNC gene family description |
Function |
Modification |
PMID for information on function |
Protein complex |
Target molecule |
Target entity |
Product |
PMID for information on target |
Comment |
Status of entry |
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A1CF
(details) |
24086 | APOBEC1 complementation factor | 29974 (SSTAR profile) |
Q9NQ94 | A1CF_HUMAN | RRM_1 PF00076 (58-126, 138-199, 233-297) DND1_DSRM PF14709 (447-522) |
A1cf | 1917115 | Q5YD48 | A1CF_MOUSE | RBM | RNA binding motif (RRM) containing | RNA modification | RNA deamination | 10781591 | APOB_mRNA_editosome | RNA | mRNA, mC | U | 10781591 | ASP=A1CF has three RNA-binding domains with homologies to poly(A)-binding proteins. Recombinant ASP complements recombinant APOBEC-1 to edit apoB RNA in vitro. Therefore, APOBEC-1 and ASP represent the minimal requirements for apoB mRNA editing in vitro. | # |
ACINU
(details) |
17066 | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | 22985 (SSTAR profile) |
Q9UKV3 | ACINU_HUMAN | SAP PF02037 (72-106) RSB_motif PF16294 (1171-1247) |
Acin1 | 1891824 | Q9JIX8 | ACINU_MOUSE | # | # | RNA modification | Alternative splicing | 22203037 | # | RNA | mRNA | # | 22203037 | Production of the proapoptotic Bcl-x(S) splice variant. | New |
ACTB
(details) |
132 | actin, beta | 60 (SSTAR profile) |
P60709 | ACTB_HUMAN | Actin PF00022 (4-375) | Actb | 87904 | P60710 | ACTB_MOUSE | # | # | Chromatin remodeling cofactor | # | 10966108 | BAF, nBAF, npBAF, PBAF, SWI/SNF-like EPAFB, bBAF, SWI/SNF BRM-BRG1, NuA4, NuA4-related complex | chromatin | # | # | 10966108 | β-actin=ACTB and actin-related proteins appear to have weak ATPase activities, which contribute ∼1% of the total activity in the BAF remodeling complex (Zhao et al. 1998). Results of experiments using the actin monomer sequestering product latrunculin B suggest that β-actin and BAF53 are required for stimulation of the ATPase activity of the BAF complex by chromatin | # |
ACTL6A
(details) |
24124 | actin-like 6A | 86 (SSTAR profile) |
O96019 | ACL6A_HUMAN | Actin PF00022 (10-428) | Actl6a | 1861453 | Q9Z2N8 | ACL6A_MOUSE | INO80 | INO80 complex subunits | Chromatin remodeling cofactor | # | 9845365 | BAF, npBAF, PBAF, SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, SWI/SNF-like_EPAFa, WINAC, SWI/SNF-like EPAFB, SWI/SNF BRM-BRG1, Ino80, NuA4, NuA4-related complex, SRCAP | chromatin | # | # | 9845365 | β-actin and BAF53 =ACTL6A are required for maximal ATPase activity of BRG1 and are also required with BRG1 for association of the complex with chromatin/matrix. | # |
ACTL6B
(details) |
160 | actin-like 6B | 51412 (SSTAR profile) |
O94805 | ACL6B_HUMAN | Actin PF00022 (9-425) | Actl6b | 1933548 | Q99MR0 | ACL6B_MOUSE | # | # | Chromatin remodeling cofactor | # | 11726552 | BAF, nBAF, PBAF, SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, SWI/SNF BRM-BRG1 | chromatin | # | # | 11726552 | Belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion. | # |
ACTR3B
(details) |
17256 | ARP3 actin-related protein 3 homolog B (yeast) | 57180 (SSTAR profile) |
Q9P1U1 | ARP3B_HUMAN | Actin PF00022 (5-237) | Actr3b | 2661120 | Q641P0 | ARP3B_MOUSE | # | # | Chromatin remodeling | # | 10911987 | # | histone | H2A, H3, H4 | # | 10911987 | Act3/Arp4 can interact through the N-terminal domains of histones H3, H4, and H2A. Since Esa1 can only acetylate nucleosomal histones as part of theNuA4 complex, it has been proposed that the Act3/Arp4 subunit functions by promoting the binding of NuA4 to chromatin. | # |
ACTR5
(details) |
14671 | ARP5 actin-related protein 5 homolog (yeast) | 79913 (SSTAR profile) |
Q9H9F9 | ARP5_HUMAN | Actin PF00022 (32-230, 427-567) | Actr5 | 1924748 | Q80US4 | ARP5_MOUSE | INO80 | INO80 complex subunits | Chromatin remodeling | # | 19014934 | Ino80 | chromatin | # | # | 19014934 | hArp5 binds to chromatin as a component of the hINO80 complex in a DSB-independent manner. | # |
ACTR6
(details) |
24025 | ARP6 actin-related protein 6 homolog (yeast) | 64431 (SSTAR profile) |
Q9GZN1 | ARP6_HUMAN | Actin PF00022 (2-394) | Actr6 | 1914269 | Q9D864 | ARP6_MOUSE | # | # | Chromatin remodeling cofactor | # | 11368909 | SRCAP | chromatin | # | # | 11368909 | The Arp6 subfamily might regulate heterochromatin formation induced by the HP1 family. | # |
ACTR8
(details) |
14672 | ARP8 actin-related protein 8 homolog (yeast) | 93973 (SSTAR profile) |
Q9H981 | ARP8_HUMAN | Actin PF00022 (48-325, 506-619) | Actr8 | 1860775 | Q8R2S9 | ARP8_MOUSE | INO80 | INO80 complex subunits | Histone modification read | # | 22977180 | Ino80 | histone | # | # | 22977180 | Arp8 and the Arp8-Arp4-actin-HSA sub-complex of INO80 strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting that Arp8 functions as a nucleosome recognition module. | # |
ADNP
(details) |
15766 | activity-dependent neuroprotector homeobox | 23394 (SSTAR profile) |
Q9H2P0 | ADNP_HUMAN | ADNP_N PF19627 (3-755) Homeodomain PF00046 (770-810) |
Adnp | 1338758 | Q9Z103 | ADNP_MOUSE | ZFHX | Homeoboxes / ZF class | Chromatin remodeling cofactor | # | 17878164 | # | chromatin | # | # | # | Identified as a member of SWI/SNF chromatin remodeling complex. UniProt: Potential transcription factor. | # |
AEBP2
(details) |
24051 | AE binding protein 2 | 121536 (SSTAR profile) |
Q6ZN18 | AEBP2_HUMAN | () | Aebp2 | 1338038 | Q9Z248 | AEBP2_MOUSE | # | # | Histone modification write cofactor | Histone methylation | 15225548 | PRC2 | DNA | # | # | 15225548 | The HMTase activity requires a minimum of three components-EZH2, EED, and SUZ12-while AEBP2 is required for optimal enzymatic activity. Using a stable SUZ12 knockdown cell line, SUZ12 knockdown results in cell growth defects, which correlate with genome-wide alteration on H3-K27 methylation as well as upregulation of a number of Hox genes. | # |
AICDA
(details) |
13203 | activation-induced cytidine deaminase | 57379 (SSTAR profile) |
Q9GZX7 | AICDA_HUMAN | APOBEC_N PF08210 (9-177) | Aicda | 1342279 | Q9WVE0 | AICDA_MOUSE | APOBEC | Apolipoprotein B mRNA editing enzymes | DNA modification | DNA demethylation | 21496894 | APOB_mRNA_editosome | DNA | ssDNA, hmC | hmU | 21496894 | AICDA or AID is required for OCT4 and NANOG promoter demethylation, 5mCs are first oxidized to 5hmCs by TET proteins. 5hmCs are then deaminated by AID/APOBEC deaminases into 5hmU. Finally, 5hmU can be excised by 5hmU glycosylases and repaired by the BER pathway with unmethylated cytosines | # |
AIRE
(details) |
360 | autoimmune regulator | 326 (SSTAR profile) |
O43918 | AIRE_HUMAN | HSR PF03172 (5-102) SAND PF01342 (200-239) PHD PF00628 (299-340) |
Aire | 1338803 | Q9Z0E3 | AIRE_MOUSE | PHF | Zinc fingers, PHD-type | Histone modification read, TF | # | 18292755 | # | histone, DNA | H3K4, H3K4me3, DNA motif | # | 18292755 | AIRE selectively interacts with histone H3 through its first plant homeodomain (PHD) finger (AIRE–PHD1) and preferentially binds to non-methylated H3K4 (H3K4me0). Accordingly, in vivo AIRE binds to and activates promoters containing low levels of H3K4me3 in human embryonic kidney 293 cells. AIRE–PHD1 is an important member of a newly identified class of PHD fingers that specifically recognize H3K4me0, thus providing a new link between the status of histone modifications. | # |
ALKBH1
(details) |
17911 | alkB, alkylation repair homolog 1 (E. coli) | 8846 (SSTAR profile) |
Q13686 | ALKB1_HUMAN | 2OG-FeII_Oxy_2 PF13532 (110-345) | Alkbh1 | 2384034 | P0CB42 | ALKB1_MOUSE | ALKB | Alkylation repair homologs | Histone modification | # | 22961808 | # | histone | H2A | # | # | ALKBH1 is a histone H2A dioxygenase involved in neural differentiation. | # |
ALKBH1
(details) |
17911 | Nucleic acid dioxygenase ALKBH1 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 1) (Alpha-ketoglutarate-dependent dioxygenase ABH1) (DNA 6mA demethylase) (DNA N6-methyl adenine demethylase ALKBH1) (EC 1.14.11.51) (DNA lyase ABH1) (EC 4.2.99.18) (DNA oxidative demethylase ALKBH1) (EC 1.14.11.33) (mRNA N(3)-methylcytidine demethylase) (EC 1.14.11.-) | 8846 (SSTAR profile) |
Q13686 | ALKB1_HUMAN | 2OG-FeII_Oxy_2 PF13532 (110-345) | Alkbh1 | 2384034 | P0CB42 | ALKB1_MOUSE | ALKBH | Alkylation repair homologs | RNA modification, DNA modification | DNA demethylation, RNA demethylation | 18603530, 31188562, 18163532 | # | DNA, RNA | m3C, m1A of mRNA | C, A | 31188562, 30392959, 30017583 | Demethylates mRNAs containing N3-methylcytidine modification. Specifically demethylates DNA methylated on the 6th position of adenine (N6-methyladenosine) DNA. | New |
ALKBH4
(details) |
21900 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (Alkylated DNA repair protein alkB homolog 4) (DNA N6-methyl adenine demethylase ALKBH4) (EC 1.14.11.51) (Lysine-specific demethylase ALKBH4) (EC 1.14.11.-) | 54784 (SSTAR profile) |
Q9NXW9 | ALKB4_HUMAN | () | Alkbh4 | 1919291 | Q9D8F1 | ALKB4_MOUSE | ALKBH | Alkylation repair homologs | DNA modification | DNA demethylation | 30982744 | # | DNA | m6A of DNA | A | 30982744 | Preserves Polycomb silencing | New |
ALKBH5
(details) |
25996 | alkB homolog 5, RNA demethylase | 54890 (SSTAR profile) |
Q6P6C2 | ALKB5_HUMAN | 2OG-FeII_Oxy_2 PF13532 (117-275) | Alkbh5 | 2144489 | Q3TSG4 | ALKB5_MOUSE | ALKBH | Alkylation repair homologs | RNA modification | RNA demethylation | 23177736 | # | RNA | m6A of mRNA | A | 23177736 | Regulates export and metabolism of mRNA | New |
ANKRD32
(details) |
25408 | ankyrin repeat domain 32 | 84250 (SSTAR profile) |
Q9BQI6 | ANR32_HUMAN | RTT107_BRCT_5 PF16770 (9-90) Ank_2 PF12796 (811-900) |
Ankrd32 | 2145448 | Q8R3P9 | ANR32_MOUSE | ANKRD | Ankyrin repeat domain containing | Histone modification read | # | 21423274 | # | histone | H2AXS139 | # | 21423274 | Table 1 in the reference (ANKRD32=BRCT repeat) | # |
ANP32A
(details) |
13233 | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 8125 (SSTAR profile) |
P39687 | AN32A_HUMAN | LRR_9 PF14580 (52-146) | Anp32a | 108447 | O35381 | AN32A_MOUSE | ANP32 | ANP32 acidic nuclear phosphoproteins | Chromatin remodeling cofactor | # | 11163245 | # | chromatin | # | # | 11163245 | pp32 = ANP32A is a member of a family of leucine-rich acidic nuclear proteins ( 7 and 19). Results suggest potential roles of INHAT subunits in chromatin remodeling and transcriptional regulation; INHAT complex including pp32 inhibits the HAT activity of p300/CBP and PCAF by binding to their substrate, histones. | # |
ANP32B
(details) |
16677 | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 10541 (SSTAR profile) |
Q92688 | AN32B_HUMAN | LRR_9 PF14580 (21-149) | Anp32b | 1914878 | Q9EST5 | AN32B_MOUSE | ANP32 | ANP32 acidic nuclear phosphoproteins | Histone chaperone | # | 20538007 | # | histone | H3, H4 | # | 20538007 | The LRR domain of ANP32B possesses histone chaperone activity and forms a curved structure with a parallel beta-sheet on the concave side and mostly helical elements on the convex side. Analyses revealed that the interaction of ANP32B with the core histones H3-H4 occurs on its concave side | # |
ANP32E
(details) |
16673 | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 81611 (SSTAR profile) |
Q9BTT0 | AN32E_HUMAN | LRR_9 PF14580 (35-146) | Anp32e | 1913721 | P97822 | AN32E_MOUSE | ANP32 | ANP32 acidic nuclear phosphoproteins | Histone chaperone, Histone modification read | # | 24463511 | SWR | histone | H2A.Z | # | 24463511 | ANP32E interacts with a short region of the docking domain of H2A.Z through a new motif termed H2A.Z interacting domain (ZID). | # |
APBB1
(details) |
581 | amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) | 322 (SSTAR profile) |
O00213 | APBB1_HUMAN | WW PF00397 (256-283) PID PF00640 (370-507, 542-664) |
Apbb1 | 107765 | Q9QXJ1 | APBB1_MOUSE | # | # | Histone modification | # | 21403922 | # | histone | H2AX | # | # | Chromatin acetylation, β-amyloid precursor protein and its binding partner FE65 in DNA double strand break repair. UniProt: May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). | # |
APEX1
(details) |
587 | APEX nuclease (multifunctional DNA repair enzyme) 1 | 328 (SSTAR profile) |
P27695 | APEX1_HUMAN | Exo_endo_phos PF03372 (65-309) | Apex1 | 88042 | P28352 | APEX1_MOUSE | # | # | DNA modification cofactor | DNA demethylation | # | # | DNA | # | # | # | UniProt: May play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. | # |
APOBEC1
(details) |
604 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 | 339 (SSTAR profile) |
P41238 | ABEC1_HUMAN | APOBEC4_like PF18774 (27-158) | Apobec1 | 103298 | P51908 | ABEC1_MOUSE | APOBEC | Apolipoprotein B mRNA editing enzymes | DNA modification, RNA modification | DNA demethylation, mRNA editing | 22001110 | APOB_mRNA_editosome | DNA, RNA | ssDNA, mRNA, mC | U | 22001110 | Fig. A2 in the reference (APOBEC1 or A1 has no known mammalian DNA substrate but it has DNA deaminase activity sufficient to induce reversion mutations when overexpressed in E. coli. In addition, A1 expressed in neurons may have a protective function against HSV (Herpers simplex virus) that involves ssDNA deamination of the viral genome). | # |
APOBEC2
(details) |
605 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 | 10930 (SSTAR profile) |
Q9Y235 | ABEC2_HUMAN | APOBEC2 PF18772 (47-223) | Apobec2 | 1343178 | Q9WV35 | ABEC2_MOUSE | APOBEC | Apolipoprotein B mRNA editing enzymes | DNA modification, RNA modification | DNA demethylation, mRNA editing | 21496894, 22001110 | # | DNA, RNA | ssDNA, mRNA, mC | hmU | 22001110, 21496894 | Fig. A2 in the reference | # |
APOBEC3A
(details) |
17343 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A | 200315 (SSTAR profile) |
P31941 | ABC3A_HUMAN | NAD2 PF18782 (13-195) | # | # | # | # | APOBEC | Apolipoprotein B mRNA editing enzymes | DNA modification, RNA modification | DNA demethylation, mRNA editing | 22001110 | # | DNA, RNA | ssDNA, mRNA, mC | dhU | 22001110 | Fig. A2 in the reference (Targets are exogenous retroviruses ssDNA like HIV, DNA viruses or transposable elements/ endogenous retroelements e.g. LINEs, SINEs and LTR). | # |
APOBEC3B
(details) |
17352 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | 9582 (SSTAR profile) |
Q9UH17 | ABC3B_HUMAN | NAD2 PF18782 (8-190, 193-379) | Apobec3 | 1933111 | Q99J72 | ABEC3_MOUSE | APOBEC | Apolipoprotein B mRNA editing enzymes | DNA modification, RNA modification | DNA demethylation, mRNA editing | 22001110 | # | DNA, RNA | ssDNA, mRNA, mC | dhU | 22001110 | Fig. A2 in the reference (Targets are DNA viruses or transposable elements/ endogenous retroelements e.g. LINEs, SINEs and LTR). | # |
APOBEC3C
(details) |
17353 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C | 27350 (SSTAR profile) |
Q9NRW3 | ABC3C_HUMAN | NAD2 PF18782 (11-189) | # | # | # | # | APOBEC | Apolipoprotein B mRNA editing enzymes | DNA modification, RNA modification | DNA demethylation, mRNA editing | 22001110 | # | DNA, RNA | ssDNA, mRNA, mC | dhU | 22001110 | Fig. A2 in the reference (Targets are transposable elements/ endogenous retroelements e.g. LINEs, SINEs and LTR). | # |
APOBEC3D
(details) |
17354 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | 140564 (SSTAR profile) |
Q96AK3 | ABC3D_HUMAN | NAD2 PF18782 (10-202, 207-381) | # | # | # | # | APOBEC | Apolipoprotein B mRNA editing enzymes | DNA modification, RNA modification | DNA demethylation, mRNA editing | 21835787 | # | DNA, RNA | ssDNA, mRNA, mC | dhU | 22001110 | Fig. A2 in the reference (Targets are exogenous retroviruses ssDNA like HIV or transposable elements/ endogenous retroelements e.g. LINEs and SINEs). | # |
APOBEC3F
(details) |
17356 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F | 200316 (SSTAR profile) |
Q8IUX4 | ABC3F_HUMAN | NAD2 PF18782 (4-190, 192-372) | # | # | # | # | APOBEC | Apolipoprotein B mRNA editing enzymes | DNA modification, RNA modification | DNA demethylation, mRNA editing | 22001110 | APOB_mRNA_editosome | DNA, RNA | ssDNA, mRNA, mC | dhU | 22001110 | Fig. A2 in the reference (Targets are exogenous retroviruses ssDNA like HIV, DNA viruses or transposable elements/ endogenous retroelements e.g. LINEs, SINEs and LTR). | # |
APOBEC3G
(details) |
17357 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | 60489 (SSTAR profile) |
Q9HC16 | ABC3G_HUMAN | NAD2 PF18782 (8-190, 200-381) | # | # | # | # | APOBEC | Apolipoprotein B mRNA editing enzymes | DNA modification, RNA modification | DNA demethylation, mRNA editing | 22001110 | APOB_mRNA_editosome | DNA, RNA | ssDNA, mRNA, mC | dhU | 22001110 | Fig. A2 in the reference (Targets are exogenous retroviruses ssDNA like HIV, DNA viruses or transposable elements/ endogenous retroelements e.g. SINEs and LTR). | # |
APOBEC3H
(details) |
24100 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H | 164668 (SSTAR profile) |
Q6NTF7 | ABC3H_HUMAN | APOBEC3 PF18771 (25-157) | # | # | # | # | APOBEC | Apolipoprotein B mRNA editing enzymes | DNA modification, RNA modification | DNA demethylation, mRNA editing | 22001110 | APOB_mRNA_editosome | DNA, RNA | ssDNA, mRNA, mC | dhU | 22001110 | Fig. A2 in the reference (Targets are exogenous retroviruses ssDNA like HIV or transposable elements/ endogenous retroelements e.g. LINEs, SINEs and LTR). | # |
ARID1A
(details) |
11110 | AT rich interactive domain 1A (SWI-like) | 8289 (SSTAR profile) |
O14497 | ARI1A_HUMAN | ARID PF01388 (1018-1104) BAF250_C PF12031 (1970-2222) |
Arid1a | 1935147 | A2BH40 | ARI1A_MOUSE | ARID | # | Chromatin remodeling cofactor | # | 18448678 | BAF, nBAF, npBAF, PBAF, SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, WINAC, bBAF, SWI/SNF BRM-BRG1 | DNA | DNA motif | # | 18448678 | BAF250a=ARID1A mediated chromatin remodeling plays a critical role in maintaining a particular chromatin configuration of its target genes that is essential for ES pluripotency and mesoderm formation. | # |
ARID1B
(details) |
18040 | AT rich interactive domain 1B (SWI1-like) | 57492 (SSTAR profile) |
Q8NFD5 | ARI1B_HUMAN | ARID PF01388 (1137-1223) BAF250_C PF12031 (2006-2266) |
Arid1b | 1926129 | # | # | ARID | # | Histone modification write | Histone ubiquitination | 20086098 | BAF, nBAF, npBAF, PBAF, SWI/SNF-like_EPAFa, SWI/SNF-like EPAFB, SWI/SNF BRM-BRG1 | histone, DNA | H2BK120, DNA motif | # | 20086098 | The characteristic member of human SWI/SNF-A is BAF250/ARID1, of which there are two isoforms, BAF250a/ARID1a and BAF250b/ARID1b. The immunopurified BAF250b E3 ubiquitin ligase was found to target histone H2B at lysine 120 for monoubiquitination in vitro. | # |
ARID2
(details) |
18037 | AT rich interactive domain 2 (ARID, RFX-like) | 196528 (SSTAR profile) |
Q68CP9 | ARID2_HUMAN | ARID PF01388 (17-101) RFX_DNA_binding PF02257 (524-602) |
Arid2 | 1924294 | # | # | ARID | # | Chromatin remodeling cofactor | # | 15640446 | PBAF | DNA | DNA motif | # | 15640446 | Extends the role of ARID-containing subunits as components of SWI/SNF-related chromatin-remodeling complexes. Analysis of ARID2 in the DNA pull-down assay (Figure 4) indicates that it binds DNA without sequence specificity, like all other known ARID-containing components of SWI/SNF-related complexes. | # |
ARID4A
(details) |
9885 | AT rich interactive domain 4A (RBP1-like) | 5926 (SSTAR profile) |
P29374 | ARI4A_HUMAN | RBB1NT PF08169 (171-268) ARID PF01388 (311-397) Tudor-knot PF11717 (577-631) |
Arid4a | 2444354 | # | # | ARID | # | Histone modification write cofactor | Histone acetylation | 15640446 | mSin3A | DNA | DNA motif | # | 15640446 | ARID4 subfamily DNA-binding activity is represented here by RBP1 (ARID4A). Amino acid identity within the ARID consensus is 75% between RBP1 (ARID4A) and RBP1L1 (ARID4B), the only other member of this class. Both RBP1 and RBP1L1/SAP180 have been found in association with the mSIN3-histone deacetylase complex. | # |
ARID4B
(details) |
15550 | AT rich interactive domain 4B (RBP1-like) | 51742 (SSTAR profile) |
Q4LE39 | ARI4B_HUMAN | RBB1NT PF08169 (169-263) ARID PF01388 (308-394) Tudor-knot PF11717 (572-626) |
Arid4b | 2137512 | A2CG63 | ARI4B_MOUSE | ARID | # | Histone modification write cofactor | Histone acetylation | 15640446 | mSin3A | DNA | DNA motif | # | 15640446 | ARID4 subfamily DNA-binding activity is represented here by RBP1 (ARID4A). Amino acid identity within the ARID consensus is 75% between RBP1 (ARID4A) and RBP1L1 (ARID4B), the only other member of this class. Both RBP1 and RBP1L1/SAP180 have been found in association with the mSIN3-histone deacetylase complex. | # |
ARNTL
(details) |
701 | aryl hydrocarbon receptor nuclear translocator-like | 406 (SSTAR profile) |
O00327 | BMAL1_HUMAN | HLH PF00010 (74-126) PAS PF00989 (149-254) PAS_11 PF14598 (339-442) |
Arntl | 1096381 | Q9WTL8 | BMAL1_MOUSE | bHLH | Basic helix-loop-helix proteins | Histone modification write cofactor, TF | TF activator | 14645221, 24395244 | # | histone | # | # | 14645221, 24395244 | The coincidence of a rhythm in histone H3 and histone H4 acetylation on the proximal E-box of hPer1 with transcriptional activation of per1 and per2 is consistent with the heterodimeric complexes of CLOCK, NPAS2 and BMAL1 = ARNTL recruiting a histone acetyltransferase (HAT)-containing transcriptional co-activation complex to achieve maximal target gene activation; CLOCK:BMAL1 functions like pioneer transcription factors and regulates the DNA accessibility of other transcription factors. | # |
ARRB1
(details) |
711 | arrestin, beta 1 | 408 (SSTAR profile) |
P49407 | ARRB1_HUMAN | Arrestin_N PF00339 (19-173) Arrestin_C PF02752 (193-355) |
Arrb1 | 99473 | Q8BWG8 | ARRB1_MOUSE | # | # | Histone modification | # | 17618287, 16325578 | # | histone | # | # | # | Recruits acetylase p300. Regulates histone acetylation and gene transcription. UniProt: Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. | # |
ASF1A
(details) |
20995 | anti-silencing function 1A histone chaperone | 25842 (SSTAR profile) |
Q9Y294 | ASF1A_HUMAN | ASF1_hist_chap PF04729 (1-154) | Asf1a | 1913653 | Q9CQE6 | ASF1A_MOUSE | # | # | Histone chaperone | # | 10759893 | # | histone | H3, H4 | # | 10759893 | CIA=ASF1A binds to histones H3/H4 in vitro, and the interacting region of histone H3 is located in the C-terminal helices. Human CIA, whose yeast homologue ASF1 is an anti-silencing factor, possesses histone chaperone activity | # |
ASF1B
(details) |
20996 | anti-silencing function 1B histone chaperone | 55723 (SSTAR profile) |
Q9NVP2 | ASF1B_HUMAN | ASF1_hist_chap PF04729 (1-154) | Asf1b | 1914179 | Q9DAP7 | ASF1B_MOUSE | # | # | Histone chaperone | # | 12842904 | # | histone | H3, H4 | # | 12842904 | hCIA-II=ASF1B interacts with histone H3 in vivo and with histones H3/H4 in vitro and that it facilitates supercoiling of circular DNA when it is incubated with core histones and topoisomerase I in vitro. These data suggest that CIA-II is a histone chaperone and is implicated in the regulation of mammalian spermatogenesis. | # |
ASH1L
(details) |
19088 | ash1 (absent, small, or homeotic)-like (Drosophila) | 55870 (SSTAR profile) |
Q9NR48 | ASH1L_HUMAN | AWS PF17907 (2105-2142) SET PF00856 (2156-2261) Bromodomain PF00439 (2462-2533) PHD_5 PF20826 (2586-2628) BAH PF01426 (2662-2798) |
Ash1l | 2183158 | Q99MY8 | ASH1L_MOUSE | KMT, PHF | Chromatin-modifying enzymes / K-methyltransferases, Zinc fingers, PHD-type | Histone modification write | Histone methylation | 21239497 | # | histone | H3K36 | H3K36me | 21239497 | Human ASH1L specifically methylates histone H3 Lys-36. Implicates that there may be a regulatory mechanism of ASH1L histone methyltransferases. | # |
ASH2L
(details) |
744 | ash2 (absent, small, or homeotic)-like (Drosophila) | 9070 (SSTAR profile) |
Q9UBL3 | ASH2L_HUMAN | PHD_ash2p_like PF21257 (105-159) ASH2L-like_WH PF21198 (161-266) SPRY PF00622 (421-494) |
Ash2l | 1344416 | Q91X20 | ASH2L_MOUSE | PHF | Zinc fingers, PHD-type | Histone modification write cofactor | Histone methylation | 21285357 | COMPASS, Menin-associated_HMT, MLL-HCF, CHD8, MLL2/3, COMPASS-like MLL1,2, MLL4/WBP7, COMPASS-like MLL3,4 | histone | # | # | 21285357 | The oncoprotein Ash2L is a component of the mixed lineage leukemia (MLL) family members 1–4, Setd1A, and Setd1B mammalian histone H3K4 methyltransferase complexes and is essential to maintain global trimethylation of histone H3K4. | # |
ASXL1
(details) |
18318 | additional sex combs like transcriptional regulator 1 | 171023 (SSTAR profile) |
Q8IXJ9 | ASXL1_HUMAN | HARE-HTH PF05066 (11-82) ASXH PF13919 (244-363) PHD_3 PF13922 (1502-1539) |
Asxl1 | 2684063 | P59598 | ASXL1_MOUSE | # | # | Histone modification erase, Polycomb group (PcG) protein | Histone deubiquitination | 20436459 | PR-DUB | histone | H2AK119 | H2AK119ub1 | 20436459 | Reconstituted recombinant Drosophila and human PR-DUB=ASXL1 complexes remove monoubiquitin from H2A but not from H2B in nucleosomes. | # |
ASXL2
(details) |
23805 | additional sex combs like transcriptional regulator 2 | 55252 (SSTAR profile) |
Q76L83 | ASXL2_HUMAN | HARE-HTH PF05066 (11-84) ASXH PF13919 (266-381) PHD_3 PF13922 (1376-1433) |
Asxl2 | 1922552 | Q8BZ32 | ASXL2_MOUSE | # | # | Histone modification read | # | 21047783 | # | histone | H3K4, H3K9 | # | 21047783 | ASXL2 occupies the aP2 promoter together with histone-lysine N-methyltransferase MLL1 and Lys-9-acetylated and Lys-4-methylated H3 histones. Microarray analysis demonstrated that ASXL1 represses, whereas ASXL2 increases, the expression of adipogenic genes. | # |
ASXL3
(details) |
29357 | additional sex combs like transcriptional regulator 3 | 80816 (SSTAR profile) |
Q9C0F0 | ASXL3_HUMAN | HARE-HTH PF05066 (11-82) ASXH PF13919 (241-361) PHD_3 PF13922 (2204-2246) |
Asxl3 | 2685175 | Q8C4A5 | ASXL3_MOUSE | # | # | Scaffold protein, Polycomb group (PcG) protein | # | 23736028 | # | histone | # | # | 23736028 | ASXL family members are epigenetic scaffolding proteins that assemble epigenetic regulators and transcription factors to specific genomic loci with histone modifications, contain PHD domain. | # |
ATAD2
(details) |
30123 | ATPase family, AAA domain containing 2 | 29028 (SSTAR profile) |
Q6PL18 | ATAD2_HUMAN | AAA PF00004 (462-597) AAA_lid_3 PF17862 (624-660) Bromodomain PF00439 (1002-1066) |
Atad2 | 1917722 | Q8CDM1 | ATAD2_MOUSE | AATP | ATPases / AAA-type | Chromatin remodeling | # | 17998543 | # | chromatin | # | # | 17998543 | Although ANCCA=ATAD2 may not be critical for ERα recruitment to its target genes, it plays an important role in the recruitment or assembly of ERα–CBP complex at the chromatin and hence the histone modifications mediated by the complex. | # |
ATAD2B
(details) |
29230 | ATPase family, AAA domain containing 2B | 54454 (SSTAR profile) |
Q9ULI0 | ATD2B_HUMAN | AAA PF00004 (437-571) AAA_lid_3 PF17862 (598-633) Bromodomain PF00439 (975-1041) |
Atad2b | 2444798 | # | # | AATP | ATPases / AAA-type | Histone modification read | # | 15308210 | # | histone | H1.4, H2A, H2B, H3 and H4 | # | 15308210 | Binds acetylated lysine residues in histone H1.4, H2A, H2B, H3 and H4 (in vitro). | # |
ATF2
(details) |
784 | activating transcription factor 2 | 1386 (SSTAR profile) |
P15336 | ATF2_HUMAN | bZIP_1 PF00170 (354-411) | Atf2 | 109349 | P16951 | ATF2_MOUSE | bZIP | Basic leucine zipper proteins | Histone modification write, TF | Histone acetylation, TF activator | 10821277 | # | histone, DNA | H2B, H4, DNA motif | # | 10821277 | ATF-2 is a histone acetyltransferase (HAT), which specifically acetylates histones H2B and H4 in vitro, exhibits histone acetyltransferase (HAT) activity. | # |
ATF7IP
(details) |
20092 | activating transcription factor 7 interacting protein | 55729 (SSTAR profile) |
Q6VMQ6 | MCAF1_HUMAN | ATF7IP_BD PF16788 (570-783) fn3_4 PF16794 (1160-1259) |
Atf7ip | 1858965 | Q7TT18 | MCAF1_MOUSE | # | # | Histone modification write cofactor | Histone methylation | 14536086 | # | histone | # | # | 14536086 | Promoter H3-K9 trimethylation is the cause of transcriptional repression and that mAM/hAM facilitates conversion of H3-K9 dimethyl to trimethyl by ESET/SETDB1. | # |
ATM
(details) |
795 | ATM serine/threonine kinase | 472 (SSTAR profile) |
Q13315 | ATM_HUMAN | TAN PF11640 (2-128) FAT PF02259 (2089-2487) PI3_PI4_kinase PF00454 (2713-2963) FATC PF02260 (3026-3056) |
Atm | 107202 | Q62388 | ATM_MOUSE | # | # | Histone modification write | Histone phosphorylation | 19261749 | # | histone | H2AXS139 | # | 19261749 | Damage-induced ATM/ATR phosphorylation on S139 of histone H2AX directly recruits MDC1 through MDC1’s BRCT domains. MDC1 itself is a substrate of ATM/ATR. | # |
ATN1
(details) |
3033 | atrophin 1 | 1822 (SSTAR profile) |
P54259 | ATN1_HUMAN | Atrophin-1 PF03154 (1-271, 407-1190) | Atn1 | 104725 | O35126 | ATN1_MOUSE | # | # | Histone modification erase cofactor | # | 10973986 | # | histone | # | # | 10973986 | When cotransfected into Neuro-2a cells, atrophin-1 and ETO/MTG8 colocalize. | # |
ATR
(details) |
882 | ATR serine/threonine kinase | 545 (SSTAR profile) |
Q13535 | ATR_HUMAN | UME PF08064 (1125-1221) FAT PF02259 (1770-2090) PI3_PI4_kinase PF00454 (2322-2567) FATC PF02260 (2613-2644) |
Atr | 108028 | Q9JKK8 | ATR_MOUSE | # | # | Histone modification write | Histone phosphorylation | 11673449 | # | histone | H2AX | # | 11673449 | While H2AX phosphorylation requires ATR, this phosphorylation event is independent of Hus1. Thus, the phosphorylated H2AX may function upstream of Hus1 in the transduction of DNA damage. | # |
ATRX
(details) |
886 | alpha thalassemia/mental retardation syndrome X-linked | 546 (SSTAR profile) |
P46100 | ATRX_HUMAN | ADD_ATRX PF17981 (162-213) SNF2-rel_dom PF00176 (1563-1888) Helicase_C PF00271 (2022-2155) |
Atrx | 103067 | Q61687 | ATRX_MOUSE | # | # | Chromatin remodeling | # | 9499421 | # | histone | H3K9me2, H3K9me3, H3K4 | # | 9499421, 21666677 | The characteristics of the helicase domains make the XNP protein a new member of the SNF2/SWI DNA helicase family. XNP could regulate gene expression by direct interaction with heterochromatin-associated proteins.A yeast two-hybrid analysis using XNP and several human heterochromatin-associated proteins showed a specific interaction between the XNP and the EZH2 proteins. | # |
ATXN7
(details) |
10560 | ataxin 7 | 6314 (SSTAR profile) |
O15265 | ATX7_HUMAN | SCA7 PF08313 (332-395) | Atxn7 | 2179277 | Q8R4I1 | ATX7_MOUSE | ATXN | Ataxins | Histone modification write cofactor | Histone acetylation | 16494529 | SAGA | histone | # | # | 16494529 | Ataxin-7 (ATXN7) is a subunit of the GCN5 histone acetyltransferase–containing coactivator complexes TFTC/STAGA. TFTC/STAGA complexes purified from SCA7 mice have normal TRRAP, GCN5, TAF12, and SPT3 levels and that their histone or nucleosomal acetylation activities are unaffected. | # |
ATXN7L3
(details) |
25416 | ataxin 7-like 3 | 56970 (SSTAR profile) |
Q14CW9 | AT7L3_HUMAN | Sgf11 PF08209 (81-112) SCA7 PF08313 (207-237) |
Atxn7l3 | 3036270 | A2AWT3 | AT7L3_MOUSE | # | # | Histone modification erase cofactor | Histone deubiquitination | 18206972 | SAGA | histone | # | # | 18206972 | ATXN7L3, USP22, and ENY2 are the human orthologs of yeast Sgf11, Ubp8, and Sus1, respectively, and they are integral components of TFTC/STAGA complex. These three proteins together form a module of the TFTC/STAGA complex, which specifically removes the ubiquitin moiety from monoubiquitinated histones H2A and H2B. | # |
AURKA
(details) |
11393 | aurora kinase A | 6790 (SSTAR profile) |
O14965 | AURKA_HUMAN | Pkinase PF00069 (133-383) | Aurka | 894678 | P97477 | AURKA_MOUSE | PPP1R | Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits | Histone modification write | Histone phosphorylation | 12576638 | # | histone | H3 | H3S10ph | 12576638 | Xenopus Aurora-A = AURKA, pEg2, phosphorylate specifically H3 at Serine10 in vitro. | # |
AURKB
(details) |
11390 | aurora kinase B | 9212 (SSTAR profile) |
Q96GD4 | AURKB_HUMAN | Pkinase PF00069 (77-327) | Aurkb | 107168 | O70126 | AURKB_MOUSE | PPP1R | Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits | Histone modification write | Histone phosphorylation | 11856369 | # | histone | H3S10, H3S28 | # | 11856369 | Aurora-B=AURKB directly phosphorylated H3, not only at Ser10 but also at Ser28. | # |
AURKC
(details) |
11391 | aurora kinase C | 6795 (SSTAR profile) |
Q9UQB9 | AURKC_HUMAN | Pkinase PF00069 (43-293) | Aurkc | 1321119 | O88445 | AURKC_MOUSE | # | # | Histone modification write | Histone phosphorylation | 15499654 | # | histone | H3S10, H3S28 | # | 15499654 | Aurora-C=AURKC, like Aurora-B kinase, is a chromosomal passenger protein localizing first to centromeres and then to the midzone of mitotic cells. Aurora-C transcript is expressed at a moderate level albeit about an order of magnitude lower than Aurora-B transcript in diploid human fibroblasts. | # |
BABAM1
(details) |
25008 | BRISC and BRCA1 A complex member 1 | 29086 (SSTAR profile) |
Q9NWV8 | BABA1_HUMAN | () | Babam1 | 1915501 | Q3UI43 | BABA1_MOUSE | # | # | Histone modification erase cofactor | Histone deubiquitination | 19261746 | BRISC, BRCA1-A | histone | # | # | 19261746 | MERIT40 (Mediator of Rap80 Interactions and Targeting 40 kD)/(C19orf62) is a Rap80-associated protein. MERIT40 is required for Rap80-associated lysine63–ubiquitin DUB activity, a critical component of BRCA1–Rap80 G2 checkpoint and viability responses to ionizing radiation. Thus, MERIT40 represents a novel factor that links BRCA1–Rap80 complex integrity, DSB recognition, and ubiquitin chain hydrolytic activities to the DNA damage response. | # |
BAHD1
(details) |
29153 | bromo adjacent homology domain containing 1 | 22893 (SSTAR profile) |
Q8TBE0 | BAHD1_HUMAN | BAH PF01426 (624-777) | Bahd1 | 2139371 | Q497V6 | BAHD1_MOUSE | # | # | Chromatin remodeling | # | 19666599 | # | histone | H3K27me3 | # | 19666599 | Two-hybrid screen suggest that BAHD1 could link chromatin condensation activities to DNA-binding transcription factors. The BAH domain does not bind H3K27me3 in vitro but is required for BAHD1 colocalization with H3K27me3 in vivo. | # |
BANP
(details) |
13450 | BTG3 associated nuclear protein | 54971 (SSTAR profile) |
Q8N9N5 | BANP_HUMAN | BEN PF10523 (251-319) | Banp | 1889023 | Q8VBU8 | BANP_MOUSE | BEND | BEN domain containing | Histone modification write | Histone acetylation | 16166625 | # | histone | H3K9, H4K8 | # | 16166625 | SMAR1 (=BANP) directs the histone modifications at a distance. Overexpression of SMAR1 deacetylates the histones in the probe II and III region and depletion of SMAR1 increases acetylation in this region. Possibly SMAR1 controls the histone acetylation status at a distance. | # |
BAP1
(details) |
950 | BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) | 8314 (SSTAR profile) |
Q92560 | BAP1_HUMAN | Peptidase_C12 PF01088 (5-214) UCH_C PF18031 (643-688) |
Bap1 | 1206586 | Q99PU7 | BAP1_MOUSE | # | # | Histone modification erase, Polycomb group (PcG) protein | Histone deubiquitination | 20436459 | PR-DUB | histone | H2AK119ub1 | H2AK119 | 19815555, 19188440, 20436459 | The Polycomb group proteins BAP1 and ASX form a conserved complex in vivo and in vitro. | # |
BARD1
(details) |
952 | BRCA1 associated RING domain 1 | 580 (SSTAR profile) |
Q99728 | BARD1_HUMAN | zf-RING_6 PF14835 (42-107) Ank_2 PF12796 (428-523) BRCT PF00533 (569-643) |
Bard1 | 1328361 | O70445 | BARD1_MOUSE | ANKRD | Ankyrin repeat domain containing | Histone modification write | Histone ubiquitination | 19916563 | BRCC, BRCA1-A | histone | H2AX, H2A, H2B, H3, H4 | H2AXub, H2Aub, H2Bub, H3ub, H4ub | 19916563, 12485996 | BARD1, like CstF-50, also interacts with RNA polymerase II. BARD1-mediated inhibition of polyadenylation may prevent inappropriate RNA processing during transcription, | # |
BAZ1A
(details) |
960 | bromodomain adjacent to zinc finger domain, 1A | 11177 (SSTAR profile) |
Q9NRL2 | BAZ1A_HUMAN | WAC_Acf1_DNA_bd PF10537 (24-123) DDT PF02791 (423-486) WHIM1 PF15612 (592-633) WSD PF15613 (802-926) PHD PF00628 (1151-1195) Bromodomain PF00439 (1439-1517) |
Baz1a | 1309478 | O88379 | BAZ1A_MOUSE | PHF | Zinc fingers, PHD-type | Histone chaperone | # | 14759371 | ACF, CHRAC | histone | # | # | 14759371 | ACF1-ISWI complex (ATP-dependent chromatin assembly and remodeling factor [ACF]) associates with histone-fold proteins (CHRAC-15 and CHRAC-17 in the human chromatin accessibility complex [CHRAC]). These histone-fold proteins facilitate ATP-dependent nucleosome sliding by ACF. Direct interaction of the CHRAC-15/17 complex with the ACF1 subunit is essential for this process. | # |
BAZ1B
(details) |
961 | bromodomain adjacent to zinc finger domain, 1B | 9031 (SSTAR profile) |
Q9UIG0 | BAZ1B_HUMAN | WAC_Acf1_DNA_bd PF10537 (22-121) WHIM1 PF15612 (726-762) WSD PF15613 (899-1026) PHD PF00628 (1187-1231) Bromodomain PF00439 (1348-1427) |
Baz1b | 1353499 | Q9Z277 | BAZ1B_MOUSE | PHF | Zinc fingers, PHD-type | Histone modification write | Histone phosphorylation | 19092802 | B-WICH, WINAC | histone | H2AXT142, H3 | H2AXY142ph | 19092802 | WSTF=BAZ1B phosphorylates Tyr 142 of H2A.X, and WSTF activity has an important role in regulating several events that are critical for the DNA damage response. | # |
BAZ2A
(details) |
962 | bromodomain adjacent to zinc finger domain, 2A | 11176 (SSTAR profile) |
Q9UIF9 | BAZ2A_HUMAN | MBD PF01429 (550-619) DDT PF02791 (850-911) WHIM1 PF15612 (951-993) WSD PF15613 (1111-1788) PHD PF00628 (1679-1723) Bromodomain PF00439 (1803-1882) |
Baz2a | 2151152 | Q91YE5 | BAZ2A_MOUSE | PHF | Zinc fingers, PHD-type | Chromatin remodeling, Histone modification erase | Histone deacetylation | 11532953 | NoRC | histone, DNA | H4K16ac, DNA motif | H4K5, H4K8, H4K12 | 11532953 | TIP5=BAZ2A is a member of a family of chromatin remodeling factors. Fig. 1 in the reference. | # |
BAZ2B
(details) |
963 | bromodomain adjacent to zinc finger domain, 2B | 29994 (SSTAR profile) |
Q9UIF8 | BAZ2B_HUMAN | MBD PF01429 (743-811) DDT PF02791 (1088-1150) domain PF15612 (1193-1227) WSD PF15613 (1374-1410) PHD PF00628 (1934-1978) Bromodomain PF00439 (2069-2151) |
Baz2b | 2442782 | # | # | PHF | Zinc fingers, PHD-type | Histone modification read | # | 22464331 | # | histone, DNA | H1.4ac, H2Aac, H2Bac, H3ac, H4Kac | # | 22464331 | Fig. 5 in the reference. | # |
BCOR
(details) |
20893 | BCL6 corepressor | 54880 (SSTAR profile) |
Q6W2J9 | BCOR_HUMAN | BCOR PF15808 (1183-1395) Ank_2 PF12796 (1467-1559) PUFD PF16553 (1634-1745) |
Bcor | 1918708 | Q8CGN4 | BCOR_MOUSE | ANKRD | Ankyrin repeat domain containing | Polycomb group (PcG) protein | # | 16943429 | BCOR | # | # | # | 16943429 | The recruitment of BCOR complex PcG proteins to target genes by BCL6=BCOR in B cells suggests that BCL6 functions as a PcG-targeting factor. | # |
BCORL1
(details) |
25657 | BCL6 corepressor-like 1 | 63035 (SSTAR profile) |
Q5H9F3 | BCORL_HUMAN | Ank_2 PF12796 (1500-1591) PUFD PF16553 (1668-1782) |
Bcorl1 | 2443910 | A2AQH4 | BCORL_MOUSE | ANKRD | Ankyrin repeat domain containing | Histone modification erase cofactor | Histone deacetylation | 23523425, 17379597 | BCOR | histone | H3K36me2 | # | 23523425 | Homologous to BCOR; which is a component of a complex (dRAF-like complex) in companion with KDM2B, a H3K36me2 demethylase. | # |
BMI1
(details) |
1066 | BMI1 proto-oncogene, polycomb ring finger | 648 (SSTAR profile) |
P35226 | BMI1_HUMAN | zf-C3HC4_2 PF13923 (18-56) RAWUL PF16207 (162-226) |
Bmi1 | 88174 | P25916 | BMI1_MOUSE | RNF, PCGF | RING-type (C3HC4) zinc fingers, Polycomb group ring fingers | Polycomb group (PcG) protein | # | 15386022 | PRC1 | # | # | # | 15386022 | The complex, termed hPRC1L (human Polycomb repressive complex 1-like), is composed of several Polycomb-group proteins including Ring1, Ring2, Bmi1 and HPH2. | # |
BPTF
(details) |
3581 | bromodomain PHD finger transcription factor | 2186 (SSTAR profile) |
Q12830 | BPTF_HUMAN | DDT PF02791 (241-299) PHD PF00628 (393-434, 2870-2915) WSD PF15613 (457-524) Bromodomain PF00439 (2939-3018) |
Bptf | 2444008 | # | # | PHF | Zinc fingers, PHD-type | Chromatin remodeling | # | 18974875 | NuRF | chromatin | # | # | 18974875 | Chromatin remodeling protein Bptf (Bromodomain PHD-finger Transcription Factor), the largest subunit of NURF (Nucleosome Remodeling Factor) in a mammal. | # |
BRCA1
(details) |
1100 | breast cancer 1, early onset | 672 (SSTAR profile) |
P38398 | BRCA1_HUMAN | zf-C3HC4 PF00097 (24-64) BRCT_assoc PF12820 (361-492) BRCT PF00533 (1649-1724, 1758-1845) |
Brca1 | 104537 | P48754 | BRCA1_MOUSE | RNF, PPP1R | RING-type (C3HC4) zinc fingers, Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits | Histone modification write cofactor, TF | Histone acetylation, Histone methylation, Histone ubiquitination, TF activator, TF repressor | 20820192 | BRCC, BRCA1-A | DNA | DNA motif | # | 20820192 | BRCA1 acts as a transcription factor, which regulates expression of many genes involved in many biological processes. DNMT1, the methylation maintenance enzyme, is a transcriptional target of BRCA1. Impaired function of BRCA1 leads to global DNA hypomethylation, loss of genomic imprinting, and an open chromatin configuration in several types of tissues examined in a BRCA1 mutant mouse model at premaligant stages. BRCA1 deficiency is also associated with significantly increased expression levels of several protooncogenes. | # |
BRCA2
(details) |
1101 | breast cancer 2, early onset | 675 (SSTAR profile) |
P51587 | BRCA2_HUMAN | BRCA2 PF00634 (1002-1036, 1216-1244, 1424-1452, 1521-1548, 1665-1847, 1842-1867, 1974-2003, 2054-2083) BRCA-2_helical PF09169 (2476-2667) BRCA-2_OB1 PF09103 (2669-2798) BRCA2DBD_OB2 PF21318 (2804-2863, 2969-3034) Tower PF09121 (2831-2868) BRCA-2_OB3 PF09104 (3053-3189) domain PF22687 (3270-3382) |
Brca2 | 109337 | P97929 | BRCA2_MOUSE | FANC | Fanconi anemia, complementation groups | Histone modification write | Histone acetylation | 9619837 | BRCC | histone, DNA | H3, H4, ssDNA | # | 9619837 | BRCA2 proteins acetylate primarily H3 and H4 of free histones. This suggests that HAT activity of BRCA2 may play an important role in the regulation of transcription and tumor suppressor function. | # |
BRCC3
(details) |
24185 | BRCA1/BRCA2-containing complex, subunit 3 | 79184 (SSTAR profile) |
P46736 | BRCC3_HUMAN | JAB PF01398 (8-147) BRCC36_C PF18110 (226-308) |
Brcc3 | 2389572 | P46737 | BRCC3_MOUSE | # | # | Histone modification erase | Histone deubiquitination | 19202061 | BRISC, BRCA1-A | histone | H2AK63, H2AXK63 | H2A, H2AX | 19202061 | Involved in DNA damage response and reverses RNF8 ubiquitination activity. Rap80-BRCC36 DUB Activity and γH2AX hydrolysis Ubiquitination. Rap80 is required for BRCA1 and BRCC36 localization to DSBs. | # |
BRD1
(details) |
1102 | bromodomain containing 1 | 23774 (SSTAR profile) |
O95696 | BRD1_HUMAN | EPL1 PF10513 (47-195) PHD_2 PF13831 (229-261) zf-HC5HC2H_2 PF13832 (270-389) Bromodomain PF00439 (572-653) PWWP PF00855 (929-1039) |
Brd1 | 1924161 | # | # | # | # | Histone modification read | # | 21720545 | MOZ/MORF | histone | H3K36me3, H3 | # | 21720545 | The PWWP domains in BRPF1, BRPF2=BRD1, HDGF2, MUM1 and the N-terminal PWWP domains of WHSC1 and WHSC1L1 show weak binding affinity to histones with H3K36, K3K79 or H4K20 methylation. | # |
BRD2
(details) |
1103 | bromodomain containing 2 | 6046 (SSTAR profile) |
P25440 | BRD2_HUMAN | Bromodomain PF00439 (85-167, 354-440) BET PF17035 (640-704) |
Brd2 | 99495 | Q7JJ13 | BRD2_MOUSE | # | # | Histone modification read | # | 18406326, 20495584 | # | histone | H3K9me2, H3K14me2, H4K5ac, H4K12ac, H3K27ac | # | 18406326, 20495584 | Brd2- and Brd3-associated chromatin is significantly enriched in H4K5, H4K12, and H3K14 acetylation and contains relatively little dimethylated H3K9. Both Brd2 and Brd3 allowed RNA polymerase II to transcribe through nucleosomes in a defined transcription system. Such activity depended on specific histone H4 modifications known to be recognized by the Brd proteins.. BRD2 is involved in recognizing acetylated lysines, including H3K27ac, and its involvement in transcriptional regulation. | # |
BRD3
(details) |
1104 | bromodomain containing 3 | 8019 (SSTAR profile) |
Q15059 | BRD3_HUMAN | Bromodomain PF00439 (46-127, 315-402) BET PF17035 (571-634) |
Brd3 | 1914632 | Q8K2F0 | BRD3_MOUSE | # | # | Histone modification read | # | 18406326 | # | histone | H3K9me2, H3K14me2, H4K5ac, H4K12ac | # | 18406326 | Brd2- and Brd3-associated chromatin is significantly enriched in H4K5, H4K12, and H3K14 acetylation and contains relatively little dimethylated H3K9. Both Brd2 and Brd3 allowed RNA polymerase II to transcribe through nucleosomes in a defined transcription system. Such activity depended on specific histone H4 modifications known to be recognized by the Brd proteins. | # |
BRD4
(details) |
13575 | bromodomain containing 4 | 23476 (SSTAR profile) |
O60885 | BRD4_HUMAN | Bromodomain PF00439 (70-151, 358-444) BET PF17035 (610-672) BRD4_CDT PF17105 (1324-1362) |
Brd4 | 1888520 | Q9ESU6 | BRD4_MOUSE | # | # | Histone modification read | # | 12840145 | # | histone | H3K9, H3K14, H4K5, H4K12 | # | 12840145 | Brd4 avidly binds to di- and tetraacetylated histone H4 and diacetylated H3, but weakly or not at all to mono- and unacetylated H3 and H4. | # |
BRD7
(details) |
14310 | bromodomain containing 7 | 29117 (SSTAR profile) |
Q9NPI1 | BRD7_HUMAN | Bromodomain PF00439 (142-223) DUF3512 PF12024 (298-483) |
Brd7 | 1349766 | O88665 | BRD7_MOUSE | # | # | Histone modification read | # | 17498659 | SWI/SNF BRM-BRG1 | histone | H3K9ac, H3K14ac, H3K8ac | # | 17498659 | BRD7 bromodomain contains the typical left-handed four-helix bundle topology, and can bind with weak affinity to lysine-acetylated peptides derived from histone H3 with K9 or K14 acetylated and from histone H4 with K8, K12 or K16 acetylated. | # |
BRD8
(details) |
19874 | bromodomain containing 8 | 10902 (SSTAR profile) |
Q9H0E9 | BRD8_HUMAN | Bromodomain PF00439 (723-797, 1115-1193) | Brd8 | 1925906 | Q8R3B7 | BRD8_MOUSE | # | # | Histone modification read | # | 14966270 | SWR, NuA4, NuA4-related complex | histone | # | # | 14966270 | Part of the NuA4 histone acetyltransferase complex. | # |
BRD9
(details) |
25818 | bromodomain containing 9 | 65980 (SSTAR profile) |
Q9H8M2 | BRD9_HUMAN | Bromodomain PF00439 (146-227) DUF3512 PF12024 (288-462) |
Brd9 | 2145317 | Q3UQU0 | BRD9_MOUSE | # | # | Histone modification read | # | 22464331 | SWI/SNF BRM-BRG1 | histone | H3 | # | 22464331 | Fig. 5 in the reference. | # |
BRDT
(details) |
1105 | bromodomain, testis-specific | 676 (SSTAR profile) |
Q58F21 | BRDT_HUMAN | Bromodomain PF00439 (39-120, 277-363) BET PF17035 (509-572) BRD4_CDT PF17105 (901-947) |
Brdt | 1891374 | Q91Y44 | BRDT_MOUSE | # | # | Histone modification read | # | 22901802 | # | histone | H4K5ac, H4K8ac | # | 22901802 | Biochemical and crystallographic studies confirm that occupancy of the BRDT acetyl-lysine binding pocket by JQ1 prevents recognition of acetylated histone H4. | # |
BRE
(details) |
1106 | brain and reproductive organ-expressed (TNFRSF1A modulator) | 9577 (SSTAR profile) |
Q9NXR7 | BRE_HUMAN | BRE PF06113 (9-334) | Bre | 1333875 | Q8K3W0 | BRE_MOUSE | # | # | Histone modification write cofactor | Histone ubiquitination | 14636569 | BRISC, BRCC, BRCA1-A | histone | # | # | 14636569 | BRCC36 and BRCC45 are novel components of the complex with sequence homology to a subunit of the signalosome and proteasome complexes. Reconstitution of a recombinant four-subunit complex containing BRCA1/BARD1/BRCC45/BRCC36 revealed an enhanced E3 ligase activity compared to that of BRCA1/BARD1 heterodimer. Furthermore, a recent report describes the ability of BRCA1-BARD1 heterodimer to autoubiquitinate BRCA1 and BARD1 and transubiquitinate the histone H2A(X). | # |
BRMS1
(details) |
17262 | breast cancer metastasis suppressor 1 | 25855 (SSTAR profile) |
Q9HCU9 | BRMS1_HUMAN | Sds3 PF08598 (60-183) | Brms1 | 2388804 | Q99N20 | BRMS1_MOUSE | # | # | Chromatin remodeling | # | 17000776 | mSin3A | chromatin | # | # | 17000776 | As a corepressor, BRMS1 can function as a more global regulator of chromatin structure, as evidenced by its ability to decrease promoter occupancy of Ac-H3 and Ac-H4 on both the cIAP2 and the Bfl-1/A1 promoters. | # |
BRMS1L
(details) |
20512 | breast cancer metastasis-suppressor 1-like | 84312 (SSTAR profile) |
Q5PSV4 | BRM1L_HUMAN | Sds3 PF08598 (62-184) | Brms1l | 1196337 | Q3U1T3 | BRM1L_MOUSE | # | # | Histone modification erase | Histone deacetylation | 15451426 | mSin3A | histone | # | # | 15451426 | p40-associated Sin3A/HDAC1 complex can deacetylate histone peptides in vitro. p40 can also repress transcription when tethered to the Gal-regulated promoter by the Gal-DNA binding domain. | # |
BRPF1
(details) |
14255 | bromodomain and PHD finger containing, 1 | 7862 (SSTAR profile) |
P55201 | BRPF1_HUMAN | EPL1 PF10513 (105-255) PHD_2 PF13831 (288-320) zf-HC5HC2H_2 PF13832 (329-448) Bromodomain PF00439 (639-718) PWWP PF00855 (1085-1196) |
Brpf1 | 1926033 | # | # | # | # | Histone modification read | # | 20400950 | MOZ/MORF | histone | H3K36me3 | # | 20400950 | Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1. | # |
BRPF3
(details) |
14256 | bromodomain and PHD finger containing, 3 | 27154 (SSTAR profile) |
Q9ULD4 | BRPF3_HUMAN | EPL1 PF10513 (48-194) PHD_2 PF13831 (227-259) zf-HC5HC2H_2 PF13832 (268-386) Bromodomain PF00439 (599-680) PWWP PF00855 (1076-1187) |
Brpf3 | 2146836 | # | # | # | # | Histone modification write cofactor | Histone acetylation | 18794358 | MOZ/MORF | histone | # | # | 18794358 | Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. BRPF proteins bridge the association of MOZ and MORF with ING5 and EAF6. | # |
BRWD1
(details) |
12760 | bromodomain and WD repeat domain containing 1 | 54014 (SSTAR profile) |
Q9NSI6 | BRWD1_HUMAN | WD40 PF00400 (182-214, 217-255, 262-302, 360-396, 457-497) Bromodomain PF00439 (1166-1251, 1325-1402) |
Brwd1 | 1890651 | Q921C3 | BRWD1_MOUSE | WDR | WD repeat domain containing | Histone modification read | # | 22464331 | # | histone | H3 | # | 22464331 | Fig. 5 in the reference. | # |
BRWD3
(details) |
17342 | bromodomain and WD repeat domain containing 3 | 254065 (SSTAR profile) |
Q6RI45 | BRWD3_HUMAN | WD40 PF00400 (176-208, 211-249, 256-296, 318-345, 355-392, 455-494, 511-536) Bromodomain PF00439 (1153-1231, 1355-1414) |
Brwd3 | 3029414 | A2AHJ4 | BRWD3_MOUSE | WDR | WD repeat domain containing | Histone modification read | # | 22464331 | # | histone | H3 | # | 22464331 | Fig. 5 in the reference. | # |
BUB1
(details) |
1148 | BUB1 mitotic checkpoint serine/threonine kinase | 699 (SSTAR profile) |
O43683 | BUB1_HUMAN | Mad3_BUB1_I PF08311 (8-125) Pkinase PF00069 (789-1007) |
Bub1 | 1100510 | O08901 | BUB1_MOUSE | # | # | Histone modification write | Histone phosphorylation | 20929775 | # | histone | H2AS121 | H2AS121ph | 20929775 | Bub1 mediates histone 2A-serine 121 (H2A-S121) phosphorylation. | # |
C11orf30
(details) |
18071 | chromosome 11 open reading frame 30 | 56946 (SSTAR profile) |
Q7Z589 | EMSY_HUMAN | ENT PF03735 (16-84) | 2210018M11Rik | 1924203 | Q8BMB0 | EMSY_MOUSE | # | # | Histone modification write cofactor | Histone methylation | 19131338 | # | histone | # | # | # | Part of a complex with histone methyltranferase activity. UniProt: Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. | # |
C14orf169
(details) |
20968 | # | # | Q9H6W3 | NO66_HUMAN | JmjC_2 PF08007 (298-427) RIOX1_C_WH PF21233 (511-637) |
- | - | Q9JJF3 | NO66_MOUSE | # | # | Histone modification erase | Histone methylation | 23160351 | # | histone | H3K4me3, H3K4me1, H3K36me2 | H3K4me2, H3K4, H3K36me1 | 23160351 | H3K4me3 demethylase Rbp2 (Kdm5a). In addition to NO66=C14orf169, at least four other H3K36me3 demethylases are known. | # |
C17orf49
(details) |
28737 | chromosome 17 open reading frame 49 | 124944 (SSTAR profile) |
Q8IXM2 | BAP18_HUMAN | () | 0610010K14Rik | 1915609 | Q9DCT6 | BAP18_MOUSE | # | # | Histone modification read | # | 20850016 | CHD8, MLL2/3, MLL4/WBP7 | histone | H3K4me3 | # | 20850016 | H3K4me3 readers Sgf29, TRRAP, PHF8, GATAD1, and BAP18=C17orf49, are associated mainly with promoters (Figures S3A and S3B) and coincide with H3K4me3 marking. | # |
CARM1
(details) |
23393 | coactivator-associated arginine methyltransferase 1 | 10498 (SSTAR profile) |
Q86X55 | CARM1_HUMAN | CARM1 PF11531 (27-139) PrmA PF06325 (184-257) domain PF22528 (291-453) |
Carm1 | 1913208 | Q9WVG6 | CARM1_MOUSE | PRMT | Protein arginine methyltransferases | Histone modification write | Histone methylation | 12237300 | # | histone | H3R17 | H3R17me, H3R17me2a | 16497732, 19405910 | Methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. CARM1-directed arginine methylation of histone H3 in the promoters of steroid hormone-responsive genes is induced by steroid hormone treatment of cells. | # |
CBLL1
(details) |
21225 | E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai) | 79872 (SSTAR profile) |
Q75N03 | HAKAI_HUMAN | zf_Hakai PF18408 (161-191) | Cbll1 | 2144842 | Q9JIY2 | HAKAI_MOUSE | RNF | Ring finger proteins | RNA modification | RNA methylation | 29507755 | WMM | RNA | A of mRNA | m6A | 29507755 | # | New |
CBX1
(details) |
1551 | chromobox homolog 1 | 10951 (SSTAR profile) |
P83916 | CBX1_HUMAN | Chromo PF00385 (21-69) Chromo_shadow PF01393 (118-170) |
Cbx1 | 105369 | P83917 | CBX1_MOUSE | # | # | Histone modification read | # | 21047797 | # | histone | H3K9me3, H3K27me3 | # | 21047797 | Binding data indicate that Cbx1, -3, and -5 bind with greater affinity to H3K9me3. | # |
CBX2
(details) |
1552 | chromobox homolog 2 | 84733 (SSTAR profile) |
Q14781 | CBX2_HUMAN | Chromo PF00385 (12-60) CBX7_C PF17218 (492-523) |
Cbx2 | 88289 | P30658 | CBX2_MOUSE | # | # | Histone modification read | # | 21047797 | PRC1 | histone | H3K9me3, H3K27me3 | # | 21047797 | Cbx2 and Cbx7 recognized both H3K9me3 and H3K27me3, whereas Cbx4 preferred H3K9me3. | # |
CBX3
(details) |
1553 | chromobox homolog 3 | 11335 (SSTAR profile) |
Q13185 | CBX3_HUMAN | Chromo PF00385 (30-78) Chromo_shadow PF01393 (123-174) |
Cbx3 | 108515 | P23198 | CBX3_MOUSE | # | # | Histone modification read | # | 21047797 | RING2-L3MBTL2, L3MBTL1 | histone | H3K9me3 | # | 21047797 | Cbx3 chromodomain binds to H3K9me3 but not to H3K27me3. | # |
CBX4
(details) |
1554 | chromobox homolog 4 | 8535 (SSTAR profile) |
O00257 | CBX4_HUMAN | Chromo PF00385 (11-60) CBX7_C PF17218 (533-559) |
Cbx4 | 1195985 | O55187 | CBX4_MOUSE | # | # | Histone modification read | # | 21047797 | PRC1 | histone | H3K9me3 | # | 21047797 | Cbx2 and Cbx7 recognizes both H3K9me3 and H3K27me3, whereas Cbx4 prefers H3K9me3. | # |
CBX5
(details) |
1555 | chromobox homolog 5 | 23468 (SSTAR profile) |
P45973 | CBX5_HUMAN | Chromo PF00385 (20-69) Chromo_shadow PF01393 (123-174) |
Cbx5 | 109372 | Q61686 | CBX5_MOUSE | # | # | Histone modification read | # | 21047797 | # | histone | H3K9me, H3K27me3 | # | 21047797 | Excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). | # |
CBX6
(details) |
1556 | chromobox homolog 6 | 23466 (SSTAR profile) |
O95503 | CBX6_HUMAN | Chromo PF00385 (11-60) CBX7_C PF17218 (358-386) |
Cbx6 | 3512628 | Q9DBY5 | CBX6_MOUSE | # | # | Histone modification read | # | 21047797 | PRC1 | histone | H3K9me3, H3K27me3 | # | 21047797 | Cbx6 and Cbx8 have functional aromatic cages and hydrophobic fingers very similar to those of Cbx2, -4, and -7, but the former bind to H3K9me3 and H3K27me3 peptides with much lower affinity. | # |
CBX7
(details) |
1557 | chromobox homolog 7 | 23492 (SSTAR profile) |
O95931 | CBX7_HUMAN | Chromo PF00385 (11-60) CBX7_C PF17218 (212-239) |
Cbx7 | 1196439 | Q8VDS3 | CBX7_MOUSE | # | # | Histone modification read | # | 21047797 | PRC1 | histone | H3K9me3, H3K27me3 | # | 21047797 | Cbx2 and Cbx7 recognize both H3K9me3 and H3K27me3, whereas Cbx4 prefers H3K9me3. | # |
CBX8
(details) |
15962 | chromobox homolog 8 | 57332 (SSTAR profile) |
Q9HC52 | CBX8_HUMAN | Chromo PF00385 (11-60) CBX7_C PF17218 (348-381) |
Cbx8 | 1353589 | Q9QXV1 | CBX8_MOUSE | # | # | Histone modification read | # | 21047797 | PRC1 | histone | H3K9me3, H3K27me3 | # | 21047797 | Cbx6 and Cbx8 have functional aromatic cages and hydrophobic fingers very similar to those of Cbx2, -4, and -7, but the former bind to H3K9me3 and H3K27me3 peptides with much lower affinity. | # |
CCDC101
(details) |
25156 | coiled-coil domain containing 101 | 112869 (SSTAR profile) |
Q96ES7 | SGF29_HUMAN | SGF29_Tudor PF07039 (159-288) | Ccdc101 | 1922815 | Q9DA08 | SGF29_MOUSE | # | # | Histone modification read | # | 21685874 | ATAC | histone | H3K4me, H3K4me3 | # | 21685874 | The crystal structures of the tandem Tudor domains of Saccharomyces cerevisiae and human Sgf29=CCDC101 and their complexes with H3K4me2 and H3K4me3 peptides, respectively, shows that Sgf29 selectively binds H3K4me2/3 marks. | # |
CDC6
(details) |
1744 | cell division cycle 6 | 990 (SSTAR profile) |
Q99741 | CDC6_HUMAN | domain PF13191 (173-315) domain PF22606 (346-403) Cdc6_C PF09079 (455-542) |
Cdc6 | 1345150 | O89033 | CDC6_MOUSE | # | # | Chromatin remodeling | # | 22358331 | # | chromatin | # | # | # | CDC6 interacts with the HP1 chromoshadow domain. | # |
CDC73
(details) |
16783 | cell division cycle 73 | 79577 (SSTAR profile) |
Q6P1J9 | CDC73_HUMAN | CDC73_N PF16050 (1-296) CDC73_C PF05179 (358-520) |
Cdc73 | 2384876 | Q8JZM7 | CDC73_MOUSE | # | # | Histone modification write cofactor | Histone methylation | # | # | histone | # | # | # | UniProt: PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). | # |
CDK1
(details) |
1722 | cyclin-dependent kinase 1 | 983 (SSTAR profile) |
P06493 | CDK1_HUMAN | Pkinase PF00069 (4-287) | Cdk1 | 88351 | P11440 | CDK1_MOUSE | CDK | Cyclin-dependent kinases | Histone modification write | Histone phosphorylation | 22509284 | # | histone | H1 | H1ph | 22509284 | Histone H1, a known CDKs target protein, was strongly phosphorylated by CDK1/cyclin B, illustrating the normal activity of CDK1/cyclin B. | # |
CDK17
(details) |
8750 | cyclin-dependent kinase 17 | 5128 (SSTAR profile) |
Q00537 | CDK17_HUMAN | Pkinase PF00069 (192-473) | Cdk17 | 97517 | Q8K0D0 | CDK17_MOUSE | CDK | Cyclin-dependent kinases | Histone modification write | Histone phosphorylation | # | # | histone | H1 | # | # | Has a Ser/Thr-phosphorylating activity for histone H1. (Annotated by similarity.) | # |
CDK2
(details) |
1771 | cyclin-dependent kinase 2 | 1017 (SSTAR profile) |
P24941 | CDK2_HUMAN | Pkinase PF00069 (4-286) | Cdk2 | 104772 | P97377 | CDK2_MOUSE | CDK | Cyclin-dependent kinases | Histone modification write | Histone phosphorylation | 15753125 | # | histone | H1S, H1T | H1Sph, H1Tph | 15753125 | Cdk2 is one of the enzymes recruited to replication foci (by Cdc45 or other fork proteins), followed by H1 phosphorylation and chromatin unfolding. | # |
CDK3
(details) |
1772 | cyclin-dependent kinase 3 | 1018 (SSTAR profile) |
Q00526 | CDK3_HUMAN | Pkinase PF00069 (4-286) | Cdk3-ps | 1916931 | Q80YP0 | CDK3_MOUSE | CDK | Cyclin-dependent kinases | Histone modification write | Histone phosphorylation | # | # | histone | H1 | # | # | Cdk3 is supposed to phosphorylate histone H1, but have found no good reference to document it. | # |
CDK5
(details) |
1774 | cyclin-dependent kinase 5 | 1020 (SSTAR profile) |
Q00535 | CDK5_HUMAN | Pkinase PF00069 (4-286) | Cdk5 | 101765 | P49615 | CDK5_MOUSE | CDK | Cyclin-dependent kinases | Histone modification write | Histone phosphorylation | 19729834 | # | histone | H1 | # | 19729834 | Reciprocal coimmunoprecipitation studies with antibodies to either myc or Cdk5 revealed that cyclin I bound to and activated endogenous Cdk5, as analyzed by histone H1 phosphorylation. | # |
CDK7
(details) |
1778 | cyclin-dependent kinase 7 | 1022 (SSTAR profile) |
P50613 | CDK7_HUMAN | Pkinase PF00069 (12-295) | Cdk7 | 102956 | Q03147 | CDK7_MOUSE | CDK, TFIIH | Cyclin-dependent kinases, General transcription factor IIH complex subunits | Histone modification write | Histone phosphorylation | 10722743 | # | histone | H1 | # | 10722743 | Cdk7, is able to phosphorylate histone H1, and the basal activity is increased 2-fold in the presence of recombinant human cyclin H (the activating partner of Cdk7). | # |
CDK9
(details) |
1780 | cyclin-dependent kinase 9 | 1025 (SSTAR profile) |
P50750 | CDK9_HUMAN | Pkinase PF00069 (19-315) | Cdk9 | 1328368 | Q99J95 | CDK9_MOUSE | CDK | Cyclin-dependent kinases | Histone modification cofactor | # | 19844166 | # | histone | # | # | # | CDK9 functions to guide a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3. UniProt: Protein kinase involved in the regulation of transcription. Part of the complex P-TEFb involved in cotranscriptional histone modification. | # |
CDY1
(details) |
1809 | chromodomain protein, Y-linked, 1 | 9085 (SSTAR profile) |
Q9Y6F8 | CDY1_HUMAN | Chromo PF00385 (6-57) ECH_1 PF00378 (303-535) |
# | # | # | # | # | # | Histone modification write | Histone acetylation | 12072557 | # | histone | H4 | # | 12072557 | Human CDY and mouse CDYL=CDY1 proteins exhibit histone acetyltransferase activity in vitro, with a strong preference for histone H4. | # |
CDY1B
(details) |
23920 | chromodomain protein, Y-linked, 1B | 253175 (SSTAR profile) |
Q9Y6F8 | CDY1_HUMAN | Chromo PF00385 (6-57) ECH_1 PF00378 (303-535) |
# | # | # | # | # | # | Histone modification write | Histone acetylation | 12072557 | # | histone | H4 | # | 12072557 | Human CDY and mouse CDYL=CDY1B proteins exhibit histone acetyltransferase activity in vitro, with a strong preference for histone H4. | # |
CDY2A
(details) |
1810 | chromodomain protein, Y-linked, 2A | 9426 (SSTAR profile) |
Q9Y6F7 | CDY2_HUMAN | Chromo PF00385 (6-57) ECH_1 PF00378 (304-537) |
# | # | # | # | # | # | Histone modification write | Histone acetylation | # | # | histone | # | # | # | May have histone acetyltransferase activity. (Annotated by similarity.) | # |
CDY2B
(details) |
23921 | chromodomain protein, Y-linked, 2B | 203611 (SSTAR profile) |
Q9Y6F7 | CDY2_HUMAN | Chromo PF00385 (6-57) ECH_1 PF00378 (304-537) |
# | # | # | # | # | # | Histone modification write | Histone acetylation | 22498752 | # | histone | # | # | # | CDY2B annotated as histone acetyltransferase in UniProt. | # |
CDYL
(details) |
1811 | chromodomain protein, Y-like | 9425 (SSTAR profile) |
Q9Y232 | CDYL1_HUMAN | Chromo PF00385 (61-112) ECH_1 PF00378 (363-594) |
Cdyl | 1339956 | Q9WTK2 | CDYL_MOUSE | # | # | Histone modification write | Histone acetylation | 12072557 | # | histone | H4 | # | 12072557 | Human CDY and mouse CDYL proteins exhibit histone acetyltransferase activity in vitro, with a strong preference for histone H4. | # |
CDYL2
(details) |
23030 | chromodomain protein, Y-like 2 | 124359 (SSTAR profile) |
Q8N8U2 | CDYL2_HUMAN | Chromo PF00385 (7-57) ECH_1 PF00378 (271-500) |
Cdyl2 | 1923046 | Q9D5D8 | CDYL2_MOUSE | # | # | Histone modification read | # | 23455924 | # | histone | H3K9me3 | # | 21774827 | Many mouse chromodomain proteins are reported to bind H3K9me3 in vitro, including CDYL, CDYL2, CBX2, CBX4, CBX7 and M-phase phosphoprotein 8 (MPP8). | # |
CECR2
(details) |
1840 | cat eye syndrome chromosome region, candidate 2 | 27443 (SSTAR profile) |
Q9BXF3 | CECR2_HUMAN | Bromodomain PF00439 (446-524) | Cecr2 | 1923799 | # | # | # | # | Histone modification read | # | 22464331 | CERF, CERF | histone | H2A, H3 | # | 22464331 | Fig. 5 in the reference. | # |
CELF1
(details) |
2549 | CUGBP Elav-like family member 1 (CELF-1) (50 kDa nuclear polyadenylated RNA-binding protein) (Bruno-like protein 2) (CUG triplet repeat RNA-binding protein 1) (CUG-BP1) (CUG-BP- and ETR-3-like factor 1) (Deadenylation factor CUG-BP) (Embryo deadenylation element-binding protein homolog) (EDEN-BP homolog) (RNA-binding protein BRUNOL-2) | 10658 (SSTAR profile) |
Q92879 | CELF1_HUMAN | RRM_1 PF00076 (19-85, 110-174, 403-473) | Celf1 | 1342295 | P28659 | CELF1_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 11158314, 12649496 | # | RNA | mRNA | # | 11158314, 12649496 | Regulates MSE-dependent alternative splicing of cTNT during development in vertebrates. | New |
CELF2
(details) |
2550 | CUGBP Elav-like family member 2 (CELF-2) (Bruno-like protein 3) (CUG triplet repeat RNA-binding protein 2) (CUG-BP2) (CUG-BP- and ETR-3-like factor 2) (ELAV-type RNA-binding protein 3) (ETR-3) (Neuroblastoma apoptosis-related RNA-binding protein) (hNAPOR) (RNA-binding protein BRUNOL-3) | 10659 (SSTAR profile) |
O95319 | CELF2_HUMAN | RRM_1 PF00076 (43-110, 134-198, 425-495) | Celf2 | 1338822 | Q9Z0H4 | CELF2_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 11158314, 12649496 | # | RNA | mRNA | # | 11158314, 12649496 | Regulates MSE-dependent alternative splicing of cTNT during development in vertebrates. | New |
CELF3
(details) |
11967 | CUGBP Elav-like family member 3 (CELF-3) (Bruno-like protein 1) (CAG repeat protein 4) (CUG-BP- and ETR-3-like factor 3) (ELAV-type RNA-binding protein 1) (ETR-1) (Expanded repeat domain protein CAG/CTG 4) (RNA-binding protein BRUNOL-1) (Trinucleotide repeat-containing gene 4 protein) | 11189 (SSTAR profile) |
Q5SZQ8 | CELF3_HUMAN | RRM_1 PF00076 (9-75, 97-161, 382-452) | Celf3 | 1926034 | Q8CIN6 | CELF3_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 11158314, 12649496 | # | RNA | mRNA | # | 11158314, 12649496 | Regulates MSE-dependent alternative splicing of cTNT during development in vertebrates. | New |
CELF4
(details) |
14015 | CUGBP Elav-like family member 4 (CELF-4) (Bruno-like protein 4) (CUG-BP- and ETR-3-like factor 4) (RNA-binding protein BRUNOL-4) | 56853 (SSTAR profile) |
Q9BZC1 | CELF4_HUMAN | RRM_1 PF00076 (56-121, 154-216, 442-473) | Celf4 | 1932407 | Q7TSY6 | CELF4_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 11158314, 12649496 | # | RNA | mRNA | # | 11158314, 12649496 | Regulates MSE-dependent alternative splicing of cTNT during development in vertebrates. | New |
CELF5
(details) |
14058 | CUGBP Elav-like family member 5 (CELF-5) (Bruno-like protein 5) (CUG-BP- and ETR-3-like factor 5) (RNA-binding protein BRUNOL-5) | 60680 (SSTAR profile) |
Q8N6W0 | CELF5_HUMAN | RRM_1 PF00076 (47-112, 136-198, 402-472) | Celf5 | 2442333 | D3Z4T1 | D3Z4T1_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 11158314, 12649496 | # | RNA | mRNA | # | 11158314, 12649496 | Regulates MSE-dependent alternative splicing of cTNT during development in vertebrates. | New |
CELF6
(details) |
14059 | CUGBP Elav-like family member 6 (CELF-6) (Bruno-like protein 6) (CUG-BP- and ETR-3-like factor 6) (RNA-binding protein BRUNOL-6) | 60677 (SSTAR profile) |
Q96J87 | CELF6_HUMAN | RRM_1 PF00076 (48-113, 136-199, 398-468) | Celf6 | 1923433 | Q7TN33 | CELF6_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 11158314, 12649496 | # | RNA | mRNA | # | 11158314, 12649496 | Regulates MSE-dependent alternative splicing of cTNT during development in vertebrates. | New |
CENPC
(details) |
1854 | centromere protein C | 1060 (SSTAR profile) |
Q03188 | CENPC_HUMAN | CENP_C_N PF15622 (1-320) CENP-C_mid PF15620 (324-596) CENP-C_C PF11699 (857-940) |
Cenpc1 | 99700 | P49452 | CENPC_MOUSE | # | # | DNA modification | DNA methylation | 19482874 | # | DNA | C | 5mC | 19482874 | CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. | # |
CHAF1A
(details) |
1910 | chromatin assembly factor 1, subunit A (p150) | 10036 (SSTAR profile) |
Q13111 | CAF1A_HUMAN | CAF1-p150_N PF15557 (18-224) CAF-1_p150 PF11600 (324-482) CAF1A PF12253 (560-633) CAF1-p150_C2 PF15539 (666-932) |
Chaf1a | 1351331 | Q9QWF0 | CAF1A_MOUSE | # | # | Chromatin remodeling | # | 7600578 | CAF-1 | histone | H3, H4 | # | 7600578 | p150=CHAF1A and p60 directly interact and are both required for DNA replication-dependent assembly of nucleosomes. Deletion of the p60-binding domain from the p150 protein prevents chromatin assembly. p150 and p60 form complexes with newly synthesized histones H3 and acetylated H4 in human cell extracts, suggesting that such complexes are intermediates between histone synthesis and assembly onto replicating DNA. | # |
CHAF1B
(details) |
1911 | chromatin assembly factor 1, subunit B (p60) | 8208 (SSTAR profile) |
Q13112 | CAF1B_HUMAN | WD40 PF00400 (60-94, 121-157, 162-199, 345-372) CAF-1_p60_C PF15512 (384-540) |
Chaf1b | 1314881 | Q9D0N7 | CAF1B_MOUSE | WDR | WD repeat domain containing | Chromatin remodeling | # | 7600578 | WINAC, CAF-1 | histone | H3, H4 | # | 7600578 | p150 and p60==CHAF1B directly interact and are both required for DNA replication-dependent assembly of nucleosomes. Deletion of the p60-binding domain from the p150 protein prevents chromatin assembly. p150 and p60 form complexes with newly synthesized histones H3 and acetylated H4 in human cell extracts, suggesting that such complexes are intermediates between histone synthesis and assembly onto replicating DNA. | # |
CHD1
(details) |
1915 | chromodomain helicase DNA binding protein 1 | 1105 (SSTAR profile) |
O14646 | CHD1_HUMAN | Chromo PF00385 (313-351, 389-443) SNF2-rel_dom PF00176 (482-764) Helicase_C PF00271 (789-902) CDH1_2_SANT_HL1 PF18375 (1124-1211) CHD1-like_C PF13907 (1409-1500) |
Chd1 | 88393 | P40201 | CHD1_MOUSE | # | # | Chromatin remodeling | # | 12592387 | # | DNA | # | # | 12592387 | These proteins have a DNA-binding domain as well as a chromodomain motif that can directly effect chromatin structure and gene transcription. There are currently four known members of this gene family in humans (CHD1–CHD4). | # |
CHD1L
(details) |
1916 | chromodomain helicase DNA binding protein 1-like | 9557 (SSTAR profile) |
Q86WJ1 | CHD1L_HUMAN | SNF2-rel_dom PF00176 (49-327) Helicase_C PF00271 (348-459) |
Chd1l | 1915308 | Q9CXF7 | CHD1L_MOUSE | # | # | Chromatin remodeling | # | 19661379 | # | DNA | # | # | 19661379 | A chromatin-remodeling enzyme, ALC1 (Amplified in Liver Cancer 1, also known as CHD1L), that interacts with poly(ADP-ribose) and catalyzes PARP1-stimulated nucleosome sliding. | # |
CHD2
(details) |
1917 | chromodomain helicase DNA binding protein 2 | 1106 (SSTAR profile) |
O14647 | CHD2_HUMAN | Chromo PF00385 (300-338, 378-447) SNF2-rel_dom PF00176 (487-767) Helicase_C PF00271 (792-905) CDH1_2_SANT_HL1 PF18375 (1129-1219) CHD1-like_C PF13907 (1465-1553) |
Chd2 | 2448567 | E9PZM4 | CHD2_MOUSE | # | # | Chromatin remodeling | # | 12592387 | # | DNA | # | # | 12592387 | These proteins have a DNA-binding domain as well as a chromodomain motif that can directly effect chromatin structure and gene transcription. There are currently four known members of this gene family in humans (CHD1–CHD4). | # |
CHD3
(details) |
1918 | chromodomain helicase DNA binding protein 3 | 1107 (SSTAR profile) |
Q12873 | CHD3_HUMAN | CHDNT PF08073 (155-201) PHD PF00628 (382-423, 458-500) Chromo PF00385 (630-682) SNF2-rel_dom PF00176 (738-1034) Helicase_C PF00271 (1061-1174) DUF1087 PF06465 (1294-1350) CHDII_SANT-like PF06461 (1376-1517) CHDCT2 PF08074 (1737-1884) |
Chd3 | 1344395 | # | # | PHF | Zinc fingers, PHD-type | Chromatin remodeling | # | 12592387 | NuRD | DNA | # | # | 12592387 | These proteins have a DNA-binding domain as well as a chromodomain motif that can directly effect chromatin structure and gene transcription. There are currently four known members of this gene family in humans (CHD1–CHD4). | # |
CHD4
(details) |
1919 | chromodomain helicase DNA binding protein 4 | 1108 (SSTAR profile) |
Q14839 | CHD4_HUMAN | CHDNT PF08073 (165-217) PHD PF00628 (373-414, 452-493) Chromo PF00385 (621-673) SNF2-rel_dom PF00176 (728-1024) Helicase_C PF00271 (1052-1164) DUF1087 PF06465 (1291-1350) CHDII_SANT-like PF06461 (1379-1520) CHDCT2 PF08074 (1726-1872) |
Chd4 | 1344380 | Q6PDQ2 | CHD4_MOUSE | PHF | Zinc fingers, PHD-type | Chromatin remodeling | # | 12592387 | NuRD | DNA | # | # | 12592387 | These proteins have a DNA-binding domain as well as a chromodomain motif that can directly effect chromatin structure and gene transcription. There are currently four known members of this gene family in humans (CHD1–CHD4). | # |
CHD5
(details) |
16816 | chromodomain helicase DNA binding protein 5 | 26038 (SSTAR profile) |
Q8TDI0 | CHD5_HUMAN | CHDNT PF08073 (149-200) PHD PF00628 (346-387, 418-460) Chromo PF00385 (590-643) SNF2-rel_dom PF00176 (701-998) Helicase_C PF00271 (1025-1138) DUF1087 PF06465 (1299-1354) CHDII_SANT-like PF06461 (1383-1527) CHDCT2 PF08074 (1733-1879) |
Chd5 | 3036258 | A2A8L1 | CHD5_MOUSE | PHF | Zinc fingers, PHD-type | Chromatin remodeling | # | 12592387 | # | histone | H3K27me3, H3K4 | # | 12592387, 23948251 | A novel gene encoding a protein with chromatin remodeling, helicase and DNA-binding motifs. This gene (CHD5) is the fifth member of the CHD gene family identified in humans. | # |
CHD6
(details) |
19057 | chromodomain helicase DNA binding protein 6 | # | Q8TD26 | CHD6_HUMAN | Chromo PF00385 (292-354, 375-428) SNF2-rel_dom PF00176 (464-750) Helicase_C PF00271 (784-897) |
Chd6 | 1918639 | A3KFM7 | CHD6_MOUSE | # | # | Chromatin remodeling | # | 12592387 | # | chromatin | # | # | 12592387 | A novel gene encoding a protein with chromatin remodeling, helicase and DNA-binding motifs. This gene (CHD5=CHD6) is the fifth member of the CHD gene family identified in humans. | # |
CHD7
(details) |
20626 | chromodomain helicase DNA binding protein 7 | 55636 (SSTAR profile) |
Q9P2D1 | CHD7_HUMAN | Chromo PF00385 (801-861, 881-935) SNF2-rel_dom PF00176 (968-1257) Helicase_C PF00271 (1291-1404) BRK PF07533 (2563-2609, 2644-2687) |
Chd7 | 2444748 | A2AJK6 | CHD7_MOUSE | # | # | Chromatin remodeling | # | 5201778 | # | chromatin | # | # | 5201778 | CHD7 protein counts several functional domains: two chromo (chromatin organization modifier), one SNF2/SWI, one helicase and two BRK domains (Figure 4). Chromo domains are implicated in the recognition of lysine-methylated histone tails and of DNA (and RNA) targets. | # |
CHD8
(details) |
20153 | chromodomain helicase DNA binding protein 8 | 57680 (SSTAR profile) |
Q9HCK8 | CHD8_HUMAN | Chromo PF00385 (642-703, 724-778) SNF2-rel_dom PF00176 (813-1100) Helicase_C PF00271 (1135-1247) BRK PF07533 (2310-2351) |
Chd8 | 1915022 | Q09XV5 | CHD8_MOUSE | # | # | Chromatin remodeling | # | 18378692 | CHD8, MLL2/3, MLL4/WBP7 | chromatin | H1 | # | 19151705, 18378692 | CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes. | # |
CHD9
(details) |
25701 | chromodomain helicase DNA binding protein 9 | 80205 (SSTAR profile) |
Q3L8U1 | CHD9_HUMAN | Chromo PF00385 (690-751, 773-827) SNF2-rel_dom PF00176 (863-1149) Helicase_C PF00271 (1183-1296) BRK PF07533 (2484-2528, 2555-2603) |
Chd9 | 1924001 | Q8BYH8 | CHD9_MOUSE | # | # | Chromatin remodeling | # | 16554032 | # | DNA | # | # | 16554032 | PRIC320=CHD9 is similar to a recently described chromodomain helicase DNA-binding protein [27]. The recognition of this chromatin remodeling function and nuclear receptor coactivator function is suggestive of the multiple roles played by these nuclear receptor cofactors. | # |
CHEK1
(details) |
1925 | checkpoint kinase 1 | 1111 (SSTAR profile) |
O14757 | CHK1_HUMAN | Pkinase PF00069 (10-264) | Chek1 | 1202065 | O35280 | CHK1_MOUSE | # | # | Histone modification write | Histone phosphorylation | # | # | histone | H3.1 | H3.1ph | # | UniProt: May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones. Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes. | # |
CHRAC1
(details) |
13544 | chromatin accessibility complex 1 | 54108 (SSTAR profile) |
Q9NRG0 | CHRC1_HUMAN | CBFD_NFYB_HMF PF00808 (18-79) | Chrac1 | 2135796 | Q9JKP8 | CHRC1_MOUSE | # | # | Histone chaperone | # | 10880450 | CHRAC | DNA | # | # | 10880450 | Human homologues of two novel putative histone-fold proteins in Drosophila CHRAC are present in HuCHRAC. The two human histone-fold proteins form a stable complex that binds naked DNA but not nucleosomes. | # |
CHTOP
(details) |
24511 | chromatin target of PRMT1 | 26097 (SSTAR profile) |
Q9Y3Y2 | CHTOP_HUMAN | FoP_duplication PF13865 (167-243) | Chtop | 1913761 | Q9CY57 | CHTOP_MOUSE | # | # | # | # | 25284789 | # | DNA | # | # | # | 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex. | # |
CHUK
(details) |
1974 | conserved helix-loop-helix ubiquitous kinase | 1147 (SSTAR profile) |
O15111 | IKKA_HUMAN | Pkinase PF00069 (16-290) IKBKB_SDD PF18397 (387-658) IKKbetaNEMObind PF12179 (708-744) |
Chuk | 99484 | Q60680 | IKKA_MOUSE | # | # | Histone modification write | Histone phosphorylation | 17434128 | # | histone | H3 | # | 17434128 | In the nucleus, IKKα=CHUK is recruited to the promoter region of the NF-κB-regulated genes by interacting with CBP, and contributes to NF-κB-mediated gene expressions through phosphorylation of histone H3. | # |
CIR1
(details) |
24217 | corepressor interacting with RBPJ, 1 | 9541 (SSTAR profile) |
Q86X95 | CIR1_HUMAN | Cir_N PF10197 (13-49) | Cir1 | 1914185 | Q9DA19 | CIR1_MOUSE | # | # | Histone modification read | # | 9874765 | # | histone | # | # | 9874765 | CIR binds to histone deacetylase and to SAP30 and serves as a linker between CBF1 and the histone deacetylase complex. | # |
CIT
(details) |
1985 | citron rho-interacting serine/threonine kinase | 11113 (SSTAR profile) |
O14578 | CTRO_HUMAN | Pkinase PF00069 (97-360) Pkinase_C PF00433 (376-422) PH PF00169 (1445-1563) CNH PF00780 (1602-1855) |
Cit | 105313 | P49025 | CTRO_MOUSE | # | # | Histone modification write cofactor, Histone modification write cofactor | Histone methylation, Histone phosphorylation | 18245345 | # | histone | H3K9 | H3K9me | 18245345 | Drosophila sticky/citron kinase (=CIT) is a regulator of cell-cycle progression, genetically interacts with Argonaute 1 and modulates epigenetic gene silencing. | # |
CLNS1A
(details) |
2080 | chloride channel, nucleotide-sensitive, 1A | 1207 (SSTAR profile) |
P54105 | ICLN_HUMAN | Voldacs PF03517 (35-159) | Clns1a | 109638 | Q61189 | ICLN_MOUSE | # | # | Histone modification write cofactor | Histone methylation | # | methylosome | # | # | # | # | Part of the methylosome complex | # |
CLOCK
(details) |
2082 | clock circadian regulator | 9575 (SSTAR profile) |
O15516 | CLOCK_HUMAN | HLH PF00010 (34-83) PAS PF00989 (109-177) PAS_11 PF14598 (274-377) |
Clock | 99698 | O08785 | CLOCK_MOUSE | KAT, bHLH | Chromatin-modifying enzymes / K-acetyltransferases, Basic helix-loop-helix proteins | Histone modification write | Histone acetylation | # | # | histone | H3, H4 | # | # | Acetylates primarily histones H3 and H4. (Annotated by similarity.) | # |
CRB2
(details) |
18688 | crumbs family member 2 | 286204 (SSTAR profile) |
Q5IJ48 | CRUM2_HUMAN | EGF PF00008 (110-144, 149-179, 188-259, 321-356, 361-384, 609-639, 811-841, 1060-1092, 1176-1209) Laminin_G_2 PF02210 (503-587, 668-775, 898-1020) hEGF PF12661 (1098-1128, 1137-1171) |
Crb2 | 2679260 | Q80YA8 | CRUM2_MOUSE | # | # | Histone modification read | # | 21423274 | # | histone | H4K20 | # | 21423274 | Table 1 in the reference. | # |
CREBBP
(details) |
2348 | CREB binding protein | 1387 (SSTAR profile) |
Q92793 | CBP_HUMAN | zf-TAZ PF02135 (351-431, 1772-1843) KIX PF02172 (590-669) Bromodomain PF00439 (1103-1176) RING_CBP-p300 PF06001 (1192-1230) HAT_KAT11 PF08214 (1340-1645) ZZ PF00569 (1702-1743) Creb_binding PF09030 (2035-2111) |
Crebbp | 1098280 | P45481 | CBP_MOUSE | KAT | Chromatin-modifying enzymes / K-acetyltransferases | Histone modification write | Histone acetylation | 8945521 | # | histone | # | # | 8945521 | The transcriptional coactivators p300 and CBP=CREBBP are histone acetyltransferases. | # |
CSNK2A1
(details) |
2457 | casein kinase 2, alpha 1 polypeptide | 1457 (SSTAR profile) |
P68400 | CSK21_HUMAN | Pkinase PF00069 (39-324) | Csnk2a1 | 88543 | Q60737 | CSK21_MOUSE | # | # | Histone modification | # | 24217316, 22325352 | RING2-FBRS | histone | # | # | 24217316, 22325352 | Part of a RING2 complex. | # |
CSRP2BP
(details) |
15904 | CSRP2 binding protein | 57325 (SSTAR profile) |
Q9H8E8 | CSR2B_HUMAN | Acetyltransf_1 PF00583 (669-751) | Csrp2bp | 1917264 | Q8CID0 | CSR2B_MOUSE | # | # | Histone modification write | Histone acetylation | 19103755 | ATAC | histone | H4 | # | 19103755 | The SANT domains in ADA2a and ZZZ3/ATAC1 might enable the complex to associate with nucleosome tails in order to potentiate the catalytic activities of GCN5 and ATAC2, similar to what has been shown for the SANT domains in yeast Ada2 and Swi3. | # |
CTBP1
(details) |
2494 | C-terminal binding protein 1 | 1487 (SSTAR profile) |
Q13363 | CTBP1_HUMAN | 2-Hacid_dh_C PF02826 (135-317) | Ctbp1 | 1201685 | O88712 | CTBP1_MOUSE | # | # | Chromatin remodeling | # | 21102443 | LSD-CoREST | chromatin | # | # | 21102443 | CtBP is a homodimer or heterodimer of CtBP1 and CtBP2 that assembles with a diverse array of factors that regulate chromatin structure. | # |
CTBP2
(details) |
2495 | C-terminal binding protein 2 | 1488 (SSTAR profile) |
P56545 | CTBP2_HUMAN | 2-Hacid_dh_C PF02826 (141-323) | Ctbp2 | 1201686 | P56546 | CTBP2_MOUSE | # | # | Histone modification write cofactor | Histone methylation | 16702210 | # | histone | H3K9 | H3K9me, H3K9me2 | 16702210 | It is possible that CtBPs or CtBP-interacting molecules have various impacts on the G9a/GLP-mediated (a SET-domain mammalian histone methyltransferase responsible for mono- and dimethylation of lysine 9 in histone H3 (H3K9)) functions through Wiz interaction. | # |
CTCF
(details) |
13723 | CCCTC-binding factor (zinc finger protein) | 10664 (SSTAR profile) |
P49711 | CTCF_HUMAN | zf-C2H2 PF00096 (266-288, 294-316, 322-345, 351-373, 379-401, 437-460, 555-575) | Ctcf | 109447 | Q61164 | CTCF_MOUSE | ZNF | Zinc fingers, C2H2-type | Chromatin remodeling, TF | TF activator | 16949368 | # | DNA | DNA motif | # | 16949368 | A CTCF-CHD8 complex is involved in both enhancer blocking and epigenetic remodeling at chromatin boundary in vivo. | # |
CTCFL
(details) |
16234 | CCCTC-binding factor (zinc finger protein)-like | 140690 (SSTAR profile) |
Q8NI51 | CTCFL_HUMAN | zf-C2H2 PF00096 (313-336, 342-364, 398-421, 428-451, 546-566) | Ctcfl | 3652571 | A2APF3 | CTCFL_MOUSE | ZNF | Zinc fingers, C2H2-type | Chromatin remodeling | # | 18765639 | # | DNA | # | # | 18765639 | BORIS=CTCFL acts as a scaffold upon which BAT3 and SET1A assemble and through which BAT3 and SET1A exert their effects upon chromatin structure and gene expression. In contrast to CTCF, BORIS appears to be a methylation-independent DNA-binding protein (28b) that activates, rather than inhibits, gene expression. | # |
CTR9
(details) |
16850 | CTR9, Paf1/RNA polymerase II complex component | 9646 (SSTAR profile) |
Q6PD62 | CTR9_HUMAN | TPR_19 PF14559 (170-231, 508-564, 715-750) TPR_8 PF13181 (312-373, 681-714) TPR_10 PF13374 (451-484) domain PF13432 (567-680) |
Ctr9 | 109345 | Q62018 | CTR9_MOUSE | TTC | Tetratricopeptide (TTC) repeat domain containing | Histone modification cofactor | # | 24036311 | # | histone | H3K36 | # | # | CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development. | # |
CUL1
(details) |
2551 | cullin 1 | 8454 (SSTAR profile) |
Q13616 | CUL1_HUMAN | Cullin PF00888 (20-662) Cullin_Nedd8 PF10557 (706-766) |
Cul1 | 1349658 | Q9WTX6 | CUL1_MOUSE | # | # | Chromatin remodeling cofactor | # | 9663463 | # | histone | H3K9me3, H3K36me3, H1.4K26me3 | H3K9, H3K36, H1.4K26 | 21757720 | The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein. The JMJD2/KDM43 histone demethylase family removes trimethylated H3K9, H3K36, and H1.4K26 . | # |
CUL2
(details) |
2552 | cullin 2 | 8453 (SSTAR profile) |
Q13617 | CUL2_HUMAN | Cullin PF00888 (13-644) Cullin_Nedd8 PF10557 (675-736) |
Cul2 | 1918995 | Q9D4H8 | CUL2_MOUSE | # | # | Chromatin remodeling cofactor | # | # | # | chromatin | HP1 (Heterochromatin protein 1) | # | 9122164 | The VHL-HP1 (heterochromatin protein 1) interaction recruits VHL to chromatin. VHL interacts with elongin B, elongin C, and cullin 2 through its α domain and these proteins form an E3 ubiquitin ligase complex. | # |
CUL3
(details) |
2553 | cullin 3 | 8452 (SSTAR profile) |
Q13618 | CUL3_HUMAN | Cullin PF00888 (34-665) Cullin_Nedd8 PF10557 (698-760) |
Cul3 | 1347360 | Q9JLV5 | CUL3_MOUSE | # | # | Histone modification write | Histone ubiquitination | 15897469 | # | histone | MACROH2A | # | 15897469 | E3 ubiquitin ligase consisting of SPOP and CULLIN3=CUL3 is able to ubiquitinate the Polycomb group protein BMI1 and the variant histone MACROH2A. | # |
CUL4A
(details) |
2554 | cullin 4A | 8451 (SSTAR profile) |
Q13619 | CUL4A_HUMAN | Cullin PF00888 (63-661) Cullin_Nedd8 PF10557 (691-751) |
Cul4a | 1914487 | Q3TCH7 | CUL4A_MOUSE | # | # | Histone modification write | Histone ubiquitination | 16678110 | # | histone | H3, H4 | # | 16678110 | Results shown in Figure 4A demonstrate that knockdown of CUL4A or CUL4B significantly reduces H3 and H4 ubiquitylation levels, indicating that both CUL4A and CUL4B contribute to histone H3 and H4 ubiquitylation in vivo. | # |
CUL4B
(details) |
2555 | cullin 4B | 8450 (SSTAR profile) |
Q13620 | CUL4B_HUMAN | Cullin PF00888 (214-814) Cullin_Nedd8 PF10557 (844-905) |
Cul4b | 1919834 | A2A432 | CUL4B_MOUSE | # | # | Histone modification write | Histone ubiquitination | 16678110 | # | histone | H3, H4 | # | 16678110 | Results shown in Figure 4A demonstrate that knockdown of CUL4A or CUL4B significantly reduces H3 and H4 ubiquitylation levels, indicating that both CUL4A and CUL4B contribute to histone H3 and H4 ubiquitylation in vivo. | # |
CUL5
(details) |
2556 | cullin 5 | 8065 (SSTAR profile) |
Q93034 | CUL5_HUMAN | Cullin PF00888 (18-671) Cullin_Nedd8 PF10557 (711-772) |
Cul5 | 1922967 | Q9D5V5 | CUL5_MOUSE | # | # | DNA modification cofactor | DNA methylation | 20847044 | # | DNA | # | # | 20847044 | In cancer cells, many promoters become aberrantly methylated through the activity of the de novo DNA methyltransferases DNMT3a and DNMT3b and acquire repressive chromatin marks, and, indeed, DNMT3b interacted with CUL1, CUL2, CUL3, CUL4A, and CUL5. | # |
CXXC1
(details) |
24343 | CXXC finger protein 1 | 30827 (SSTAR profile) |
Q9P0U4 | CXXC1_HUMAN | PHD PF00628 (29-73) zf-CXXC PF02008 (163-208) CpG_bind_C PF12269 (400-636) |
Cxxc1 | 1921572 | Q9CWW7 | CXXC1_MOUSE | PHF | Zinc fingers, PHD-type | Chromatin remodeling, TF | # | 21407193 | COMPASS | DNA | CG, DNA motif | # | 21407193 | CFP1=CXXC1 is a CXXC domain-containing protein. CXXC domain proteins direct different chromatin-modifying activities to various chromatin regions. | # |
DAPK3
(details) |
2676 | death-associated protein kinase 3 | 1613 (SSTAR profile) |
O43293 | DAPK3_HUMAN | Pkinase PF00069 (13-275) | Dapk3 | 1203520 | O54784 | DAPK3_MOUSE | # | # | Histone modification write | Histone phosphorylation | 12560483 | # | histone | H3T11 | # | 12560483 | Dlk/ZIP=DAPK3 kinase phosphorylates histone H3 at a novel site, Thr11, rather than Ser10, which is characteristic of mitotic chromosomes. | # |
DAXX
(details) |
2681 | death-domain associated protein | 1616 (SSTAR profile) |
Q9UER7 | DAXX_HUMAN | Daxx PF03344 (56-145) DAXX_hist_bd PF20920 (301-381) |
Daxx | 1197015 | O35613 | DAXX_MOUSE | # | # | # | # | 23075851 | # | histone | H3.3 | # | # | DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition. | # |
DDB1
(details) |
2717 | damage-specific DNA binding protein 1, 127kDa | 1642 (SSTAR profile) |
Q16531 | DDB1_HUMAN | MMS1_N PF10433 (75-542) CPSF_A PF03178 (788-1100) |
Ddb1 | 1202384 | Q3U1J4 | DDB1_MOUSE | # | # | Histone modification write | Histone ubiquitination | 16678110 | # | histone | H2A | # | 16678110 | DDB1-CUL4ADDB2 E3 in vivo targets histone H2A for ubiquitination at UV-damage DNA sites, where DDB2 serves as the substrate receptor. | # |
DDB2
(details) |
2718 | damage-specific DNA binding protein 2, 48kDa | 1643 (SSTAR profile) |
Q92466 | DDB2_HUMAN | WD40 PF00400 (234-271, 284-316) | Ddb2 | 1355314 | Q99J79 | DDB2_MOUSE | WDR | WD repeat domain containing | Histone modification write cofactor | Histone ubiquitination | 16678110 | # | histone | # | # | 16678110 | DDB1-CUL4ADDB2 E3 in vivo targets histone H2A for ubiquitination at UV-damage DNA sites, where DDB2 serves as the substrate receptor. | # |
DDX17
(details) |
2740 | Probable ATP-dependent RNA helicase DDX17 (EC 3.6.4.13) (DEAD box protein 17) (DEAD box protein p72) (DEAD box protein p82) (RNA-dependent helicase p72) | 10521 (SSTAR profile) |
Q92841 | DDX17_HUMAN | DEAD PF00270 (195-365) Helicase_C PF00271 (405-512) |
Ddx17 | 1914290 | Q501J6 | DDX17_MOUSE | DDX | DEAD-box helicases | RNA modification | Alternative splicing | 24910439 | # | RNA | mRNA | # | 24910439 | Coregulator of master transcriptional regulators of differentiation | New |
DDX21
(details) |
2744 | DEAD (Asp-Glu-Ala-Asp) box helicase 21 | 9188 (SSTAR profile) |
Q9NR30 | DDX21_HUMAN | DEAD PF00270 (211-383) Helicase_C PF00271 (434-532) GUCT PF08152 (620-708) |
Ddx21 | 1860494 | Q9JIK5 | DDX21_MOUSE | DDX | DEAD-boxes | RNA modification | # | 11237763 | B-WICH | RNA | # | # | 11237763 | Human RNA helicase II/Gu (hRH II/Gu) protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. | # |
DDX5
(details) |
2746 | Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) | 1655 (SSTAR profile) |
P17844 | DDX5_HUMAN | DEAD PF00270 (118-288) Helicase_C PF00271 (328-435) P68HR PF08061 (500-532, 551-583) |
Ddx5 | 105037 | Q61656 | DDX5_MOUSE | DDX | DEAD-box helicases | RNA modification | Alternative splicing | 24910439 | # | RNA | RNA | # | 24910439 | Coregulator of master transcriptional regulators of differentiation | New |
DDX50
(details) |
17906 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 | 79009 (SSTAR profile) |
Q9BQ39 | DDX50_HUMAN | DEAD PF00270 (162-334) Helicase_C PF00271 (385-483) GUCT PF08152 (574-662) |
Ddx50 | 2182303 | Q99MJ9 | DDX50_MOUSE | DDX | DEAD-boxes | RNA modification | # | 11823437 | # | RNA | # | # | 11823437 | In addition to the proposed role of DEAD-box RNA helicases in transcription, some of these enzymes promote mRNA translation. | # |
DEK
(details) |
2768 | DEK proto-oncogene | 7913 (SSTAR profile) |
P35659 | DEK_HUMAN | DEK_C PF08766 (320-374) | Dek | 1926209 | Q7TNV0 | DEK_MOUSE | # | # | Chromatin remodeling | # | 17524367 | B-WICH | histone | H4 | # | 17524367 | It has been suggested that DEK functions as an “architectural” protein in chromatin. This is because DEK changes the structure of the DNA to which it is bound and could therefore influence gene activity. | # |
DHX9
(details) |
2750 | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | 1660 (SSTAR profile) |
Q08211 | DHX9_HUMAN | dsrm PF00035 (4-70, 180-251) DEAD PF00270 (395-547) Helicase_C PF00271 (639-768) HA2_N PF04408 (832-860) HA2_C PF21010 (861-919) OB_NTP_bind PF07717 (991-1073) |
Dhx9 | 108177 | O70133 | DHX9_MOUSE | DHX | DEAH-box helicases | RNA modification | Alternative splicing | 28221134 | # | RNA | mRNA | # | 28221134 | Regulates alternative splicing of E1A | New |
DMAP1
(details) |
18291 | DNA methyltransferase 1 associated protein 1 | 55929 (SSTAR profile) |
Q9NPF5 | DMAP1_HUMAN | SANT_DAMP1_like PF16282 (124-202) DMAP1 PF05499 (242-400) |
Dmap1 | 1913483 | Q9JI44 | DMAP1_MOUSE | # | # | Chromatin remodeling | # | 14966270 | NuA4, NuA4-related complex, SRCAP | chromatin | # | # | 14966270 | SANT-domain protein DMAP1 links NuA4 to DNA replication and is also present in distinct proteins | # |
DNAJC1
(details) |
20090 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 64215 (SSTAR profile) |
Q96KC8 | DNJC1_HUMAN | DnaJ PF00226 (65-126) Myb_DNA-binding PF00249 (496-541) |
Dnajc1 | 103268 | Q61712 | DNJC1_MOUSE | DNAJ | Heat shock proteins / DNAJ (HSP40) | Histone modification write cofactor, Histone modification erase cofactor | Histone acetylation, Histone deacetylation | 16271702 | # | histone | # | # | 16271702 | HTJ1=DNAJC1 consists of two SANT domains separated by a spacer region. SANT domains can also mediate protein–protein interaction, particularly with histone deacetylases and histone acetyl transferases. | # |
DNAJC2
(details) |
13192 | DnaJ (Hsp40) homolog, subfamily C, member 2 | 27000 (SSTAR profile) |
Q99543 | DNJC2_HUMAN | DnaJ PF00226 (88-157) domain PF21884 (178-283) RAC_head PF16717 (340-426) Myb_DNA-binding PF00249 (553-599) |
Dnajc2 | 99470 | P54103 | DNJC2_MOUSE | DNAJ | Heat shock proteins / DNAJ (HSP40) | Histone modification read | # | 21179169 | # | histone | H2A | # | 21179169 | The ubiquitin mark at histone H2A may be a docking site for ZRF1. | # |
DND1
(details) |
23799 | DND microRNA-mediated repression inhibitor 1 | 373863 (SSTAR profile) |
Q8IYX4 | DND1_HUMAN | RRM_1 PF00076 (60-122) DND1_DSRM PF14709 (256-331) |
Dnd1 | 2447763 | Q6VY05 | DND1_MOUSE | RBM | RNA binding motif (RRM) containing | RNA modification | # | 23890083 | # | RNA | # | # | 23890083 | The RNA binding protein DEAD-END (DND1) is one of the few proteins known to regulate microRNA (miRNA) activity at the level of miRNA-mRNA interaction. APOBEC3G may bind mRNAs (maybe together with DND1) and subsequently interact with components of the miRISC to activate translation repression or interact with translation initiation factors to inhibit them. APOBEC3G may bind to DND1 and sequester it away from mRNAs and miRNAs, the cytidine deaminase activity of APOBEC3 may allow it to edit the 3′-UTR sequences of P27, LATS2 and CX43 to inhibit DND1 binding. | # |
DNMT1
(details) |
2976 | DNA (cytosine-5-)-methyltransferase 1 | 1786 (SSTAR profile) |
P26358 | DNMT1_HUMAN | DMAP_binding PF06464 (19-101) DNMT1-RFD PF12047 (394-535) zf-CXXC PF02008 (646-691) BAH PF01426 (755-878, 931-1100) DNA_methylase PF00145 (1140-1592) |
Dnmt1 | 94912 | P13864 | DNMT1_MOUSE | # | # | DNA modification | DNA methylation | 18754681 | # | DNA | dhC | dhU | 18754681 | The CXXC region (C is cysteine; X is any amino acid) of DNMT1 binds specifically to unmethylated CpG dinucleotides. Thus, the CXXC domain encompassing the amino terminus region of DNMT1 cooperates with the catalytic domain for DNA methyltransferase activity. | # |
DNMT3A
(details) |
2978 | DNA (cytosine-5-)-methyltransferase 3 alpha | 1788 (SSTAR profile) |
Q9Y6K1 | DNM3A_HUMAN | domain PF22855 (1-283) PWWP PF00855 (293-374) ADD_DNMT3 PF17980 (476-530) ADDz_Dnmt3b PF21255 (537-586) DNA_methylase PF00145 (634-766) |
Dnmt3a | 1261827 | O88508 | DNM3A_MOUSE | # | # | DNA modification | DNA methylation | 12138111 | # | DNA | dhC | dhU | 12138111 | One form of Dnmt3a has been identified and shown to be capable of methylating DNA bothin vitro and in vivo. | # |
DNMT3B
(details) |
2979 | DNA (cytosine-5-)-methyltransferase 3 beta | 1789 (SSTAR profile) |
Q9UBC3 | DNM3B_HUMAN | PWWP PF00855 (226-309) ADD_DNMT3 PF17980 (423-471) ADDz_Dnmt3b PF21255 (478-527) DNA_methylase PF00145 (575-707) |
Dnmt3b | 1261819 | O88509 | DNM3B_MOUSE | # | # | DNA modification | DNA methylation | 10325416 | # | DNA | dhC | dhU | 10325416 | DNA methyltransferases (Dnmt3a and Dnmt3b) in mouse methylate hemimethylated and unmethylated templates with equal efficiencies and are candidates for de novo methyltransferases. | # |
DNMT3L
(details) |
2980 | DNA (cytosine-5-)-methyltransferase 3-like | 29947 (SSTAR profile) |
Q9UJW3 | DNM3L_HUMAN | ADD_DNMT3 PF17980 (37-87) ADDz_Dnmt3b PF21255 (96-146) |
Dnmt3l | 1859287 | Q9CWR8 | DNM3L_MOUSE | # | # | Histone modification read | # | 17687327 | # | histone | H3K4 | # | 17687327 | DNMT3L specifically interacts with the extreme amino terminus of histone H3, this interaction is strongly inhibited by methylation at lysine 4 of histone H3. | # |
DNTTIP2
(details) |
24013 | deoxynucleotidyltransferase, terminal, interacting protein 2 | 30836 (SSTAR profile) |
Q5QJE6 | TDIF2_HUMAN | Fcf2 PF08698 (640-732) | Dnttip2 | 1923173 | Q8R2M2 | TDIF2_MOUSE | # | # | Chromatin remodeling | # | 12786946 | # | histone | H2A, H2B | # | 12786946 | TdIF2 would function as a chromatin remodeling protein at the N region synthesis. | # |
DOT1L
(details) |
24948 | DOT1-like histone H3K79 methyltransferase | 84444 (SSTAR profile) |
Q8TEK3 | DOT1L_HUMAN | DOT1 PF08123 (117-317) | Dot1l | 2143886 | - | - | KMT | Chromatin-modifying enzymes / K-methyltransferases | Histone modification write | Histone methylation | 12123582 | # | histone | H3K79 | # | 12123582 | Human DOT1-like (DOT1L) protein possesses intrinsic H3-K79-specific histone methyltransferase (HMTase) activity in vitro and in vivo. | # |
DPF1
(details) |
20225 | D4, zinc and double PHD fingers family 1 | # | Q92782 | DPF1_HUMAN | DPF1-3_N PF14051 (14-83) PHD PF00628 (274-325, 327-372) |
Dpf1 | 1352748 | Q9QX66 | DPF1_MOUSE | PHF | Zinc fingers, PHD-type | Chromatin remodeling cofactor | # | 21931736 | nBAF, SWI/SNF BRM-BRG1 | chromatin | # | # | 21931736 | Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). Baf45b=DPF1 and Baf53b are both brain specific components of the SWI/SNF complex varaint nBAF. | # |
DPF2
(details) |
9964 | D4, zinc and double PHD fingers family 2 | 5977 (SSTAR profile) |
Q92785 | REQU_HUMAN | DPF1-3_N PF14051 (14-81) PHD PF00628 (273-327, 330-374) |
Dpf2 | 109529 | Q61103 | REQU_MOUSE | PHF | Zinc fingers, PHD-type | Chromatin remodeling | # | 21888896 | SWI/SNF BRM-BRG1 | histone, DNA | # | # | 21888896 | The different domains of DPF2 may function in a cooperative manner in some intracellular processes, which could bind histone and DNA via tandem PHD domain and C2H2 ZF domain, respectively in the context of nucleosome. | # |
DPF3
(details) |
17427 | D4, zinc and double PHD fingers, family 3 | 8110 (SSTAR profile) |
Q92784 | DPF3_HUMAN | DPF1-3_N PF14051 (14-84) PHD PF00628 (261-316, 319-363) |
Dpf3 | 1917377 | P58269 | DPF3_MOUSE | PHF | Zinc fingers, PHD-type | Chromatin remodeling | # | 21423274 | BAF, nBAF, SWI/SNF BRM-BRG1 | histone | H3, H4 | # | 21423274 | Table 1 in the reference. DPF3 is associated with the BAF chromatin remodeling complex and binds methylated and acetylated lysine residues of histone 3 and 4. | # |
DPPA3
(details) |
19199 | developmental pluripotency associated 3 | 359787 (SSTAR profile) |
Q6W0C5 | DPPA3_HUMAN | PGC7_Stella PF15549 (4-143) | Dppa3 | 1920958 | Q8QZY3 | DPPA3_MOUSE | # | # | Histone modification read | # | # | # | histone | H3K9me2 | # | # | Specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, | # |
DPY30
(details) |
24590 | dpy-30 homolog (C. elegans) | 84661 (SSTAR profile) |
Q9C005 | DPY30_HUMAN | Dpy-30 PF05186 (52-92) | Dpy30 | 1913560 | Q99LT0 | DPY30_MOUSE | # | # | Histone modification write cofactor | Histone methylation | 19556245 | COMPASS, Menin-associated_HMT, MLL-HCF, CHD8, MLL2/3, COMPASS-like MLL1,2, MLL4/WBP7, COMPASS-like MLL3,4 | histone | # | # | 19556245 | The isolated MLL1 SET domain is an H3K4 monomethyltransferase. When the MLL1 SET domain fragment is assembled with a complex containing WDR5, RbBP5, Ash2L, and DPY-30, the rate of lysine methylation is dramatically increased, but only to the dimethyl form of H3K4, suggesting that the MLL1 core complex is predominantly a dimethyltransferase. | # |
DR1
(details) |
3017 | down-regulator of transcription 1, TBP-binding (negative cofactor 2) | 1810 (SSTAR profile) |
Q01658 | NC2B_HUMAN | CBFD_NFYB_HMF PF00808 (12-75) | Dr1 | 1100515 | Q91WV0 | NC2B_MOUSE | # | # | Histone chaperone | # | 18838386 | ATAC | histone | # | # | 18838386 | YEATS2-NC2beta=DR1 histone fold module that interacts with the TATA-binding protein (TBP) and negatively regulates transcription when recruited to a promoter. | # |
DTX3L
(details) |
30323 | deltex 3 like, E3 ubiquitin ligase | 151636 (SSTAR profile) |
Q8TDB6 | DTX3L_HUMAN | DTX3L_a-b PF21717 (134-194) DTX3L_KH-like PF21718 (235-357, 373-508) zf-C3HC4_2 PF13923 (561-599) DTC PF18102 (608-739) |
Dtx3l | 2656973 | Q3UIR3 | DTX3L_MOUSE | RNF | RING-type (C3HC4) zinc fingers | Histone modification write | Histone ubiquitination | 19818714 | # | histone | H4K91 | # | 19818714 | BBAP=DTX3L selectively monoubiquitylates histone H4 lysine 91 and protects cells exposed to DNA-damaging agents. | # |
DZIP3
(details) |
30938 | DAZ interacting zinc finger protein 3 | 9666 (SSTAR profile) |
Q86Y13 | DZIP3_HUMAN | TTC3_DZIP3_dom PF19179 (229-330) HEPN_DZIP3 PF18738 (421-546) zf-RING_2 PF13639 (1148-1188) |
Dzip3 | 1917433 | Q7TPV2 | DZIP3_MOUSE | RNF, PPP1R | RING-type (C3HC4) zinc fingers, Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits | Histone modification write | Histone ubiquitination | 18206970 | # | histone, RNA | H2AK119 | H2AK119ub | 18206970 | The N-CoR/HDAC1/3 complex specifically recruits a previously-unidentified specific histone H2A ubiquitin ligase, 2A-HUB/hRUL138 = DZIP3, to a subset of regulated gene promoters. | # |
E2F6
(details) |
3120 | E2F transcription factor 6 | 1876 (SSTAR profile) |
O75461 | E2F6_HUMAN | E2F_TDP PF02319 (65-128) E2F_CC-MB PF16421 (143-237) |
E2f6 | 1354159 | O54917 | E2F6_MOUSE | # | # | TF | TF repressor | # | RING2-L3MBTL2, CHD8, MLL2/3, MLL4/WBP7 | DNA | DNA motif | # | # | Epigenetic complex (MLL) partner. | # |
EED
(details) |
3188 | embryonic ectoderm development | 8726 (SSTAR profile) |
O75530 | EED_HUMAN | WD40 PF00400 (181-219, 233-264, 400-437) | Eed | 95286 | Q921E6 | EED_MOUSE | WDR | WD repeat domain containing | Polycomb group (PcG) protein | # | 9584199 | PRC2 | # | # | # | 9584199 | Enx1/EZH2 and EED are members of a class of PcG proteins that is distinct from previously described human PcG proteins. | # |
EEF1AKMT3
(details) |
24936 | EEF1A lysine methyltransferase 3 | 25895 (SSTAR profile) |
Q96AZ1 | EFMT3_HUMAN | Methyltransf_16 PF10294 (38-195) | Eef1akmt3 | 3645330 | D3YWP0 | EFMT3_MOUSE | METTL | Methyltransferase like | Protein modification | Protein methylation | 28108655 | # | protein | Lys165 of eEF1A | K165m | 28108655 | Modulates mRNA translation | New |
EEF1AKMT4
(details) |
53611 | EEF1A lysine methyltransferase 4 | 110599564 (SSTAR profile) |
P0DPD7 | EFMT4_HUMAN | Methyltransf_11 PF08241 (63-172) | Eef1akmt4 | 5903914 | P0DPE0 | EFMT4_MOUSE | # | # | Protein modification | Protein methylation | 28520920 | # | protein | eEF1A (elongation factor alpha) | methylation K36 | 28520920 | Regulates interaction between eEF1A and aminoacyl-t-RNA and gene expression. | New |
EEF1AKNMT
(details) |
24248 | eEF1A lysine and N-terminal methyltransferase | 51603 (SSTAR profile) |
Q8N6R0 | EFNMT_HUMAN | domain PF13649 (53-157) Spermine_synth PF01564 (493-616) |
Eef1aknmt | 1918699 | Q91YR5 | EFNMT_MOUSE | METTL | Methyltransferase like | Protein modification | Protein methylation | 30143613 | # | protein | Lys55 of eEF1A | K55m | 30143613 | Modulates mRNA translation | New |
EHMT1
(details) |
24650 | euchromatic histone-lysine N-methyltransferase 1 | 79813 (SSTAR profile) |
Q9H9B1 | EHMT1_HUMAN | EHMT1-2_CRR PF21533 (539-633) Ank_4 PF13637 (772-836) Ank_2 PF12796 (838-904, 907-990) Pre-SET PF05033 (1015-1118) SET PF00856 (1137-1243) |
Ehmt1 | 1924933 | Q5DW34 | EHMT1_MOUSE | KMT, ANKRD | Chromatin-modifying enzymes / K-methyltransferases, Ankyrin repeat domain containing | Histone modification write | Histone methylation | 18264113 | # | histone | H3K9 | H3K9me1, H3K9me2 | 18264113 | G9a and G9a-like protein (GLP)=EHMT1 are euchromatin-associated methyltransferases that repress transcription by mono- and dimethylating histone H3 at Lys9 (H3K9). | # |
EHMT2
(details) |
14129 | euchromatic histone-lysine N-methyltransferase 2 | 10919 (SSTAR profile) |
Q96KQ7 | EHMT2_HUMAN | EHMT1-2_CRR PF21533 (447-540) Ank_2 PF12796 (655-746, 750-816) Ank PF00023 (850-882) Pre-SET PF05033 (927-1030) SET PF00856 (1049-1155) |
Ehmt2 | 2148922 | Q9Z148 | EHMT2_MOUSE | KMT, ANKRD | Chromatin-modifying enzymes / K-methyltransferases, Ankyrin repeat domain containing | Histone modification write | Histone methylation | 18264113 | # | histone | H3K9 | H3K9me1, H3K9me2 | 18264113 | G9a=EHMT2 and G9a-like protein (GLP) are euchromatin-associated methyltransferases that repress transcription by mono- and dimethylating histone H3 at Lys9 (H3K9). | # |
EID1
(details) |
1191 | EP300 interacting inhibitor of differentiation 1 | 23741 (SSTAR profile) |
Q9Y6B2 | EID1_HUMAN | () | Eid1 | 1889651 | Q9DCR4 | EID1_MOUSE | # | # | Histone modification write cofactor | Histone acetylation | 11073990 | # | histone | # | # | 11073990 | Inhibition of MyoD may be explained by EID-1's ability to bind and inhibit p300's histone acetylase activity, an essential MyoD coactivator. Thus, EID-1 binds both Rb and p300 and is a novel repressor of MyoD function. | # |
EID2
(details) |
28292 | EP300 interacting inhibitor of differentiation 2 | 163126 (SSTAR profile) |
Q8N6I1 | EID2_HUMAN | () | Eid2 | 2681174 | Q6X7S9 | EID2_MOUSE | # | # | Histone modification write cofactor | Histone acetylation | 14585496 | # | histone | # | # | 14585496 | Overexpression of EID-2 inhibits muscle-specific gene expression through inhibition of MyoD-dependent transcription. This inhibitory effect on gene expression can be explained by EID-2's ability to associate with and inhibit the acetyltransferase activity of p300. These data suggest that EID-1 and -2 represent a novel family of proteins that negatively regulate differentiation through a p300-dependent mechanism. | # |
EID2B
(details) |
26796 | EP300 interacting inhibitor of differentiation 2B | 126272 (SSTAR profile) |
Q96D98 | EID2B_HUMAN | () | Eid2b | 1924095 | # | # | # | # | Histone modification erase cofactor | Histone acetylation | 15970276 | # | histone | # | # | 15970276 | The transrepressional function of EID-2 depends on recruitment of class I histone deacetylases (HDACs). HDACs participate in the dynamic process of chromatin remodeling, forming corepressor complexes that repress transcription by deacetylating histones and transcription factors. | # |
EIF4A3
(details) |
18683 | Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed] | 9775 (SSTAR profile) |
P38919 | IF4A3_HUMAN | DEAD PF00270 (63-225) Helicase_C PF00271 (264-372) |
EIf4A3 | 1923731 | Q91VC3 | IF4A3_MOUSE | DDX | DEAD-box helicases | RNA modification | Alternative splicing | 22203037 | # | RNA | mRNA | # | 22203037 | Production of the proapoptotic Bcl-x(S) splice variant. | New |
ELP2
(details) |
18248 | elongator acetyltransferase complex subunit 2 | 55250 (SSTAR profile) |
Q6IA86 | ELP2_HUMAN | WD40 PF00400 (51-91, 103-143, 200-237, 275-320, 381-415, 606-641, 665-696) | Elp2 | 1889642 | Q91WG4 | ELP2_MOUSE | ELP, WDR | Elongator acetyltransferase complex subunits, WD repeat domain containing | Histone modification write cofactor | Histone acetylation | 11818576 | Pol2 elongator | histone | # | # | 11818576 | Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. | # |
ELP3
(details) |
20696 | elongator acetyltransferase complex subunit 3 | 55140 (SSTAR profile) |
Q9H9T3 | ELP3_HUMAN | Radical_SAM PF04055 (107-295) Radical_SAM_C PF16199 (312-392) |
Elp3 | 1921445 | Q9CZX0 | ELP3_MOUSE | KAT, ELP | Chromatin-modifying enzymes / K-acetyltransferases, Elongator acetyltransferase complex subunits | Histone modification write | Histone acetylation | 11818576 | Pol2 elongator | histone | H3, H4? | # | 11818576 | Elp3 contains domains characteristic of proteins with acetyltransferase activity, and its complex was found to acetylate histones, with specificity to H3 and to a much lesser extent H4. | # |
ELP4
(details) |
1171 | elongator acetyltransferase complex subunit 4 | 26610 (SSTAR profile) |
Q96EB1 | ELP4_HUMAN | PAXNEB PF05625 (48-400) | Elp4 | 1925016 | Q9ER73 | ELP4_MOUSE | ELP | Elongator acetyltransferase complex subunits | Histone modification write cofactor | Histone acetylation | 11714725 | Pol2 elongator | histone | # | # | 11714725 | The three small holo-Elongator subunits, hELP4, p38, and p30, are required to activate the HAT activity of hELP3, or one of these proteins may have intrinsic HAT activity. | # |
ELP5
(details) |
30617 | elongator acetyltransferase complex subunit 5 | 23587 (SSTAR profile) |
Q8TE02 | ELP5_HUMAN | Elong_Iki1 PF10483 (11-181, 222-281) | Elp5 | 1859017 | Q99L85 | ELP5_MOUSE | ELP | Elongator acetyltransferase complex subunits | Histone modification write cofactor | Histone acetylation | 11904415 | Pol2 elongator | histone | H3K14, H4K8 | # | 11904415 | The elongating, hyperphosphorylated form of RNA polymerase II is associated with the Elongator complex, which has the histone acetyltransferase (HAT) Elp3 as a subunit. The three smallest Elongator subunits--Elp4, Elp5, and Elp6--are required for HAT activity, and Elongator binds to both naked and nucleosomal DNA. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. | # |
ELP6
(details) |
25976 | elongator acetyltransferase complex subunit 6 | 54859 (SSTAR profile) |
Q0PNE2 | ELP6_HUMAN | ELP6 PF09807 (4-251) | Elp6 | 1919349 | Q8BK75 | ELP6_MOUSE | ELP | Elongator acetyltransferase complex subunits | Histone modification write cofactor | Histone acetylation | 22854966 | Pol2 elongator | histone | # | # | 22854966 | The Elongator complex is composed of 6 subunits (Elp1-Elp6) and promotes RNAPII transcript elongation through histone acetylation in the nucleus as well as tRNA modification in the cytoplasm. DERP6/ELP5 and C3ORF75/ELP6 are key players for migration, invasion and tumorigenicity of melanoma cells, as integral subunits of Elongator. | # |
ENY2
(details) |
24449 | enhancer of yellow 2 homolog (Drosophila) | 56943 (SSTAR profile) |
Q9NPA8 | ENY2_HUMAN | EnY2 PF10163 (13-95) | Eny2 | 1919286 | Q9JIX0 | ENY2_MOUSE | # | # | Histone modification erase cofactor | Histone ubiquitination | 18206972 | SAGA | histone | # | # | 18206972 | ATXN7L3, USP22, and ENY2 are required as cofactors for the full transcriptional activity by nuclear receptors. Thus, the deubiquitinase activity of the TFTC/STAGA HAT complex is necessary to counteract heterochromatin silencing and acts as a positive cofactor for activation by nuclear receptors in vivo. | # |
EP300
(details) |
3373 | E1A binding protein p300 | 2033 (SSTAR profile) |
Q09472 | EP300_HUMAN | zf-TAZ PF02135 (335-415, 1734-1806) KIX PF02172 (567-648) Bromodomain PF00439 (1067-1141) RING_CBP-p300 PF06001 (1156-1194) HAT_KAT11 PF08214 (1306-1611) ZZ PF00569 (1665-1706) Creb_binding PF09030 (2015-2097) |
Ep300 | 1276116 | B2RWS6 | EP300_MOUSE | KAT | Chromatin-modifying enzymes / K-acetyltransferases | Histone modification write | Histone acetylation | 17065153 | # | histone | H2A, H2B, H3, H4 | # | 17065153 | Acetylation of proteins by p300=EP300 histone acetyltransferase plays a critical role in the regulation of gene expression. | # |
EP400
(details) |
11958 | E1A binding protein p400 | 57634 (SSTAR profile) |
Q96L91 | EP400_HUMAN | EP400_N PF15790 (30-489) HSA PF07529 (803-869, 2178-2241) SNF2-rel_dom PF00176 (1094-1372) Helicase_C PF00271 (1899-2012) |
Ep400 | 1276124 | Q8CHI8 | EP400_MOUSE | # | # | Chromatin remodeling, Histone modification write | Histone acetylation | 20876283 | SWR, NuA4, NuA4-related complex | histone | # | # | 20876283 | p400 is a novel DNA damage response protein and p400-mediated alterations in nucleosome and chromatin structure promote both chromatin ubiquitination and the accumulation of brca1 and 53BP1 at sites of DNA damage. | # |
EPC1
(details) |
19876 | enhancer of polycomb homolog 1 (Drosophila) | 80314 (SSTAR profile) |
Q9H2F5 | EPC1_HUMAN | EPL1 PF10513 (6-148) E_Pc_C PF06752 (581-836) |
Epc1 | 1278322 | Q8C9X6 | EPC1_MOUSE | # | # | Polycomb group (PcG) protein | # | 14966270 | NuA4, Piccolo_NuA4, NuA4-related complex | histone | # | # | 14966270 | The Enhancer of Polycomb homology domain of human EPC1, like Epl1 in yeast (7), is a conserved functional key for histone acetylation since it bridges the MYST HAT with the ING protein to enable potent nucleosome histone acetyltransferase activity. | # |
EPC2
(details) |
24543 | enhancer of polycomb homolog 2 (Drosophila) | 26122 (SSTAR profile) |
Q52LR7 | EPC2_HUMAN | EPL1 PF10513 (4-148) E_Pc_C PF06752 (575-807) |
Epc2 | 1278321 | Q8C0I4 | EPC2_MOUSE | # | # | Chromatin remodeling | # | 19898529 | # | chromatin | # | # | # | NuA4 and SWR1-C: two chromatin-modifying complexes with overlapping functions and components | # |
ERBB4
(details) |
3432 | v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 | 2066 (SSTAR profile) |
Q15303 | ERBB4_HUMAN | Recep_L_domain PF01030 (55-166, 358-477) Furin-like PF00757 (184-335) GF_recep_IV PF14843 (502-633) TM_ErbB1 PF21314 (653-687) PK_Tyr_Ser-Thr PF07714 (718-974) |
Erbb4 | 104771 | Q61527 | ERBB4_MOUSE | # | # | Histone modification cofactor | # | 23230144 | # | histone | H3K9me3 | # | 23230144 | ErbB4 intracellular domain (4ICD) that translocates into the nucleus to control gene expression through inhibiting an increase of H3K9me3. | # |
ERCC6
(details) |
3438 | excision repair cross-complementation group 6 | 2074 (SSTAR profile) |
Q03468 | ERCC6_HUMAN | SNF2-rel_dom PF00176 (509-810) Helicase_C PF00271 (843-952) |
Ercc6 | 1100494 | # | # | # | # | Chromatin remodeling | # | 15226310 | B-WICH | chromatin | # | # | 15226310 | CSB=ERCC6 is a DNA-dependent ATPase and is able to remodel chromatin at the expense of ATP. | # |
EXOSC1
(details) |
17286 | exosome component 1 | 51013 (SSTAR profile) |
Q9Y3B2 | EXOS1_HUMAN | ECR1_N PF14382 (8-43) EXOSC1 PF10447 (95-135) |
Exosc1 | 1913833 | Q9DAA6 | EXOS1_MOUSE | # | # | Scaffold protein, RNA modification | RNA degradation | 17174896 | RNA exosome | RNA | # | # | 17174896 | RNA abundance is regulated by balancing transcription and RNA degradation, processes that control the temporal and spatial distribution of cellular RNA. After decapping, 5′ to 3′ RNA degradation is accomplished by Xrn1, a 5′ to 3′ exoribonuclease. In the 3′ to 5′ pathway, RNA degradation is catalyzed by a multisubunit 3′ to 5′ exoribonuclease complex termed the RNA exosome. Three additional exosome subunits, Csl4=EXOSC1, Rrp4=EXOSC2, and Rrp40=EXOSC3, include S1 or KH domains, which are postulated to bind RNA. | # |
EXOSC2
(details) |
17097 | exosome component 2 | 23404 (SSTAR profile) |
Q13868 | EXOS2_HUMAN | ECR1_N PF14382 (26-64) RRP4_S1 PF21266 (75-146) KH_6 PF15985 (169-210) |
Exosc2 | 2385133 | Q8VBV3 | EXOS2_MOUSE | # | # | Scaffold protein, RNA modification | RNA degradation | 17174896 | RNA exosome | RNA | # | # | 17174896 | RNA abundance is regulated by balancing transcription and RNA degradation, processes that control the temporal and spatial distribution of cellular RNA. After decapping, 5′ to 3′ RNA degradation is accomplished by Xrn1, a 5′ to 3′ exoribonuclease. In the 3′ to 5′ pathway, RNA degradation is catalyzed by a multisubunit 3′ to 5′ exoribonuclease complex termed the RNA exosome. Three additional exosome subunits, Csl4=EXOSC1, Rrp4=EXOSC2, and Rrp40=EXOSC3, include S1 or KH domains, which are postulated to bind RNA. | # |
EXOSC3
(details) |
17944 | exosome component 3 | 51010 (SSTAR profile) |
Q9NQT5 | EXOS3_HUMAN | RRP40_N_mamm PF21261 (26-106) RRP40_S1 PF21262 (108-191) KH_6 PF15985 (197-244) |
Exosc3 | 1913612 | Q7TQK4 | EXOS3_MOUSE | # | # | Scaffold protein, RNA modification | RNA degradation | 17174896 | RNA exosome | RNA | # | # | 17174896 | RNA abundance is regulated by balancing transcription and RNA degradation, processes that control the temporal and spatial distribution of cellular RNA. After decapping, 5′ to 3′ RNA degradation is accomplished by Xrn1, a 5′ to 3′ exoribonuclease. In the 3′ to 5′ pathway, RNA degradation is catalyzed by a multisubunit 3′ to 5′ exoribonuclease complex termed the RNA exosome. Three additional exosome subunits, Csl4=EXOSC1, Rrp4=EXOSC2, and Rrp40=EXOSC3, include S1 or KH domains, which are postulated to bind RNA. | # |
EXOSC4
(details) |
18189 | exosome component 4 | 54512 (SSTAR profile) |
Q9NPD3 | EXOS4_HUMAN | RNase_PH PF01138 (21-152) RNase_PH_C PF03725 (155-219) |
Exosc4 | 1923576 | Q921I9 | EXOS4_MOUSE | # | # | Scaffold protein, RNA modification | RNA degradation | 17174896 | RNA exosome | RNA | # | # | 17174896 | RNA abundance is regulated by balancing transcription and RNA degradation, processes that control the temporal and spatial distribution of cellular RNA. After decapping, 5′ to 3′ RNA degradation is accomplished by Xrn1, a 5′ to 3′ exoribonuclease. In the 3′ to 5′ pathway, RNA degradation is catalyzed by a multisubunit 3′ to 5′ exoribonuclease complex termed the RNA exosome. Three additional exosome subunits, Csl4=EXOSC1, Rrp4=EXOSC2, and Rrp40=EXOSC3, include S1 or KH domains, which are postulated to bind RNA. | # |
EXOSC5
(details) |
24662 | exosome component 5 | 56915 (SSTAR profile) |
Q9NQT4 | EXOS5_HUMAN | RNase_PH PF01138 (28-147) RNase_PH_C PF03725 (151-215) |
Exosc5 | 107889 | Q9CRA8 | EXOS5_MOUSE | # | # | Scaffold protein, RNA modification | RNA degradation | 17174896 | RNA exosome | RNA | # | # | 17174896 | RNA abundance is regulated by balancing transcription and RNA degradation, processes that control the temporal and spatial distribution of cellular RNA. After decapping, 5′ to 3′ RNA degradation is accomplished by Xrn1, a 5′ to 3′ exoribonuclease. In the 3′ to 5′ pathway, RNA degradation is catalyzed by a multisubunit 3′ to 5′ exoribonuclease complex termed the RNA exosome. Three additional exosome subunits, Csl4=EXOSC1, Rrp4=EXOSC2, and Rrp40=EXOSC3, include S1 or KH domains, which are postulated to bind RNA. | # |
EXOSC6
(details) |
19055 | exosome component 6 | 118460 (SSTAR profile) |
Q5RKV6 | EXOS6_HUMAN | RNase_PH PF01138 (37-175) | Exosc6 | 1919794 | Q8BTW3 | EXOS6_MOUSE | # | # | Scaffold protein, RNA modification | RNA degradation | 17174896 | RNA exosome | RNA | # | # | 17174896 | RNA abundance is regulated by balancing transcription and RNA degradation, processes that control the temporal and spatial distribution of cellular RNA. After decapping, 5′ to 3′ RNA degradation is accomplished by Xrn1, a 5′ to 3′ exoribonuclease. In the 3′ to 5′ pathway, RNA degradation is catalyzed by a multisubunit 3′ to 5′ exoribonuclease complex termed the RNA exosome. Three additional exosome subunits, Csl4=EXOSC1, Rrp4=EXOSC2, and Rrp40=EXOSC3, include S1 or KH domains, which are postulated to bind RNA. | # |
EXOSC7
(details) |
28112 | exosome component 7 | 23016 (SSTAR profile) |
Q15024 | EXOS7_HUMAN | RNase_PH PF01138 (32-166) RNase_PH_C PF03725 (196-261) |
Exosc7 | 1913696 | Q9D0M0 | EXOS7_MOUSE | # | # | Scaffold protein, RNA modification | RNA degradation | 17174896 | RNA exosome | RNA | # | # | 17174896 | RNA abundance is regulated by balancing transcription and RNA degradation, processes that control the temporal and spatial distribution of cellular RNA. After decapping, 5′ to 3′ RNA degradation is accomplished by Xrn1, a 5′ to 3′ exoribonuclease. In the 3′ to 5′ pathway, RNA degradation is catalyzed by a multisubunit 3′ to 5′ exoribonuclease complex termed the RNA exosome. Three additional exosome subunits, Csl4=EXOSC1, Rrp4=EXOSC2, and Rrp40=EXOSC3, include S1 or KH domains, which are postulated to bind RNA. | # |
EXOSC8
(details) |
17035 | exosome component 8 | 11340 (SSTAR profile) |
Q96B26 | EXOS8_HUMAN | RNase_PH PF01138 (31-166) RNase_PH_C PF03725 (192-257) |
Exosc8 | 1916889 | Q9D753 | EXOS8_MOUSE | # | # | Scaffold protein, RNA modification | RNA degradation | 17174896 | RNA exosome | RNA | # | # | 17174896 | RNA abundance is regulated by balancing transcription and RNA degradation, processes that control the temporal and spatial distribution of cellular RNA. After decapping, 5′ to 3′ RNA degradation is accomplished by Xrn1, a 5′ to 3′ exoribonuclease. In the 3′ to 5′ pathway, RNA degradation is catalyzed by a multisubunit 3′ to 5′ exoribonuclease complex termed the RNA exosome. Three additional exosome subunits, Csl4=EXOSC1, Rrp4=EXOSC2, and Rrp40=EXOSC3, include S1 or KH domains, which are postulated to bind RNA. | # |
EXOSC9
(details) |
9137 | exosome component 9 | 5393 (SSTAR profile) |
Q06265 | EXOS9_HUMAN | RNase_PH PF01138 (32-163) RNase_PH_C PF03725 (189-254) |
Exosc9 | 1355319 | Q9JHI7 | EXOS9_MOUSE | # | # | Scaffold protein, RNA modification | RNA degradation | 17174896 | RNA exosome | RNA | # | # | 17174896 | RNA abundance is regulated by balancing transcription and RNA degradation, processes that control the temporal and spatial distribution of cellular RNA. After decapping, 5′ to 3′ RNA degradation is accomplished by Xrn1, a 5′ to 3′ exoribonuclease. In the 3′ to 5′ pathway, RNA degradation is catalyzed by a multisubunit 3′ to 5′ exoribonuclease complex termed the RNA exosome. Three additional exosome subunits, Csl4=EXOSC1, Rrp4=EXOSC2, and Rrp40=EXOSC3, include S1 or KH domains, which are postulated to bind RNA. | # |
EYA1
(details) |
3519 | EYA transcriptional coactivator and phosphatase 1 | 2138 (SSTAR profile) |
Q99502 | EYA1_HUMAN | Hydrolase PF00702 (323-566) | Eya1 | 109344 | P97767 | EYA1_MOUSE | PTPE | Protein tyrosine phosphatases / Asp-based PTPs | Histone modification erase | Histone phosphorylation | 19234442 | # | histone | H2AXT142 | # | 19234442 | Eya effectively removes the phosphotyrosine mark from H2AX, while the phosphatase-inactive mutant Eya proteins (Eya1 D323A or Eya3 D246A) have little or no effect. | # |
EYA2
(details) |
3520 | EYA transcriptional coactivator and phosphatase 2 | 2139 (SSTAR profile) |
O00167 | EYA2_HUMAN | Hydrolase PF00702 (269-512) | Eya2 | 109341 | O08575 | EYA2_MOUSE | PTPE | Protein tyrosine phosphatases / Asp-based PTPs | Histone modification erase | Histone phosphorylation | 19351884 | # | histone | H2AXT142 | # | 19351884 | EYA2 and EYA3 display specificity (dephosphorylation) for Tyr-142 of H2A.X in assays in vitro. | # |
EYA3
(details) |
3521 | EYA transcriptional coactivator and phosphatase 3 | 2140 (SSTAR profile) |
Q99504 | EYA3_HUMAN | Hydrolase PF00702 (304-548) | Eya3 | 109339 | P97480 | EYA3_MOUSE | PTPE | Protein tyrosine phosphatases / Asp-based PTPs | Histone modification erase | Histone phosphorylation | 19351884 | # | histone | H2AXT142 | # | 19351884 | EYA2 and EYA3 display specificity (dephosphorylation) for Tyr-142 of H2A.X in assays in vitro. | # |
EYA4
(details) |
3522 | EYA transcriptional coactivator and phosphatase 4 | 2070 (SSTAR profile) |
O95677 | EYA4_HUMAN | Hydrolase PF00702 (370-614) | Eya4 | 1337104 | Q9Z191 | EYA4_MOUSE | PTPE | Protein tyrosine phosphatases / Asp-based PTPs | Histone modification erase | Histone phosphorylation | # | # | histone | H2AXY142ph | H2AXY142 | 24096489 | In response to double-stranded breaks, EYA4 dephosphorylates the Tyr-142 residue of H2AX facilitating phosphorylation of Ser-139 of H2AX (forming γH2AX), leading to the recruitment of DNA repair complex components to sites of double-stranded break. | # |
EZH1
(details) |
3526 | enhancer of zeste 1 polycomb repressive complex 2 subunit | 2145 (SSTAR profile) |
Q92800 | EZH1_HUMAN | EZH2_WD-Binding PF11616 (39-68) PRC2_HTH_1 PF18118 (160-262) Ezh2_MCSS PF21358 (267-322) preSET_CXC PF18264 (560-591) SET PF00856 (624-727) |
Ezh1 | 1097695 | P70351 | EZH1_MOUSE | KMT | Chromatin-modifying enzymes / K-methyltransferases | Histone modification write, Polycomb group (PcG) protein | Histone methylation | 19026781 | PRC2 | histone | H3K27 | H3K27me1, H3K27me2, H3K27me3 | 19026781 | Polycomb group proteins are critical to maintaining gene repression established during Drosophila development. Part of this group forms the PRC2 complex containing Ez that catalyzes di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), marks repressive to transcription. The mammalian homologs Ezh1 and Ezh2 form similar PRC2 complexes but exhibit contrasting repressive roles. While PRC2-Ezh2 catalyzes H3K27me2/3 and its knockdown affects global H3K27me2/3 levels, PRC2-Ezh1 performs this function weakly. | # |
EZH2
(details) |
3527 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 2146 (SSTAR profile) |
Q15910 | EZH2_HUMAN | EZH2_WD-Binding PF11616 (39-68) PRC2_HTH_1 PF18118 (159-249) Ezh2_MCSS PF21358 (259-309) preSET_CXC PF18264 (559-590) SET PF00856 (623-726) |
Ezh2 | 107940 | Q61188 | EZH2_MOUSE | KMT | Chromatin-modifying enzymes / K-methyltransferases | Histone modification write, Polycomb group (PcG) protein | Histone methylation | 19026781 | PRC2 | histone | H3K27 | H3K27me1, H3K27me2, H3K27me3 | 19026781 | Polycomb group proteins are critical to maintaining gene repression established during Drosophila development. Part of this group forms the PRC2 complex containing Ez that catalyzes di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), marks repressive to transcription. The mammalian homologs Ezh1 and Ezh2 form similar PRC2 complexes, but exhibit contrasting repressive roles. While PRC2-Ezh2 catalyzes H3K27me2/3 and its knockdown affects global H3K27me2/3 levels, PRC2-Ezh1 performs this function weakly. | # |
FAM175A
(details) |
25829 | family with sequence similarity 175, member A | 84142 (SSTAR profile) |
Q6UWZ7 | F175A_HUMAN | MPN_2A_DUB_like PF21125 (9-172) | Fam175a | 1917931 | Q8BPZ8 | F175A_MOUSE | # | # | Scaffold protein | # | 19261749 | BRCA1-A | TF | # | # | 19261749 | Abra1=FAM175A protein, which appears to act as a scaffold for the A complex. Abra1 is known to mediate the interaction of Rap80 with BRCA1. | # |
FAM175B
(details) |
28975 | family with sequence similarity 175, member B | 23172 (SSTAR profile) |
Q15018 | F175B_HUMAN | MPN_2A_DUB_like PF21125 (3-167) | Fam175b | 1926116 | Q3TCJ1 | F175B_MOUSE | # | # | Histone modification erase cofactor | Histone ubiquitination | 20656690 | BRISC | histone | H2AK63 | H2AK63ub | 20656690 | # | # |
FBL
(details) |
3599 | fibrillarin | 2091 (SSTAR profile) |
P22087 | FBRL_HUMAN | Fibrillarin PF01269 (88-314) | Fbl | 95486 | P35550 | FBRL_MOUSE | # | # | Histone modification write | Histone methylation | 24352239 | # | histone | H2AQ104 | H2AQ104me | 24352239 | Nop1 is a methyltransferase in yeast, and fibrillarin is the orthologue enzyme in human cells. The modification is exclusively enriched over the 35S ribosomal DNA transcriptional unit. Glutamine methylation of H2A is the first histone epigenetic mark dedicated to a specific RNA polymerase and define its function as a regulator of FACT interaction with nucleosomes. | # |
FBRS
(details) |
20442 | fibrosin | 64319 (SSTAR profile) |
Q9HAH7 | FBRS_HUMAN | Auts2 PF15336 (82-273) | Fbrs | 104648 | Q8R089 | FBRS_MOUSE | # | # | Histone modification | # | 24217316, 22325352 | RING2-FBRS | histone | # | # | 24217316, 22325352 | Part of a RING2 complex. | # |
FBRSL1
(details) |
29308 | fibrosin-like 1 | 57666 (SSTAR profile) |
Q9HCM7 | FBSL_HUMAN | Auts2 PF15336 (587-788) | Fbrsl1 | 1920907 | # | # | # | # | Histone modification | # | 24217316, 22325352 | RING2-FBRS | histone | # | # | 24217316, 22325352 | Part of a RING2 complex. | # |
FOXA1
(details) |
5021 | forkhead box A1 | 3169 (SSTAR profile) |
P55317 | FOXA1_HUMAN | Forkhead_N PF08430 (16-169) Forkhead PF00250 (170-255) HNF_C PF09354 (396-455) |
Foxa1 | 1347472 | P35582 | FOXA1_MOUSE | FOX | Forkhead boxes | Chromatin remodeling, TF | # | 22406422 | # | chromatin, DNA | DNA motif | # | # | FOXA1 functions in organizing nucleosome positioning. | # |
FOXO1
(details) |
3819 | forkhead box O1 | 2308 (SSTAR profile) |
Q12778 | FOXO1_HUMAN | Forkhead PF00250 (160-244) FOXO_KIX_bdg PF16675 (430-506) FOXO-TAD PF16676 (597-635) |
Foxo1 | 1890077 | Q9R1E0 | FOXO1_MOUSE | FOX | Forkhead boxes | TF | # | 22406422 | # | histone, DNA | DNA motif, H3, H4 | # | # | FOXO1 interacts with core histones H3 and H4. | # |
FOXP1
(details) |
3823 | forkhead box P1 | 27086 (SSTAR profile) |
Q9H334 | FOXP1_HUMAN | FOXP-CC PF16159 (302-370) Forkhead PF00250 (465-541) |
Foxp1 | 1914004 | P58462 | FOXP1_MOUSE | FOX | Forkhead boxes | TF | # | 22406422 | # | histone, DNA | DNA motif | # | # | Recruitment of specific chromatin-modifying complexes with HDAC activity. | # |
FOXP2
(details) |
13875 | forkhead box P2 | 93986 (SSTAR profile) |
O15409 | FOXP2_HUMAN | FOXP-CC PF16159 (342-410) Forkhead PF00250 (504-581) |
Foxp2 | 2148705 | P58463 | FOXP2_MOUSE | FOX | Forkhead boxes | TF | # | 22406422 | # | histone, DNA | DNA motif | # | # | Recruitment of specific chromatin-modifying complexes with HDAC activity. | # |
FOXP3
(details) |
6106 | forkhead box P3 | 50943 (SSTAR profile) |
Q9BZS1 | FOXP3_HUMAN | FOXP-CC PF16159 (193-263) Forkhead PF00250 (337-414) |
Foxp3 | 1891436 | Q99JB6 | FOXP3_MOUSE | FOX | Forkhead boxes | TF | # | 22406422 | # | histone, DNA | DNA motif | # | # | Recruitment of specific chromatin-modifying complexes with HDAC activity. | # |
FOXP4
(details) |
20842 | forkhead box P4 | 116113 (SSTAR profile) |
Q8IVH2 | FOXP4_HUMAN | FOXP-CC PF16159 (305-371) Forkhead PF00250 (467-544) |
Foxp4 | 1921373 | Q9DBY0 | FOXP4_MOUSE | FOX | Forkhead boxes | TF | # | 22406422 | # | histone, DNA | DNA motif | # | # | Recruitment of specific chromatin-modifying complexes with HDAC activity. | # |
FTO
(details) |
24678 | FTO alpha-ketoglutarate dependent dioxygenase | 79068 (SSTAR profile) |
Q9C0B1 | FTO_HUMAN | FTO_NTD PF12933 (37-325) FTO_CTD PF12934 (329-496) |
Fto | 1347093 | Q8BGW1 | FTO_MOUSE | ALKBH | Alkylation repair homologs | RNA modification | RNA demethylation | 23653210 | # | RNA | m6A of mRNA | hm6A, f6A, A | 3218240 | # | New |
GADD45A
(details) |
4095 | growth arrest and DNA-damage-inducible, alpha | 1647 (SSTAR profile) |
P24522 | GA45A_HUMAN | Ribosomal_L7Ae PF01248 (21-114) | Gadd45a | 107799 | P48316 | GA45A_MOUSE | # | # | Chromatin remodeling | # | 21986581 | # | histone | H2A, H2B, H3, H4 | # | 21986581 | Active DNA demethylation is partially attributed to the ability of Gadd45(A, B, C) proteins to bind histones and modify accessibility of DNA on damaged chromatin. | # |
GADD45B
(details) |
4096 | growth arrest and DNA-damage-inducible, beta | 4616 (SSTAR profile) |
O75293 | GA45B_HUMAN | Ribosomal_L7Ae PF01248 (22-116) | Gadd45b | 107776 | P22339 | GA45B_MOUSE | # | # | Chromatin remodeling | # | 21986581 | # | histone | H2A, H2B, H3, H4 | # | 21986581 | Active DNA demethylation is partially attributed to the ability of Gadd45(A, B, C) proteins to bind histones and modify accessibility of DNA on damaged chromatin. | # |
GADD45G
(details) |
4097 | growth arrest and DNA-damage-inducible, gamma | 10912 (SSTAR profile) |
O95257 | GA45G_HUMAN | Ribosomal_L7Ae PF01248 (25-106) | Gadd45g | 1346325 | Q9Z111 | GA45G_MOUSE | # | # | Chromatin remodeling | # | 21986581 | # | histone | H2A, H2B, H3, H4 | # | 21986581 | Active DNA demethylation is partially attributed to the ability of Gadd45(A, B, C) proteins to bind histones and modify accessibility of DNA on damaged chromatin. | # |
GATAD1
(details) |
29941 | GATA zinc finger domain containing 1 | 57798 (SSTAR profile) |
Q8WUU5 | GATD1_HUMAN | () | Gatad1 | 1914460 | Q920S3 | GATD1_MOUSE | GATAD | GATA zinc finger domain containing | Histone modification read | # | 20850016 | # | histone | H3K4me3 | # | # | GATA zinc finger domain containing 1 (GATAD1) has been identified as a H3K4me3 interactor. | # |
GATAD2A
(details) |
29989 | GATA zinc finger domain containing 2A | 54815 (SSTAR profile) |
Q86YP4 | P66A_HUMAN | P66_CC PF16563 (137-179) GATA PF00320 (417-451) |
Gatad2a | 2384585 | Q8CHY6 | P66A_MOUSE | GATAD | GATA zinc finger domain containing | Histone modification read | # | 16415179 | NuRD | histone | H2A, H2B, H3, H4 | # | 16415179 | In vitro translated p66α=GATAD2A and p66β showed a strong affinity for all histone tails tested. | # |
GATAD2B
(details) |
30778 | GATA zinc finger domain containing 2B | 57459 (SSTAR profile) |
Q8WXI9 | P66B_HUMAN | P66_CC PF16563 (158-199) GATA PF00320 (420-454) |
Gatad2b | 2443225 | Q8VHR5 | P66B_MOUSE | GATAD | GATA zinc finger domain containing | Histone modification read | # | 16415179 | NuRD | histone | H2A, H2B, H3, H4 | # | 16415179 | In vitro translated p66α and p66β=GATAD2B showed a strong affinity for all histone tails tested. | # |
GFI1
(details) |
4237 | growth factor independent 1 transcription repressor | 2672 (SSTAR profile) |
Q99684 | GFI1_HUMAN | zf-C2H2 PF00096 (255-278, 284-306, 312-334, 340-362, 368-390, 396-419) | Gfi1 | 103170 | P70338 | GFI1_MOUSE | ZNF | Zinc fingers, C2H2-type | Chromatin remodeling | # | 16287849 | # | # | # | # | # | Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1. | # |
GFI1B
(details) |
4238 | growth factor independent 1B transcription repressor | 8328 (SSTAR profile) |
Q5VTD9 | GFI1B_HUMAN | zf-C2H2 PF00096 (163-186, 192-214, 220-242, 248-270, 276-298, 304-327) | Gfi1b | 1276578 | O70237 | GFI1B_MOUSE | ZNF | Zinc fingers, C2H2-type | Histone modification cofactor | # | 24395799 | # | # | # | # | # | The principal hematopoietic regulator T-cell acute lymphocytic leukemia-1 (TAL1) is involved in regulating H3K27me3 variations in collaboration with the transcription factor growth factor independent 1B (GFI1B). | # |
GLYR1
(details) |
24434 | glyoxylate reductase 1 homolog (Arabidopsis) | 84656 (SSTAR profile) |
Q49A26 | GLYR1_HUMAN | PWWP PF00855 (8-89) NAD_binding_2 PF03446 (269-425) NAD_binding_11 PF14833 (431-551) |
Glyr1 | 1921272 | Q922P9 | GLYR1_MOUSE | # | # | Histone modification read | # | 20850016 | # | histone | H3K4me3 | # | 20850016 | N-PAC=GLYR1, MSH-6, and NSD1 as well as NSD2 were identified as H3K36me3 interactors (Figure 1C; Table S2). Interestingly, these four proteins share a PWWP domain which is part of the Tudor domain “Royal Family” and includes the Tudor, chromo and MBT domains that can interact with methylated lysine residues. | # |
GSE1
(details) |
28979 | Gse1 coiled-coil protein | 23199 (SSTAR profile) |
Q14687 | GSE1_HUMAN | DUF3736 PF12540 (718-861) | Gse1 | 1098275 | Q3U3C9 | GSE1_MOUSE | # | # | Histone modification erase | Histone acetylation | 8724849 | BHC, LSD-CoREST | RNA | # | # | 8724849 | A novel repeat composed of alternating Arg and Glu (RE repeat) was observed in KIAA0182. Alternating Arg-Asp tracts have been found in many RNA-binding proteins as a characteristic sequence. The presence of the RE repeat with structural similarity to the RD repeat strongly suggests that KIAA0182=GSE1 exhibits an RNA-binding activity. | # |
GSG2
(details) |
19682 | germ cell associated 2 (haspin) | 83903 (SSTAR profile) |
Q8TF76 | HASP_HUMAN | Haspin_kinase PF12330 (420-783) | Gsg2 | 1194498 | Q9Z0R0 | HASP_MOUSE | # | # | Histone modification write | Histone phosphorylation | 20705812 | # | histone | H3T3 | H3T3ph | 20705812 | Phosphorylation of histone H3 threonine 3 (H3T3ph) by Haspin=GSG2 is necessary for CPC accumulation at centromeres and that CPC subunit Survivin binds directly to H3T3ph. | # |
GTF2I
(details) |
4659 | general transcription factor IIi | 2969 (SSTAR profile) |
P78347 | GTF2I_HUMAN | GTF2I PF02946 (112-188, 360-436, 465-541, 569-647, 733-809, 868-942) | Gtf2i | 1202722 | Q9ESZ8 | GTF2I_MOUSE | # | # | TF | # | 9334314 | BHC | DNA | DNA motif | # | # | Added because it is a complex partner. | # |
GTF3C4
(details) |
4667 | general transcription factor IIIC, polypeptide 4, 90kDa | 9329 (SSTAR profile) |
Q9UKN8 | TF3C4_HUMAN | TFIIIC_delta PF12657 (61-517) DUF5921 PF19336 (516-592) zf-TFIIIC PF12660 (741-789) |
Gtf3c4 | 2138937 | Q8BMQ2 | TF3C4_MOUSE | KAT, GTF | Chromatin-modifying enzymes / K-acetyltransferases, General transcription factors | Histone modification write | Histone acetylation | 10523658 | # | histone | H3 | # | 10523658 | hTFIIIC90=GTF3C4 has an intrinsic histone acetyltransferase activity with a substrate specificity for histone H3. | # |
HAT1
(details) |
4821 | histone acetyltransferase 1 | 8520 (SSTAR profile) |
O14929 | HAT1_HUMAN | Hat1_N PF10394 (26-187) HAT1_C PF21183 (287-337) |
Hat1 | 96013 | Q8BY71 | HAT1_MOUSE | KAT | Chromatin-modifying enzymes / K-acetyltransferases | Histone modification write | Histone acetylation | 9427644 | # | histone | H4, H2A | # | 9427644 | The human holoenzyme consists of two subunits: a catalytic subunit, Hat1, and a subunit that binds core histones, p46, which greatly stimulates the acetyltransferase activity of Hat1. On the other hand, given that the Hat1 holoenzyme bound weakly to H2A and also acetylated the H2A | # |
HCFC1
(details) |
4839 | host cell factor C1 | 3054 (SSTAR profile) |
P51610 | HCFC1_HUMAN | Kelch_1 PF01344 (32-69) Kelch_5 PF13854 (78-114, 319-361) Kelch_3 PF13415 (216-263) |
Hcfc1 | 105942 | Q61191 | HCFC1_MOUSE | # | # | Chromatin remodeling | # | 12670868 | NSL, COMPASS, MLL-HCF, CHD8, MLL2/3, COMPASS-like MLL1,2, MLL4/WBP7 | chromatin | # | # | 12670868 | A series of molecular activities are associated with the N-terminal subunit of HCF-1 in HSV uninfected cells. Two of these activities are associated with opposing roles in the regulation of transcription through the modulation of chromatin structure: Sin3 HDAC and a novel human Set1/Ash2 HMT. | # |
HCFC2
(details) |
24972 | host cell factor C2 | 29915 (SSTAR profile) |
Q9Y5Z7 | HCFC2_HUMAN | Kelch_1 PF01344 (22-60) Kelch_5 PF13854 (69-104, 312-354) Kelch_3 PF13415 (207-253) |
Hcfc2 | 1915183 | Q9D968 | HCFC2_MOUSE | # | # | Histone modification write cofactor, Histone modification write cofactor | Histone methylation, Histone acetylation | 15199122 | MLL-HCF, CHD8, MLL2/3, MLL4/WBP7 | histone | H3 | # | 15199122 | HCF-2 (HCFC2), which specifically interact with a conserved binding motif in the MLL(N) (p300) subunit of MLL (histone methyltransferase ) and provide a potential mechanism for regulating its antagonistic transcriptional properties. | # |
HDAC1
(details) |
4852 | histone deacetylase 1 | 3065 (SSTAR profile) |
Q13547 | HDAC1_HUMAN | Hist_deacetyl PF00850 (28-318) | Hdac1 | 108086 | O09106 | HDAC1_MOUSE | # | # | Histone modification erase | Histone acetylation | 10220385 | SWI/SNF_Brm, NuRD, BHC, MeCP1, mSin3A, core HDAC, mSin3A-like complex, RING2-L3MBTL2, CREST-BRG1, LSD-CoREST | histone | H3, H4 | # | 10220385 | HDAC1, HDAC4, HDAC5, and HDAC6 deacetylate all four core histones equally well, though deacetylation by HDAC4 and HDAC5 is incomplete. | # |
HDAC10
(details) |
18128 | histone deacetylase 10 | 83933 (SSTAR profile) |
Q969S8 | HDA10_HUMAN | Hist_deacetyl PF00850 (24-321) | Hdac10 | 2158340 | Q6P3E7 | HDA10_MOUSE | # | # | Histone modification erase | Histone acetylation | 11861901 | # | histone | H2AKac, H2BKac, H3Kac, H4Kac | H2AK, H2BK, H3K, H4K | 11861901 | HDAC10 can deacetylate histones. | # |
HDAC11
(details) |
19086 | histone deacetylase 11 | 79885 (SSTAR profile) |
Q96DB2 | HDA11_HUMAN | Hist_deacetyl PF00850 (35-318) | Hdac11 | 2385252 | Q91WA3 | HDA11_MOUSE | # | # | Histone modification erase | Histone acetylation | 9346952 | # | histone | H2AKac, H2BKac, H3Kac, H4Kac | H2AK, H2BK, H3K, H4K | 9346952 | HDAC11 is a bona fide histone deacetylase. | # |
HDAC2
(details) |
4853 | histone deacetylase 2 | 3066 (SSTAR profile) |
Q92769 | HDAC2_HUMAN | Hist_deacetyl PF00850 (29-319) | Hdac2 | 1097691 | P70288 | HDAC2_MOUSE | # | # | Histone modification erase | Histone acetylation | 9346952 | SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, NuRD, BHC, MeCP1, mSin3A, core HDAC, mSin3A-like complex, RING2-L3MBTL2, LSD-CoREST | histone | H2AKac, H2BKac, H3Kac, H4Kac | H2AK, H2BK, H3K, H4K | 9346952 | HDAC1, HDAC2, and HDAC3 constitute a human HDAC family. All three proteins possess histone deacetylase activity, and repress transcription when bound to a promoter. | # |
HDAC3
(details) |
4854 | histone deacetylase 3 | 8841 (SSTAR profile) |
O15379 | HDAC3_HUMAN | Hist_deacetyl PF00850 (22-313) | Hdac3 | 1343091 | O88895 | HDAC3_MOUSE | # | # | Histone modification erase | Histone acetylation | 10655483 | # | histone | H2AKac, H2BKac, H3Kac, H4Kac | H2AK, H2BK, H3K, H4K | 10655483 | HDAC1, HDAC2, and HDAC3 constitute a human HDAC family. All three proteins possess histone deacetylase activity, and repress transcription when bound to a promoter. | # |
HDAC4
(details) |
14063 | histone deacetylase 4 | 9759 (SSTAR profile) |
P56524 | HDAC4_HUMAN | HDAC4_Gln PF12203 (63-153) Hist_deacetyl PF00850 (675-992) |
Hdac4 | 3036234 | Q6NZM9 | HDAC4_MOUSE | # | # | Histone modification erase | Histone acetylation | 10220385 | # | histone | H2AKac, H2BKac, H3Kac, H4Kac | H2AK, H2BK, H3K, H4K | 10220385 | HDAC1, HDAC4, HDAC5, and HDAC6 deacetylate all four core histones equally well, though deacetylation by HDAC4 and HDAC5 is incomplete. | # |
HDAC5
(details) |
14068 | histone deacetylase 5 | 10014 (SSTAR profile) |
Q9UQL6 | HDAC5_HUMAN | HDAC4_Gln PF12203 (67-162) Hist_deacetyl PF00850 (704-1022) |
Hdac5 | 1333784 | Q9Z2V6 | HDAC5_MOUSE | # | # | Histone modification erase | Histone acetylation | 10220385 | # | histone | H2AKac, H2BKac, H3Kac, H4Kac | H2AK, H2BK, H3K, H4K | 10220385 | HDAC1, HDAC4, HDAC5, and HDAC6 deacetylate all four core histones equally well, though deacetylation by HDAC4 and HDAC5 is incomplete. | # |
HDAC6
(details) |
14064 | histone deacetylase 6 | 10013 (SSTAR profile) |
Q9UBN7 | HDAC6_HUMAN | Hist_deacetyl PF00850 (106-402, 499-798) zf-UBP PF02148 (1132-1193) |
Hdac6 | 1333752 | Q9Z2V5 | HDAC6_MOUSE | # | # | Histone modification erase | Histone acetylation | 10220385 | # | histone | H2AKac, H2BKac, H3Kac, H4Kac | H2AK, H2BK, H3K, H4K | 10220385 | HDAC1, HDAC4, HDAC5, and HDAC6 deacetylate all four core histones equally well, though deacetylation by HDAC4 and HDAC5 is incomplete. (HDAC6 is possibly not involved in epigenetic signalling, but it deacetylates microtubules and heat shock protein 90; PMID:22498752) | # |
HDAC7
(details) |
14067 | histone deacetylase 7 | 51564 (SSTAR profile) |
Q8WUI4 | HDAC7_HUMAN | Hist_deacetyl PF00850 (541-858) | Hdac7 | 1891835 | Q8C2B3 | HDAC7_MOUSE | # | # | Histone modification erase | Histone acetylation | 18285338 | # | histone | H2AKac, H2BKac, H3Kac, H4Kac | H2AK, H2BK, H3K, H4K | 18285338 | The isolated and purified catalytic domain of the human class IIa HDAC, cdHDAC7, has an intrinsic low level of deacetylase activity in the absence of any complex partner which can be inhibited by known HDAC inhibitors such as the hydroxamic acid TSA. It has been showen that the isolated catalytic domain of class IIa HDACs have weak but measurable intrinsic catalytic activity on chemically acetylated core histones. | # |
HDAC8
(details) |
13315 | histone deacetylase 8 | 55869 (SSTAR profile) |
Q9BY41 | HDAC8_HUMAN | Hist_deacetyl PF00850 (33-320) | Hdac8 | 1917565 | Q8VH37 | HDAC8_MOUSE | # | # | Histone modification erase | Histone acetylation | 10748112 | # | histone | H2AKac, H2BKac, H3Kac, H4Kac | H2AK, H2BK, H3K, H4K | 10748112 | HDAC8 exhibited deacetylase activity toward acetylated histone, indicating that this protein is a bona fide histone deacetylase. | # |
HDAC9
(details) |
14065 | histone deacetylase 9 | 9734 (SSTAR profile) |
Q9UKV0 | HDAC9_HUMAN | HDAC4_Gln PF12203 (37-119) Hist_deacetyl PF00850 (654-972) |
Hdac9 | 1931221 | Q99N13 | HDAC9_MOUSE | # | # | Histone modification erase | Histone acetylation | 12590135 | # | histone | H3Kac, H4Kac | H3K, H4K | 12590135 | A new member of the Class II HDAC family, HDAC9. The enzyme contains a conserved deacetylase domain, represses reporter activity when recruited to a promoter, and utilizes histones H3 and H4 as substrates in vitro and in vivo. | # |
HDGF
(details) |
4856 | hepatoma-derived growth factor | 3068 (SSTAR profile) |
P51858 | HDGF_HUMAN | PWWP PF00855 (13-93) | Hdgf | 1194494 | P51859 | HDGF_MOUSE | # | # | Chromatin remodeling, TF | TF repressor | 18331345, 17974029 | # | DNA | DNA motif | # | 18331345 | SUMOylated HDGF is not bound to chromatin. | # |
HDGFL2
(details) |
14680 | HDGF like 2 | 84717 (SSTAR profile) |
Q7Z4V5 | HDGR2_HUMAN | PWWP PF00855 (7-86) LEDGF PF11467 (472-568) |
Hdgfrp2 | 1194492 | Q3UMU9 | HDGR2_MOUSE | # | # | Histone modification read | # | 217205545 | # | histone | H3K79me3, H4K20me3, H3K36me3 | # | 217205545 | The crystal structures of the PWWP domains from seven different human proteins and three PWWP domain complex structures with histone peptides, i.e., BRPF1-H3K36me3, HDGF2-H3K79me3 and HDGF2-H4K20me3 shows that the PWWP domain can not only bind DNA but also histones. | # |
HELLS
(details) |
4861 | helicase, lymphoid-specific | 3070 (SSTAR profile) |
Q9NRZ9 | HELLS_HUMAN | SNF2-rel_dom PF00176 (226-576) Helicase_C PF00271 (600-712) |
Hells | 106209 | Q60848 | HELLS_MOUSE | # | # | Chromatin remodeling | # | 14612388 | # | chromatin | # | # | 14517253, 14612388 | Lymphoid-specific helicase (Lsh=HELLS) is another member of the SNF2 family of chromatin remodeling proteins. | # |
HIF1AN
(details) |
17113 | hypoxia inducible factor 1, alpha subunit inhibitor | 55662 (SSTAR profile) |
Q9NWT6 | HIF1N_HUMAN | Cupin_8 PF13621 (51-299) | Hif1an | 2442345 | Q8BLR9 | HIF1N_MOUSE | # | # | Histone modification erase cofactor | Histone acetylation | 11641274 | # | histone | # | # | 11641274 | VHL and FIH-1=HIF1AN interact with histone deacetylases in vitro. | # |
HINFP
(details) |
17850 | histone H4 transcription factor | 25988 (SSTAR profile) |
Q9BQA5 | HINFP_HUMAN | zf-C2H2_4 PF13894 (229-251) zf-C2H2 PF00096 (255-278, 345-368) |
Hinfp | 2429620 | Q8K1K9 | HINFP_MOUSE | ZNF | Zinc fingers, C2H2-type | Histone modification read, TF | TF activator, TF repressor | 14585971 | # | histone, DNA | H4, DNA motif | # | 14585971 | HiNF-P interacts with conserved H4 cell cycle regulatory sequences in vivo. | # |
HIRA
(details) |
4916 | histone cell cycle regulator | 7290 (SSTAR profile) |
P54198 | HIRA_HUMAN | WD40 PF00400 (9-44, 64-97, 122-159, 166-201) Hira PF07569 (764-962) |
Hira | 99430 | Q61666 | HIRA_MOUSE | WDR | WD repeat domain containing | Histone modification read | # | 9710638 | # | histone | H2B, H4 | # | 9710638 | HIRA interacts with core histone H4. H2B- and H4-binding domains are overlapping but distinguishable in the carboxy-terminal region of HIRA, and the region for HIRA interaction has been mapped to the amino-terminal tail of H2B and the second alpha helix of H4. | # |
HIRIP3
(details) |
4917 | HIRA interacting protein 3 | 8479 (SSTAR profile) |
Q9BW71 | HIRP3_HUMAN | CHZ PF09649 (486-556) | Hirip3 | 2142364 | Q8BLH7 | HIRP3_MOUSE | # | # | Histone modification read | # | 9710638 | # | histone | H2A, H3 | # | 9710638 | In vitro, HIRIP3 directly interacted with HIRA but also with core histones H2B and H3, suggesting that a HIRA-HIRIP3-containing complex could function in some aspects of chromatin and histone metabolism. | # |
HJURP
(details) |
25444 | Holliday junction recognition protein | 55355 (SSTAR profile) |
Q8NCD3 | HJURP_HUMAN | Scm3 PF10384 (11-71) HJURP_mid PF12346 (123-391) HJURP_C PF12347 (416-466, 560-620) |
Hjurp | 2685821 | Q6PG16 | HJURP_MOUSE | # | # | Histone chaperone | # | 21478274 | # | histone | H4 | # | 21478274 | Deposition of CENP-A to the centromere requires histone chaperone HJURP (Holliday junction recognition protein). The crystal structure of an HJURP–CENP-A–histone H4 complex shows that HJURP binds a CENP-A–H4 heterodimer. | # |
HLCS
(details) |
4976 | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) | 3141 (SSTAR profile) |
P50747 | BPL1_HUMAN | BPL_LplA_LipB PF03099 (472-603) BPL_C PF02237 (669-716) |
Hlcs | 894646 | Q920N2 | BPL1_MOUSE | # | # | Histone modification write | # | 14613969 | # | histone | H1, H2A, H2B, H4 | # | 14613969 | Nuclear HCS =HLCS retains its biotinylating activity and has been shown to biotinylate purified histones in vitro. | # |
HLTF
(details) |
11099 | helicase-like transcription factor | 6596 (SSTAR profile) |
Q14527 | HLTF_HUMAN | HIRAN PF08797 (61-154) SNF2-rel_dom PF00176 (242-720) zf-C3HC4_2 PF13923 (760-800) Helicase_C PF00271 (834-950) |
Hltf | 1196437 | Q6PCN7 | HLTF_MOUSE | RNF | RING-type (C3HC4) zinc fingers | Chromatin remodeling cofactor | # | 18719106 | # | chromatin | # | # | 18719106 | Acts as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. | # |
HMG20A
(details) |
5001 | high mobility group 20A | 10363 (SSTAR profile) |
Q9NP66 | HM20A_HUMAN | HMG_box PF00505 (103-170) | Hmg20a | 1914117 | Q9DC33 | HM20A_MOUSE | HMGX | High mobility group / Non-canonical | Chromatin remodeling cofactor | # | 24227653 | LSD-CoREST | histone | H3K4 | # | 24227653 | Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4. | # |
HMG20B
(details) |
5002 | high mobility group 20B | 10362 (SSTAR profile) |
Q9P0W2 | HM20B_HUMAN | HMG_box PF00505 (70-138) | Hmg20b | 1341190 | Q9Z104 | HM20B_MOUSE | HMGX | High mobility group / Non-canonical | Chromatin remodeling | # | 11997092 | BHC, LSD-CoREST | DNA | # | # | 11997092 | The high-mobility-group (HMG) proteins are chromatin-associated proteins that are common to all higher organisms. They bind DNA in a sequence-specific or non-sequence-specific way to induce DNA bending, and regulate chromatin function and gene expression. | # |
HMGB1
(details) |
4983 | high mobility group box 1 | 3146 (SSTAR profile) |
P09429 | HMGB1_HUMAN | HMG_box_2 PF09011 (6-79) HMG_box PF00505 (95-163) |
Hmgb1 | 96113 | P63158 | HMGB1_MOUSE | HMG | High-mobility group / Canonical | Chromatin remodeling | # | 19158276 | # | chromatin | # | # | # | Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance. | # |
HMGN1
(details) |
4984 | high mobility group nucleosome binding domain 1 | 3150 (SSTAR profile) |
P05114 | HMGN1_HUMAN | HMG14_17 PF01101 (2-96) | Hmgn1 | 96120 | P18608 | HMGN1_MOUSE | HMG | High-mobility group / Canonical | Chromatin remodeling | # | 22395460, 20123071 | # | histone | H1 | # | # | HMGB1-4 proteins are believed to dock to the H1 linker. | # |
HMGN2
(details) |
4986 | high mobility group nucleosomal binding domain 2 | 3151 (SSTAR profile) |
P05204 | HMGN2_HUMAN | HMG14_17 PF01101 (2-89) | Hmgn2 | 96136 | P09602 | HMGN2_MOUSE | HMG | High-mobility group / Canonical | Chromatin remodeling | # | 22395460, 20123071 | # | histone | H1 | # | # | HMGB1-4 proteins are believed to dock to the H1 linker. | # |
HMGN3
(details) |
12312 | high mobility group nucleosomal binding domain 3 | 9324 (SSTAR profile) |
Q15651 | HMGN3_HUMAN | HMG14_17 PF01101 (2-95) | Hmgn3 | 2138069 | Q9DCB1 | HMGN3_MOUSE | HMG | High-mobility group / Canonical | Chromatin remodeling | # | 22395460, 20123071 | # | histone | H1 | # | # | HMGB1-4 proteins are believed to dock to the H1 linker. | # |
HMGN4
(details) |
4989 | high mobility group nucleosomal binding domain 4 | 10473 (SSTAR profile) |
O00479 | HMGN4_HUMAN | HMG14_17 PF01101 (2-89) | # | # | # | # | HMG | High-mobility group / Canonical | Chromatin remodeling | # | 22395460, 20123071 | # | histone | H1 | # | # | HMGB1-4 proteins are believed to dock to the H1 linker. | # |
HMGN5
(details) |
8013 | high mobility group nucleosome binding domain 5 | 79366 (SSTAR profile) |
P82970 | HMGN5_HUMAN | HMG14_17 PF01101 (1-112) | Hmgn5 | 1355295 | Q9JL35 | HMGN5_MOUSE | HMG | High-mobility group / Canonical | Chromatin remodeling | # | 22395460, 20123071 | # | histone | H1 | # | # | HMGB1-4 proteins are believed to dock to the H1 linker. | # |
HNRNPU
(details) |
5048 | Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (GRIP120) (Nuclear p120 ribonucleoprotein) (Scaffold-attachment factor A) (SAF-A) (p120) (pp120) | 3192 (SSTAR profile) |
Q00839 | HNRPU_HUMAN | SAP PF02037 (8-42) SPRY PF00622 (355-462) AAA_33 PF13671 (499-643) |
Hnrpu | 1858195 | Q8VEK3 | HNRPU_MOUSE | HNRNP | Heterogeneous nuclear ribonucleoproteins | RNA modification | Alternative splicing | 22325991 | # | RNA | mRNA | # | 22325991 | Regulates SMN2 alternative splicing | New |
HNRPL
(details) |
5045 | Heterogeneous nuclear ribonucleoprotein L (hnRNP L) | 3191 (SSTAR profile) |
P14866 | HNRPL_HUMAN | RRM_1 PF00076 (106-155) RRM_8 PF11835 (191-269) RRM_5 PF13893 (361-480) domain PF22976 (492-587) |
Hnrpl | 104816 | Q8R081 | HNRPL_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 25623890 | # | RNA | mRNA | # | 25623890 | Regulates exon inclusion of CD44 | New |
HNRPM
(details) |
5046 | Heterogeneous nuclear ribonucleoprotein M (hnRNP M) | 4670 (SSTAR profile) |
P52272 | HNRPM_HUMAN | HnRNP_M_NLS PF11532 (41-70) RRM_1 PF00076 (74-143, 206-274, 655-722) |
Hnrpm | 1926465 | Q9D0E1 | HNRPM_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 19874820 | # | RNA | mRNA | # | 19874820 | Regulates alternative splicing FGFR2. | New |
HP1BP3
(details) |
24973 | heterochromatin protein 1, binding protein 3 | 50809 (SSTAR profile) |
Q5SSJ5 | HP1B3_HUMAN | Linker_histone PF00538 (159-229, 262-328, 342-411) | Hp1bp3 | 109369 | Q3TEA8 | HP1B3_MOUSE | # | # | Chromatin remodeling | # | 25100860 | # | chromatin | # | # | # | Chromatin organizer protein HP1BP3 is mediating chromatin condensation during hypoxia. | # |
HR
(details) |
5172 | hair growth associated | 55806 (SSTAR profile) |
O43593 | HAIR_HUMAN | JmjC PF02373 (1051-1139) | Hr | 96223 | Q61645 | HAIR_MOUSE | # | # | Histone modification erase | Histone methylation | 24334705 | # | histone | H3K9me1, H3K9me2 | H3K9 | 24334705 | HR can demethylate monomethylated or dimethylated histone H3 lysine 9 (H3K9me1 or me2). | # |
HSFX3
(details) |
52395 | heat shock transcription factor family, X-linked member 3 | 101928917 (SSTAR profile) |
A0A1B0GWH4 | HSFX3_HUMAN | HSF_DNA-bind PF00447 (83-181) | # | # | # | # | # | # | # | # | # | # | # | # | # | # | # | New |
HSPA1A
(details) |
5232 | heat shock 70kDa protein 1A | 3303 (SSTAR profile) |
P08107 | HSP71_HUMAN | () | Hspa1a | 96244 | Q61696 | HS71A_MOUSE | HSP70 | Heat shock proteins / HSP70 | Histone modification write cofactor, Histone modification write cofactor | Histone methylation, Histone acetylation | 22123078 | CHD8, MLL2/3, MLL4/WBP7 | histone | # | # | 22123078 | # | # |
HSPA1A
(details) |
5232 | heat shock protein family A (Hsp70) member 1B | 3303 (SSTAR profile) |
P0DMV8 | HS71A_HUMAN | HSP70 PF00012 (6-611) | Hspa1a | 96244 | Q61696 | HS71A_MOUSE | HSPA | Heat shock 70kDa proteins | Histone modification write cofactor | Histone acetylation, Histone methylation, Histone ubiquitination | 16809764, 2123078 | # | Protein | HDAC | # | 16809764, 2123078, 24613385 | Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling. | New |
HSPA1B
(details) |
5233 | heat shock 70kDa protein 1B | 3304 (SSTAR profile) |
P08107 | HSP71_HUMAN | () | Hspa1a | 96244 | Q61696 | HS71A_MOUSE | HSP70 | Heat shock proteins / HSP70 | Histone modification write cofactor, Histone modification write cofactor | Histone methylation, Histone acetylation | 22123078 | CHD8, MLL2/3, MLL4/WBP7 | histone | # | # | 22123078 | # | # |
HSPA1B
(details) |
5233 | heat shock protein family A (Hsp70) member 1B | 3304 (SSTAR profile) |
P0DMV9 | HS71B_HUMAN | HSP70 PF00012 (6-611) | Hspa1b | 99517 | P17879 | HS71B_MOUSE | HSPA | Heat shock 70kDa proteins | Histone modification write cofactor | Histone acetylation, Histone methylation, Histone ubiquitination | 16809764, 2123078 | # | Protein | HDAC | # | 16809764, 2123078, 24613385 | Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling. | New |
HUWE1
(details) |
30892 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 10075 (SSTAR profile) |
Q7Z6Z7 | HUWE1_HUMAN | DUF908 PF06012 (25-338) DUF913 PF06025 (404-820) domain PF22562 (1317-1355) WWE PF02825 (1617-1679) UBM PF14377 (2962-2994, 3055-3081) HECT PF00632 (4067-4373) |
Huwe1 | 1926884 | Q7TMY8 | HUWE1_MOUSE | # | # | Histone modification write | Histone ubiquitination | 15767685 | # | histone | H3K9 | # | 15767685 | A HECT=HUWE1 domain-containing E3 that ubiquitinates histones. | # |
IKBKAP
(details) |
5959 | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein | 8518 (SSTAR profile) |
O95163 | ELP1_HUMAN | IKI3 PF04762 (2-955) | Ikbkap | 1914544 | Q7TT37 | ELP1_MOUSE | ELP | Elongator acetyltransferase complex subunits | Scaffold protein | # | 11818576, 11714725 | Pol2 elongator | # | RNA | # | 11818576, 11714725 | The human Elongator facilitates transcription by RNA polymerase II in a chromatin- and acetyl-CoA-dependent manner. Several human homologues of the yeast Elongator subunits have been identified as subunits of the human Elongator complex, including StIP1 (STAT-interacting protein 1) and IKAP (IKK complex-associated protein) =IKBKAP. | # |
IKZF1
(details) |
13176 | IKAROS family zinc finger 1 (Ikaros) | 10320 (SSTAR profile) |
Q13422 | IKZF1_HUMAN | zf-C2H2 PF00096 (145-167, 173-195, 201-224) | Ikzf1 | 1342540 | Q03267 | IKZF1_MOUSE | ZNF, IKZF | Zinc fingers, C2H2-type, IKAROS zinc fingers | Chromatin remodeling, TF | # | 19141594 | # | DNA | DNA motif | # | 19141594 | Ikaros=IKZF1 forms dimers and multimers efficiently, and it has been proposed that Ikaros induces heterochromatization or chromatin remodeling of mouse DNA, resulting in repression or activation of target genes. The results provide insight into possible structural and functional roles of pericentromeric regions in mouse and human chromosomes. | # |
IKZF3
(details) |
13178 | IKAROS family zinc finger 3 (Aiolos) | 22806 (SSTAR profile) |
Q9UKT9 | IKZF3_HUMAN | zf-C2H2 PF00096 (146-168, 202-222) | Ikzf3 | 1342542 | O08900 | IKZF3_MOUSE | ZNF, IKZF | Zinc fingers, C2H2-type, "IKAROS zinc fingers" | TF | # | # | # | DNA | DNA motif | # | # | Associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A. (UniProt) | # |
ING1
(details) |
6062 | inhibitor of growth family, member 1 | 3621 (SSTAR profile) |
Q9UK53 | ING1_HUMAN | ING PF12998 (186-254) | Ing1 | 1349481 | Q9QXV3 | ING1_MOUSE | PHF | Zinc fingers, PHD-type | Histone modification read | # | 18533182 | # | histone | H3K4me3 | # | 18533182 | Both DNA repair and apoptotic activities of ING1 require the interaction of the C-terminal plant homeodomain (PHD) finger with histone H3 trimethylated at Lys4 (H3K4me3). The ING1 PHD finger recognizes methylated H3K4 but not other histone modifications as revealed by peptide microarrays. | # |
ING2
(details) |
6063 | inhibitor of growth family, member 2 | 3622 (SSTAR profile) |
Q9H160 | ING2_HUMAN | ING PF12998 (27-122) | Ing2 | 1916510 | Q9ESK4 | ING2_MOUSE | PHF | Zinc fingers, PHD-type | Histone modification read | # | 16728974 | mSin3A-like complex | histone | H3K4me3 | # | 16728974 | ING2, a native subunit of a repressive mSin3a-HDAC1 histone deacetylase complex, binds with high affinity to the trimethylated species. In response to DNA damage, recognition of H3K4me3 by the ING2 PHD domain stabilizes the mSin3a-HDAC1 complex at the promoters of proliferation genes. | # |
ING3
(details) |
14587 | inhibitor of growth family, member 3 | 54556 (SSTAR profile) |
Q9NXR8 | ING3_HUMAN | ING PF12998 (3-104) | Ing3 | 1919027 | Q8VEK6 | ING3_MOUSE | PHF | Zinc fingers, PHD-type | Chromatin remodeling, Histone modification write cofactor | Histone acetylation | 12545155 | SWR, NuA4, Piccolo_NuA4 | histone | H2A, H4 | # | 12545155 | p47ING3 has a PHD-finger motif at its C-terminal region similar to p33ING1 and p33ING2. Although the precise function of the PHD-finger motif is not fully clarified, it is found in proteins involved in chromatin remodeling. | # |
ING4
(details) |
19423 | inhibitor of growth family, member 4 | 51147 (SSTAR profile) |
Q9UNL4 | ING4_HUMAN | ING PF12998 (6-107) | Ing4 | 107307 | Q8C0D7 | ING4_MOUSE | PHF | Zinc fingers, PHD-type | Histone modification read | # | 18381289 | HBO1 | histone | H3K4me3 | # | 18381289 | Crystal structure of ING4-PHD bound to H3K4me3. | # |
ING5
(details) |
19421 | inhibitor of growth family, member 5 | 84289 (SSTAR profile) |
Q8WYH8 | ING5_HUMAN | ING PF12998 (6-107) | Ing5 | 1922816 | Q9D8Y8 | ING5_MOUSE | PHF | Zinc fingers, PHD-type | Histone modification read | # | 18623064 | HBO1, MOZ/MORF | histone | H3K4me3, H3K4me2 | # | 18623064 | Crystal structure of the ING5 PHD finger in complex with its histone target (H3K4me3). Binding affinities for unmodified, mono-, di-, and tri-methylated histone peptides showed that both full-length ING5 and methylated H3K4 are essential for the acetyltransferase activity of the MOZ/MORF and HBO1 complexes. | # |
INO80
(details) |
26956 | INO80 complex subunit | 54617 (SSTAR profile) |
Q9ULG1 | INO80_HUMAN | DBINO PF13892 (277-405) SNF2-rel_dom PF00176 (521-821) Helicase_C PF00271 (1102-1214) |
Ino80 | 1915392 | Q6ZPV2 | INO80_MOUSE | INO80 | INO80 complex subunits | Chromatin remodeling | # | 16298340 | Ino80 | DNA | # | # | 16298340 | The proteins belonging to SWI2/SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. Functional activity of the domains from hINO80 gene both in terms of the DNA dependent ATPase as well as DNA binding activity. | # |
INO80B
(details) |
13324 | INO80 complex subunit B | 83444 (SSTAR profile) |
Q9C086 | IN80B_HUMAN | PAPA-1 PF04795 (187-284) zf-HIT PF04438 (308-336) |
Ino80b | 1917270 | Q99PT3 | IN80B_MOUSE | ZNHIT, INO80 | Zinc fingers, HIT-type, INO80 complex subunits | Chromatin remodeling cofactor | # | 21303910 | Ino80 | chromatin | # | # | 21303910 | Composed of the hIno80 Snf2 ATPase domain, the Ies2=INO80B and Ies6 proteins, the AAA+ ATPases Tip49a and Tip49b, and the actin-related protein Arp5. | # |
INO80C
(details) |
26994 | INO80 complex subunit C | 125476 (SSTAR profile) |
Q6PI98 | IN80C_HUMAN | YL1_C PF08265 (142-170) | Ino80c | 2443014 | Q8BHA0 | IN80C_MOUSE | INO80 | INO80 complex subunits | Chromatin remodeling cofactor | # | 16230350 | Ino80, CHD8, MLL2/3, MLL4/WBP7 | chromatin | # | # | 16230350 | FLAG-tagged PAPA-1, C18orf37, Amida, FLJ20309, and FLJ90652 each copurified with the hINO80 helicase and the Tip49a, Tip49b, PAPA-1, C18orf37, Arp4, Arp5, Arp8, Amida, NFRKB, MCRS1, FLJ90652, and FLJ20309 proteins, which argues that they are all components of a multiprotein hINO80-containing complex. | # |
INO80D
(details) |
25997 | INO80 complex subunit D | 54891 (SSTAR profile) |
Q53TQ3 | IN80D_HUMAN | zf-C3Hc3H PF13891 (18-79, 453-511) | Ino80d | 3027003 | Q66JY2 | IN80D_MOUSE | INO80 | INO80 complex subunits | Chromatin remodeling cofactor | # | 21303910 | Ino80 | chromatin | # | # | 21303910 | Component of the chromatin remodeling INO80 complex. | # |
INO80E
(details) |
26905 | INO80 complex subunit E | 283899 (SSTAR profile) |
Q8NBZ0 | IN80E_HUMAN | () | Ino80e | 2141881 | # | # | INO80 | INO80 complex subunits | Chromatin remodeling cofactor | # | 21303910 | # | chromatin | # | # | 21303910 | Component of the chromatin remodeling INO80 complex. | # |
JADE1
(details) |
30027 | jade family PHD finger 1 | 79960 (SSTAR profile) |
Q6IE81 | JADE1_HUMAN | EPL1 PF10513 (17-181) PHD_2 PF13831 (218-251) zf-HC5HC2H_2 PF13832 (256-369) |
Jade1 | 1925835 | Q6ZPI0 | JADE1_MOUSE | PHF | Zinc fingers, PHD-type | Histone modification write | Histone acetylation | 16387653 | HBO1 | histone | H3, H4 | H3ac, H4ac | 16387653 | HBO1-JADE(1,2,3=PHF15,PHF16,PHF17)-ING-hEAF6 tetramer complexes are likely responsible for the majority of histone H4 acetylation higher eukaryotes. | # |
JADE2
(details) |
22984 | jade family PHD finger 2 | 23338 (SSTAR profile) |
Q9NQC1 | JADE2_HUMAN | EPL1 PF10513 (16-177) PHD_2 PF13831 (214-247) zf-HC5HC2H_2 PF13832 (253-364) |
Jade2 | 1924151 | Q6ZQF7 | JADE2_MOUSE | PHF | Zinc fingers, PHD-type | Histone modification write | Histone acetylation | 16387653 | HBO1 | histone | H3, H4 | H3ac, H4ac | 16387653 | HBO1-JADE(1,2,3=PHF15,PHF16,PHF17)-ING-hEAF6 tetramer complexes are likely responsible for the majority of histone H4 acetylation higher eukaryotes. | # |
JADE3
(details) |
22982 | jade family PHD finger 3 | 9767 (SSTAR profile) |
Q92613 | JADE3_HUMAN | EPL1 PF10513 (47-177) PHD_2 PF13831 (215-248) zf-HC5HC2H_2 PF13832 (254-366) |
Jade3 | 2148019 | Q6IE82 | JADE3_MOUSE | PHF | Zinc fingers, PHD-type | Histone modification write | Histone acetylation | 14612400 | HBO1 | histone | H3, H4 | H3ac, H4ac | 14612400 | Function in the activation and/or repression of Hox complex genes via modulation of chromatin structure. | # |
JAK2
(details) |
6192 | Janus kinase 2 | 3717 (SSTAR profile) |
O60674 | JAK2_HUMAN | FERM_F1 PF18379 (39-133) FERM_F2 PF18377 (144-261) Jak1_Phl PF17887 (306-381) domain PF21990 (398-502) PK_Tyr_Ser-Thr PF07714 (545-805, 849-1122) |
Jak2 | 96629 | Q62120 | JAK2_MOUSE | SH2D | SH2 domain containing | Histone modification write | Histone phosphorylation | 19783980 | # | histone | H3T41 | H3T41ph | 19783980 | Human JAK2 is present in the nucleus of haematopoietic cells and directly phosphorylates Tyr 41 (Y41) on histone H3. | # |
JARID2
(details) |
6196 | jumonji, AT rich interactive domain 2 | 3720 (SSTAR profile) |
Q92833 | JARD2_HUMAN | JmjN PF02375 (558-591) ARID PF01388 (624-709) JmjC PF02373 (916-1031) zf-C5HC2 PF02928 (1139-1191) |
Jarid2 | 104813 | Q62315 | JARD2_MOUSE | # | # | Histone modification write cofactor | Histone methylation | 20075857 | PRC2 | histone | H3K27, H3K9 | # | 20075857 | JARID2 is sufficient to recruit PcG proteins to a heterologous promoter, and inhibition of JARID2 expression leads to a major loss of PcG binding and to a reduction of H3K27me3 levels on target genes. | # |
JDP2
(details) |
17546 | Jun dimerization protein 2 | 122953 (SSTAR profile) |
Q8WYK2 | JDP2_HUMAN | bZIP_1 PF00170 (70-128) | Jdp2 | 1932093 | P97875 | JDP2_MOUSE | bZIP | basic leucine zipper proteins | Chromatin remodeling, Histone modification erase cofactor | Histone acetylation | 16518400 | # | DNA | # | # | 16518400 | JDP2 has histone-chaperone activity in vitro. The sequence-specific DNA-binding protein JDP2 may control transcription via direct regulation of the modification of histones and the assembly of chromatin. | # |
JMJD1C
(details) |
12313 | jumonji domain containing 1C | 221037 (SSTAR profile) |
Q15652 | JHD2C_HUMAN | domain PF22989 (11-86) domain PF22988 (108-181) domain PF22987 (179-254) JmjC PF02373 (2379-2481) |
Jmjd1c | 1918614 | Q69ZK6 | JHD2C_MOUSE | # | # | Histone modification erase | Histone methylation | 17549425 | # | histone | H3K9me | H3K9 | 17549425 | JMJD1A (TSGA), JMJD1B (5qNCA) and JMJD1C with the common domain architecture are histone H3K9 demethylases implicated in the nuclear hormone receptor-based transcriptional regulation. | # |
JMJD6
(details) |
19355 | jumonji domain containing 6 | 23210 (SSTAR profile) |
Q6NYC1 | JMJD6_HUMAN | JmjC PF02373 (174-288) | Jmjd6 | 1858910 | Q9ERI5 | JMJD6_MOUSE | # | # | Histone modification erase | Histone methylation | 17947579 | # | histone | H3R2me, H4R3me | H3R2, H4R3 | 17947579 | The Jumonji domain-containing 6 protein (JMJD6) is a JmjC-containing iron- and 2-oxoglutarate-dependent dioxygenase that demethylates histone H3 at arginine 2 (H3R2) and histone H4 at arginine 3 (H4R3) in both biochemical and cell-based assays. | # |
KANSL1
(details) |
24565 | KAT8 regulatory NSL complex subunit 1 | 284058 (SSTAR profile) |
Q7Z3B3 | KANL1_HUMAN | PEHE PF15275 (887-1020) | Kansl1 | 1923969 | Q80TG1 | KANL1_MOUSE | # | # | Histone modification write cofactor, Histone modification write cofactor | Histone methylation, Histone acetylation | 20018852 | NSL, CHD8, MLL2/3, MLL4/WBP7 | histone | H4 | H4ac | 20018852 | As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. | # |
KANSL2
(details) |
26024 | KAT8 regulatory NSL complex subunit 2 | 54934 (SSTAR profile) |
Q9H9L4 | KANL2_HUMAN | zf-C3Hc3H PF13891 (28-92, 308-365) | Kansl2 | 1916862 | Q8BQR4 | KANL2_MOUSE | # | # | Histone modification write cofactor | Histone acetylation | 20018852 | NSL | histone | H5 | H4ac | 20018852 | As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. | # |
KANSL3
(details) |
25473 | KAT8 regulatory NSL complex subunit 3 | 55683 (SSTAR profile) |
Q9P2N6 | KANL3_HUMAN | Abhydrolase_11 PF20408 (329-449) | Kansl3 | 1918055 | A2RSY1 | KANL3_MOUSE | # | # | Histone modification write cofactor | Histone acetylation | 20018852 | NSL | histone | H6 | H4ac | 20018852 | As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. | # |
KAT2A
(details) |
4201 | K(lysine) acetyltransferase 2A | 2648 (SSTAR profile) |
Q92830 | KAT2A_HUMAN | PCAF_N PF06466 (92-335) Acetyltransf_1 PF00583 (536-627) Bromodomain PF00439 (738-819) |
Kat2a | 1343101 | Q9JHD2 | KAT2A_MOUSE | KAT | Chromatin-modifying enzymes / K-acetyltransferases | Histone modification write | Histone acetylation | 10611234 | TFTC-HAT, SAGA, ATAC, STAGA | histone | # | # | 10611234 | Current models of HAT protein activity suggest that one hypothesis for the role of hGCN5=KAT2A in c-Myc's activities might be due to the relaxing of chromatin packaging at target genes following histone acetylation by hGCN5. | # |
KAT2B
(details) |
8638 | K(lysine) acetyltransferase 2B | 8850 (SSTAR profile) |
Q92831 | KAT2B_HUMAN | PCAF_N PF06466 (77-323) Acetyltransf_1 PF00583 (531-622) Bromodomain PF00439 (733-814) |
Kat2b | 1343094 | Q9JHD1 | KAT2B_MOUSE | KAT | Chromatin-modifying enzymes / K-acetyltransferases | Histone modification write | Histone acetylation | 8945521 | # | histone | # | # | 8945521 | The cellular p300/CBP associated factor (PCAF=KAT2B) possesses intrinsic histone acetyltransferase activity. | # |
KAT5
(details) |
5275 | K(lysine) acetyltransferase 5 | 10524 (SSTAR profile) |
Q92993 | KAT5_HUMAN | Tudor-knot PF11717 (7-65) zf-MYST PF17772 (229-283) MOZ_SAS PF01853 (288-470) |
Kat5 | 1932051 | Q8CHK4 | KAT5_MOUSE | KAT, ZC2HC | Chromatin-modifying enzymes / K-acetyltransferases, Zinc fingers, C2HC-type containing | Histone modification write | Histone acetylation | 10096020 | SWR, NuA4, Piccolo_NuA4 | histone | H2AK5, H3K14, H4K5,H4K8, H4K12, H4K16 | H2AK5ac, H3K14ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac | 10096020 | Tip60=KAT5 significantly acetylates amino-terminal tail peptides of histones H2A, H3 and H4, but not H2B, consistent with substrate preference on intact histones. Preferred acetylation sites for Tip60 are the Lys-5 of histone H2A, the Lys-14 of histone H3, and the Lys-5, -8, -12, -16 of histone H4. | # |
KAT6A
(details) |
13013 | K(lysine) acetyltransferase 6A | 7994 (SSTAR profile) |
Q92794 | KAT6A_HUMAN | SAMD1_WH PF21524 (10-73) PHD PF00628 (208-263, 264-310) zf-MYST PF17772 (507-560) MOZ_SAS PF01853 (564-741) |
Kat6a | 2442415 | Q8BZ21 | KAT6A_MOUSE | KAT, ZC2HC, PHF | Chromatin-modifying enzymes / K-acetyltransferases, Zinc fingers, C2HC-type containing, Zinc fingers, PHD-type | Histone modification write | Histone acetylation | 11313971 | MOZ/MORF | histone | H3, H4 | H3ac, H4ac | 11313971 | The monocytic leukemia zinc finger protein MOZ=KAT6A is a histone acetyltransferase. | # |
KAT6B
(details) |
17582 | K(lysine) acetyltransferase 6B | 23522 (SSTAR profile) |
Q8WYB5 | KAT6B_HUMAN | SAMD1_WH PF21524 (9-73) PHD PF00628 (271-317) zf-MYST PF17772 (718-771) MOZ_SAS PF01853 (776-979) |
Kat6b | 1858746 | Q8BRB7 | KAT6B_MOUSE | KAT, ZC2HC, PHF | Chromatin-modifying enzymes / K-acetyltransferases, Zinc fingers, C2HC-type containing, Zinc fingers, PHD-type | Histone modification write | Histone acetylation | 10497217 | MOZ/MORF | histone | H3 | H3ac | 10497217 | A novel human histone acetyltransferase, termed MORF=KAT6B (monocytic leukemia zinc finger protein-related factor). | # |
KAT7
(details) |
17016 | K(lysine) acetyltransferase 7 | 11143 (SSTAR profile) |
O95251 | KAT7_HUMAN | zf-C2HC PF01530 (184-212) zf-MYST PF17772 (337-388) MOZ_SAS PF01853 (393-570) |
Kat7 | 2182799 | Q5SVQ0 | KAT7_MOUSE | KAT, ZC2HC | Chromatin-modifying enzymes / K-acetyltransferases, Zinc fingers, C2HC-type containing | Histone modification write | Histone acetylation | 10438470 | HBO1 | histone | H4 | H4ac | 10438470 | A novel protein, HBO1=KAT7 (histone acetyltransferase binding to ORC), that interacts with human ORC1 protein. | # |
KAT8
(details) |
17933 | K(lysine) acetyltransferase 8 | 84148 (SSTAR profile) |
Q9H7Z6 | KAT8_HUMAN | Tudor-knot PF11717 (54-110) zf-MYST PF17772 (176-230) MOZ_SAS PF01853 (235-412) |
Kat8 | 1915023 | Q9D1P2 | KAT8_MOUSE | KAT, ZC2HC | Chromatin-modifying enzymes / K-acetyltransferases, Zinc fingers, C2HC-type containing | Histone modification write | Histone acetylation | 10786633 | NSL, CHD8, MLL2/3, COMPASS-like MLL1,2, MLL4/WBP7 | histone | H2A, H3, H4 | H2Aac, H3ac, H4ac | 10786633 | A recombinant C-terminal portion of hMOF=KAT8 has histone acetyltransferase activity directed toward histones H3, H2A and H4, a specificity characteristic of other MYST family histone acetyltransferases. | # |
KDM1A
(details) |
29079 | lysine (K)-specific demethylase 1A | 23028 (SSTAR profile) |
O60341 | KDM1A_HUMAN | SWIRM PF04433 (183-264) Amino_oxidase PF01593 (288-826) |
Kdm1a | 1196256 | Q6ZQ88 | KDM1A_MOUSE | KDM | Chromatin-modifying enzymes / K-demethylases | Histone modification erase | Histone methylation | 16223729 | NuRD, BHC, SCL | histone | H3K4me1, H3K4me2, H3K9me | H3K4, H3K9 | 16223729 | Human histone demethylase LSD1=KDM1A is a flavin-dependent amine oxidase that catalyzes the specific removal of methyl groups from mono- and dimethylated Lys4 of histone H3. | # |
KDM1B
(details) |
21577 | lysine (K)-specific demethylase 1B | 221656 (SSTAR profile) |
Q8NB78 | KDM1B_HUMAN | zf-CW PF07496 (137-189) SWIRM PF04433 (292-364) Amino_oxidase PF01593 (392-819) |
Kdm1b | 2145261 | Q8CIG3 | KDM1B_MOUSE | KDM | Chromatin-modifying enzymes / K-demethylases | Histone modification erase | Histone methylation | 19727073 | # | histone | H3K4me1, H3K4me2 | H3K4 | 19727073 | KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints. | # |
KDM2A
(details) |
13606 | lysine (K)-specific demethylase 2A | 22992 (SSTAR profile) |
Q9Y2K7 | KDM2A_HUMAN | JHD PF17811 (304-343) zf-CXXC PF02008 (565-609) PHD_4 PF16866 (615-676) F-box-like PF12937 (896-935) |
Kdm2a | 1354736 | P59997 | KDM2A_MOUSE | FBXL, KDM | F-boxes / Leucine-rich repeats, Chromatin-modifying enzymes / K-demethylases | Histone modification erase | Histone methylation | 20417597 | # | histone | H3K36me2 | H3K36 | 20417597 | CpG islands directly recruit the H3K36-specific lysine demethylase enzyme KDM2A. Nucleation of KDM2A at these elements results in removal of H3K36 methylation, creating CpG island chromatin that is uniquely depleted of this modification. | # |
KDM2B
(details) |
13610 | lysine (K)-specific demethylase 2B | 84678 (SSTAR profile) |
Q8NHM5 | KDM2B_HUMAN | Cupin_8 PF13621 (150-331) JHD PF17811 (334-375) zf-CXXC PF02008 (607-651) PHD_4 PF16866 (657-723) F-box-like PF12937 (1068-1107) |
Kdm2b | 1354737 | Q6P1G2 | KDM2B_MOUSE | FBXL, KDM | F-boxes / Leucine-rich repeats, Chromatin-modifying enzymes / K-demethylases | Histone modification erase | Histone methylation | 17994099 | BCOR | histone | H3K4me3, H3K36me2 | H3K4, H3K36 | 17994099 | JHDM1B =KDM2B is a histone demethylase that catalyses the demethylation of H3K4me3. | # |
KDM3A
(details) |
20815 | lysine (K)-specific demethylase 3A | 55818 (SSTAR profile) |
Q9Y4C1 | KDM3A_HUMAN | domain PF22989 (8-82) domain PF22988 (92-182) domain PF22987 (184-249) JmjC PF02373 (1158-1264) |
Kdm3a | 98847 | Q6PCM1 | KDM3A_MOUSE | KDM | Chromatin-modifying enzymes / K-demethylases | Histone modification erase | Histone methylation | 16603237 | # | histone | H3K9me1, H3K9me2 | H3K9 | 16603237 | JHDM2A =KDM3A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. | # |
KDM3B
(details) |
1337 | lysine (K)-specific demethylase 3B | 51780 (SSTAR profile) |
Q7LBC6 | KDM3B_HUMAN | domain PF22989 (10-83) domain PF22988 (91-188) domain PF22987 (189-254) JmjC PF02373 (1599-1704) |
Kdm3b | 1923356 | Q6ZPY7 | KDM3B_MOUSE | KDM | Chromatin-modifying enzymes / K-demethylases | Histone modification erase | Histone methylation | 16603237 | # | histone | H3K9me1, H3K9me2 | H3K9 | 16603237 | A JmjC domain-containing protein (KDM3B=JmjC domain-containing histone demethylation protein 2B), JHDM2A, which specifically demethylates mono- and dimethyl-H3K9. | # |
KDM4A
(details) |
22978 | lysine (K)-specific demethylase 4A | 9682 (SSTAR profile) |
O75164 | KDM4A_HUMAN | JmjN PF02375 (14-49) JmjC PF02373 (175-291) PHD_2 PF13831 (732-767) zf-HC5HC2H_2 PF13832 (774-884) Tudor_2 PF18104 (902-936, 959-994) |
Kdm4a | 2446210 | Q8BW72 | KDM4A_MOUSE | KDM, TDRD | Chromatin-modifying enzymes / K-demethylases, Tudor domain containing | Histone modification erase | Histone methylation | 16603238 | # | histone | H3K4me3, H3K36me3 | H3K4me2, H3K36me2 | 16603238 | The JmjC domain-containing protein JMJD2A =KDM4A reverses trimethylated H3-K9/K36 to di- but not mono- or unmethylated products. Overexpression of JMJD2A (but not a catalytically inactive mutant) reduces H3-K9/K36 trimethylation levels in cultured cells. | # |
KDM4B
(details) |
29136 | lysine (K)-specific demethylase 4B | 23030 (SSTAR profile) |
O94953 | KDM4B_HUMAN | JmjN PF02375 (16-50) JmjC PF02373 (176-292) PHD_2 PF13831 (754-789) zf-HC5HC2H_2 PF13832 (796-907) Tudor_2 PF18104 (922-956, 978-1014) |
Kdm4b | 2442355 | Q91VY5 | KDM4B_MOUSE | KDM, TDRD | Chromatin-modifying enzymes / K-demethylases, Tudor domain containing | Histone modification erase | Histone methylation | 16603238 | # | histone | H3K9me3 | H3K9me1, H3K9me2 | 16603238 | Human JMJD2(B, C, D) =KDM4(B, C, D) subfamily members function as trimethylation-specific demethylases, converting H3-K9Me3 to H3-K9Me2 and H3-K9Me1, respectively. | # |
KDM4C
(details) |
17071 | lysine (K)-specific demethylase 4C | 23081 (SSTAR profile) |
Q9H3R0 | KDM4C_HUMAN | JmjN PF02375 (17-51) JmjC PF02373 (177-293) PHD_2 PF13831 (712-747) zf-HC5HC2H_2 PF13832 (754-864) Tudor_2 PF18104 (881-916, 939-974) |
Kdm4c | 1924054 | Q8VCD7 | KDM4C_MOUSE | KDM, TDRD | Chromatin-modifying enzymes / K-demethylases, Tudor domain containing | Histone modification erase | Histone methylation | 16603238 | # | histone | H3K9me3, H3K36me3 | H3K9me1, H3K9me2 | 16603238 | Human JMJD2(B, C, D) =KDM4(B, C, D) subfamily members function as trimethylation-specific demethylases, converting H3-K9Me3 to H3-K9Me2 and H3-K9Me1, respectively. | # |
KDM4D
(details) |
25498 | lysine (K)-specific demethylase 4D | 55693 (SSTAR profile) |
Q6B0I6 | KDM4D_HUMAN | JmjN PF02375 (19-53) JmjC PF02373 (179-295) |
Kdm4d | 3606484 | Q3U2K5 | KDM4D_MOUSE | KDM | Chromatin-modifying enzymes / K-demethylases | Histone modification erase | Histone methylation | 16603238 | # | histone | H3K9me3 | H3K9me1, H3K9me2 | 16603238 | Human JMJD2(B, C, D) =KDM4(B, C, D) subfamily members function as trimethylation-specific demethylases, converting H3-K9Me3 to H3-K9Me2 and H3-K9Me1, respectively. | # |
KDM4E
(details) |
37098 | lysine (K)-specific demethylase 4E | 390245 (SSTAR profile) |
B2RXH2 | KDM4E_HUMAN | JmjN PF02375 (16-50) JmjC PF02373 (176-292) |
# | # | # | # | KDM | Chromatin-modifying enzymes / K-demethylases | Histone modification erase | Histone methylation | 21914792 | # | histone | H3K9me2, H3K9me3 | H3K9 | 21914792 | KDM4D and KDM4E (which is catalytically active) catalyze demethylation of H3K9me3/me2. | # |
KDM5A
(details) |
9886 | lysine (K)-specific demethylase 5A | 5927 (SSTAR profile) |
P29375 | KDM5A_HUMAN | JmjN PF02375 (20-53) ARID PF01388 (86-170) PHD PF00628 (296-340, 1164-1215) JmjC PF02373 (470-586) KDM5_C-hel PF21323 (590-644) zf-C5HC2 PF02928 (676-728) PLU-1 PF08429 (741-1070) |
Kdm5a | 2136980 | Q3UXZ9 | KDM5A_MOUSE | KDM, PHF | Chromatin-modifying enzymes / K-demethylases, Zinc fingers, PHD-type | Histone modification erase | Histone methylation | 17320163 | # | histone | H3K4me3 | H3K4 | 17320163 | The retinoblastoma binding protein RBP2 =KDM5A is an H3K4 demethylase. | # |
KDM5B
(details) |
18039 | lysine (K)-specific demethylase 5B | 10765 (SSTAR profile) |
Q9UGL1 | KDM5B_HUMAN | JmjN PF02375 (33-66) ARID PF01388 (99-183) PHD PF00628 (312-356, 1178-1221, 1487-1535) JmjC PF02373 (486-602) KDM5_C-hel PF21323 (606-660) zf-C5HC2 PF02928 (692-744) PLU-1 PF08429 (758-1088) |
Kdm5b | 1922855 | Q80Y84 | KDM5B_MOUSE | KDM, PHF | Chromatin-modifying enzymes / K-demethylases, Zinc fingers, PHD-type | Histone modification erase | Histone methylation | 17363312 | # | histone | H3K4me3 | H3K4 | 17363312 | PLU-1 =KDM5B, a transcriptional repressor implicated in breast cancer, is a histone demethylase enzyme that has the ability to reverse the trimethyl H3K4 modification state. | # |
KDM5C
(details) |
11114 | lysine (K)-specific demethylase 5C | 8242 (SSTAR profile) |
P41229 | KDM5C_HUMAN | JmjN PF02375 (15-48) ARID PF01388 (80-165) PHD PF00628 (327-371) JmjC PF02373 (501-617) KDM5_C-hel PF21323 (621-675) zf-C5HC2 PF02928 (707-759) PLU-1 PF08429 (771-1098) |
Kdm5c | 99781 | P41230 | KDM5C_MOUSE | KDM, PHF | Chromatin-modifying enzymes / K-demethylases, Zinc fingers, PHD-type | Histone modification erase | Histone methylation | 17320160 | # | histone | H3K4me3 | H3K4me2, H3K4me1 | 17320160 | The X-linked mental retardation (XLMR) gene SMCX (JARID1C)=KDM5C, which encodes a JmjC-domain protein, reverses H3K4me3 to di- and mono- but not unmethylated products. | # |
KDM5D
(details) |
11115 | lysine (K)-specific demethylase 5D | 8284 (SSTAR profile) |
Q9BY66 | KDM5D_HUMAN | JmjN PF02375 (15-48) ARID PF01388 (81-165) PHD PF00628 (317-361) JmjC PF02373 (491-607) KDM5_C-hel PF21323 (611-665) zf-C5HC2 PF02928 (697-749) PLU-1 PF08429 (763-1085) |
Kdm5d | 99780 | Q62240 | KDM5D_MOUSE | KDM, PHF | Chromatin-modifying enzymes / K-demethylases, Zinc fingers, PHD-type | Histone modification erase | Histone methylation | 17320160 | # | histone | H3K4me3, H3K4me2 | H3K4 | 17320160 | SMCX family members, including SMCY=KDM5D, RBP2, and PLU-1, demethylate H3K4me3. | # |
KDM6A
(details) |
12637 | lysine (K)-specific demethylase 6A | 7403 (SSTAR profile) |
O15550 | KDM6A_HUMAN | TPR_8 PF13181 (205-237) JmjC PF02373 (1133-1241) KDM6_C-hel PF21322 (1248-1303) KDM6_GATAL PF21326 (1320-1380) |
Kdm6a | 1095419 | O70546 | KDM6A_MOUSE | KDM, TTC | Chromatin-modifying enzymes / K-demethylases, Tetratricopeptide (TTC) repeat domain containing | Histone modification erase | Histone methylation | 17851529 | CHD8, MLL2/3, MLL4/WBP7, COMPASS-like MLL3,4 | histone | H3K27me2. H3K27me3 | H3K27 | 17851529 | The JmjC-domain-containing proteins UTX=KDM6A and JMJD3 catalyse demethylation of H3K27me3/2. | # |
KDM6B
(details) |
29012 | lysine (K)-specific demethylase 6B | 23135 (SSTAR profile) |
O15054 | KDM6B_HUMAN | JmjC PF02373 (1377-1485) KDM6_C-hel PF21322 (1492-1547) KDM6_GATAL PF21326 (1560-1623) |
Kdm6b | 2448492 | Q5NCY0 | KDM6B_MOUSE | KDM | Chromatin-modifying enzymes / K-demethylases | Histone modification erase | Histone methylation | 17851529 | # | histone | H3K27me2. H3K27me4 | H3K28 | 17851529 | The JmjC-domain-containing proteins UTX=KDM6A and JMJD3=KDM6B catalyse demethylation of H3K27me3/2. | # |
KDM7A
(details) |
22224 | lysine (K)-specific demethylase 7A | 80853 (SSTAR profile) |
Q6ZMT4 | KDM7A_HUMAN | PHD PF00628 (40-85) JmjC PF02373 (269-369) JHD PF17811 (373-480) |
Kdm7a | 2443388 | Q3UWM4 | KDM7A_MOUSE | KDM, PHF | Chromatin-modifying enzymes / K-demethylases, Zinc fingers, PHD-type | Histone modification erase | Histone methylation | 20194436 | # | histone | H3K9me2, H3K27me2, H4K20me1 | H3K9, H3K27, H4K20 | 20194436 | KDM7 (also known as JHDM1D) is a dual demethylase for H3K9 and H3K27 that functions as an eraser of silencing marks on chromatin during brain development. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. | # |
KDM8
(details) |
25840 | lysine (K)-specific demethylase 8 | 79831 (SSTAR profile) |
Q8N371 | KDM8_HUMAN | Cupin_8 PF13621 (194-416) | Kdm8 | 1924285 | Q9CXT6 | KDM8_MOUSE | KDM | Chromatin-modifying enzymes / K-demethylases | Histone modification erase | Histone methylation | 20457893 | # | histone | H3K36me2 | H3K36 | 20457893 | JMJD5 (now renamed KDM8), a JmjC family member, demethylates H3K36me2 and is required for cell cycle progression. | # |
KEAP1
(details) |
23177 | kelch-like ECH-associated protein 1 | 9817 (SSTAR profile) |
Q14145 | KEAP1_HUMAN | BTB PF00651 (67-178) BACK PF07707 (184-285) Kelch_1 PF01344 (327-359, 361-410, 412-457, 459-504, 507-551, 553-598) |
Keap1 | 1858732 | Q9Z2X8 | KEAP1_MOUSE | KLHL, BTBD | Kelch-like, "BTB/POZ domain containing" | Chromatin remodeling | # | 21920360 | # | chromatin | # | # | # | Interacts with the NURF Nucleosome Remodeling Factor complex. | # |
KHDRBS1
(details) |
18116 | KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68) | 10657 (SSTAR profile) |
Q07666 | KHDR1_HUMAN | Qua1 PF16274 (102-153) KH_1 PF00013 (159-209) Sam68-YY PF16568 (368-420) |
Khdrbs1 | 893579 | Q60749 | KHDR1_MOUSE | KHDRBS | Signal transduction and activation of RNA metabolism family | RNA modification | Alternative splicing | 24514149 | # | RNA | mRNA | # | 24514149 | Regulates BCL-X and VEGF alternative splicing | New |
KLF18
(details) |
51793 | Kruppel like factor 18 | 105378952 (SSTAR profile) |
A0A0U1RQI7 | KLF18_HUMAN | zf-C2H2 PF00096 (994-1018, 1024-1046) | Zfp352 | 2387418 | A2AML7 | A2AML7_MOUSE | KLF | Kruppel like factors | TF | # | 24244731 | # | DNA | DNA | # | 24244731 | # | New |
KMT2A
(details) |
7132 | lysine (K)-specific methyltransferase 2A | 4297 (SSTAR profile) |
Q03164 | KMT2A_HUMAN | zf-CXXC PF02008 (1149-1194) PHD PF00628 (1481-1530, 1569-1624) zf-HC5HC2H PF13771 (1897-1978) FYRN PF05964 (2016-2077) FYRC PF05965 (3666-3747) SET PF00856 (3840-3945) |
Kmt2a | 96995 | P55200 | KMT2A_MOUSE | KMT, PHF | Chromatin-modifying enzymes / K-methyltransferases, Zinc fingers, PHD-type | Histone modification write | Histone methylation | 19187761 | MLL-HCF, CHD8, COMPASS-like MLL1,2 | histone | H3K4 | H3K4me | 19187761 | MLL1 SET domain can incorporate methyl groups into unmodified or H3K4me1 substrates, signifying both mono- and dimethylation activity. | # |
KMT2B
(details) |
15840 | lysine (K)-specific methyltransferase 2B | 9757 (SSTAR profile) |
Q9UMN6 | KMT2B_HUMAN | zf-CXXC PF02008 (959-1005) PHD PF00628 (1203-1250, 1251-1300, 1337-1393) zf-HC5HC2H PF13771 (1605-1685) FYRN PF05964 (1731-1784) FYRC PF05965 (2415-2494) SET PF00856 (2580-2691) |
Kmt2b | 109565 | O08550 | KMT2B_MOUSE | KMT | Chromatin-modifying enzymes / K-methyltransferases | Histone modification write | Histone methylation | 17707229 | Menin-associated_HMT, MLL2/3, COMPASS-like MLL3,4 | histone | H3K4 | H3K4me3 | 17707229 | MLL (=KMT2B)-containing complexes methylate histone H3 at lysine 4 (H3K4) and have been implicated in the regulation of transcription. | # |
KMT2C
(details) |
13726 | lysine (K)-specific methyltransferase 2C | 58508 (SSTAR profile) |
Q8NEZ4 | KMT2C_HUMAN | zf-HC5HC2H PF13771 (248-331) PHD PF00628 (343-389, 390-436, 466-519, 958-1008) zf-HC5HC2H_2 PF13832 (4401-4506) FYRN PF05964 (4546-4604) FYRC PF05965 (4608-4692) SET PF00856 (4781-4887) |
Kmt2c | 2444959 | Q8BRH4 | KMT2C_MOUSE | KMT, PHF | Chromatin-modifying enzymes / K-methyltransferases, Zinc fingers, PHD-type | Histone modification write | Histone methylation | 20937768 | MLL2/3, COMPASS-like MLL3,4 | histone | H3K4 | H3K4me | 20937768 | In humans, multiple Set1-like HMT complexes with H3K4 HMT activities have been identified. Each of these complexes contains the SET domain-containing homologs of yeast Set1, including human Set1 (hSet1), MLL1 (mixed lineage leukemia 1, also known as MLL, HRX, ALL1, or KMT2A), MLL2 (mixed-lineage leukemia 2, also known as HRX2 or KMT2B), MLL3 (mixed-lineage leukemia 3, also known as HALR or KMT2C), and MLL4 (mixed-lineage leukemia 4, also known as ALR or KMT2D), which carry the enzymatic activity for the associated complexes. | # |
KMT2D
(details) |
7133 | lysine (K)-specific methyltransferase 2D | 8085 (SSTAR profile) |
O14686 | KMT2D_HUMAN | zf-HC5HC2H PF13771 (139-218) PHD PF00628 (228-274, 276-321, 1379-1428, 1429-1474) zf-HC5HC2H_2 PF13832 (5031-5136) FYRN PF05964 (5176-5233) FYRC PF05965 (5236-5322) SET PF00856 (5408-5513) |
Kmt2d | 2682319 | Q6PDK2 | KMT2D_MOUSE | KMT, PHF | Chromatin-modifying enzymes / K-methyltransferases, Zinc fingers, PHD-type | Histone modification write | Histone methylation | 20937768 | COMPASS-like MLL1,2, MLL4/WBP7, COMPASS-like MLL3,4 | histone | H3K4 | H3K4me | 20937768 | In humans, multiple Set1-like HMT complexes with H3K4 HMT activities have been identified. Each of these complexes contains the SET domain-containing homologs of yeast Set1, including human Set1 (hSet1), MLL1 (mixed lineage leukemia 1, also known as MLL, HRX, ALL1, or KMT2A), MLL2 (mixed-lineage leukemia 2, also known as HRX2 or KMT2B), MLL3 (mixed-lineage leukemia 3, also known as HALR or KMT2C), and MLL4 (mixed-lineage leukemia 4, also known as ALR or KMT2D), which carry the enzymatic activity for the associated complexes. | # |
KMT2E
(details) |
18541 | lysine (K)-specific methyltransferase 2E | 55904 (SSTAR profile) |
Q8IZD2 | KMT2E_HUMAN | PHD_5 PF20826 (118-164) SET PF00856 (343-447) |
Kmt2e | 1924825 | Q3UG20 | KMT2E_MOUSE | KMT, PHF | Chromatin-modifying enzymes / K-methyltransferases, Zinc fingers, PHD-type | Histone modification write | Histone methylation | 19377461 | # | histone | H3K4 | H3K4me1, H3K4me2 | 19377461 | Nuclear GlcNAcylation of the histone lysine methyltransferase (HKMT), MLL5, by O-GlcNAc transferase facilitates retinoic-acid-induced granulopoiesis in human HL60 promyelocytes through methylation of H3K4. | # |
L3MBTL1
(details) |
15905 | l(3)mbt-like 1 (Drosophila) | 26013 (SSTAR profile) |
Q9Y468 | LMBL1_HUMAN | MBT PF02820 (310-377, 417-484, 521-586) zf-C2HC PF01530 (622-650) |
L3mbtl1 | 2676663 | A2A5N8 | LMBL1_MOUSE | ZC2HC, SAMD | Zinc fingers, C2HC-type containing, Sterile alpha motif (SAM) domain containing | Histone modification read | # | 18026117 | L3MBTL1 | histone | H1BK26, H4K20 | # | 18026117 | Crystal structures of the L3MBTL1 MBT repeats in complex with histone H4 peptides dimethylated on Lys20 (H4K20me2). Only the second of the three MBT repeats can bind mono- and dimethylated histone peptides. Its binding pocket has similarities to that of 53BP1 and is able to recognize the degree of histone lysine methylation. | # |
L3MBTL2
(details) |
18594 | l(3)mbt-like 2 (Drosophila) | 83746 (SSTAR profile) |
Q969R5 | LMBL2_HUMAN | zf-FCS_1 PF21319 (87-118) MBT PF02820 (214-286, 327-390, 432-503, 540-604) |
L3mbtl2 | 2443584 | P59178 | LMBL2_MOUSE | # | # | Histone modification read | # | 19233876 | RING2-L3MBTL2 | histone | H3K4, H3K9, H3K27, H4K20 | # | 19233876 | Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2. | # |
L3MBTL3
(details) |
23035 | l(3)mbt-like 3 (Drosophila) | 84456 (SSTAR profile) |
Q96JM7 | LMBL3_HUMAN | MBT PF02820 (268-335, 375-441, 479-544) SAM_1 PF00536 (707-770) |
L3mbtl3 | 2143628 | Q8BLB7 | LMBL3_MOUSE | SAMD | Sterile alpha motif (SAM) domain containing | Histone modification read | # | 23292653 | # | histone | H4K20me | # | 23292653 | Binds L3MBTL3 with a similar affinity to H4K20me histone | # |
L3MBTL4
(details) |
26677 | l(3)mbt-like 4 (Drosophila) | 91133 (SSTAR profile) |
Q8NA19 | LMBL4_HUMAN | MBT PF02820 (88-155, 196-263, 300-366) zf-C2HC PF01530 (379-407) SAM_1 PF00536 (543-605) |
L3mbtl4 | 2444889 | B1B1A0 | LMBL4_MOUSE | SAMD | Sterile alpha motif (SAM) domain containing | Histone modification read | # | 20698951 | # | histone | HKme | # | 20698951 | The L3MBTL4 protein contains three "malignant brain tumor" (MBT) domains. The MBT domain binds methylated histone residues. | # |
LAS1L
(details) |
25726 | LAS1-like (S. cerevisiae) | 81887 (SSTAR profile) |
Q9Y4W2 | LAS1L_HUMAN | Las1 PF04031 (43-187) | Las1l | 1923380 | A2BE28 | LAS1L_MOUSE | # | # | Histone modification write cofactor, Histone modification write cofactor | Histone methylation, Histone acetylation | 20442285 | CHD8, MLL2/3, MLL4/WBP7 | histone | H3K4, H3,H4,H2A | H3K4me, H3K4me2, H3Ac, H4Ac, H2AAc | 15960975 | Facultative member of the MLL1/MLL complex. | # |
LBR
(details) |
6518 | lamin B receptor | 3930 (SSTAR profile) |
Q14739 | LBR_HUMAN | LBR_tudor PF09465 (2-56) ERG4_ERG24 PF01222 (199-615) |
Lbr | 2138281 | Q3U9G9 | LBR_MOUSE | TDRD | Tudor domain containing | # | # | 22498752 | # | chromatin | # | # | # | Anchors the lamina and the heterochromatin to the inner nuclear membrane. | # |
LEO1
(details) |
30401 | Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) | 123169 (SSTAR profile) |
Q8WVC0 | LEO1_HUMAN | Leo1 PF04004 (374-538) | Leo1 | 2685031 | Q5XJE5 | LEO1_MOUSE | # | # | Histone modification write cofactor | Histone ubiquitination | 24038468 | # | histone | # | # | # | Part of the PAF1 complex, which may be involved in recruitment of ubiquitination complexes. Important for PAF1 binding to H3. | # |
LRWD1
(details) |
21769 | leucine-rich repeats and WD repeat domain containing 1 | 222229 (SSTAR profile) |
Q9UFC0 | LRWD1_HUMAN | domain PF12799 (48-104) WD40 PF00400 (384-421) |
Lrwd1 | 1918985 | Q8BUI3 | LRWD1_MOUSE | WDR | WD repeat domain containing | Chromatin remodeling | # | 20932478 | # | histone, DNA | H3K9me3, H3K27me3 | # | 20932478 | A highly conserved, leucine-rich repeats and WD40 repeat domain-containing protein 1 (LRWD1) or ORC-associated (ORCA) in human cells that interacts with ORC and modulates chromatin association of ORC. ORCA colocalizes with ORC and shows similar cell-cycle dynamics. ORCA efficiently recruits ORC to chromatin. | # |
MAGOH
(details) |
6815 | Protein mago nashi homolog | 4116 (SSTAR profile) |
P61326 | MGN_HUMAN | Mago_nashi PF02792 (5-146) | Magoh | 1330312 | P61327 | MGN_MOUSE | # | # | RNA modification | Alternative splicing | 22203037 | # | RNA | mRNA | # | 22203037 | Regulates alternative splicing of apoptotic regulators | New |
MAP3K7
(details) |
6859 | mitogen-activated protein kinase kinase kinase 7 | 6885 (SSTAR profile) |
O43318 | M3K7_HUMAN | PK_Tyr_Ser-Thr PF07714 (36-284) | Map3k7 | 1346877 | Q62073 | M3K7_MOUSE | MAP3K | Mitogen-activated protein kinase cascade / Kinase kinase kinases | Histone modification write | # | 18838386 | # | histone | # | # | # | A member of the ATAC complex. | # |
MAPKAPK3
(details) |
6888 | mitogen-activated protein kinase-activated protein kinase 3 | 7867 (SSTAR profile) |
Q16644 | MAPK3_HUMAN | Pkinase PF00069 (47-304) | Mapkapk3 | 2143163 | Q3UMW7 | MAPK3_MOUSE | # | # | Chromatin remodeling | # | 15563468 | # | chromatin | # | # | 15563468 | MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1. | # |
MASTL
(details) |
19042 | microtubule associated serine/threonine kinase-like | 84930 (SSTAR profile) |
Q96GX5 | GWL_HUMAN | Pkinase PF00069 (36-188, 736-835) | Mastl | 1914371 | Q8C0P0 | GWL_MOUSE | # | # | Histone modification write | Histone phosphorylation | 20818157 | # | histone | H1, H3 | H1p, H3p | 20818157 | Phosphorylates histone protein in vitro; however such activity is unsure in vivo (UniProt). | # |
MAX
(details) |
6913 | MYC associated factor X | 4149 (SSTAR profile) |
P61244 | MAX_HUMAN | HLH PF00010 (24-74) | Max | 96921 | P28574 | MAX_MOUSE | bHLH | Basic helix-loop-helix proteins | Histone modification write cofactor, TF | Histone methylation, Histone acetylation, TF activator, TF repressor | 18271930, 12004135 | CHD8, MLL2/3, MLL4/WBP7 | DNA | DNA motif | # | 18271930, 12004135 | Part of a multimeric protein complex that contains E2F6, Mga and Max. The complex contains chromatin modifiers such as a novel histone methyltransferase that modifies lysine 9 of histone H3, HP1gamma, and Polycomb group (PcG) proteins. | # |
MAZ
(details) |
6914 | MYC-associated zinc finger protein (purine-binding transcription factor) | 4150 (SSTAR profile) |
P56270 | MAZ_HUMAN | zf-C2H2 PF00096 (279-301, 337-360, 366-388) zf-C2H2_4 PF13894 (307-329) |
Maz | 1338823 | P56671 | MAZ_MOUSE | ZNF | Zinc fingers, C2H2-type | Chromatin remodeling | # | 21920360 | # | chromatin | # | # | # | Interacts with the NURF Nucleosome Remodeling Factor complex. | # |
MBD1
(details) |
6916 | methyl-CpG binding domain protein 1 | 4152 (SSTAR profile) |
Q9UIS9 | MBD1_HUMAN | MBD PF01429 (2-70) zf-CXXC PF02008 (169-215, 219-262, 331-377) |
Mbd1 | 1333811 | Q9Z2E2 | MBD1_MOUSE | # | # | Histone modification write cofactor, TF | Histone methylation, TF repressor | 15327775 | # | DNA | mCG, DNA motif | # | 15327775 | MBD1 recruits SETDB1 to the large subunit of chromatin assembly factor CAF-1 to form an S phase-specific CAF-1/MBD1/SETDB1 complex that facilitates methylation of H3-K9 during replication-coupled chromatin assembly. In the absence of MBD1, H3-K9 methylation is lost at multiple genomic loci and results in activation of p53BP2 gene, normally repressed by MBD1 in HeLa cells. Data suggest a model in which H3-K9 methylation by SETDB1 is dependent on MBD1 and is heritably maintained through DNA replication to support the formation of stable heterochromatin at methylated DNA. | # |
MBD2
(details) |
6917 | methyl-CpG binding domain protein 2 | 8932 (SSTAR profile) |
Q9UBB5 | MBD2_HUMAN | MBD PF01429 (150-213) MBDa PF16564 (221-294) MBD_C PF14048 (296-385) |
Mbd2 | 1333813 | Q9Z2E1 | MBD2_MOUSE | # | # | Histone modification write cofactor, Histone modification erase cofactor, TF | Histone methylation, Histone acetylation, TF repressor | 16415179 | NuRD, MeCP1 | DNA | mCG, DNA motif | # | 16415179 | Wild-type subnuclear distribution of p66alpha and p66beta depends on the presence of MBD2. Both proteins interact with the tails of all octamer histones in vitro, and acetylation of histone tails interferes with p66 binding. | # |
MBD3
(details) |
6918 | methyl-CpG binding domain protein 3 | 53615 (SSTAR profile) |
O95983 | MBD3_HUMAN | MBD PF01429 (2-69) MBDa PF16564 (79-149) MBD_C PF14048 (152-241) |
Mbd3 | 1333812 | Q9Z2D8 | MBD3_MOUSE | # | # | Histone modification erase cofactor | Histone acetylation | 12124384 | NuRD | histone | # | # | 12124384 | MBD3 has been identified as a component of the NuRD/Mi2 complex that shows chromatin remodeling and histone deacetylase activities. MBD3 MBD is necessary and sufficient for binding to HDAC1 and MTA2, two components of the NuRD/Mi2 complex. It has been suggested that mCpG-binding-defective MBD3 has evolutionarily conserved its MBD because of the secondary role played by the MBD in protein-protein interactions. | # |
MBD4
(details) |
6919 | methyl-CpG binding domain protein 4 | 8930 (SSTAR profile) |
O95243 | MBD4_HUMAN | MBD PF01429 (81-149) domain PF00730 (463-560) |
Mbd4 | 1333850 | Q9Z2D7 | MBD4_MOUSE | # | # | DNA modification | # | 10930409 | # | DNA | G:T, G:U | # | 10930409 | MED1 functions as a mismatch-specific DNA repair enzyme. MED1 lacks uracil glycosylase activity on single-strand DNA and abasic site lyase activity. The glycosylase activity of MED1 prefers substrates containing a G:T mismatch within methylated or unmethylated CpG sites; since G:T mismatches can originate via deamination of 5-methylcytosine to thymine, MED1 may act as a caretaker of genomic fidelity at CpG sites. | # |
MBD5
(details) |
20444 | methyl-CpG binding domain protein 5 | 55777 (SSTAR profile) |
Q9P267 | MBD5_HUMAN | () | Mbd5 | 2138934 | B1AYB6 | MBD5_MOUSE | # | # | Chromatin remodeling | # | 20700456 | # | chromatin | # | # | 20700456 | MBD5 and MBD6 may contribute to the unique epigenetic machinery of neurons or to the global reorganization of chromatin during spermatogenesis. | # |
MBD6
(details) |
20445 | methyl-CpG binding domain protein 6 | 114785 (SSTAR profile) |
Q96DN6 | MBD6_HUMAN | () | Mbd6 | 106378 | Q3TY92 | MBD6_MOUSE | # | # | Chromatin remodeling | # | 20700456 | # | chromatin | # | # | 20700456 | MBD5 and MBD6 may contribute to the unique epigenetic machinery of neurons or to the global reorganization of chromatin during spermatogenesis. | # |
MBIP
(details) |
20427 | MAP3K12 binding inhibitory protein 1 | 51562 (SSTAR profile) |
Q9NS73 | MBIP1_HUMAN | () | Mbip | 1918320 | Q99LQ1 | MBIP1_MOUSE | # | # | Histone modification write cofactor | Histone acetylation | 19103755 | ATAC | histone | # | # | 19103755 | Novel proteins identified as STAGA/ TFTC subunits, such as ATAC2, DR1, MBIP, WDR5, YEATS2, and ZZZ3/ATAC1. | # |
MBNL1
(details) |
6923 | Muscleblind-like protein 1 (Triplet-expansion RNA-binding protein) | 4154 (SSTAR profile) |
Q9NR56 | MBNL1_HUMAN | zf-CCCH_2 PF14608 (19-39) domain PF22628 (48-86, 216-253) zf-CCCH PF00642 (183-205) |
Mbnl1 | 1928482 | Q9JKP5 | MBNL1_MOUSE | ZC3H | Zinc fingers CCCH-type | RNA modification | Alternative splicing | 16946708, 19470458, 15257297 | # | RNA | mRNA | # | 16946708, 19470458, 15257297 | Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonistic regulator with CELF proteins. | New |
MBNL3
(details) |
20564 | Muscleblind-like protein 3 (Cys3His CCG1-required protein) (Muscleblind-like X-linked protein) (Protein HCHCR) | 55796 (SSTAR profile) |
Q9NUK0 | MBNL3_HUMAN | zf-CCCH_2 PF14608 (20-40) domain PF22628 (49-87, 211-248) zf-CCCH_4 PF18044 (179-200) |
Mbnl3 | 2444912 | Q8R003 | MBNL3_MOUSE | ZC3H | Zinc fingers CCCH-type | RNA modification | Alternative splicing | 15257297 | # | RNA | mRNA | # | 15257297 | Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonistic regulator with CELF proteins. | New |
MBTD1
(details) |
19866 | mbt domain containing 1 | 54799 (SSTAR profile) |
Q05BQ5 | MBTD1_HUMAN | zf-FCS_1 PF21319 (52-82) MBT PF02820 (189-248, 289-352, 388-459, 496-560) |
Mbtd1 | 2143977 | Q6P5G3 | MBTD1_MOUSE | # | # | Polycomb group (PcG) protein | # | 19841675 | # | histone | H4K20me1, H4K20me2 | # | 19841675 | MBTD1, Malignant Brain Tumor domain-containing protein 1, is a PcG protein. | # |
MCRS1
(details) |
6960 | microspherule protein 1 | 10445 (SSTAR profile) |
Q96EZ8 | MCRS1_HUMAN | MCRS_N PF13325 (134-331) FHA PF00498 (363-435) |
Mcrs1 | 1858420 | Q99L90 | MCRS1_MOUSE | INO80 | INO80 complex subunits | Histone modification write | Histone acetylation | 20018852 | Ino80, NSL, CHD8, MLL2/3, MLL4/WBP7 | histone | H4K5, H4K8, H4K16 | H4K5ac, H4K8ac, H4K16ac | 20018852 | Human MOF (MYST1), a member of the MYST (Moz-Ybf2/Sas3-Sas2-Tip60) family of histone acetyltransferases (HATs), is the human ortholog of the Drosophila males absent on the first (MOF) protein. | # |
MDC1
(details) |
21163 | mediator of DNA-damage checkpoint 1 | 9656 (SSTAR profile) |
Q14676 | MDC1_HUMAN | FHA PF00498 (54-122) RTT107_BRCT_5 PF16770 (1888-1970) BRCT_2 PF16589 (1994-2074) |
Mdc1 | 3525201 | Q5PSV9 | MDC1_MOUSE | # | # | Histone modification read | # | 16377563 | # | histone | H2AX | # | 16377563 | Mammalian MDC1/NFBD1 directly binds to phospho-H2AX (gammaH2AX) by specifically interacting with the phosphoepitope at the gammaH2AX carboxyl terminus. | # |
MEAF6
(details) |
25674 | MYST/Esa1-associated factor 6 | 64769 (SSTAR profile) |
Q9HAF1 | EAF6_HUMAN | NuA4 PF09340 (18-95) | Meaf6 | 1917338 | Q2VPQ9 | EAF6_MOUSE | # | # | Histone modification write cofactor | Histone acetylation | 18794358 | HBO1, NuA4, MOZ/MORF | histone | H2A, H3K14, H4K5, H4K8, H4K12 | H2Aac, H3K14ac, H4K5ac, H4K8ac, H4K12ac | 18794358 | BRPF proteins bridge the association of MOZ and MORF with ING5 and EAF6=MEAF6. An N-terminal region of BRPF1 interacts with the acetyltransferases; the enhancer of polycomb (EPc) homology domain in the middle part binds to ING5 and EAF6. The association of BRPF1 with EAF6 is weak, but ING5 increases the affinity. These three proteins form a trimeric core that is conserved from Drosophila melanogaster to humans, although authentic orthologs of MOZ and MORF are absent in invertebrates. Deletion mapping studies revealed that the acetyltransferase domain of MOZ/MORF is sufficient for BRPF1 interaction. At the functional level, complex formation with BRPF1 and ING5 drastically stimulates the activity of the acetyltransferase domain in acetylation of nucleosomal histone H3 and free histones H3 and H4. | # |
MECP2
(details) |
6990 | methyl CpG binding protein 2 | 4204 (SSTAR profile) |
P51608 | MECP2_HUMAN | MBD PF01429 (97-159) | Mecp2 | 99918 | Q9Z2D6 | MECP2_MOUSE | # | # | Histone modification write cofactor, Histone modification write cofactor, TF | Histone methylation, Histone acetylation, TF repressor | 10773092 | # | DNA | mCG, DNA motif | # | 10773092 | Methyl-CpG-binding protein 2 (MeCP2) contains a transcriptional repression domain (TRD), which can act by recruitment of a large transcriptional co-repressor complex containing histone deacetylases HDAC1 and 2. | # |
MEN1
(details) |
7010 | multiple endocrine neoplasia I | # | O00255 | MEN1_HUMAN | Menin PF05053 (4-499, 550-610) | Men1 | 1316736 | O88559 | MEN1_MOUSE | # | # | Histone modification write cofactor | Histone methylation | 14992727 | Menin-associated_HMT, MLL-HCF, CHD8, MLL2/3, COMPASS-like MLL1,2, MLL4/WBP7 | histone | H3K4 | H3K4me | 14992727, 15199122 | Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4) (UniProt). | # |
METTL11B
(details) |
31932 | methyltransferase like 11B | 149281 (SSTAR profile) |
Q5VVY1 | NTM1B_HUMAN | Methyltransf_PK PF05891 (65-278) | Mettl11b | 2685053 | B2RXM4 | NTM1B_MOUSE | METTL | Methyltransferase like | Histone modification writer | Histone methylation | 26543159 | # | protein | CENP-A | K55m | 26543159 | Regulates centromere function and mitosis | New |
METTL14
(details) |
29330 | methyltransferase like 14 | 57721 (SSTAR profile) |
Q9HCE5 | MET14_HUMAN | MT-A70 PF05063 (186-363) | Mettl14 | 2442926 | Q3UIK4 | MET14_MOUSE | METTL | Methyltransferase like | RNA modification | RNA methylation | 24316715 | WMM | RNA | A of mRNA | m(6)A | 24316715 | Regulates mRNA stability, processing miRNA, DNA-reparation | New |
METTL16
(details) |
28484 | methyltransferase like 16 | 79066 (SSTAR profile) |
Q86W50 | MET16_HUMAN | Methyltransf_10 PF05971 (1-291) | Mettl16 | 1914743 | Q9CQG2 | MET16_MOUSE | METTL | Methyltransferase like | RNA modification | RNA methylation | 29051200 | # | RNA | U6 snRNA (A43) | m6A43 | 32266935 | Tunes snRNA–pre‐mRNA interactions, controls alternative splicing | New |
METTL21A
(details) |
30476 | methyltransferase like 21A | 151194 (SSTAR profile) |
Q8WXB1 | MT21A_HUMAN | Methyltransf_16 PF10294 (26-189) | Mettl21a | 1914349 | Q9CQL0 | MT21A_MOUSE | METTL | Methyltransferase like | Protein modification | Protein methylation | # | # | protein | Hsp70 | Km3 | 23921388 | Modulates the affinity of Hsp70 for targets | New |
METTL3
(details) |
17563 | methyltransferase like 3 | 56339 (SSTAR profile) |
Q86U44 | MTA70_HUMAN | MT-A70 PF05063 (389-550) | Mettl3 | 1927165 | Q8C3P7 | MTA70_MOUSE | METTL | Methyltransferase like | RNA modification | RNA methylation | 24316715 | WMM | RNA | A of mRNA | m(6)A | 24316715 | Regulates mRNA stability, processing miRNA, DNA-reparation | New |
METTL4
(details) |
24726 | methyltransferase like 4 | 64863 (SSTAR profile) |
Q8N3J2 | METL4_HUMAN | MT-A70 PF05063 (281-454) | Mettl4 | 1924031 | Q3U034 | METL4_MOUSE | METTL | Methyltransferase like | RNA modification, DNA modification | RNA methylation, DNA methylation | 30982744 | # | DNA, RNA | A of DNA, U2 snRNA | m(6)A | 31913360 | Regulates transcriptional silencing, Polycomb silencing, splicing regulation | New |
MGA
(details) |
14010 | MGA, MAX dimerization protein | 23269 (SSTAR profile) |
Q8IWI9 | MGAP_HUMAN | T-box PF00907 (77-259) MGA_dom PF16059 (1043-1085) HLH PF00010 (2425-2474) |
Mga | 1352483 | A2AWL7 | MGAP_MOUSE | # | # | Histone modification write cofactor, TF | Histone methylation, Histone acetylation, TF activator, TF repressor | # | RING2-L3MBTL2, CHD8, MLL2/3, MLL4/WBP7 | DNA | DNA motif | # | # | Added because it is a complex partner | # |
MGEA5
(details) |
7056 | meningioma expressed antigen 5 (hyaluronidase) | 10724 (SSTAR profile) |
O60502 | NCOAT_HUMAN | NAGidase PF07555 (61-341) | Mgea5 | 1932139 | Q9EQQ9 | NCOAT_MOUSE | # | # | Histone modification write | Histone acetylation | 15485860 | # | histone | H3K14, H4K8 | H3K14ac, H4K8ac | 15485860 | The HAT domain of NCOAT=MGEA5 has the ability to acetylate all four core histones when either free or bound by DNA in the context of oligonucleosome arrays. | # |
MINA
(details) |
19441 | MYC induced nuclear antigen | 84864 (SSTAR profile) |
Q8IUF8 | MINA_HUMAN | JmjC_2 PF08007 (137-261) ROXA-like_wH PF20514 (331-431) |
Mina | 1914264 | Q8CD15 | MINA_MOUSE | # | # | Histone modification erase | Histone methylation | 19502796 | # | histone | H3K9me3 | H3K9 | 19502796 | mdig=MINA is involved in demethylation of tri-methyl lysine 9 on histone H3. | # |
MIS18A
(details) |
1286 | MIS18 kinetochore protein A | 54069 (SSTAR profile) |
Q9NYP9 | MS18A_HUMAN | Yippee-Mis18 PF03226 (81-186) | Mis18a | 1913828 | Q9CZJ6 | MIS18A_MOUSE | # | # | Chromatin remodeling | # | 17199038 | Mis18 | histone | CENPA | # | 17199038 | Recruits CENPA to centromeres. Regulates normal chromosome segregation during mitosis. | New |
MIS18BP1
(details) |
20190 | MIS18 binding protein 1 | 55320 (SSTAR profile) |
Q6P0N0 | M18BP_HUMAN | SANTA PF09133 (376-470) | Mis18bp1 | 2145099 | Q80WQ8 | M18BP_MOUSE | Myb/SANT domain containing | Myb/SANT domain containing | Chromatin remodeling | # | 17199038 | Mis18 | histone | CENPA | # | 17199038 | Recruits CENPA to centromeres. Regulates normal chromosome segregation during mitosis. | New |
MLLT1
(details) |
7134 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 | 4298 (SSTAR profile) |
Q03111 | ENL_HUMAN | YEATS PF03366 (27-107) AHD PF17793 (496-555) |
Mllt1 | 1927238 | # | # | # | # | Chromatin remodeling cofactor | # | 23623499 | SWI/SNF-like_EPAFa, SWI/SNF-like EPAFB | chromatin | # | # | 23623499 | MLL-ENL (=MLLT1) inhibits polycomb repressive complex 1. | # |
MLLT10
(details) |
16063 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 8028 (SSTAR profile) |
P55197 | AF10_HUMAN | PHD_2 PF13831 (37-72) zf-HC5HC2H_2 PF13832 (80-197) |
Mllt10 | 1329038 | O54826 | AF10_MOUSE | PHF | Zinc fingers, PHD-type | Histone modification write cofactor | Histone methylation | 20203130 | # | histone | H3K79 | H3K79me3 | 20203130 | MLLT10 =AF10 plays an important role in Dot1’s HMTase activity through either DotCom stability, catalytic activity, or the recruitment of the complex to chromatin. | # |
MLLT6
(details) |
7138 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | 4302 (SSTAR profile) |
P55198 | AF17_HUMAN | PHD_2 PF13831 (20-55) zf-HC5HC2H_2 PF13832 (63-180) |
Mllt6 | 1935145 | # | # | PHF | Zinc fingers, PHD-type | Histone modification write cofactor | Histone methylation | 20203130 | # | histone | H3K79 | H3K79me3 | 20203130 | MLLT6 =AF17, nucleosomes containing monoubiquitinated H2B are a better substrate for DotCom in the generation of trimethylated H3K79. DotCom requires monoubiquitination of H2B for H3K79 trimethylation. | # |
MORF4L1
(details) |
16989 | mortality factor 4 like 1 | 10933 (SSTAR profile) |
Q9UBU8 | MO4L1_HUMAN | Tudor-knot PF11717 (11-52) MRG PF05712 (175-351) |
Morf4l1 | 1096551 | P60762 | MO4L1_MOUSE | # | # | Histone modification read | # | 21423274 | NuA4 | histone | H4 | # | 21423274 | Table 1 in reference (MRG15 =MORF4L1). | # |
MORF4L2
(details) |
16849 | mortality factor 4 like 2 | 9643 (SSTAR profile) |
Q15014 | MO4L2_HUMAN | MRG PF05712 (101-280) | Morf4l2 | 1927167 | Q9R0Q4 | MO4L2_MOUSE | # | # | Histone modification erase cofactor | Histone acetylation | 12963728 | NuA4 | histone | # | # | 12963728 | The FLJ10914 protein is associated with components of the TRRAP/TIP60 histone acetyltransferase complex and binds directly to the MORF4-related MRG15 and MRGX proteins. | # |
MOV10
(details) |
7200 | Mov10 RISC complex RNA helicase | 4343 (SSTAR profile) |
Q9HCE1 | MOV10_HUMAN | MOV-10_N PF21632 (15-85) MOV-10_Ig-like PF21633 (119-240) Mov-10_helical PF21635 (291-358) MOV-10_beta-barrel PF21634 (358-448) AAA_11 PF13086 (499-572, 610-690) AAA_12 PF13087 (699-921) |
Mov10 | 97054 | P23249 | MOV10_MOUSE | # | # | # | # | 20543829 | # | histone | # | # | # | MOV10 may be directly involved in transcriptional silencing by PcG complexes. | # |
MPHOSPH8
(details) |
29810 | M-phase phosphoprotein 8 | 54737 (SSTAR profile) |
Q99549 | MPP8_HUMAN | Chromo PF00385 (59-108) Ank_2 PF12796 (571-665) Ank PF00023 (666-695) |
Mphosph8 | 1922589 | Q3TYA6 | MPP8_MOUSE | ANKRD | Ankyrin repeat domain containing | Histone modification read | # | 21419134 | # | histone | H3K9me3, H3K9me2 | # | 21419134 | M-phase phosphoprotein 8 (MPP8=MPHOSPH8) harbors an N-terminal chromodomain and a C-terminal ankyrin repeat domain. MPP8, via its chromodomain, binds histone H3 peptide tri- or di-methylated at lysine 9 (H3K9me3/H3K9me2) in submicromolar affinity. | # |
MPND
(details) |
25934 | MPN domain-containing | 84954 (SSTAR profile) |
Q8N594 | MPND_HUMAN | RAMA PF18755 (66-169) JAB PF01398 (271-369) |
Mpnd | 1915297 | Q3TV65 | MPND_MOUSE | # | # | Histone modification erase | Histone ubiquitination | 30982744 | # | histone | H2A-Ub (K119) | H2A | 30982744 | Polycomb repressing deubiquitinase | New |
MRGBP
(details) |
15866 | MRG/MORF4L binding protein | 55257 (SSTAR profile) |
Q9NV56 | MRGBP_HUMAN | Eaf7 PF07904 (36-96) | Mrgbp | 1920497 | Q9DAT2 | MRGBP_MOUSE | # | # | Histone modification write cofactor | Histone acetylation | 12963728 | NuA4 | histone | # | # | 12963728 | TRCp120, DMAP1, and MRGBP are components of the mammalian TRRAP/TIP60 histone acetyltransferase complex. | # |
MSH6
(details) |
7329 | mutS homolog 6 | 2956 (SSTAR profile) |
P52701 | MSH6_HUMAN | PWWP PF00855 (92-182) MutS_I PF01624 (408-524) MutS_II PF05188 (538-693) MutS_III PF05192 (738-1064) MutS_IV PF05190 (932-1024) MutS_V PF00488 (1130-1324) |
Msh6 | 1343961 | P54276 | MSH6_MOUSE | # | # | Histone modification read | # | 21423274 | # | histone | H3K36me3 | # | 21423274, 23622243 | Table 1 in the reference. Via its PWWP domain it specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. | # |
MSL1
(details) |
27905 | male-specific lethal 1 homolog (Drosophila) | 339287 (SSTAR profile) |
Q68DK7 | MSL1_HUMAN | MSL1_dimer PF16801 (216-250) PEHE PF15275 (478-591) |
Msl1 | 1921276 | Q6PDM1 | MSL1_MOUSE | # | # | Histone modification write | Histone ubiquitination | 21726816 | # | histone | H2BK34 | H2BK34ub | 21726816 | MSL1/2 ubiquitylates nucleosomal H2B on K34 in vitro. | # |
MSL2
(details) |
25544 | male-specific lethal 2 homolog (Drosophila) | 55167 (SSTAR profile) |
Q9HCI7 | MSL2_HUMAN | zf-RING_10 PF16685 (39-110) MSL2-CXC PF16682 (455-506) |
Msl2 | 1925103 | Q69ZF8 | MSL2_MOUSE | RNF | RING-type (C3HC4) zinc fingers | Histone modification write | Histone ubiquitination | 21726816 | # | histone | H2BK34 | H2BK34ub | 21726816 | RING finger protein MSL2 in the MOF-MSL complex is a histone ubiquitin E3 ligase. MSL2, together with MSL1, has robust histone ubiquitylation activity that mainly targets nucleosomal H2B on lysine 34 (H2B K34ub), a site within a conserved basic patch on H2B tail. | # |
MSL3
(details) |
7370 | male-specific lethal 3 homolog (Drosophila) | 10943 (SSTAR profile) |
Q8N5Y2 | MS3L1_HUMAN | domain PF22732 (11-87) MRG PF05712 (161-505) |
Msl3 | 1341851 | Q9WVG9 | MS3L1_MOUSE | # | # | Histone modification read | # | 20943666 | # | histone | H4K20me1 | # | 20943666 | MSL3 plays an important role in targeting the male specific lethal complex to chromatin in both humans and flies by binding to H4K20Me. | # |
MST1
(details) |
7380 | macrophage stimulating 1 (hepatocyte growth factor-like) | 4485 (SSTAR profile) |
P26927 | HGFL_HUMAN | PAN_1 PF00024 (26-104) Kringle PF00051 (109-186, 190-268, 283-361, 370-448) Trypsin PF00089 (485-704) |
Mst1 | 96080 | P26928 | HGFL_MOUSE | # | # | Histone modification | # | 17320507 | # | histone | # | # | # | Classified as histone-modifying enzymes in paper. | # |
MTA1
(details) |
7410 | metastasis associated 1 | 9112 (SSTAR profile) |
Q13330 | MTA1_HUMAN | BAH PF01426 (5-162) ELM2 PF01448 (167-219) Myb_DNA-binding PF00249 (287-331) GATA PF00320 (393-429) MTA_R1 PF17226 (464-543) |
Mta1 | 2150037 | Q8K4B0 | MTA1_MOUSE | GATAD | GATA zinc finger domain containing | Chromatin remodeling cofactor | # | 9885572 | NuRD | chromatin | # | # | 9885572 | One subunit of NURD was identified as MTA1, a metastasis-associated protein with a region similar to the nuclear receptor corepressor, N-CoR; and antibodies against NURD partially relieve transcriptional repression by thyroid hormone receptor. These results suggest that ATP-dependent chromatin remodeling can participate in transcriptional repression by assisting repressors in gaining access to chromatin. | # |
MTA2
(details) |
7411 | metastasis associated 1 family, member 2 | 9219 (SSTAR profile) |
O94776 | MTA2_HUMAN | BAH PF01426 (4-142) ELM2 PF01448 (147-199) Myb_DNA-binding PF00249 (266-311) GATA PF00320 (367-403) MTA_R1 PF17226 (450-525) |
Mta2 | 1346340 | Q9R190 | MTA2_MOUSE | GATAD | GATA zinc finger domain containing | Histone modification erase cofactor | Histone acetylation | 10444591 | NuRD | histone | # | # | 10444591 | MTA2 directs the assembly of an active histone deacetylase complex, and the association of MTA2 with the core HDAC/RbAp complex requires MBD3. | # |
MTA3
(details) |
23784 | metastasis associated 1 family, member 3 | 57504 (SSTAR profile) |
Q9BTC8 | MTA3_HUMAN | BAH PF01426 (4-145) ELM2 PF01448 (150-202) Myb_DNA-binding PF00249 (269-314) GATA PF00320 (379-415) MTA_R1 PF17226 (462-537) |
Mta3 | 2151172 | Q924K8 | MTA3_MOUSE | GATAD | GATA zinc finger domain containing | Chromatin remodeling cofactor | # | 12705869 | NuRD | chromatin | # | # | 12705869 | The product of human MTA3 is an estrogen-dependent component of the Mi-2/NuRD transcriptional corepressor in breast epithelial cells. MTA3 constitutes a key component of an estrogen-dependent pathway regulating growth and differentiation. | # |
MTF2
(details) |
29535 | metal response element binding transcription factor 2 | 22823 (SSTAR profile) |
Q9Y483 | MTF2_HUMAN | Tudor_2 PF18104 (49-84) PHD PF00628 (105-154) Mtf2_C PF14061 (544-590) |
Mtf2 | 105050 | Q02395 | MTF2_MOUSE | TDRD, PHF | Tudor domain containing, "Zinc fingers, PHD-type" | Polycomb group (PcG) protein | # | 21881606 | PRC2 | histone | H3K36me3 | # | 21881606 | Polycomb group (PcG) that binds histone H3 trimethylated at Lys-36. | # |
MUM1
(details) |
29641 | melanoma associated antigen (mutated) 1 | 84939 (SSTAR profile) |
Q2TAK8 | MUM1_HUMAN | PWP3A-B_N PF20887 (1-105) MUM1-like_PWWP PF20884 (411-484) PWP3A-B_C PF20886 (561-707) |
Mum1 | 1915364 | Q6DID5 | MUM1_MOUSE | # | # | Histone modification read | # | 217205545 | # | histone | H3K36me, K3K79me, H4K20me | # | 217205545 | The PWWP domains in BRPF1, BRPF2, HDGF2, MUM1 and the N-terminal PWWP domains of WHSC1 and WHSC1L1 show weak binding affinity to histones with H3K36, K3K79 or H4K20 | # |
MYBBP1A
(details) |
7546 | MYB binding protein (P160) 1a | 10514 (SSTAR profile) |
Q9BQG0 | MBB1A_HUMAN | DNA_pol_phi PF04931 (38-834) | Mybbp1a | 106181 | Q7TPV4 | MBB1A_MOUSE | # | # | Chromatin remodeling cofactor | # | 16603771 | B-WICH | chromatin | # | # | 16603771 | The WSTF (Williams syndrome transcription factor) protein is involved in vitamin D-mediated transcription and replication as a component of two distinct ATP-dependent chromatin remodeling complexes, WINAC and WICH, respectively. The WICH complex (WSTF-SNF2h) interacts with several nuclear proteins as follows: Sf3b155/SAP155, RNA helicase II/Guα, Myb-binding protein 1a, CSB. | # |
MYO1C
(details) |
7597 | myosin IC | 4641 (SSTAR profile) |
O00159 | MYO1C_HUMAN | Myosin_head PF00063 (49-718) IQ PF00612 (737-755, 758-778) Myosin_TH1 PF06017 (887-1058) |
Myo1c | 106612 | Q9WTI7 | MYO1C_MOUSE | MYOI | Myosins / Myosin superfamily : Class I | Chromatin remodeling cofactor | # | 16603771 | B-WICH | chromatin | # | # | 16603771 | The WSTF (Williams syndrome transcription factor) protein is involved in vitamin D-mediated transcription and replication as a component of two distinct ATP-dependent chromatin remodeling complexes, WINAC and WICH, respectively. The WICH complex (WSTF-SNF2h) interacts with several nuclear proteins as follows: Sf3b155/SAP155, RNA helicase II/Gualpha, Myb-binding protein 1a, CSB, the proto-oncogene Dek, and nuclear myosin 1 in a large 3-MDa assembly, B-WICH, during active transcription. | # |
MYSM1
(details) |
29401 | Myb-like, SWIRM and MPN domains 1 | 114803 (SSTAR profile) |
Q5VVJ2 | MYSM1_HUMAN | Myb_DNA-binding PF00249 (120-163) SWIRM PF04433 (382-461) JAB PF01398 (576-679) |
Mysm1 | 2444584 | Q69Z66 | MYSM1_MOUSE | # | # | Histone modification erase | Histone ubiquitination | 17707232 | # | histone | H2Aub | H2A | 17707232 | JAMM/MPN(+) domain-containing histone H2A deubiquitinase (2A-DUB, or KIAA1915/MYSM1) is specific for monoubiquitinated H2A (uH2A) that has permitted delineation of a strategy for specific regulatory pathways of gene activation. | # |
NAA60
(details) |
25875 | N(alpha)-acetyltransferase 60, NatF catalytic subunit | 79903 (SSTAR profile) |
Q9H7X0 | NAA60_HUMAN | Acetyltransf_1 PF00583 (27-155) | Naa60 | 1922013 | Q9DBU2 | NAA60_MOUSE | NAA | N(alpha)-acetyltransferase subunits | Histone modification write | Histone acetylation | 21981917 | # | histone | H4K20, H4K79, H4K91 | H4K20ac, H4K79ac, H4K91ac | 21981917 | HAT4 =NAA60 is localized in the Golgi apparatus and displays a substrate preference for lysine residues of free histone H4, including H4K79 and H4K91, that reside in the globular domain of H4. | # |
NAP1L1
(details) |
7637 | nucleosome assembly protein 1-like 1 | 4673 (SSTAR profile) |
P55209 | NP1L1_HUMAN | NAP PF00956 (77-344) | Nap1l1 | 1855693 | P28656 | NP1L1_MOUSE | # | # | Histone chaperone | # | 18226242 | # | histone | # | # | 18226242 | Human Nucleosome Assembly Protein-1 (hNAP-1) =NAP1L1 is known to act as a histone chaperone that shuttles histones H2A/H2B into the nucleus, assembles nucleosomes and promotes chromatin fluidity, thereby affecting transcription of several cellular genes. | # |
NAP1L2
(details) |
7638 | nucleosome assembly protein 1-like 2 | 4674 (SSTAR profile) |
Q9ULW6 | NP1L2_HUMAN | NAP PF00956 (111-408) | Nap1l2 | 106654 | P51860 | NP1L2_MOUSE | # | # | Histone modification cofactor | # | 21333655, 17591696 | # | histone | H3, H4 | # | # | Interacts with H3 and H4 and may be involved in regulation of acetylation. | # |
NAP1L4
(details) |
7640 | nucleosome assembly protein 1-like 4 | 4676 (SSTAR profile) |
Q99733 | NP1L4_HUMAN | NAP PF00956 (65-338) | Nap1l4 | 1316687 | Q78ZA7 | NP1L4_MOUSE | # | # | Histone modification cofactor | # | 21333655 | # | histone | H3, H4 | # | # | Interacts with H3 and H4 and may be involved in regulation of acetylation. | # |
NASP
(details) |
7644 | nuclear autoantigenic sperm protein (histone-binding) | 4678 (SSTAR profile) |
P49321 | NASP_HUMAN | SHNi-TPR PF10516 (542-575) TPR_8 PF13181 (584-615) |
Nasp | 1355328 | Q99MD9 | NASP_MOUSE | TTC | Tetratricopeptide (TTC) repeat domain containing | Chromatin remodeling | # | 8724350 | # | histone | H1 | # | 8724350 | Binds to linker H1 histones, but not to core histones. | # |
NAT10
(details) |
29830 | N-acetyltransferase 10 (GCN5-related) | 55226 (SSTAR profile) |
Q9H0A0 | NAT10_HUMAN | TmcA_N PF08351 (9-201) Helicase_RecD PF05127 (282-486) GNAT_acetyltr_2 PF13718 (529-753) tRNA_bind_2 PF13725 (763-974) |
Nat10 | 2138939 | Q8K224 | NAT10_MOUSE | # | # | Histone modification write | Histone acetylation | 14592445 | # | histone | # | # | 14592445 | hALP =NAT10 can specifically acetylate free histones in vitro. hALP may influence the activity of histone acetylation and possibly up-regulate telomerase activity through transactivation of hTERT promoter. | # |
NAT10
(details) |
29830 | N-acetyltransferase 10 | 55226 (SSTAR profile) |
Q9H0A0 | NAT10_HUMAN | TmcA_N PF08351 (9-201) Helicase_RecD PF05127 (282-486) GNAT_acetyltr_2 PF13718 (529-753) tRNA_bind_2 PF13725 (763-974) |
Nat10 | 2138939 | Q8K224 | NAT10_MOUSE | GNAT | GCN5 related N-acetyltransferase | RNA modification | RNA acetylation | 30449621 | # | RNA | C of mRNA | ac4C | 30449621 | Regulates mRNA stabiility and therefore translation efficiency | New |
NBN
(details) |
7652 | nibrin | 4683 (SSTAR profile) |
O60934 | NBN_HUMAN | FHA PF00498 (24-100) BRCT PF00533 (114-181) NIBRIN_BRCT_II PF16508 (217-323) Nbs1_C PF08599 (685-749) |
Nbn | 1351625 | Q9R207 | NBN_MOUSE | # | # | Chromatin remodeling | # | 19338747 | # | histone | H2AX | # | # | Interacts with H2AX. UniProt: It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. | # |
NCL
(details) |
7667 | nucleolin | 4691 (SSTAR profile) |
P19338 | NUCL_HUMAN | RRM_1 PF00076 (309-377, 395-459, 488-554, 574-641) | Ncl | 97286 | P09405 | NUCL_MOUSE | RBM | RNA binding motif (RRM) containing | Histone chaperone | # | 16601700 | # | histone, DNA, RNA | DNA motif, RNA motif | # | 16601700, 15371412 | The nuclear protein nucleolin =NCL possesses a histone chaperone activity and this factor greatly enhances the activity of the chromatin remodeling machineries SWI/SNF and ACF. | # |
NCOA1
(details) |
7668 | nuclear receptor coactivator 1 | 8648 (SSTAR profile) |
Q15788 | NCOA1_HUMAN | PAS PF00989 (116-176) PAS_11 PF14598 (259-368) NCOA_u2 PF16665 (437-682) SRC-1 PF08832 (630-699) Nuc_rec_co-act PF08815 (921-974) DUF1518 PF07469 (1142-1189, 1208-1268) |
Ncoa1 | 1276523 | P70365 | NCOA1_MOUSE | KAT, bHLH | Chromatin-modifying enzymes / K-acetyltransferases, Basic helix-loop-helix proteins | Histone modification write | Histone acetylation | 9296499 | # | histone | H3, H4 | # | 9296499 | The HAT activity of SRC-1=NCOA1 maps to its carboxy-terminal region and is primarily specific for histones H3 and H4. Acetylation by SRC-1 and PCAF of histones bound at specific promoters may result from ligand binding to steroid receptors and could be a mechanism by which the activation functions of steroid receptors and associated coactivators enhance formation of a stable preinitiation complex, thereby increasing transcription of specific genes from transcriptionally repressed chromatin templates. | # |
NCOA2
(details) |
7669 | nuclear receptor coactivator 2 | 10499 (SSTAR profile) |
Q15596 | NCOA2_HUMAN | PAS PF00989 (119-182) PAS_11 PF14598 (268-375) NCOA_u2 PF16665 (463-581) SRC-1 PF08832 (635-709) DUF4927 PF16279 (730-821) Nuc_rec_co-act PF08815 (1072-1115) DUF1518 PF07469 (1274-1340) |
Ncoa2 | 1276533 | Q61026 | NCOA2_MOUSE | KAT, bHLH | Chromatin-modifying enzymes / K-acetyltransferases, Basic helix-loop-helix proteins | Chromatin remodeling cofactor | # | 9590696 | # | chromatin | # | # | 9590696 | GR, SRC-1/NcoA1 and GRIP-1/TIF-2/NcoA2 are known to bind to distinct regions. The chromatin remodeling complexes and coactivators may contribute to the transcriptional activation of organized chromatin templates. | # |
NCOA3
(details) |
7670 | nuclear receptor coactivator 3 | 8202 (SSTAR profile) |
Q9Y6Q9 | NCOA3_HUMAN | PAS PF00989 (117-179) PAS_11 PF14598 (265-372) NCOA_u2 PF16665 (490-572) SRC-1 PF08832 (588-707) DUF4927 PF16279 (722-817) Nuc_rec_co-act PF08815 (1045-1092) DUF1518 PF07469 (1273-1348) |
Ncoa3 | 1276535 | O09000 | NCOA3_MOUSE | KAT, bHLH | Chromatin-modifying enzymes / K-acetyltransferases, Basic helix-loop-helix proteins | Histone modification write | Histone acetylation | 9267036 | # | histone | # | # | 9267036 | ACTR =NCOA3 is a potent histone acetyltransferase and appears to define a distinct evolutionary branch. | # |
NCOA6
(details) |
15936 | nuclear receptor coactivator 6 | 23054 (SSTAR profile) |
Q14686 | NCOA6_HUMAN | NCOA6_TRADD-N PF13820 (47-182) | Ncoa6 | 1929915 | Q9JL19 | NCOA6_MOUSE | # | # | Histone modification write cofactor | Histone methylation | 17500065 | CHD8, MLL2/3, COMPASS-like MLL3,4 | histone | # | # | 17500065 | Ectopically expressed PTIP is capable of interacting with DNA damage response proteins including 53BP1, while endogenous PTIP, and a novel protein PA1 are both components of a Set1-like histone methyltransferase (HMT) complex that also contains ASH2L, RBBP5, WDR5, hDPY-30, NCOA6, SET domain-containing HMTs MLL3 and MLL4, and substoichiometric amount of JmjC domain-containing putative histone demethylase UTX. | # |
NCOR1
(details) |
7672 | nuclear receptor corepressor 1 | 9611 (SSTAR profile) |
O75376 | NCOR1_HUMAN | GPS2_interact PF15784 (151-235) Myb_DNA-binding PF00249 (626-670) |
Ncor1 | 1349717 | Q60974 | NCOR1_MOUSE | # | # | Histone modification erase cofactor | Histone acetylation | 14527417 | # | histone | # | # | # | UniProt: Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. | # |
NCOR2
(details) |
7673 | nuclear receptor corepressor 2 | 9612 (SSTAR profile) |
Q9Y618 | NCOR2_HUMAN | GPS2_interact PF15784 (150-228) Myb_DNA-binding PF00249 (431-474, 613-657) |
Ncor2 | 1337080 | Q9WU42 | NCOR2_MOUSE | # | # | Histone modification erase cofactor | Histone acetylation | 14527417, 25006126 | # | # | # | # | # | Ncor2 knockdown upregulates fos transcription by modulating the acetylation level in the fos promoter region. | # |
NEK6
(details) |
7749 | NIMA-related kinase 6 | 10783 (SSTAR profile) |
Q9HC98 | NEK6_HUMAN | Pkinase PF00069 (45-296) | Nek6 | 1891638 | Q9ES70 | NEK6_MOUSE | # | # | Histone modification write | Histone phosphorylation | 12054534 | # | histone | H1, H3 | H1ph, H3ph | 12054534 | Recombinant hNek6 protein produced in insect cells effectively phosphorylates histones H1 and H3, but not casein. Thus Nek6 is a mitotic histone kinase which regulates chromatin condensation in mammalian cells. | # |
NEK9
(details) |
18591 | NIMA-related kinase 9 | 91754 (SSTAR profile) |
Q8TD19 | NEK9_HUMAN | Pkinase PF00069 (54-308) RCC1 PF00415 (399-441, 445-496, 499-547) RCC1_2 PF13540 (655-683) |
Nek9 | 2387995 | Q8K1R7 | NEK9_MOUSE | # | # | Histone modification write | Histone phosphorylation | 14660563 | # | histone | H1 | H1ph | 14660563 | Endogenous, immunoprecipitated Nek9 kinase can become activated (i.e. phosphorylation on histone H1). | # |
NFRKB
(details) |
7802 | nuclear factor related to kappaB binding protein | 4798 (SSTAR profile) |
Q6P4R8 | NFRKB_HUMAN | NFRKB_winged PF14465 (375-480) | Nfrkb | 2442410 | Q6PIJ4 | NFRKB_MOUSE | INO80 | INO80 complex subunits | Chromatin remodeling cofactor, TF | # | 16230350 | Ino80 | DNA | DNA motif | # | 16230350 | Five proteins appear to be unique to the human INO80 complex. NFRKB is a large (more than 1300 amino acids) protein. The C-terminal half of NFRKB contains low complexity, mucin-like repeats. | # |
NFYB
(details) |
7805 | nuclear transcription factor Y, beta | 4801 (SSTAR profile) |
P25208 | NFYB_HUMAN | CBFD_NFYB_HMF PF00808 (58-122) | Nfyb | 97317 | P63139 | NFYB_MOUSE | # | # | Chromatin remodeling, TF | TF activator | 15243141, 23332751 | # | DNA | DNA motif | # | 23332751 | NF-Y is a sequence-specific transcription factor with nucleosome-like properties of nonspecific DNA binding and helps establish permissive chromatin modifications at CCAAT promoters. | # |
NFYC
(details) |
7806 | nuclear transcription factor Y, gamma | 4802 (SSTAR profile) |
Q13952 | NFYC_HUMAN | Histone PF00125 (24-105) | Nfyc | 107901 | P70353 | NFYC_MOUSE | # | # | Histone modification | # | 21445285 | # | histone | # | # | # | NF-Y recruits Ash2L to impart H3K4 trimethylation on CCAAT promoters | # |
NIPBL
(details) |
28862 | Nipped-B homolog (Drosophila) | 25836 (SSTAR profile) |
Q6KC79 | NIPBL_HUMAN | Cohesin_HEAT PF12765 (1794-1835) Nipped-B_C PF12830 (2276-2449) |
Nipbl | 1918425 | Q6KCD5 | NIPBL_MOUSE | # | # | Histone modification erase cofactor | Histone acetylation | 25255084, 18854353 | # | # | # | # | # | Probably involved in cohesin loading and promoter-enhancer interaction. Attracts histone deacetylases. | # |
NOC2L
(details) |
24517 | nucleolar complex associated 2 homolog (S. cerevisiae) | 26155 (SSTAR profile) |
Q9Y3T9 | NOC2L_HUMAN | Noc2 PF03715 (331-624) | Noc2l | 1931051 | Q9WV70 | NOC2L_MOUSE | # | # | Chromatin remodeling, TF | TF repressor | 15100215 | # | histone | H3 | # | 15100215 | INHAT =NOC2L (inhibitor of acetyltransferases) is a specific histone H3 N-terminal tail-binding complex. | # |
NPAS2
(details) |
7895 | neuronal PAS domain protein 2 | 4862 (SSTAR profile) |
Q99743 | NPAS2_HUMAN | HLH PF00010 (11-58) PAS PF00989 (84-151) PAS_11 PF14598 (250-353) |
Npas2 | 109232 | P97460 | NPAS2_MOUSE | bHLH | Basic helix-loop-helix proteins | Chromatin remodeling, TF | TF activator | 14645221, 24196956 | # | DNA | DNA motif | # | 14645221 | There is a time-dependent recruitment of chromatin remodeling machinery by NPAS2 in vivo. | # |
NPM1
(details) |
7910 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 4869 (SSTAR profile) |
P06748 | NPM_HUMAN | Nucleoplasmin PF03066 (17-117) NPM1-C PF16276 (244-293) |
Npm1 | 106184 | Q61937 | NPM_MOUSE | # | # | Histone chaperone | # | 25349213 | # | histone | H3, H2B, H4 | # | # | Co-immunoprecipitation shows that NPM1 is associated with HP1γ, core and linker histones. Uniprot: Acts as a chaperonin for the core histones H3, H2B and H4. | # |
NPM2
(details) |
7930 | nucleophosmin/nucleoplasmin 2 | 10361 (SSTAR profile) |
Q86SE8 | NPM2_HUMAN | Nucleoplasmin PF03066 (19-119) | Npm2 | 1890811 | Q80W85 | NPM2_MOUSE | # | # | Histone chaperone | # | 21863821 | # | histone | H2A, H2B | # | # | Core histone chaperon. In the absence of histone tetramers, these chaperones bind H2A-H2B dimers. | # |
NSD1
(details) |
14234 | nuclear receptor binding SET domain protein 1 | 64324 (SSTAR profile) |
Q96L73 | NSD1_HUMAN | PWWP PF00855 (318-408, 1756-1846) domain PF23011 (1542-1587) domain PF22908 (1591-1639) domain PF23004 (1640-1692) PHD PF00628 (1710-1748) AWS PF17907 (1900-1940) SET PF00856 (1953-2059) C5HCH PF17982 (2162-2210) |
Nsd1 | 1276545 | O88491 | NSD1_MOUSE | KMT, PHF | Chromatin-modifying enzymes / K-methyltransferases, Zinc fingers, PHD-type | Histone modification write | Histone methylation | 21196496 | # | histone | H3K36, H4K20 | H3K36me, H4K20me | 21196496 | NSD1 is a SET domain histone methyltransferase that primarily dimethylates nucleosomal histone H3 lysine 36 (H3K36). | # |
NSL1
(details) |
24548 | NSL1, MIS12 kinetochore complex component | 25936 (SSTAR profile) |
Q96IY1 | NSL1_HUMAN | Mis14 PF08641 (80-190) | Nsl1 | 2685830 | Q8K305 | NSL1_MOUSE | # | # | Histone modification write cofactor | Histone acetylation | 20018852 | # | histone | H4K16 | H4K16ac | 20018852 | Binding of NSL1 to MOF enhances MOF acetylation of histone H4 on lysine 16 and of the DNA binding transcription factor p53. | # |
NSRP1
(details) |
25305 | Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) (Nuclear speckle-related protein 70) (NSrp70) | 84081 (SSTAR profile) |
Q9H0G5 | NSRP1_HUMAN | NSRP1_N PF09745 (59-174) NRP1_C PF20427 (310-489) |
Nsrp1 | 2144305 | Q5NCR9 | NSRP1_MOUSE | MicroRNA protein coding host genes | MicroRNA protein coding host genes | RNA modification | Alternative splicing | 21296756 | # | RNA | mRNA | # | 21296756 | Regultes alternative splicing site selection | New |
NSUN2
(details) |
25994 | NOP2/Sun RNA methyltransferase 2 | 54888 (SSTAR profile) |
Q08J23 | NSUN2_HUMAN | Methyltr_RsmB-F PF01189 (170-341) | Nsun2 | 107252 | Q1HFZ0 | NSUN2_MOUSE | NSUN | NOP2/Sun RNA methyltransferase family | RNA modification | RNA methylation | 27444144 | # | RNA | C of mRNA | m5C | 33622495 | Regulates cell proliferation by methylation of 5`-UTR or 3`-UTR of CDK1 and p27 mRNA | New |
NSUN6
(details) |
23529 | NOP2/Sun RNA methyltransferase 6 | 221078 (SSTAR profile) |
Q8TEA1 | NSUN6_HUMAN | Methyltr_RsmB-F PF01189 (229-399) | Nsun6 | 1921705 | Q7TS68 | NSUN6_MOUSE | NSUN | NOP2/Sun RNA methyltransferase family | RNA modification | RNA methylation | 33330931 | # | RNA | C of mRNA | m5C | 33330931 | Marks translation termination by methylation of cytosine within the CTCCA motif | New |
NTMT1
(details) |
23373 | N-terminal Xaa-Pro-Lys N-methyltransferase 1 | 28989 (SSTAR profile) |
Q9BV86 | NTM1A_HUMAN | Methyltransf_PK PF05891 (8-222) | Ntmt1 | 1913867 | Q8R2U4 | NTM1A_MOUSE | METTL | Methyltransferase like | Histone modification writer | Histone methylation | 26543159 | # | protein | CENP-A, CENP-B, RCC1 | Km1/m2/m3, Rm, Pm | 26543159 | Regulates centromere function and mitosis | New |
NUP98
(details) |
8068 | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | 4928 (SSTAR profile) |
P52948 | NUP98_HUMAN | Nup98_GLEBS PF21240 (169-209) Nucleoporin2 PF04096 (738-884) Nup96 PF12110 (1331-1629) |
Nup98 | 109404 | Q6PFD9 | NUP98_MOUSE | NUP | Nucleoporins | RNA modification | Alternative splicing | 28221134 | # | RNA | mRNA | # | 28221134 | Regulates alternative splicing of E1A | New |
OGT
(details) |
8127 | O-linked N-acetylglucosamine (GlcNAc) transferase | 8473 (SSTAR profile) |
O15294 | OGT1_HUMAN | TPR_11 PF13414 (90-144, 363-410, 429-471) TPR_8 PF13181 (157-190, 225-258) TPR_1 PF00515 (191-224, 259-292) TPR_12 PF13424 (293-360) Glyco_transf_41 PF13844 (477-1016) |
Ogt | 1339639 | Q8CGY8 | OGT1_MOUSE | TTC | Tetratricopeptide (TTC) repeat domain containing | Histone modification write | Histone GlcNAcylation | 22121020 | NSL | histone | H2BS112 | H2BS112GlcNa | 22121020 | Histone H2B is GlcNAcylated at residue S112 by OGT in vitro and in living cells. Histone GlcNAcylation fluctuated in response to extracellular glucose through the hexosamine biosynthesis pathway (HBP). | # |
OIP5
(details) |
20300 | Opa interacting protein 5 | 11339 (SSTAR profile) |
O43482 | MS18B_HUMAN | Yippee-Mis18 PF03226 (76-182) | Oip5 | 1917895 | A2AQ14 | MS18B_MOUSE | # | # | Chromatin remodeling | # | 17199038 | Mis18 | histone | CENPA | # | 17199038 | Recruits CENPA to centromeres. Regulates normal chromosome segregation during mitosis. | New |
PADI1
(details) |
18367 | peptidyl arginine deiminase, type I | 29943 (SSTAR profile) |
Q9ULC6 | PADI1_HUMAN | PAD_N PF08526 (2-114) PAD_M PF08527 (115-277) PAD PF03068 (285-662) |
Padi1 | 1338893 | Q9Z185 | PADI1_MOUSE | PADI | Peptidyl arginine deiminases | Histone modification | Histone citrullination | 15087120 | # | histone | H2AR, H3R, H4R | H2ARci, H3Rci, H4Rci | 15087120 | Peptidylarginine deiminases (PADs) convert arginine residues in proteins into citrullines. They are suspected to be involved in multiple sclerosis and rheumatoid arthritis pathophysiology, and they play a role in epidermis homeostasis and possibly in regulation of gene expression through histone modification | # |
PADI2
(details) |
18341 | peptidyl arginine deiminase, type II | 11240 (SSTAR profile) |
Q9Y2J8 | PADI2_HUMAN | PAD_N PF08526 (2-114) PAD_M PF08527 (115-274) PAD PF03068 (286-664) |
Padi2 | 1338892 | Q08642 | PADI2_MOUSE | PADI | Peptidyl arginine deiminases | Histone modification | Histone citrullination | 15087120 | # | histone | H2AR, H3R, H4R | H2ARci, H3Rci, H4Rci | 15087120 | Peptidylarginine deiminases (PADs) convert arginine residues in proteins into citrullines. They are suspected to be involved in multiple sclerosis and rheumatoid arthritis pathophysiology, and they play a role in epidermis homeostasis and possibly in regulation of gene expression through histone modification | # |
PADI3
(details) |
18337 | peptidyl arginine deiminase, type III | 51702 (SSTAR profile) |
Q9ULW8 | PADI3_HUMAN | PAD_N PF08526 (1-113) PAD_M PF08527 (115-281) PAD PF03068 (290-661) |
Padi3 | 1338891 | Q9Z184 | PADI3_MOUSE | PADI | Peptidyl arginine deiminases | Histone modification | Histone citrullination | 15087120 | # | histone | H2AR, H3R, H4R | H2ARci, H3Rci, H4Rci | 15087120 | Peptidylarginine deiminases (PADs) convert arginine residues in proteins into citrullines. They are suspected to be involved in multiple sclerosis and rheumatoid arthritis pathophysiology, and they play a role in epidermis homeostasis and possibly in regulation of gene expression through histone modification | # |
PADI4
(details) |
18368 | peptidyl arginine deiminase, type IV | 23569 (SSTAR profile) |
Q9UM07 | PADI4_HUMAN | PAD_N PF08526 (1-113) PAD_M PF08527 (113-275) PAD PF03068 (286-661) |
Padi4 | 1338898 | Q9Z183 | PADI4_MOUSE | PADI | Peptidyl arginine deiminases | Histone modification | Histone citrullination | 15339660 | # | histone | H2AR, H3R2, H3R8, H3R17, H3R26, H4R | H2ARci, H3R2ci, H3R8ci, H3R17ci, H3R26ci, H4Rci | 15339660 | Deimination converts histone arginine to citrulline and antagonizes arginine methylation. Peptidyl arginine deiminase 4 (PADI4) specifically deiminates, arginine residues R2, R8, R17, and R26 in the H3 tail. Deimination by PADI4 prevents arginine methylation by CARM1. | # |
PAF1
(details) |
25459 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 54623 (SSTAR profile) |
Q8N7H5 | PAF1_HUMAN | Paf1 PF03985 (31-420) | Paf1 | 1923988 | Q8K2T8 | PAF1_MOUSE | # | # | Histone modification write cofactor | Histone ubiquitination | 16307923 | # | histone | H2, H3 | # | # | Involved in H2 and H3 ubiquitination. Involved in H2 and H3 ubiquitination. UniProt: PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). | # |
PAGR1
(details) |
28707 | PAXIP1 associated glutamate-rich protein 1 | 79447 (SSTAR profile) |
Q9BTK6 | PAGR1_HUMAN | PAXIP1_C PF15364 (88-226) | 2900092E17Rik | 1914528 | Q99L02 | PAGR1_MOUSE | # | # | Histone modification write cofactor, Histone modification write cofactor | Histone methylation, Histone acetylation | 17500065 | CHD8, MLL2/3, MLL4/WBP7, COMPASS-like MLL3,4 | histone | # | # | 17500065 | Component of the MLL2/MLL3 complex (UniProt). | # |
PAK2
(details) |
8591 | p21 protein (Cdc42/Rac)-activated kinase 2 | 5062 (SSTAR profile) |
Q13177 | PAK2_HUMAN | PBD PF00786 (73-130) Pkinase PF00069 (249-500) |
Pak2 | 1339984 | Q8CIN4 | PAK2_MOUSE | # | # | Histone modification write | Histone phosphorylation | 21724829 | # | histone | H4S47 | H4S47ph | 21724829 | Phosphorylation of histone H4 Ser 47 (H4S47ph), catalyzed by the PAK2 kinase, promotes nucleosome assembly of H3.3-H4 and inhibits nucleosome assembly of H3.1-H4 by increasing the binding affinity of HIRA to H3.3-H4 and reducing association of CAF-1 with H3.1-H4. | # |
PARG
(details) |
8605 | poly (ADP-ribose) glycohydrolase | 8505 (SSTAR profile) |
Q86W56 | PARG_HUMAN | PARG_cat_N PF20811 (582-699) PARG_cat_C PF05028 (705-909) |
Parg | 1347094 | O88622 | PARG_MOUSE | # | # | Chromatin remodeling | # | 23102699, 21398629 | # | histone | H3K9 | # | 23102699, 21398629 | Reverses PARP activity. Both PAR and PARP-1 have an influence on PARG recruitment. Also recruitment through a PBD-mediated interaction of PARG with PCNA. | # |
PARP1
(details) |
270 | poly (ADP-ribose) polymerase 1 | 142 (SSTAR profile) |
P09874 | PARP1_HUMAN | zf-PARP PF00645 (11-88, 115-198) PADR1_N PF21728 (232-290) PADR1_Zn_ribbon PF08063 (291-332) BRCT PF00533 (387-463) WGR PF05406 (554-632) PARP_reg PF02877 (662-794) PARP PF00644 (808-1007) |
Parp1 | 1340806 | P11103 | PARP1_MOUSE | PARP | Poly (ADP-ribose) polymerases | Chromatin remodeling | # | 20926656, 17177976, 17396150 | # | histone | H1 | # | 20926656 | Histone H1 poly[ADP]-ribosylation = PARP1, and its loss at specific loci, may be an epigenetic mechanism involved in the reprogramming of neuronal gene expression required for memory consolidation. | # |
PARP2
(details) |
272 | poly (ADP-ribose) polymerase 2 | 10038 (SSTAR profile) |
Q9UGN5 | PARP2_HUMAN | WGR PF05406 (116-194) PARP_reg PF02877 (231-363) PARP PF00644 (376-577) |
Parp2 | 1341112 | O88554 | PARP2_MOUSE | PARP | Poly (ADP-ribose) polymerases | Chromatin remodeling cofactor | # | 20092359 | # | # | # | # | 20092359 | PARP activity is involved in processes such as chromatin remodeling. Component of a base excision repair (BER) complex, containing at least XRCC1, PARP1, POLB and LRIG3. Homo- and heterodimer with PARP1. | # |
PARP3
(details) |
273 | poly (ADP-ribose) polymerase family, member 3 | 10039 (SSTAR profile) |
Q9Y6F1 | PARP3_HUMAN | WGR PF05406 (66-144) PARP_reg PF02877 (181-320) PARP PF00644 (334-532) |
Parp3 | 1891258 | # | # | PARP | Poly (ADP-ribose) polymerases | Polycomb group (PcG) protein | # | 16924674 | # | # | # | # | 16924674 | PARP-3 is part of Polycomb group protein complexes. | # |
PAXIP1
(details) |
8624 | PAX interacting (with transcription-activation domain) protein 1 | 22976 (SSTAR profile) |
Q6ZW49 | PAXI1_HUMAN | PTCB-BRCT PF12738 (102-165, 710-771) BRCT PF00533 (604-684) RTT107_BRCT_5 PF16770 (860-947) BRCT_2 PF16589 (973-1062) |
Paxip1 | 1890430 | Q6NZQ4 | PAXI1_MOUSE | # | # | Histone modification write cofactor | Histone methylation | 17178841 | CHD8, MLL2/3, MLL4/WBP7, COMPASS-like MLL3,4 | histone | H3K4 | H3K4me3 | 17178841 | ALR (MLL2) is a member of the human MLL family, which belongs to a larger SET1 family of histone methyltransferases. ALR is present within a stable multiprotein complex containing a cohort of proteins shared with other SET1 family complexes and several unique components, such as PTIP and the jumonji family member UTX. | # |
PBK
(details) |
18282 | PDZ binding kinase | 55872 (SSTAR profile) |
Q96KB5 | TOPK_HUMAN | Pkinase PF00069 (35-317) | Pbk | 1289156 | Q9JJ78 | TOPK_MOUSE | # | # | Histone modification write | Histone phosphorylation | 16982762 | # | histone | H3S10 | H3S10ph | # | PBK/TOPK can phosphorylate histone H3 at Ser10 in vitro and in vivo, and mediate its growth-promoting effect through histone H3 modification. Can phosphorylate histone H3 at Ser10 in vitro and in vivo. | # |
PBRM1
(details) |
30064 | polybromo 1 | 55193 (SSTAR profile) |
Q86U86 | PB1_HUMAN | Bromodomain PF00439 (64-136, 200-272, 400-470, 541-608, 677-746, 790-865) BAH PF01426 (957-1074, 1156-1272) HMG_box PF00505 (1379-1441) |
Pbrm1 | 1923998 | Q8BSQ9 | PB1_MOUSE | # | # | Histone modification read | # | 22464331 | PBAF, SWI/SNF BRM-BRG1 | histone | H3 | # | 22464331 | Fig. 5 in the reference (PBRM1 =PB1). | # |
PCGF1
(details) |
17615 | polycomb group ring finger 1 | 84759 (SSTAR profile) |
Q9BSM1 | PCGF1_HUMAN | zf-C3HC4_2 PF13923 (47-85) RAWUL PF16207 (190-253) |
Pcgf1 | 1917087 | Q8R023 | PCGF1_MOUSE | RNF, PCGF | RING-type (C3HC4) zinc fingers, Polycomb group ring fingers | Polycomb group (PcG) protein | # | 15620699 | PRC1, BCOR | # | # | # | 15620699 | Nervous system polycomb 1 (NSPc1=PCGF1) shares high homology with vertebrate PcG proteins Mel-18 and Bmi-1. | # |
PCGF2
(details) |
12929 | polycomb group ring finger 2 | 7703 (SSTAR profile) |
P35227 | PCGF2_HUMAN | zf-C3HC4_2 PF13923 (18-56) RAWUL PF16207 (164-228) |
Pcgf2 | 99161 | P23798 | PCGF2_MOUSE | RNF, PCGF | RING-type (C3HC4) zinc fingers, Polycomb group ring fingers | Polycomb group (PcG) protein | # | 21282530 | PRC1 | # | # | # | 21282530 | CBX7 and CBX8, two Polycomb (Pc) homologs that repress INK4a, both participate in PRC1-like complexes with at least two Posterior sex combs (Psc) proteins, MEL18 =PCGF2 and BMI1. | # |
PCGF3
(details) |
10066 | polycomb group ring finger 3 | 10336 (SSTAR profile) |
Q3KNV8 | PCGF3_HUMAN | zf-C3HC4_2 PF13923 (17-55) RAWUL PF16207 (172-236) |
Pcgf3 | 1916837 | Q8BTQ0 | PCGF3_MOUSE | RNF, PCGF | RING-type (C3HC4) zinc fingers, Polycomb group ring fingers | Polycomb group (PcG) protein | # | 21282530 | PRC1, RING2-FBRS | # | # | # | 21282530 | There are multiple orthologs of the archetypal PRC1 proteins; five Pc proteins (CBX2, CBX4, CBX6, CBX7 and CBX8), six Psc proteins (BMI1, MEL18, MBLR, NSPC1, RNF159 and RNF3=PCGF3). | # |
PCGF5
(details) |
28264 | polycomb group ring finger 5 | 84333 (SSTAR profile) |
Q86SE9 | PCGF5_HUMAN | zf-C3HC4_2 PF13923 (18-56) RAWUL PF16207 (163-216) |
Pcgf5 | 1923505 | Q3UK78 | PCGF5_MOUSE | RNF, PCGF | RING-type (C3HC4) zinc fingers, Polycomb group ring fingers | Polycomb group (PcG) protein | # | 21282530 | PRC1, RING2-FBRS | # | # | # | 21282530 | There are multiple orthologs of the archetypal PRC1 proteins; five Pc proteins (CBX2, CBX4, CBX6, CBX7 and CBX8), six Psc proteins (BMI1, MEL18, MBLR, NSPC1, RNF159==PCGF5 and RNF3). | # |
PCGF6
(details) |
21156 | polycomb group ring finger 6 | 84108 (SSTAR profile) |
Q9BYE7 | PCGF6_HUMAN | zf-C3HC4_2 PF13923 (134-172) RAWUL PF16207 (275-323) |
Pcgf6 | 1918291 | Q99NA9 | PCGF6_MOUSE | RNF, PCGF | RING-type (C3HC4) zinc fingers, Polycomb group ring fingers | Polycomb group (PcG) protein | # | 21282530 | PRC1, RING2-L3MBTL2 | # | # | # | 21282530 | There are multiple orthologs of the archetypal PRC1 proteins; five Pc proteins (CBX2, CBX4, CBX6, CBX7 and CBX8), six Psc proteins (BMI1, MEL18, MBLR=PCGF6, NSPC1, RNF159 and RNF3). | # |
PCNA
(details) |
8729 | proliferating cell nuclear antigen | 5111 (SSTAR profile) |
P12004 | PCNA_HUMAN | PCNA_N PF00705 (1-124) PCNA_C PF02747 (127-254) |
Pcna | 97503 | P17918 | PCNA_MOUSE | # | # | Chromatin remodeling | # | 12786946 | # | histone | H2A, H2B | # | 12786946 | PCNA forms a ternary complex with DNTTIP2 and core histone. | # |
PDP1
(details) |
9279 | pyruvate dehyrogenase phosphatase catalytic subunit 1 | 54704 (SSTAR profile) |
Q9P0J1 | PDP1_HUMAN | PP2C PF00481 (202-439) | Pdp1 | 2685870 | Q3UV70 | PDP1_MOUSE | PPM | Serine/threonine phosphatases / Protein phosphatases, Mg2+/Mn2+ dependent | Histone modification read | # | 22150589 | # | histone, DNA | H4K20me3 | # | 22150589 | The PWWP domain of Pdp1 binds not only to H4K20me3 (trimethylated Lys(20) of histone H4), but also to dsDNA (double-stranded DNA) via an aromatic cage and a positively charged area respectively. Pdp1 is a PWWP (proline-tryptophan-tryptophan-proline) domain-containing protein, which associates with Set9 to regulate its chromatin localization and methyltransferase activity towards H4K20. | # |
PELP1
(details) |
30134 | proline, glutamate and leucine rich protein 1 | 27043 (SSTAR profile) |
Q8IZL8 | PELP1_HUMAN | RIX1 PF08167 (75-231) PELP1_HEAT PF08166 (425-473, 558-635) |
Pelp1 | 1922523 | Q9DBD5 | PELP1_MOUSE | # | # | Histone modification read, Histone modification write cofactor | Histone methylation, Histone acetylation | 15456770, 11481323 | CHD8, MLL2/3, MLL4/WBP7 | histone | H1, H3, H4 | # | 15456770, 15374949 | C-terminal glutamic acid-abundant region bound to the hypoacetylated histones H3 and H4 and prevents them from becoming substrates of histone acetyltransferase. Thus PELP1 promotes and maintains the hypoacetylated state of histones at the target genomic site, and ER binding reverses its role to hyperacetylate histones through an as yet unidentified mechanism. | # |
PHC1
(details) |
3182 | polyhomeotic homolog 1 (Drosophila) | 1911 (SSTAR profile) |
P78364 | PHC1_HUMAN | zf-FCS_1 PF21319 (798-827) PHC2_SAM_assoc PF16616 (829-936) SAM_1 PF00536 (939-1002) |
Phc1 | 103248 | Q64028 | PHC1_MOUSE | SAMD | Sterile alpha motif (SAM) domain containing | Polycomb group (PcG) protein | # | 16024804 | PRC1 | # | # | # | 16024804 | Phc1 plays a pivotal role in mediating the PcG-dependent bridging of distant chromatin templates. | # |
PHC2
(details) |
3183 | polyhomeotic homolog 2 (Drosophila) | 1912 (SSTAR profile) |
Q8IXK0 | PHC2_HUMAN | zf-FCS_1 PF21319 (640-669) PHC2_SAM_assoc PF16616 (670-789) SAM_1 PF00536 (791-856) |
Phc2 | 1860454 | Q9QWH1 | PHC2_MOUSE | SAMD | Sterile alpha motif (SAM) domain containing | Polycomb group (PcG) protein | # | 16024804 | PRC1 | # | # | # | 16024804 | Phc2 is involved in the anterior-posterior (A-P) specification of the vertebral column through the regulation of Hox gene expression, as well as other PcG proteins. | # |
PHC3
(details) |
15682 | polyhomeotic homolog 3 (Drosophila) | 80012 (SSTAR profile) |
Q8NDX5 | PHC3_HUMAN | zf-FCS_1 PF21319 (783-812) SAM_1 PF00536 (919-981) |
Phc3 | 2181434 | Q8CHP6 | PHC3_MOUSE | SAMD | Sterile alpha motif (SAM) domain containing | Polycomb group (PcG) protein | # | 16024804 | PRC1 | # | # | # | 16024804 | All known components of the PRC1 protein complex are found stably associated with CBX proteins. In particular, all the human Psc orthologs (BMI1, PCGF1, PCGF2, PCGF3, PCGF5, and PCGF6), the Ph orthologs (PHC1, PHC2, and PHC3). | # |
PHF1
(details) |
8919 | PHD finger protein 1 | 5252 (SSTAR profile) |
O43189 | PHF1_HUMAN | Tudor_2 PF18104 (34-69) PHD PF00628 (90-139) Mtf2_C PF14061 (534-564) |
Phf1 | 98647 | Q9Z1B8 | PHF1_MOUSE | TDRD, PHF | Tudor domain containing, Zinc fingers, PHD-type | Polycomb group (PcG) protein | # | 18086877 | PRC2 | # | # | # | 18086877 | The EED-EZH2 complex, containing the core subunits EZH2, EED, SUZ12, and RbAp48, functions as a histone H3K27-specific methyltransferase. The related EED-EZH2 protein complex is distinguished from the previous complex by the presence of another PcG protein, hPHF1. | # |
PHF10
(details) |
18250 | PHD finger protein 10 | 55274 (SSTAR profile) |
Q8WUB8 | PHF10_HUMAN | PHD PF00628 (380-433, 436-478) | Phf10 | 1919307 | Q9D8M7 | PHF10_MOUSE | PHF | Zinc fingers, PHD-type | Chromatin remodeling | # | 20068294 | npBAF, SWI/SNF BRM-BRG1 | chromatin | # | # | 20068294 | PHF10 belongs to a family of plant homeodomain (PHD) containing proteins which play a role in transcription regulation via chromatin remodeling. | # |
PHF12
(details) |
20816 | PHD finger protein 12 | 57649 (SSTAR profile) |
Q96QT6 | PHF12_HUMAN | PHD PF00628 (59-102, 273-318) PHF12_MRG_bd PF16737 (201-236) |
Phf12 | 1924057 | Q5SPL2 | PHF12_MOUSE | PHF | Zinc fingers, PHD-type | Histone modification erase cofactor | Histone acetylation | 11390640 | # | histone | # | # | 11390640 | Pf1 =PHF12 is a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex. | # |
PHF13
(details) |
22983 | PHD finger protein 13 | 148479 (SSTAR profile) |
Q86YI8 | PHF13_HUMAN | PHD_5 PF20826 (226-279) | Phf13 | 2446217 | Q8K2W6 | PHF13_MOUSE | PHF | Zinc fingers, PHD-type | Histone modification read | # | 19638409 | # | histone | H3K4me3 | # | 19638409 | Interacts with histone H3 that is trimethylated at 'Lys-4' (H3K4me3). | # |
PHF14
(details) |
22203 | PHD finger protein 14 | 9678 (SSTAR profile) |
O94880 | PHF14_HUMAN | PHD_2 PF13831 (334-359) zf-HC5HC2H_2 PF13832 (384-498) PHD PF00628 (728-776, 871-918) |
Phf14 | 1923539 | Q9D4H9 | PHF14_MOUSE | PHF | Zinc fingers, PHD-type | Histone modification read | # | 23688586 | # | histone | H2A, H2B, H3 | H2Aac, H2Bac, H3ac | 23688586 | PHF14α is bound to histones. Histone H3, H2A, and H2B can be co-immunoprecipitated with GFP-PHF14α, but not with GFP alone, from total cell lysate. Histones H3, H2A, and H2B can be pulled down together with non-tagged exogenous PHF14α using an anti-PHF14 antibody. | # |
PHF19
(details) |
24566 | PHD finger protein 19 | 26147 (SSTAR profile) |
Q5T6S3 | PHF19_HUMAN | Tudor_2 PF18104 (43-78) PHD PF00628 (99-148) Mtf2_C PF14061 (531-578) |
Phf19 | 1921266 | Q9CXG9 | PHF19_MOUSE | TDRD, PHF | Tudor domain containing, Zinc fingers, PHD-type | Chromatin remodeling, Histone modification write cofactor | Histone acetylation | 15563832 | PRC2 | histone | # | # | 15563832 | Based on motifs identified within the hPCL3 =PHF19 open reading frames, hPCL3 proteins are likely to be nuclear proteins that regulate transcription and/or chromatin structure. | # |
PHF2
(details) |
8920 | PHD finger protein 2 | 5253 (SSTAR profile) |
O75151 | PHF2_HUMAN | PHD PF00628 (8-53) JmjC PF02373 (237-336) JHD PF17811 (340-443) |
Phf2 | 1338034 | Q9WTU0 | PHF2_MOUSE | KDM, PHF | Chromatin-modifying enzymes / K-demethylases, Zinc fingers, PHD-type | Histone modification erase | Histone methylation | 21532585 | # | histone | H3K9me2 | H3K9 | 21532585 | The protein kinase A (PKA)-dependent histone lysine demethylase complex, PHF2-ARID5B. PHF2, a jmjC demethylase, is enzymatically inactive by itself, but becomes an active H3K9Me2 demethylase through PKA-mediated phosphorylation. | # |
PHF20
(details) |
16098 | PHD finger protein 20 | 51230 (SSTAR profile) |
Q9BVI0 | PHF20_HUMAN | Tudor_3 PF18115 (89-136) PHF20_AT-hook PF12618 (147-282) PHD_5 PF20826 (647-699) |
Phf20 | 2444148 | Q8BLG0 | PHF20_MOUSE | TDRD, PHF | Tudor domain containing, Zinc fingers, PHD-type | Histone modification write | Histone acetylation | 22449972 | NSL, CHD8, MLL2/3, MLL4/WBP7 | histone | H4 | H4ac | 22449972 | The second Tudor domain of PHF20 displays preference for dimethylated histones substrates. | # |
PHF20L1
(details) |
24280 | PHD finger protein 20-like 1 | 51105 (SSTAR profile) |
A8MW92 | P20L1_HUMAN | Tudor_2 PF18104 (90-124) PHD20L1_u1 PF16660 (309-439) PHD_5 PF20826 (675-729) |
Phf20l1 | 2444412 | Q8CCJ9 | P20L1_MOUSE | TDRD, PHF | Tudor domain containing, Zinc fingers, PHD-type | Histone modification read | # | 21423274 | # | histone | H3K4me | # | 21423274 | Table 1 in the reference. Via its PWWP domain it specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair rea | # |
PHF21A
(details) |
24156 | PHD finger protein 21A | 51317 (SSTAR profile) |
Q96BD5 | PF21A_HUMAN | PHD PF00628 (491-532) | Phf21a | 2384756 | Q6ZPK0 | PF21A_MOUSE | PHF | Zinc fingers, PHD-type | Histone modification erase cofactor | Histone methylation | 16140033 | BHC, LSD-CoREST | histone | # | # | 16140033 | LSD1 is a recently identified human lysine (K)-specific histone demethylase. LSD1 is associated with HDAC1/2; CoREST, a SANT domain-containing corepressor; and BHC80=PHF21A, a PHD domain-containing protein, among others. | # |
PHF8
(details) |
20672 | PHD finger protein 8 | 23133 (SSTAR profile) |
Q9UPP1 | PHF8_HUMAN | PHD PF00628 (44-89) JmjC PF02373 (270-370) JHD PF17811 (374-481) |
Phf8 | 2444341 | Q80TJ7 | PHF8_MOUSE | KDM, PHF | Chromatin-modifying enzymes / K-demethylases, Zinc fingers, PHD-type | Histone modification erase | Histone methylation | 21423274 | # | histone | H3K9me1, H3K9me2, H3K27me2, H4K20me1, H3K36me2, H3K36me3, H3K4me3 | H3K9, H3K27, H4K20, H3K36, H3K4 | 21423274 | Table 1 in the reference. Via its PWWP domain it specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair rea | # |
PHIP
(details) |
15673 | pleckstrin homology domain interacting protein | 55023 (SSTAR profile) |
Q8WWQ0 | PHIP_HUMAN | WD40 PF00400 (179-211, 214-252, 259-298, 357-393, 456-495) Bromodomain PF00439 (1166-1250, 1327-1404) |
Phip | 1932404 | Q8VDD9 | PHIP_MOUSE | WDR, DCAF | WD repeat domain containing, DDB1 and CUL4 associated factors | Histone modification read | # | 22464331 | # | histone | H3 | # | 22464331 | Fig. 5 in the reference. | # |
PIWIL4
(details) |
18444 | piwi-like RNA-mediated gene silencing 4 | 143689 (SSTAR profile) |
Q7Z3Z4 | PIWL4_HUMAN | PAZ PF02170 (272-405) Piwi PF02171 (546-837) |
Piwil4 | 3041167 | Q8CGT6 | PIWL4_MOUSE | AGO | Argonaute/PIWI family | Chromatin remodeling, Histone modification erase cofactor | Histone methylation | 17544373 | # | histone | H3K9 | # | 17544373 | Induced histone H3 lysine 9 methylation at the p16(Ink4a) (CDKN2A) locus. Suggests that PIWIL4 plays important roles in the chromatin-modifying pathway in human somatic cells. | # |
PKM
(details) |
9021 | pyruvate kinase, muscle | 5315 (SSTAR profile) |
P14618 | KPYM_HUMAN | PK PF00224 (43-375) PK_C PF02887 (411-528) |
Pkm | 97591 | P52480 | KPYM_MOUSE | # | # | Histone modification write cofactor | Histone phosphorylation | 24706538 | # | histone | H3S10, H3S28, H2BS32 | H3S10ph, H3S28ph, H2BS32ph, H3T11ph | 24706538 | Transcriptional activation by epidermal growth factor (EGF) is mediated via phosphorylation of H3S10, H3S28, and H2BS32 by Rsk-2 and PKM2. | # |
PKN1
(details) |
9405 | protein kinase N1 | 5585 (SSTAR profile) |
Q16512 | PKN1_HUMAN | HR1 PF02185 (38-98, 127-194, 214-278) Pkinase PF00069 (616-874) Pkinase_C PF00433 (895-937) |
Pkn1 | 108022 | P70268 | PKN1_MOUSE | # | # | Histone modification write | Histone phosphorylation | 18066052 | # | histone | H3T11 | H3T11ph | 18066052 | Protein-kinase-C-related kinase 1 (PRK1=PKN1) phosphorylates histone H3 at threonine 11 (H3T11) upon ligand-dependent recruitment to androgen receptor target genes. | # |
POGZ
(details) |
18801 | pogo transposable element with ZNF domain | 23126 (SSTAR profile) |
Q7Z3K3 | POGZ_HUMAN | HTH_Tnp_Tc5 PF03221 (1025-1082) DDE_1 PF03184 (1157-1287) |
Pogz | 2442117 | Q8BZH4 | POGZ_MOUSE | # | # | Histone modification read | Histone methylation | 20562864, 20850016 | # | histone | H3K9me3 | # | # | Part of a H3K9me3 reader complex; modulates dissociation of HP1alpha. | # |
POLE3
(details) |
13546 | polymerase (DNA directed), epsilon 3, accessory subunit | 54107 (SSTAR profile) |
Q9NRF9 | DPOE3_HUMAN | CBFD_NFYB_HMF PF00808 (9-73) | Pole3 | 1933378 | Q9JKP7 | DPOE3_MOUSE | POL | DNA polymerases | Histone chaperone | # | 10880450 | CHRAC | histone | # | # | 10880450 | The human homologues of two novel putative histone-fold proteins in Drosophila CHRAC are present in HuCHRAC. The two human histone-fold proteins form a stable complex that binds naked DNA but not nucleosomes. | # |
PPARGC1A
(details) |
9237 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | 10891 (SSTAR profile) |
Q9UBK2 | PRGC1_HUMAN | RRM_1 PF00076 (679-739) | Ppargc1a | 1342774 | O70343 | PRGC1_MOUSE | RBM | RNA binding motif (RRM) containing | Histone modification cofactor | # | 10558993 | # | histone | # | # | # | PPARgamma coactivator-1 (PGC-1) promotes transcription through the assembly of a complex that includes the histone acetyltransferases steroid receptor coactivator-1 (SRC-1). Promotes transcription through the assembly of a complex that includes HAT p300. | # |
PPM1G
(details) |
9278 | protein phosphatase, Mg2+/Mn2+ dependent, 1G | 5496 (SSTAR profile) |
O15355 | PPM1G_HUMAN | PP2C PF00481 (26-108, 303-489) | Ppm1g | 106065 | Q61074 | PPM1G_MOUSE | PPM | Serine/threonine phosphatases / Protein phosphatases, Mg2+/Mn2+ dependent | Chromatin remodeling | # | 23723158 | # | chromatin | # | # | 23723158 | Together with CHRAC1, ACF1 and ISWI/SNF2H proteins, it forms the ISWI chromatin-remodeling complex, CHRAC (UniProt). | # |
PPP2CA
(details) |
9299 | protein phosphatase 2, catalytic subunit, alpha isozyme | 5515 (SSTAR profile) |
P67775 | PP2AA_HUMAN | Metallophos PF00149 (51-244) | Ppp2ca | 1321159 | P63330 | PP2AA_MOUSE | PPP | Serine/threonine phosphatases / Protein phosphatase, catalytic subunits | Histone modification write | Histone phosphorylation | 18758438 | # | histone | H2AX | H2AXph | 18758438 | PP2A =PPP2CA (rather than PP4) has been implicated as a mammalian γH2AX phosphatase. | # |
PPP4C
(details) |
9319 | protein phosphatase 4, catalytic subunit | 5531 (SSTAR profile) |
P60510 | PP4C_HUMAN | Metallophos PF00149 (48-241) | Ppp4c | 1891763 | P97470 | PP4C_MOUSE | PPP | Serine/threonine phosphatases / Protein phosphatase, catalytic subunits | Histone modification erase | Histone phosphorylation | 18758438 | PPP4C-PPP4R2-PPP4R3A | histone | H2AXS139ph | H2AXS139 | 18758438 | PP4 and PP2A counteract phosphorylation of H2AX. | # |
PPP4R2
(details) |
18296 | protein phosphatase 4, regulatory subunit 2 | 151987 (SSTAR profile) |
Q9NY27 | PP4R2_HUMAN | PPP4R2 PF09184 (5-309) | Ppp4r2 | 3027896 | Q0VGB7 | PP4R2_MOUSE | PPP4R | Serine/threonine phosphatases / Protein phosphatase 4, regulatory subunits | Histone modification cofactor | # | 18614045 | PPP4C-PPP4R2-PPP4R3A | histone | # | # | # | Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4) complex. PPARgamma coactivator-1 (PGC-1) promotes transcription through the assembly of a complex that includes the histone acetyltransferases steroid receptor coactivator-1 | # |
PQBP1
(details) |
9330 | Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1) | 10084 (SSTAR profile) |
O60828 | PQBP1_HUMAN | () | Pqbp1 | 1859638 | Q91VJ5 | PQBP1_MOUSE | # | # | RNA modification | Alternative splicing | 23512658 | # | RNA | mRNA | # | 23512658 | Regulates alternative splcing of BCL-X and another apoptotic factors. | New |
PRDM1
(details) |
9346 | PR domain containing 1, with ZNF domain | 639 (SSTAR profile) |
O75626 | PRDM1_HUMAN | PRDM2_PR PF21549 (95-209) zf-C2H2 PF00096 (575-597, 603-625, 631-653, 659-681) |
Prdm1 | 99655 | Q60636 | PRDM1_MOUSE | ZNF | Zinc fingers, C2H2-type | Histone modification write cofactor | Histone methylation | 23856557 | # | histone | H3K9 | H3K9me | 23856557 | The Prdm family may possess HKMTase properties. Some Prdms show intrinsic HKMTase activity (Prdm2, Prdm3, Prdm8, Prdm9, and Prdm16). In addition, Prdm1, Prdm5, and Prdm6 lack intrinsic HKMTase activity, but instead recruit G9a/Ehmt2/KMT1C, a strong mammalian histone H3 lysine 9 (H3K9) methyltransferase, to mediate HKMTase activity (see Fog et al., 2012 for a review). Another structural feature is that the Prdm family has multiple kruppel-type zinc finger (ZF) domains in the C-terminus involved in sequence-specific DNA binding and protein-protein interactions. | # |
PRDM11
(details) |
13996 | PR domain containing 11 | 56981 (SSTAR profile) |
Q9NQV5 | PRD11_HUMAN | PRDM2_PR PF21549 (152-268) | Prdm11 | 2685553 | A2AGX3 | PRD11_MOUSE | # | # | Histone modification write | Histone methylation | 23508829 | # | histone | # | # | 23508829 | The PR (PRDI-BF1 and RIZ) domain is 20–30% identical to the SET module, which is directly responsible for the catalytic activity of several histone lysine-methyltransferases . | # |
PRDM12
(details) |
13997 | PR domain containing 12 | 59335 (SSTAR profile) |
Q9H4Q4 | PRD12_HUMAN | PRDM2_PR PF21549 (89-213) zf-C2H2 PF00096 (244-265, 271-293) |
Prdm12 | 2685844 | A2AJ77 | PRD12_MOUSE | ZNF | Zinc fingers, C2H2-type | Histone modification write cofactor | Histone methylation | 23856557 | # | histone | H3K9 | H3K9me | 23856557 | Prdm12 recruits G9a to methylate histone H3 on lysine 9 through its zinc finger domains. | # |
PRDM13
(details) |
13998 | PR domain containing 13 | 59336 (SSTAR profile) |
Q9H4Q3 | PRD13_HUMAN | PRDM2_PR PF21549 (11-120) zf-C2H2 PF00096 (137-159, 574-595, 601-623, 630-653) |
Prdm13 | 2448528 | E9PZZ1 | PRD13_MOUSE | # | # | Histone modification write | Histone methylation | 24370451 | # | histone | # | # | # | PRDM13 identified as a histone methyltransferase. | # |
PRDM14
(details) |
14001 | PR domain containing 14 | 63978 (SSTAR profile) |
Q9GZV8 | PRD14_HUMAN | PRDM2_PR PF21549 (262-377) zf-C2H2 PF00096 (461-483, 489-511, 546-568) |
Prdm14 | 3588194 | E9Q3T6 | PRD14_MOUSE | ZNF | Zinc fingers, C2H2-type | DNA modification | DNA demethylation | 24335252 | # | DNA | mC | # | 24335252 | PRDM14 promotes active DNA demethylation. | # |
PRDM16
(details) |
14000 | PR domain containing 16 | 63976 (SSTAR profile) |
Q9HAZ2 | PRD16_HUMAN | PRDM2_PR PF21549 (84-212) zf-C2H2_6 PF13912 (230-250) zf-C2H2 PF00096 (281-303, 309-331, 337-360, 366-388, 394-416, 424-443, 951-973, 979-1002, 1008-1030) |
Prdm16 | 1917923 | A2A935 | PRD16_MOUSE | ZNF | Zinc fingers, C2H2-type | Histone modification write cofactor, TF | Histone methylation, TF repressor | 12816872, 23856557 | # | histone, DNA | H3K9, DNA motif | H3K9me | 23856557 | The Prdm family may possess HKMTase properties. Some Prdms show intrinsic HKMTase activity (Prdm2, Prdm3, Prdm8, Prdm9, and Prdm16). In addition, Prdm1, Prdm5, and Prdm6 lack intrinsic HKMTase activity, but instead recruit G9a/Ehmt2/KMT1C, a strong mammalian histone H3 lysine 9 (H3K9) methyltransferase, to mediate HKMTase activity (see Fog et al., 2012 for a review). Another structural feature is that the Prdm family has multiple kruppel-type zinc finger (ZF) domains in the C-terminus involved in sequence-specific DNA binding and protein-protein interactions. | # |
PRDM2
(details) |
9347 | PR domain containing 2, with ZNF domain | 7799 (SSTAR profile) |
Q13029 | PRDM2_HUMAN | PRDM2_PR PF21549 (30-144) zf-C2H2 PF00096 (360-382, 390-412) zf-C2H2_6 PF13912 (483-506, 1455-1475) |
Prdm2 | 107628 | # | # | KMT | Chromatin-modifying enzymes / K-methyltransferases | Histone modification write | Histone methylation | 20084102 | # | histone | H3K9 | H3K9me | 20084102 | The structures of the catalytic domains of GLP, G9a, Suv39H2 and PRDM2, four of the eight known human H3K9 methyltransferases in their apo conformation or in complex with the methyl donating cofactor, and peptide substrates. | # |
PRDM4
(details) |
9348 | PR domain containing 4 | 11108 (SSTAR profile) |
Q9UKN5 | PRDM4_HUMAN | zf_PR_Knuckle PF18445 (366-404) PRDM2_PR PF21549 (414-537) zf-C2H2 PF00096 (618-640, 646-668, 674-696) |
Prdm4 | 1920093 | Q80V63 | PRDM4_MOUSE | ZNF | Zinc fingers, C2H2-type | Histone modification write | Histone methylation | 23048031 | # | histone | H4R3 | H4R3me2s | 23048031 | Transcription factor positive regulatory domain 4 (PRDM4) recruits protein arginine methyltransferase 5 (PRMT5) to mediate histone arginine methylation and control neural stem cell proliferation and differentiation. | # |
PRDM5
(details) |
9349 | PR domain containing 5 | 11107 (SSTAR profile) |
Q9NQX1 | PRDM5_HUMAN | PRDM2_PR PF21549 (8-127) zf-C2H2 PF00096 (199-219, 262-287, 295-317, 320-342, 376-398, 404-426, 432-455, 489-511, 517-539, 545-567, 573-595, 602-625) zf-met PF12874 (234-254) zf-C2H2_6 PF13912 (348-370, 461-483) |
Prdm5 | 1918029 | Q9CXE0 | PRDM5_MOUSE | ZNF | Zinc fingers, C2H2-type | Histone modification write | Histone methylation | 23856557 | # | histone | H3K9 | H3K9me | 23856557 | Some Prdms show intrinsic HKMTase activity (Prdm2, Prdm3, Prdm8, Prdm9, and Prdm16). In addition, Prdm1, Prdm5, and Prdm6 lack intrinsic HKMTase activity, but instead recruit G9a/Ehmt2/KMT1C, a strong mammalian histone H3 lysine 9 (H3K9) methyltransferase, to mediate HKMTase activity (see Fog et al., 2012 for a review). Another structural feature is that the Prdm family has multiple kruppel-type zinc finger (ZF) domains in the C-terminus involved in sequence-specific DNA binding and protein-protein interactions. | # |
PRDM6
(details) |
9350 | PR domain containing 6 | 93166 (SSTAR profile) |
Q9NQX0 | PRDM6_HUMAN | PRDM2_PR PF21549 (255-374) zf-C2H2 PF00096 (501-523, 529-551, 557-577) |
Prdm6 | 2684938 | Q3UZD5 | PRDM6_MOUSE | ZNF | Zinc fingers, C2H2-type | Histone modification write | Histone methylation | 17898714, 16537907 | # | histone | H3R2, H4K20 | H3R2me1, H3R2me2, H4K20me1 | 17898714, 18057026 | The arginine methyltransferase PRMT6 catalyses H3R2 di-methylation in vitro and controls global levels of H3R2me2a in vivo. H3R2 methylation by PRMT6 was prevented by the presence of H3K4me3 on the H3 tail. PRISM =PRDM6 acts as a transcriptional repressor by interacting with class I histone deacetylases and the G9a histone methyltransferase, thereby identifying PRISM as a novel SMC-restricted epigenetic regulator. | # |
PRDM7
(details) |
9351 | PR domain containing 7 | 11105 (SSTAR profile) |
Q9NQW5 | PRDM7_HUMAN | KRAB PF01352 (28-65) SSXRD PF09514 (169-204) PRDM2_PR PF21549 (245-365) |
# | # | # | # | ZNF, ZKRAB | Zinc fingers, C2H2-type | Histone modification write | Histone methylation | # | # | histone | # | # | # | Probable histone methyltransferase (by similarity). | # |
PRDM8
(details) |
13993 | PR domain containing 8 | 56978 (SSTAR profile) |
Q9NQV8 | PRDM8_HUMAN | PRDM2_PR PF21549 (26-138) zf-C2H2_4 PF13894 (667-688) |
Prdm8 | 1924880 | Q8BZ97 | PRDM8_MOUSE | # | # | Histone modification write | Histone methylation | 23856557 | # | histone | # | # | 23856557 | Some Prdms show intrinsic HKMTase activity (Prdm2, Prdm3, Prdm8, Prdm9, and Prdm16). In addition, Prdm1, Prdm5, and Prdm6 lack intrinsic HKMTase activity, but instead recruit G9a/Ehmt2/KMT1C, a strong mammalian histone H3 lysine 9 (H3K9) methyltransferase, to mediate HKMTase activity (see Fog et al., 2012 for a review). Another structural feature is that the Prdm family has multiple kruppel-type zinc finger (ZF) domains in the C-terminus involved in sequence-specific DNA binding and protein-protein interactions. | # |
PRDM9
(details) |
13994 | PR domain containing 9 | 56979 (SSTAR profile) |
Q9NQV7 | PRDM9_HUMAN | KRAB PF01352 (32-62) SSXRD PF09514 (89-97) PRDM2_PR PF21549 (246-366) zf-C2H2_5 PF21225 (390-411) zf-C2H2 PF00096 (552-574, 580-602, 608-630, 636-658, 670-714, 720-742, 748-770, 776-798, 804-826, 832-854, 860-882) |
Prdm9 | 2384854 | Q96EQ9 | PRDM9_MOUSE | ZKRAB, ZNF | Zinc fingers, C2H2-type | Histone modification write | Histone methylation | 17916234 | # | histone | H3K4 | H3K4me3 | 17916234 | Meisetz, the mouse ortholog of the long PRDM9 isoform, is able to activate the progression into meiosis through the trimethylation of the lysine 4 on histone H3. | # |
PRKAA1
(details) |
9376 | protein kinase, AMP-activated, alpha 1 catalytic subunit | 5562 (SSTAR profile) |
Q13131 | AAPK1_HUMAN | Pkinase PF00069 (27-279) AMPK_alpha_AID PF21147 (299-343) AdenylateSensor PF16579 (406-479) |
Prkaa1 | 2145955 | Q5EG47 | AAPK1_MOUSE | # | # | Histone modification write | Histone phosphorylation | 20647423 | # | histone | H2BS36 | H2BS36ph | # | In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Part of AMPK. | # |
PRKAA2
(details) |
9377 | protein kinase, AMP-activated, alpha 2 catalytic subunit | 5563 (SSTAR profile) |
P54646 | AAPK2_HUMAN | Pkinase PF00069 (16-268) AMPK_alpha_AID PF21147 (288-333) AdenylateSensor PF16579 (401-477) |
Prkaa2 | 1336173 | Q8BRK8 | AAPK2_MOUSE | # | # | Histone modification write | Histone phosphorylation | 20647423 | # | histone | H2BS36 | H2BS36ph | # | In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph) as a part of AMPK. | # |
PRKAB1
(details) |
9378 | protein kinase, AMP-activated, beta 1 non-catalytic subunit | 5564 (SSTAR profile) |
Q9Y478 | AAKB1_HUMAN | AMPK1_CBM PF16561 (79-160) AMPKBI PF04739 (200-269) |
Prkab1 | 1336167 | Q9R078 | AAKB1_MOUSE | # | # | Histone modification write cofactor | Histone phosphorylation | 20647423 | # | histone | # | # | # | Non-catalytic subunit of AMP-activated protein kinase (AMPK). | # |
PRKAB2
(details) |
9379 | protein kinase, AMP-activated, beta 2 non-catalytic subunit | 5565 (SSTAR profile) |
O43741 | AAKB2_HUMAN | AMPK1_CBM PF16561 (78-160) AMPKBI PF04739 (202-271) |
Prkab2 | 1336185 | Q6PAM0 | AAKB2_MOUSE | # | # | Histone modification write cofactor | Histone phosphorylation | 20647423 | # | histone | # | # | # | Non-catalytic subunit of AMP-activated protein kinase (AMPK). | # |
PRKAG1
(details) |
9385 | protein kinase, AMP-activated, gamma 1 non-catalytic subunit | 5571 (SSTAR profile) |
P54619 | AAKG1_HUMAN | CBS PF00571 (45-96, 127-176, 203-249, 276-323) | Prkag1 | 108411 | O54950 | AAKG1_MOUSE | # | # | Histone modification write cofactor | Histone phosphorylation | 20647423 | # | histone | # | # | # | AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK). | # |
PRKAG2
(details) |
9386 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 51422 (SSTAR profile) |
Q9UGJ0 | AAKG2_HUMAN | CBS PF00571 (277-328, 359-409, 435-481, 510-555) | Prkag2 | 1336153 | Q91WG5 | AAKG2_MOUSE | # | # | Histone modification write cofactor | Histone phosphorylation | 20647423 | # | histone | # | # | # | AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK). | # |
PRKAG3
(details) |
9387 | protein kinase, AMP-activated, gamma 3 non-catalytic subunit | 53632 (SSTAR profile) |
Q9UGI9 | AAKG3_HUMAN | CBS PF00571 (283-332, 358-404, 430-478) | Prkag3 | 1891343 | Q8BGM7 | AAKG3_MOUSE | # | # | Histone modification write cofactor | Histone phosphorylation | 20647423 | # | histone | # | # | # | AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK). | # |
PRKCA
(details) |
9393 | protein kinase C, alpha | 5578 (SSTAR profile) |
P17252 | KPCA_HUMAN | C1_1 PF00130 (37-86, 102-152) C2 PF00168 (172-276) Pkinase PF00069 (341-584) Pkinase_C PF00433 (624-658) |
Prkca | 97595 | P20444 | KPCA_MOUSE | # | # | Histone modification write cofactor | Histone phosphorylation | 22796964 | # | histone | H3 | # | # | Modifies H3, but may be a quite general kinase. | # |
PRKCB
(details) |
9395 | protein kinase C, beta | 5579 (SSTAR profile) |
P05771 | KPCB_HUMAN | C1_1 PF00130 (37-86, 102-153) C2 PF00168 (172-277) Pkinase PF00069 (344-596) Pkinase_C PF00433 (621-662) |
Prkcb | 97596 | P68404 | KPCB_MOUSE | # | # | Histone modification write | Histone methylation | 20228790 | # | histone | H3T6 | H3T6ph | 20228790 | Phosphorylation of histone H3 at threonine 6 (H3T6) by protein kinase C beta I (PKCbeta(I), also known as PRKCbeta) is the key event that prevents LSD1 from demethylating H3K4 during AR-dependent gene activation. | # |
PRKCD
(details) |
9399 | protein kinase C, delta | 5580 (SSTAR profile) |
Q05655 | KPCD_HUMAN | PKC_C2 PF21494 (3-112) C1_1 PF00130 (159-209, 231-281) Pkinase PF00069 (350-603) Pkinase_C PF00433 (624-665) |
Prkcd | 97598 | P28867 | KPCD_MOUSE | # | # | Histone modification | # | 17984964 | # | histone | # | # | # | Cross-regulation of histone modifications | # |
PRKDC
(details) |
9413 | protein kinase, DNA-activated, catalytic polypeptide | 5591 (SSTAR profile) |
P78527 | PRKDC_HUMAN | DNA-PKcs_N PF20500 (15-874) DNAPKcs_CC1-2 PF20502 (1001-1796) DNAPKcs_CC3 PF08163 (1596-1947, 1825-2207) DNAPKcs_CC5 PF19704 (2131-2890) FAT PF02259 (2943-3468) PI3_PI4_kinase PF00454 (3749-4013) FATC PF02260 (4098-4128) |
Prkdc | 104779 | P97313 | PRKDC_MOUSE | # | # | Histone modification write | Histone phosphorylation | 14627815 | # | histone | H2AXS139, H2AFXS139 | H2AXS139ph, H2AFXS139ph | 14627815 | Acetylation largely enhances the phosphorylation of H2AX by DNA-PK=PRKDC, and this acetylation effect is observed when H2AX exists in the context of nucleosomes but not in a free form. | # |
PRMT1
(details) |
5187 | protein arginine methyltransferase 1 | 3276 (SSTAR profile) |
Q99873 | ANM1_HUMAN | Methyltransf_25 PF13649 (92-189) domain PF22528 (194-358) |
Prmt1 | 107846 | Q9JIF0 | ANM1_MOUSE | PRMT | Protein arginine methyltransferases | Histone modification write | Histone methylation | 11387442 | # | histone | H4R3 | H4R3me1, H4R3me2a | 11387442 | PRMT1 specifically methylates arginine 3 (Arg 3) of H4 in vitro and in vivo. Methylation of Arg 3 by PRMT1 facilitates subsequent acetylation of H4 tails by p300. | # |
PRMT2
(details) |
5186 | protein arginine methyltransferase 2 | 3275 (SSTAR profile) |
P55345 | ANM2_HUMAN | SH3_1 PF00018 (36-82) MTS PF05175 (131-210) domain PF22528 (244-415) |
Prmt2 | 1316652 | Q9R144 | ANM2_MOUSE | PRMT | Protein arginine methyltransferases | Histone modification write | Histone methylation | 19405910 | # | histone | H4 | H4me | 19405910 | PRMT2 activity is substantially lower than PRMT1 in vitro, but both enzymes selectively methylate histone H4 and PRMT2, like PRMT1, may act as a transcription co-activator through this modification. | # |
PRMT5
(details) |
10894 | protein arginine methyltransferase 5 | 10419 (SSTAR profile) |
O14744 | ANM5_HUMAN | PRMT5_TIM PF17285 (36-290) PRMT5 PF05185 (299-464) PRMT5_C PF17286 (467-635) |
Prmt5 | 1351645 | Q8CIG8 | ANM5_MOUSE | PRMT | Protein arginine methyltransferases | Histone modification write | Histone methylation | 18404153 | methylosome | histone | H3R8, H4R3 | H3R8me, H4R3me | 18404153 | PRMT5 regulates gene transcription by methylating histones H3 (R8) and H4. | # |
PRMT6
(details) |
18241 | protein arginine methyltransferase 6 | 55170 (SSTAR profile) |
Q96LA8 | ANM6_HUMAN | Methyltransf_25 PF13649 (85-182) domain PF22528 (188-362) |
Prmt6 | 2139971 | Q6NZB1 | ANM6_MOUSE | PRMT | Protein arginine methyltransferases | Histone modification write | Histone methylation | 18079182 | # | histone | H2AR3, H3R2, H4R4 | H2AR3me, H4R3me, H3R2me2a | 18079182 | PRMT6 methylates histone H3 at R2 and histones H4/H2A at R3 in vitro. Overexpression and knockdown analysis identify PRMT6 as the major H3 R2 methyltransferase in vivo. | # |
PRMT7
(details) |
25557 | protein arginine methyltransferase 7 | 54496 (SSTAR profile) |
Q9NVM4 | ANM7_HUMAN | PrmA PF06325 (64-124) domain PF22528 (177-348, 515-686) |
Prmt7 | 2384879 | Q922X9 | ANM7_MOUSE | PRMT | Protein arginine methyltransferases | Histone modification write | Histone methylation | 15494416 | # | histone | H2A, H4R3 | H2A, H4R3me2 | 15494416 | PRMT7 contains methyltransferase activity, the methylated (labeled) histones are H2A and H4. | # |
PRMT8
(details) |
5188 | protein arginine methyltransferase 8 | 56341 (SSTAR profile) |
Q9NR22 | ANM8_HUMAN | PrmA PF06325 (111-184) domain PF22528 (217-380) |
Prmt8 | 3043083 | Q6PAK3 | ANM8_MOUSE | PRMT | Protein arginine methyltransferases | Histone modification write | Histone methylation | 16051612 | # | histone | H4R | H4Rme | 16051612 | PRMT8 preferentially methylates histone H4 and the recombinant forms of GAR and Npl3, thus displaying PRMT1-like substrate specificity. | # |
PRMT9
(details) |
25099 | protein arginine methyltransferase 9 | 90826 (SSTAR profile) |
Q6P2P2 | ANM9_HUMAN | PrmA PF06325 (175-235) domain PF22528 (366-461, 750-837) |
Prmt10 | 2142651 | Q3U3W5 | ANM9_MOUSE | PRMT | Protein arginine methyltransferases | Histone modification write | Histone methylation | 18007657 | # | histone | H4R3 | H4R3me2 | 18007657 | Arabidopsis thaliana protein arginine methyltransferase 10 (AtPRMT10)--the Arabidopsis homologue of PHRMT10 (=PRMT9)--has been shown to be a type I PRMT, which preferentially asymmetrically methylated histone H4R3 in vitro. Belongs to SAM-binding ethyltransferase superfamily. | # |
PRPF31
(details) |
15446 | pre-mRNA processing factor 31 | 26121 (SSTAR profile) |
Q8WWY3 | PRP31_HUMAN | Nop PF01798 (100-332) Prp31_C PF09785 (341-465) |
Prpf31 | 1916238 | Q8CCF0 | PRP31_MOUSE | # | # | Histone modification write cofactor, Histone modification write cofactor | Histone methylation, Histone acetylation | # | CHD8, MLL2/3, MLL4/WBP7 | histone | # | # | # | Added because it is a complex partner | # |
PRR14
(details) |
28458 | proline rich 14 | 78994 (SSTAR profile) |
Q9BWN1 | PRR14_HUMAN | Tantalus PF15386 (463-519) | Prr14 | 2384565 | Q7TPN9 | PRR14_MOUSE | # | # | Histone modification write | Histone phosphorylation | 24209742 | # | histone | H3K9me2, H3K9me3 | # | # | Binds to H3K9me2/3 through interaction with HP1, and not by direct interaction. PRR14 is incorporated rapidly into chromatin through HP1 binding, tethering heterochromatin to nuclear lamina. | # |
PSIP1
(details) |
9527 | PC4 and SFRS1 interacting protein 1 | 11168 (SSTAR profile) |
O75475 | PSIP1_HUMAN | PWWP PF00855 (8-88) LEDGF PF11467 (350-446) |
Psip1 | 2142116 | Q99JF8 | PSIP1_MOUSE | # | # | Chromatin remodeling | # | 217205545 | # | chromatin | # | # | 217205545 | The PWWP domain in PSIP1 displays affinity for DNA and chromatin and its chromatin binding ability is crucial for the HIV-1 integration. PSIP1 has been found to promote association of the MLL complex with transcriptionally active chromatin through its PWWP domain. | # |
PTBP1
(details) |
9583 | Polypyrimidine tract-binding protein 1 (PTB) (57 kDa RNA-binding protein PPTB-1) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I) | 5725 (SSTAR profile) |
P26599 | PTBP1_HUMAN | RRM_5 PF13893 (59-144, 340-460) RRM_8 PF11835 (178-258) RRM_1 PF00076 (484-544) |
Ptbp1 | 97791 | P17225 | PTBP1_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 21518792, 16260624 | # | RNA | mRNA | # | 21518792, 16260624 | Regulates exon selection in alpha-tropomyosin mRNA | New |
PTBP1
(details) |
9583 | Polypyrimidine tract-binding protein 1 (PTB) (57 kDa RNA-binding protein PPTB-1) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I) | 5725 (SSTAR profile) |
P26599 | PTBP1_HUMAN | RRM_5 PF13893 (59-144, 340-460) RRM_8 PF11835 (178-258) RRM_1 PF00076 (484-544) |
Ptbp1 | 97791 | P17225 | PTBP1_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 16260624, 21518792 | # | RNA | mRNA | # | 16260624, 21518792 | Modulates alternative 5'-splice site and muscle-cell specific exon selection. | New |
PUF60
(details) |
17042 | Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1) | 22827 (SSTAR profile) |
Q9UHX1 | PUF60_HUMAN | RRM_1 PF00076 (131-201, 228-297) | Puf60 | 1915209 | Q3UEB3 | PUF60_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 17579712, 16452196 | # | RNA | mRNA | # | 17579712, 16452196 | Regulates alternative splcing of FIR | New |
RAD51
(details) |
9817 | RAD51 recombinase | 5888 (SSTAR profile) |
Q06609 | RAD51_HUMAN | HHH_5 PF14520 (32-79) Rad51 PF08423 (95-336) |
Rad51 | 97890 | Q08297 | RAD51_MOUSE | # | # | Histone modification erase | Histone ubiquitination | 15665856 | BRCC | # | histone | # | 15665856 | # | # |
RAD54B
(details) |
17228 | RAD54 homolog B (S. cerevisiae) | 25788 (SSTAR profile) |
Q9Y620 | RA54B_HUMAN | SNF2-rel_dom PF00176 (299-595) Helicase_C PF00271 (643-758) |
Rad54b | 3605986 | Q6PFE3 | RA54B_MOUSE | # | # | Chromatin remodeling | # | 21357745 | # | chromatin | # | # | 21357745 | Rad54’s ATPase =RAD54B affects the chromatin association of the protein and Rad54 ATPase activity specifically influences its dissociation from foci. | # |
RAD54L
(details) |
9826 | RAD54-like (S. cerevisiae) | 8438 (SSTAR profile) |
Q92698 | RAD54_HUMAN | SNF2-rel_dom PF00176 (156-462) Helicase_C PF00271 (499-611) |
Rad54l | 894697 | P70270 | RAD54_MOUSE | # | # | Chromatin remodeling | # | 8805304 | # | chromatin | # | # | 8805304 | V(D)J recombination does not involve homologous recombination, but mHR54 =RAD54L could mediate a substrate preparation step that V(D)J and meiotic recombination have in common, such as changing the chromatin structure of the loci that will be rearranged. | # |
RAD54L2
(details) |
29123 | RAD54-like 2 (S. cerevisiae) | 23132 (SSTAR profile) |
Q9Y4B4 | ARIP4_HUMAN | SNF2-rel_dom PF00176 (274-598) Helicase_C PF00271 (725-854) |
Rad54l2 | 1933196 | Q99NG0 | ARIP4_MOUSE | # | # | Chromatin remodeling | # | 19692572 | # | chromatin | # | # | 19692572 | ARIP4 =RAD54L2 contains SNF2 domain that functions as a motor protein in chromatin remodeling complexes. | # |
RAG1
(details) |
9831 | recombination activating gene 1 | 5896 (SSTAR profile) |
P15918 | RAG1_HUMAN | RAG1_imp_bd PF12560 (1-291) zf-C3HC4 PF00097 (293-331) zf-RAG1 PF10426 (354-383) RAG1 PF12940 (387-1022) |
Rag1 | 97848 | P15919 | RAG1_MOUSE | RNF | RING-type (C3HC4) zinc fingers | Histone modification write | Histone ubiquitination | 21256161 | # | histone, DNA | H3.3K, DNA motif | H3.3Kub | 21256161 | It has been suggested that RAG1 targets H3.3, the H3 variant known to be associated with recombining loci, and thus most likely to be encountered by RAG1 during V(D)J recombination. This reaction is absolutely dependent on an intact RAG1 RING domain, and requires regions of the far N-terminus of RAG1 where the H3.3 binding sight is likely to reside and regions within the H3 amino-terminal tail. Several H3.3 lysines are subject to ubiquitylation. | # |
RAG2
(details) |
9832 | recombination activating gene 2 | 5897 (SSTAR profile) |
P55895 | RAG2_HUMAN | RAG2 PF03089 (52-390) RAG2_PHD PF13341 (414-490) |
Rag2 | 97849 | P21784 | RAG2_MOUSE | # | # | Histone modification read | # | 21423274 | # | histone | H3K4me3 | # | 21423274 | Recombination-activating protein, RAG2, binds to H3K4me3 at transcribed genes while RAG1 recognizes the recombination signal sequence. | # |
RAI1
(details) |
9834 | retinoic acid induced 1 | 10743 (SSTAR profile) |
Q7Z5J4 | RAI1_HUMAN | zf-HC5HC2H PF13771 (1825-1903) | Rai1 | 103291 | Q61818 | RAI1_MOUSE | # | # | Chromatin remodeling | # | 22498752 | # | chromatin | # | # | # | RAI1 regulates transcription through chromatin remodeling, according to UniProt. | # |
RARA
(details) |
9864 | retinoic acid receptor, alpha | 5914 (SSTAR profile) |
P10276 | RARA_HUMAN | zf-C4 PF00105 (87-155) Hormone_recep PF00104 (227-399) |
Rara | 97856 | P11416 | RARA_MOUSE | NR | Nuclear hormone receptors | Histone modification write cofactor, TF | Histone methylation, TF activator, TF repressor | 19377461 | # | histone | H3K4 | H3K4me, H3K4me2 | 19377461 | MLL5 is biochemically identified in a GlcNAcylation-dependent multi-subunit complex associating with nuclear retinoic acid receptor RARalpha (also known as RARA), serving as a mono- and di-methyl transferase to H3K4. | # |
RB1
(details) |
9884 | retinoblastoma 1 | 5925 (SSTAR profile) |
P06400 | RB_HUMAN | DUF3452 PF11934 (110-229) RB_A PF01858 (375-573) RB_B PF01857 (647-765) Rb_C PF08934 (768-925) |
Rb1 | 97874 | P13405 | RB_MOUSE | ENDOLIG | Endogenous ligands | Chromatin remodeling, Histone modification write | Histone ubiquitination | 19149898 | CREST-BRG1, L3MBTL1 | histone | # | # | 19149898 | Hypophosphorylated pRb can repress gene transcription at least partly by remodeling chromatin structure through its interactions with proteins such as HDAC1, BRM and BRG1. | # |
RBBP4
(details) |
9887 | retinoblastoma binding protein 4 | 5928 (SSTAR profile) |
Q09028 | RBBP4_HUMAN | CAF1C_H4-bd PF12265 (19-88) WD40 PF00400 (173-206, 221-256, 265-302, 309-346, 367-402) |
Rbbp4 | 1194912 | Q60972 | RBBP4_MOUSE | WDR | WD repeat domain containing | Histone chaperone | # | 8858152 | NuRF, SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, NuRD, mSin3A, core HDAC, mSin3A-like complex, PRC2, CAF-1 | histone | H4 | # | 8858152 | RbAp46 and RbAp48 (pRB-associated proteins p46 and p48, also known as RBBP7 and RBBP4, respectively) are highly homologous histone chaperones that play key roles in establishing and maintaining chromatin structure. Human p48 =RBBP4 can bind to histone H4 in the absence of CAF-1 p150 and p60. p48, also a known subunit of a histone deacetylase, copurifies with a chromatin assembly complex (CAC), which contains the three subunits of CAF-1 (p150, p60, p48) and H3 and H4, and promotes DNA replication-dependent chromatin assembly. | # |
RBBP5
(details) |
9888 | retinoblastoma binding protein 5 | 5929 (SSTAR profile) |
Q15291 | RBBP5_HUMAN | WD40 PF00400 (29-52, 62-94) | Rbbp5 | 1918367 | Q8BX09 | RBBP5_MOUSE | WDR | WD repeat domain containing | Histone modification write cofactor | Histone methylation | 19556245 | COMPASS, Menin-associated_HMT, MLL-HCF, CHD8, MLL2/3, COMPASS-like MLL1,2, MLL4/WBP7, COMPASS-like MLL3,4 | histone | H3K4 | H3K4me1, H3K4me2, H3K4me3 | 19556245 | A five-component 200-kDa MLL1 core complex containing human MLL1, WDR5, RbBP5, Ash2L, and DPY-30. | # |
RBBP7
(details) |
9890 | retinoblastoma binding protein 7 | 5931 (SSTAR profile) |
Q16576 | RBBP7_HUMAN | CAF1C_H4-bd PF12265 (18-87) WD40 PF00400 (172-205, 220-255, 264-301, 308-345, 366-402) |
Rbbp7 | 1194910 | Q60973 | RBBP7_MOUSE | WDR | WD repeat domain containing | Histone chaperone | # | 18571423 | NuRF, NuRD, mSin3A, core HDAC, mSin3A-like complex, PRC2 | histone | H4 | # | 18571423 | RbAp46 and RbAp48 (pRB-associated proteins p46 and p48, also known as RBBP7 and RBBP4, respectively) are highly homologous histone chaperones that play key roles in establishing and maintaining chromatin structure. When a histone H3/H4 dimer (or tetramer) binds to RbAp46 or RbAp48, helix 1 of histone H4 unfolds to interact with the histone chaperone. | # |
RBFOX1
(details) |
9910 | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | 27316 (SSTAR profile) |
P38159 | RBMX_HUMAN | RRM_1 PF00076 (10-80) RBM1CTR PF08081 (169-221) |
Rbmx | 1343044 | Q9WV02 | RBMX_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 12165565 | # | RNA | mRNA | # | 12165565 | Promotes exon 7 inclusion of SMN | New |
RBM11
(details) |
9897 | Splicing regulator RBM11 (RNA-binding motif protein 11) | 54033 (SSTAR profile) |
P57052 | RBM11_HUMAN | RRM_1 PF00076 (12-80) | Rbm11 | 2447622 | Q80YT9 | RBM11_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 21984414 | # | RNA | mRNA | # | 21984414 | Regulates alternative splicing of Bcl-X and potentialy another genes during neuron and germ cell differentiation. | New |
RBM15
(details) |
14959 | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | 64783 (SSTAR profile) |
Q96T37 | RBM15_HUMAN | RRM_1 PF00076 (182-245, 376-444) SPOC PF07744 (783-956) |
Rbm15 | 2443205 | Q0VBL3 | RBM15_MOUSE | RBM | RNA binding motif containing | RNA modification | RNA methylation | 27602518 | WMM | RNA | A of mRNA | m6A | 27602518 | Recognition of RNA sites for m6A-methylation and recruitment of methylation complexes | New |
RBM15B
(details) |
24303 | Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B) | 29890 (SSTAR profile) |
Q8NDT2 | RB15B_HUMAN | RRM_1 PF00076 (339-408, 420-480) SPOC PF07744 (705-888) |
Rbm15B | 1923598 | Q6PHZ5 | RB15B_MOUSE | RBM | RNA binding motif containing | RNA modification | RNA methylation | 27602518 | WMM | RNA | A of mRNA | m6A | 27602518 | Recognition of RNA sites for m6A-methylation and recruitment of methylation complexes | New |
RBM17
(details) |
16944 | Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17) | 84991 (SSTAR profile) |
Q96I25 | SPF45_HUMAN | G-patch PF01585 (236-276) RRM_1 PF00076 (328-383) |
Rbm17 | 1924188 | Q8JZX4 | SPF45_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 17589525 | # | RNA | mRNA | # | 17589525 | Regulates alternative splicing of apoptosis regulator FAS | New |
RBM24
(details) |
21539 | RNA-binding protein 24 (RNA-binding motif protein 24) (RNA-binding region-containing protein 6) | 221662 (SSTAR profile) |
Q9BX46 | RBM24_HUMAN | RRM_1 PF00076 (13-70) | Rbm24 | 3610364 | D3Z4I3 | RBM24_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 29104163, 26990106 | # | RNA | mRNA | # | 29104163, 26990106 | Promotes alternative splicing events of several pluripotency and/or differentiation genes. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation | New |
RBM25
(details) |
23244 | RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7) | 58517 (SSTAR profile) |
P49756 | RBM25_HUMAN | RRM_1 PF00076 (89-157) PWI PF01480 (770-835) |
Rbm25 | 1914289 | B2RY56 | RBM25_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 18663000 | # | RNA | RNA | # | 18663000 | alternative splicing site selection | New |
RBM4
(details) |
9901 | RNA-binding protein 4 (Lark homolog) (hLark) (RNA-binding motif protein 4) (RNA-binding motif protein 4a) | 5936 (SSTAR profile) |
Q9BWF3 | RBM4_HUMAN | RRM_1 PF00076 (4-65, 80-142) zf-CCHC PF00098 (161-176) |
Rbm4 | 1100865 | Q8C7Q4 | RBM4_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 16777844, 21518792 | # | RNA | RNA | # | 16777844, 21518792 | Modulates alternative 5'-splice site and exon selection. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation | New |
RBM5
(details) |
9902 | RNA-binding protein 5 (Protein G15) (Putative tumor suppressor LUCA15) (RNA-binding motif protein 5) (Renal carcinoma antigen NY-REN-9) | 10181 (SSTAR profile) |
P52756 | RBM5_HUMAN | RRM_1 PF00076 (100-163, 233-295) zf-RanBP PF00641 (181-209) OCRE PF17780 (456-507) G-patch PF01585 (743-787) |
Rbm5 | 1933204 | Q91YE7 | RBM5_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 18840686 | # | RNA | mRNA | # | 18840686 | Regulates the ratio of proapoptotic/antiapoptotic casp-2 splicing isoforms | New |
RBM7
(details) |
9904 | RNA-binding protein 7 (RNA-binding motif protein 7) | 10179 (SSTAR profile) |
Q9Y580 | RBM7_HUMAN | RRM_1 PF00076 (12-81) | Rbm7 | 1914260 | Q9CQT2 | RBM7_MOUSE | RBM | RNA binding motif containing | RNA modification | RNA degradation, alternative splicing | 25578728 | # | RNA | snRNA | # | 25578728 | Component of exosome | New |
RBM8A
(details) |
9905 | RNA-binding protein 8A (Binder of OVCA1-1) (BOV-1) (RNA-binding motif protein 8A) (RNA-binding protein Y14) (Ribonucleoprotein RBM8A) | 9939 (SSTAR profile) |
Q9Y5S9 | RBM8A_HUMAN | RRM_1 PF00076 (75-144) | Rbm8A | 1913129 | Q9CWZ3 | RBM8A_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 22203037 | # | RNA | mRNA | # | 22203037 | Production of the proapoptotic Bcl-x(S) splice variant. | New |
RBMY1A1
(details) |
9912 | RNA-binding motif protein, Y chromosome, family 1 member A1 (RNA-binding motif protein 1) (RNA-binding motif protein 2) (Y chromosome RNA recognition motif 1) (hRBMY) | 5940 (SSTAR profile) |
P0DJD3 | RBY1A_HUMAN | RRM_1 PF00076 (10-79) | Rbmy | 104732 | O35698 | RBY1A_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 12165565 | # | RNA | mRNA | # | 12165565 | Regulates alternative splicing of SMN gene | New |
RBX1
(details) |
9928 | ring-box 1, E3 ubiquitin protein ligase | 9978 (SSTAR profile) |
P62877 | RBX1_HUMAN | zf-rbx1 PF12678 (40-98) | Rbx1 | 1891829 | P62878 | RBX1_MOUSE | RNF | RING-type (C3HC4) zinc fingers | Histone modification write cofactor | Histone ubiquitination | 18593899 | # | histone | H3, H4 | H3ub, H4ub | 18593899 | Histones H3 and H4 are targets of the CUL4-DDB-RBX1 E3 ligase ( 34). It has been proposed that both DDB1-CUL4DDB2 and Ring2 ligases are recruited to UV-induced lesions to modify histones. | # |
RCC1
(details) |
1913 | regulator of chromosome condensation 1 | 1104 (SSTAR profile) |
P18754 | RCC1_HUMAN | RCC1 PF00415 (35-82, 86-134, 138-187, 191-257, 259-309, 313-358, 364-414) | Rcc1 | 1913989 | Q8VE37 | RCC1_MOUSE | # | # | Chromatin remodeling | # | 11375490 | # | histone | H2A, H2B | # | # | Binds to histones H2A and H2B. | # |
RCOR1
(details) |
17441 | REST corepressor 1 | 23186 (SSTAR profile) |
Q9UKL0 | RCOR1_HUMAN | ELM2 PF01448 (107-158) Myb_DNA-binding PF00249 (194-237, 385-428) REST_helical PF20878 (311-375) |
Rcor1 | 106340 | Q8CFE3 | RCOR1_MOUSE | # | # | Histone modification erase cofactor, Histone modification erase cofactor | Histone acetylation, Histone methylation | 10449787 | BHC, SCL, LSD-CoREST | histone | # | # | 10449787 | CoREST=RCOR1 may function as a repressor by recruiting, either directly or indirectly, histone deacetylase activity. | # |
RCOR3
(details) |
25594 | REST corepressor 3 | 55758 (SSTAR profile) |
Q9P2K3 | RCOR3_HUMAN | ELM2 PF01448 (1-52) Myb_DNA-binding PF00249 (88-131, 289-332) REST_helical PF20878 (215-278) |
Rcor3 | 2441920 | Q6PGA0 | RCOR3_MOUSE | # | # | Histone modification erase cofactor | Histone acetylation | 23752268 | LSD-CoREST | histone | # | # | 23752268 | Part of the HDAC interactome. | # |
REST
(details) |
9966 | RE1-silencing transcription factor | 5978 (SSTAR profile) |
Q13127 | REST_HUMAN | zf-C2H2 PF00096 (304-326) | Rest | 104897 | Q8VIG1 | REST_MOUSE | # | # | Histone modification erase cofactor, TF | Histone acetylation, TF activator, TF repressor | 12399542 | # | DNA | DNA motif | # | 12399542 | REST/NRSF can mediate repression, in part, through the association of its NH2-terminal repression domain with the mSin3/histone deacethylase 1,2 (HDAC1,2) complex. | # |
RFOX1
(details) |
18222 | RNA binding protein fox-1 homolog 1 (Ataxin-2-binding protein 1) (Fox-1 homolog A) (Hexaribonucleotide-binding protein 1) | 54715 (SSTAR profile) |
Q9NWB1 | RFOX1_HUMAN | RRM_1 PF00076 (120-186) Fox-1_C PF12414 (254-342) |
Rbfox1 | 1926224 | Q9JJ43 | RFOX1_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 16537540 | # | RNA | mRNA | # | 16537540 | Activates inclusion of 4.1R exon 16 | New |
RING1
(details) |
10018 | ring finger protein 1 | 6015 (SSTAR profile) |
Q06587 | RING1_HUMAN | zf-C3HC4_2 PF13923 (47-87) RAWUL PF16207 (282-400) |
Ring1 | 1101770 | O35730 | RING1_MOUSE | RNF | RING-type (C3HC4) zinc fingers | Histone modification write, Polycomb group (PcG) protein | Histone ubiquitination | 15386022 | PRC1, BCOR, RING2-L3MBTL2, RING2-FBRS | histone | H2AK119 | H2AK119ub | 15386022 | The complex hPRC1L (human Polycomb repressive complex 1-like) is composed of several Polycomb-group proteins including Ring1, Ring2, Bmi1 and HPH2. hPRC1L monoubiquitinates nucleosomal histone H2A at lysine 119. | # |
RLIM
(details) |
13429 | ring finger protein, LIM domain interacting | 51132 (SSTAR profile) |
Q9NVW2 | RNF12_HUMAN | zf-RING_2 PF13639 (569-611) | Rlim | 1342291 | Q9WTV7 | RNF12_MOUSE | RNF | RING-type (C3HC4) zinc fingers | Histone modification erase cofactor | Histone acetylation | 10431247 | # | histone | # | # | # | Recruits the Sin3A/histone deacetylase corepressor complex. | # |
RMI1
(details) |
25764 | RecQ mediated genome instability 1 | 80010 (SSTAR profile) |
Q9H9A7 | RMI1_HUMAN | RMI1_N_N PF21000 (16-62) RMI1_N_C PF08585 (67-206) RMI1_C PF16099 (481-623) |
Rmi1 | 1921636 | Q9D4G9 | RMI1_MOUSE | # | # | DNA modification | # | 16537486 | # | DNA | # | # | 16537486 | # | # |
RNF168
(details) |
26661 | ring finger protein 168, E3 ubiquitin protein ligase | 165918 (SSTAR profile) |
Q8IYW5 | RN168_HUMAN | zf-C3HC4 PF00097 (16-55) | Rnf168 | 1917488 | Q80XJ2 | RN168_MOUSE | RNF | RING-type (C3HC4) zinc fingers | Histone modification write | Histone ubiquitination | 22980979 | # | histone | H2AK13, H2AK15, H2AXK13, H2AXK15 | H2AK13ub, H2AK15ub, H2AXK13ub, H2AXK15ub | 22980979 | RNF8 and RNF168 targets histone H2A and H2AX. RNF8 is the first ligase recruited to the damage site, and RNF168 follows RNF8-dependent ubiquitination. This suggests that RNF8 initiates H2A/H2AX ubiquitination with K63-linked ubiquitin chains and RNF168 extends them. RNF8 is inactive toward nucleosomal H2A, whereas RNF168 catalyzes the monoubiquitination of the histones specifically on K13-15. | # |
RNF2
(details) |
10061 | ring finger protein 2 | 6045 (SSTAR profile) |
Q99496 | RING2_HUMAN | zf-C3HC4_2 PF13923 (50-90) RAWUL PF16207 (246-330) |
Rnf2 | 1101759 | Q9CQJ4 | RING2_MOUSE | RNF | RING-type (C3HC4) zinc fingers | Histone modification write | Histone ubiquitination | 16943429 | PRC1, BCOR, RING2-L3MBTL2, RING2-FBRS, CHD8, MLL2/3, MLL4/WBP7 | histone | H2AK119 | H2AK119ub | 16943429 | RNF2 is the only BCOR complex PcG protein with a known enzymatic activity: an E3 ligase for the histone protein H2A (12, 78). Ub-H2A is thought to be involved in maintaining a repressed chromatin state. | # |
RNF20
(details) |
10062 | ring finger protein 20, E3 ubiquitin protein ligase | 56254 (SSTAR profile) |
Q5VTR2 | BRE1A_HUMAN | zf-C3HC4 PF00097 (922-960) | Rnf20 | 1925927 | Q5DTM8 | BRE1A_MOUSE | RNF | RING-type (C3HC4) zinc fingers | Histone modification write | Histone ubiquitination | 16307923 | # | histone | H2BK120 | H2BK120ub1 | 16307923 | Two copies each of the E3 ligases RNF20 and RNF40 are present in the same complex catalyzing histone H2B-K120 monoubiquitination. The complex that catalyzes histone H2A-K119 monoubiquitination also contains two E3 ligases, Ring1 and Ring2. | # |
RNF40
(details) |
16867 | ring finger protein 40, E3 ubiquitin protein ligase | 9810 (SSTAR profile) |
O75150 | BRE1B_HUMAN | zf-C3HC4 PF00097 (948-986) | Rnf40 | 2142048 | Q3U319 | BRE1B_MOUSE | RNF | RING-type (C3HC4) zinc fingers | Histone modification write cofactor | Histone ubiquitination | 16307923 | # | histone | H2BK121 | H2BK120ub2 | 16307923 | Two copies each of the E3 ligases RNF20 and RNF40 are present in the same complex catalyzing histone H2B-K120 monoubiquitination. The complex that catalyzes histone H2A-K119 monoubiquitination also contains two E3 ligases, Ring1 and Ring2. | # |
RNF8
(details) |
10071 | ring finger protein 8, E3 ubiquitin protein ligase | 9025 (SSTAR profile) |
O76064 | RNF8_HUMAN | FHA PF00498 (38-109) zf-C3HC4_3 PF13920 (400-446) |
Rnf8 | 1929069 | Q8VC56 | RNF8_MOUSE | RNF | RING-type (C3HC4) zinc fingers | Histone modification write | Histone ubiquitination | 22980979 | # | histone | H2AK63, H2AXK63, H2AK48, H2AXK48 | H2AK63ub, H2AXK63ub, H2AK48ub, H2AXK48ub | 22980979 | Ubiquitin-dependent signaling during the DNA damage response (DDR) to double-strand breaks (DSBs) is initiated by two E3 ligases, RNF8 and RNF168, targeting histone H2A and H2AX. RNF8 is the first ligase recruited to the damage site, and RNF168 follows RNF8-dependent ubiquitination. This suggests that RNF8 initiates H2A/H2AX ubiquitination with K63-linked ubiquitin chains and RNF168 extends them. | # |
RNPS1
(details) |
10080 | RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2) | 10921 (SSTAR profile) |
Q15287 | RNPS1_HUMAN | RRM_1 PF00076 (164-233) | Rnps1 | 97960 | Q99M28 | RNPS1_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 22203037 | # | RNA | mRNA | # | 22203037 | Production of the proapoptotic Bcl-x(S) splice variant. | New |
RPS6KA3
(details) |
10432 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 6197 (SSTAR profile) |
P51812 | KS6A3_HUMAN | Pkinase PF00069 (68-327, 422-679) Pkinase_C PF00433 (351-387) |
Rps6ka3 | 104557 | P18654 | KS6A3_MOUSE | # | # | Histone modification write cofactor | Histone phosphorylation | 10436156 | # | histone | H3S10 | H3S10ph | 10436156 | Is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes. | # |
RPS6KA4
(details) |
10433 | ribosomal protein S6 kinase, 90kDa, polypeptide 4 | 8986 (SSTAR profile) |
O75676 | KS6A4_HUMAN | Pkinase PF00069 (33-301, 413-673) Pkinase_C PF00433 (322-361) |
Rps6ka4 | 1930076 | Q9Z2B9 | KS6A4_MOUSE | # | # | Histone modification write | Histone phosphorylation | 12773393 | # | histone | H3S10, H3S28 | H3S10ph, H3S28ph | 12773393 | The MSKs, particularly MSK2=RPS6KA4, but not RSK2, are the major histone H3 and HMG-14 kinases. | # |
RPS6KA5
(details) |
10434 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | 9252 (SSTAR profile) |
O75582 | KS6A5_HUMAN | Pkinase PF00069 (49-318, 426-687) Pkinase_C PF00433 (339-377) |
Rps6ka5 | 1920336 | Q8C050 | KS6A5_MOUSE | # | # | Histone modification write | Histone phosphorylation | 12773393 | # | histone | H2AS1, H3S10, H3S28 | H2AS1ph, H3S10ph, H3S28ph | 12773393 | The MSKs=(RPS6KA4, RPS6KA5), particularly MSK2, but not RSK2, are the major histone H3 and HMG-14 kinases. | # |
RPUSD3
(details) |
28437 | Mitochondrial mRNA pseudouridine synthase RPUSD3 (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 3) | 285367 (SSTAR profile) |
Q6P087 | RUSD3_HUMAN | PseudoU_synth_2 PF00849 (90-252) | Rpusd3 | 2141440 | Q14AI6 | RUSD3_MOUSE | RPUSD | RNA pseudouridylate synthase domain containing | RNA modification | RNA pseudouridinilation | 27974379 | # | RNA | mt--mRNA | U | 27974379 | Pseudouridinilation of mitochondrial mRNA | New |
RRP8
(details) |
29030 | ribosomal RNA processing 8, methyltransferase, homolog (yeast) | 23378 (SSTAR profile) |
O43159 | RRP8_HUMAN | Methyltransf_8 PF05148 (239-456) | Rrp8 | 1914251 | Q9DB85 | RRP8_MOUSE | # | # | Histone modification cofactor | # | 18485871 | eNoSc | histone | H3ac | H3K9me2 | # | A component of the eNoSC complex, that mediates silencing of rDNA by recruiting histone-modifying enzymes, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. | # |
RSF1
(details) |
18118 | remodeling and spacing factor 1 | 51773 (SSTAR profile) |
Q96T23 | RSF1_HUMAN | WHIM1 PF15612 (96-141) PHD PF00628 (894-938) |
Rsf1 | 2682305 | # | # | PHF | Zinc fingers, PHD-type | Histone modification read | # | 12972596 | RSF | histone | # | # | 12972596 | Recombinant RSF complex coimmunoprecipitates with core histones, and Rsf-1 alone also interacts with core histones. | # |
RSRC1
(details) |
24152 | Serine/Arginine-related protein 53 (SRrp53) (Arginine/serine-rich coiled-coil protein 1) | 51319 (SSTAR profile) |
Q96IZ7 | RSRC1_HUMAN | () | Rsrc1 | 1914130 | Q9DBU6 | RSRC1_MOUSE | # | # | RNA modification | Alternative splicing | 29522154 | # | RNA | mRNA | # | 29522154 | Regulates alternative splicing of E1A | New |
RUVBL1
(details) |
10474 | RuvB-like AAA ATPase 1 | 8607 (SSTAR profile) |
Q9Y265 | RUVB1_HUMAN | TIP49 PF06068 (14-368) TIP49_C PF17856 (374-439) |
Ruvbl1 | 1928760 | P60122 | RUVB1_MOUSE | INO80, AATP | INO80 complex subunits, ATPases / AAA-type | Chromatin remodeling, Histone modification write | Histone phosphorylation | 14695187 | Ino80, SWR, NuA4, NuA4-related complex, CHD8, MLL2/3, MLL4/WBP7, SRCAP | chromatin | # | # | 14695187 | The ability of TIP49=RUVBL1 to inhibit ITF-2 gene expression has been linked to decreased acetylation of histones in the vicinity of the TCF-binding sites in the ITF-2 promoter region. It has been suggested that TIP49 is an important cofactor in beta-catenin/TCF gene regulation in normal and neoplastic cells, likely functioning in chromatin remodeling. | # |
RUVBL2
(details) |
10475 | RuvB-like AAA ATPase 2 | 10856 (SSTAR profile) |
Q9Y230 | RUVB2_HUMAN | TIP49 PF06068 (21-364) TIP49_C PF17856 (370-435) |
Ruvbl2 | 1342299 | Q9WTM5 | RUVB2_MOUSE | INO80, AATP | INO80 complex subunits, ATPases / AAA-type | Chromatin remodeling cofactor | # | 18026119 | Ino80, SWR, NuA4, NuA4-related complex, CHD8, MLL2/3, MLL4/WBP7, SRCAP | chromatin | # | # | 18026119 | The seven human INO80 complex components include TIP49A and TIP49B (previously identified as ‘RuvB-like’ proteins, and labeled RUVBL1 and RUVBL2). | # |
RYBP
(details) |
10480 | RING1 and YY1 binding protein | 23429 (SSTAR profile) |
Q8N488 | RYBP_HUMAN | zf-RanBP PF00641 (22-45) YAF2_RYBP PF17219 (146-178) |
Rybp | 1929059 | Q8CCI5 | RYBP_MOUSE | # | # | Polycomb group (PcG) protein | # | 19098711 | BCOR, RING2-L3MBTL2, RING2-FBRS | # | # | # | 19098711 | RYBP (RING1- and YY1-binding protein), a member of the polycomb group (PcG), interacts with MDM2 and decreases MDM2-mediated p53 ubiquitination, leading to stabilization of p53 and an increase in p53 activity. | # |
SAFB
(details) |
10520 | scaffold attachment factor B | 6294 (SSTAR profile) |
Q15424 | SAFB1_HUMAN | SAP PF02037 (31-65) RRM_1 PF00076 (408-478) |
Safb | 2146974 | D3YXK2 | SAFB1_MOUSE | RBM | RNA binding motif (RRM) containing | Chromatin remodeling | # | 24055346 | # | chromatin | # | # | # | The chromatine scaffold protein, a component of the DNA damage response cooperating with histone acetylation to allow for efficient γH2AX spreading. | # |
SAP130
(details) |
29813 | Sin3A-associated protein, 130kDa | 79595 (SSTAR profile) |
Q9H0E3 | SP130_HUMAN | SAP130_C PF16014 (654-1033) | Sap130 | 1919782 | Q8BIH0 | SP130_MOUSE | # | # | Histone modification erase cofactor | Histone acetylation | 12724404 | # | histone | # | # | 12724404 | SAP130 has a repression domain at its C terminus that interacts with the mSin3A-HDAC complex and an N-terminal domain that probably mediates an interaction with a transcriptional activator. | # |
SAP18
(details) |
10530 | Sin3A-associated protein, 18kDa | 10284 (SSTAR profile) |
O00422 | SAP18_HUMAN | SAP18 PF06487 (21-137) | Sap18 | 1277978 | O55128 | SAP18_MOUSE | # | # | Histone modification erase cofactor | Histone acetylation | 9150135 | mSin3A | histone | # | # | 9150135 | SAP18 Interacts with mSin3 and enhances the ability of mSin3-mediated repression of transcription. | # |
SAP25
(details) |
41908 | Sin3A-associated protein, 25kDa | 100316904 (SSTAR profile) |
Q8TEE9 | SAP25_HUMAN | SAP25 PF15476 (17-193) | Sap25 | 3802945 | Q1EHW4 | SAP25_MOUSE | # | # | Histone modification erase cofactor | Histone acetylation | 16449650 | # | histone | # | # | 16449650 | SAP25 binds to the PAH1 domain of mSin3A, associates with the mSin3A-HDAC complex in vivo, and represses transcription when tethered to DNA. SAP25 is required for mSin3A-mediated, but not N-CoR-mediated, repression. | # |
SAP30
(details) |
10532 | Sin3A-associated protein, 30kDa | 8819 (SSTAR profile) |
O75446 | SAP30_HUMAN | zf-SAP30 PF13866 (64-134) SAP30_Sin3_bdg PF13867 (153-205) |
Sap30 | 1929129 | O88574 | SAP30_MOUSE | # | # | Histone modification erase cofactor | Histone acetylation | 9651585 | mSin3A, mSin3A-like complex | histone | # | # | 9651585 | The human SAP30 complex is active in deacetylating core histone octamers. | # |
SAP30L
(details) |
25663 | SAP30-like | 79685 (SSTAR profile) |
Q9HAJ7 | SP30L_HUMAN | zf-SAP30 PF13866 (26-95) SAP30_Sin3_bdg PF13867 (114-166) |
Sap30l | 1354709 | Q5SQF8 | SP30L_MOUSE | # | # | Histone modification erase cofactor | Histone acetylation | 16820529 | # | histone | # | # | 16820529 | SAP30L induces transcriptional repression, possibly via recruitment of Sin3A and histone deacetylases. A functional nucleolar localization signal in SAP30L means that SAP30L and SAP30 are able to target Sin3A to the nucleolus. | # |
SATB1
(details) |
10541 | SATB homeobox 1 | 6304 (SSTAR profile) |
Q01826 | SATB1_HUMAN | ULD PF16534 (72-169) CUTL PF16557 (177-248) CUT PF02376 (371-446, 493-568) Homeodomain PF00046 (646-701) |
Satb1 | 105084 | Q60611 | SATB1_MOUSE | CUT | Homeoboxes / CUT class | Chromatin remodeling cofactor | # | 15713622, 24055346, 12374985, 12374985, 24055346 | # | chromatin | # | # | # | Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Forms chromatin loops. SATB1 also targets ACF1 and ISWI, subunits of CHRAC and ACF nucleosome mobilizing complexes. SAFB1 is a component of the DNA damage response and shows that SAFB1 cooperates with histone acetylation to allow for efficient γH2AX spreading. | # |
SATB2
(details) |
21637 | SATB homeobox 2 | 23314 (SSTAR profile) |
Q9UPW6 | SATB2_HUMAN | ULD PF16534 (58-155) CUTL PF16557 (162-234) CUT PF02376 (360-435, 482-557) Homeodomain PF00046 (615-671) |
Satb2 | 2679336 | Q8VI24 | SATB2_MOUSE | CUT | Homeoboxes / CUT class | Chromatin remodeling cofactor | # | 18255031 | # | chromatin | # | # | # | Cromatin remodeling in mouse. UniProt: Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. | # |
SCMH1
(details) |
19003 | sex comb on midleg homolog 1 (Drosophila) | 22955 (SSTAR profile) |
Q96GD3 | SCMH1_HUMAN | MBT PF02820 (62-129, 171-236) RBR PF17208 (269-333) SLED PF12140 (357-471) SAM_1 PF00536 (592-656) |
Scmh1 | 1352762 | Q8K214 | SCMH1_MOUSE | SAMD | Sterile alpha motif (SAM) domain containing | Polycomb group (PcG) protein | # | 23356856 | PRC1 | # | # | # | 23356856 | SCMH1 is part of a polycomb group complex 1 (PcG1) involved in transcriptional silencing and proteosomal degradation for the Geminin protein, important for regulation of replication and maintenance of undifferentiated states. | # |
SCML2
(details) |
10581 | sex comb on midleg-like 2 (Drosophila) | 10389 (SSTAR profile) |
Q9UQR0 | SCML2_HUMAN | MBT PF02820 (67-134, 176-241) RBR PF17208 (281-321) SLED PF12140 (355-464) SAM_1 PF00536 (628-695) |
# | # | # | # | SAMD | Sterile alpha motif (SAM) domain containing | Polycomb group (PcG) protein | # | 24727478 | PRC1 | # | # | # | 24727478 | Scml2 is a member of the Polycomb group of proteins involved in epigenetic gene silencing. Human Scml2 is a part of a multisubunit protein complex, PRC1 (Polycomb repressive complex 1), which is responsible for maintenance of gene repression, prevention of chromatin remodeling, preservation of the "stemness" of the cell, and cell differentiation. | # |
SCML4
(details) |
21397 | sex comb on midleg-like 4 (Drosophila) | 256380 (SSTAR profile) |
Q8N228 | SCML4_HUMAN | RBR PF17208 (1-61) SLED PF12140 (96-207) SAM_1 PF00536 (343-410) |
Scml4 | 2446140 | Q80VG1 | SCML4_MOUSE | SAMD | Sterile alpha motif (SAM) domain containing | Polycomb group (PcG) protein | # | # | # | # | # | # | # | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. (Annotated by similarity.) | # |
SENP1
(details) |
17927 | SUMO1/sentrin specific peptidase 1 | 29843 (SSTAR profile) |
Q9P0U3 | SENP1_HUMAN | Peptidase_C48 PF02902 (464-638) | Senp1 | 2445054 | P59110 | SENP1_MOUSE | # | # | Histone modification erase cofactor | Histone sumoylation | 15199155 | # | histone | H4 | # | 15199155 | SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1. | # |
SENP3
(details) |
17862 | SUMO1/sentrin/SMT3 specific peptidase 3 | 26168 (SSTAR profile) |
Q9H4L4 | SENP3_HUMAN | SENP3_5_N PF19722 (306-387) Peptidase_C48 PF02902 (400-570) |
Senp3 | 2158736 | Q9EP97 | SENP3_MOUSE | # | # | Histone modification erase, Histone modification write cofactor | Histone sumoylation, Histone acetylation | # | CHD8, MLL2/3, MLL4/WBP7 | histone | H3 | H3ac | 18850004 | Facultative member of the MLL1/MLL complex (UniProt). | # |
SET
(details) |
10760 | SET nuclear proto-oncogene | 6418 (SSTAR profile) |
Q01105 | SET_HUMAN | NAP PF00956 (92-234) | Set | 1860267 | Q9EQU5 | SET_MOUSE | # | # | Histone modification | # | 17320507 | # | histone | # | # | # | Classified as histone-modifying enzymes in paper. | # |
SETD1A
(details) |
29010 | SET domain containing 1A | 9739 (SSTAR profile) |
O15047 | SET1A_HUMAN | RRM_1 PF00076 (97-166) N-SET PF11764 (1419-1559) SET PF00856 (1580-1685) |
Setd1a | 2446244 | # | # | KMT, RBM | Chromatin-modifying enzymes / K-methyltransferases, RNA binding motif (RRM) containing | Histone modification write | Histone methylation | 17355966 | COMPASS | histone | H3K4 | H3K4me | 17355966 | The CFP1 complex contains human homologues of the COMPASS complex, including Set1A=SETD1A, Wdr5, Ash2, Rbbp5, and Wdr82 (previously denoted hSwd2). The human Set1A-CFP1 complex exhibits histone H3-Lys4 methyltransferase activity in vitro. | # |
SETD1B
(details) |
29187 | SET domain containing 1B | 23067 (SSTAR profile) |
Q9UPS6 | SET1B_HUMAN | RRM_1 PF00076 (104-175) N-SET PF11764 (1676-1821) SET PF00856 (1839-1944) |
Setd1b | 2652820 | Q8CFT2 | SET1B_MOUSE | KMT, RBM | Chromatin-modifying enzymes / K-methyltransferases, RNA binding motif (RRM) containing | Histone modification write | Histone methylation | 17355966 | COMPASS | histone | H3K4 | H3K4me | 17355966 | The extensive homology between Set1A and Set1B=SETD1B, particularly throughout the SET domain, suggests that Set1B functions as a histone methyltransferase. | # |
SETD2
(details) |
18420 | SET domain containing 2 | 29072 (SSTAR profile) |
Q9BYW2 | SETD2_HUMAN | AWS PF17907 (1513-1547) SET PF00856 (1561-1667) WW PF00397 (2391-2421) SRI PF08236 (2471-2552) |
Setd2 | 1918177 | E9Q5F9 | SETD2_MOUSE | KMT | Chromatin-modifying enzymes / K-methyltransferases | Histone modification write | Histone methylation | 16118227 | # | histone | H3K36me2 | H3K36me3 | 16118227 | HYPB HMTase=SETD2 may coordinate histone methylation and transcriptional regulation in mammals. | # |
SETD3
(details) |
20493 | SET domain containing 3 | 84193 (SSTAR profile) |
Q86TU7 | SETD3_HUMAN | SET PF00856 (105-314) Rubis-subs-bind PF09273 (345-475) |
Setd3 | 1289184 | Q91WC0 | SETD3_MOUSE | # | # | Histone modification write | Histone methylation | # | # | histone | H3K36 | H3K36me | # | Histone methyltransferase that methylates 'Lys-36' of histone H3 (H3K36me). H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation. (Annotated by similarity.) | # |
SETD5
(details) |
25566 | SET domain containing 5 | 55209 (SSTAR profile) |
Q9C0A6 | SETD5_HUMAN | SET PF00856 (285-389) | Setd5 | 1920145 | Q5XJV7 | SETD5_MOUSE | # | # | Histone modification write | Histone methylation | 24680889 | # | histone | # | # | 24680889 | Encoding methyltransferases regulating histone modification. | # |
SETD6
(details) |
26116 | SET domain containing 6 | 79918 (SSTAR profile) |
Q8TBK2 | SETD6_HUMAN | SET PF00856 (75-286) Rubis-subs-bind PF09273 (328-465) |
Setd6 | 1913333 | Q9CWY3 | SETD6_MOUSE | # | # | Chromatin remodeling, Histone modification write | Histone methylation | 21131967 | # | histone | # | # | 21131967 | SETD6 monomethylation of nuclear RelA at K310 attenuates NF-κB signaling by docking GLP (via its ankyrin repeats) at target genes to generate a silent chromatin state, effectively rendering chromatin-bound RelA inert. As deregulation of NF-κB is linked to pathologic inflammatory processes and cancer8 and SETD6 inhibits NF-κB signaling in diverse cell types, including primary human cells, SETD6 may provide a new link by which protein lysine methylation and chromatin regulation influence tumor suppression and anti-inflammatory respons. | # |
SETD7
(details) |
30412 | SET domain containing (lysine methyltransferase) 7 | 80854 (SSTAR profile) |
Q8WTS6 | SETD7_HUMAN | MORN PF02493 (19-34, 36-58, 60-81) domain PF22648 (110-184) SET PF00856 (227-336) |
Setd7 | 1920501 | Q8VHL1 | SETD7_MOUSE | KMT | Chromatin-modifying enzymes / K-methyltransferases | Histone modification write | Histone methylation | 11779497 | # | histone | H3K4 | H3K4me1 | 11779497 | SET7 methylates H3-K4 in vitro and in vivo. In addition, methylation of H3-K4 and H3-K9 inhibit each other. Furthermore, H3-K4 and H3-K9 methylation by SET7 and SUV39H1, respectively, have differential effects on subsequent histone acetylation by p300. May explain differential effects of H3-K4 and H3-K9 methylation on transcription. | # |
SETD8
(details) |
29489 | SET domain containing (lysine methyltransferase) 8 | 387893 (SSTAR profile) |
Q9NQR1 | SETD8_HUMAN | SET PF00856 (268-378) | Setd8 | 1915206 | Q2YDW7 | SETD8_MOUSE | KMT | Chromatin-modifying enzymes / K-methyltransferases | Histone modification write | Histone methylation | 12086618 | # | histone | H4K20 | H4K20me1 | 12086618 | The encoding gene PR/SET07 =SETD8 of a human histone H4 lysine 20 methyltransferase. | # |
SETDB1
(details) |
10761 | SET domain, bifurcated 1 | 9869 (SSTAR profile) |
Q15047 | SETB1_HUMAN | DUF5604 PF18300 (193-250) Tudor_5 PF18359 (258-311) Tudor_4 PF18358 (348-398) MBD PF01429 (596-667) Pre-SET PF05033 (683-798) SET PF00856 (1199-1266) |
Setdb1 | 1934229 | O88974 | SETB1_MOUSE | KMT, TDRD | Chromatin-modifying enzymes / K-methyltransferases, Tudor domain containing | Histone modification write | Histone methylation | 11959841 | # | histone | H3K9 | H3K9me3 | 11959841 | In vitro methylation of the N-terminal tail of histone H3 by SETDB1 is sufficient to enhance the binding of HP1 proteins, which requires both an intact chromodomain and chromoshadow domain. | # |
SETDB2
(details) |
20263 | SET domain, bifurcated 2 | 83852 (SSTAR profile) |
Q96T68 | SETB2_HUMAN | MBD PF01429 (163-229) Pre-SET PF05033 (247-359) SET PF00856 (623-694) |
Setdb2 | 2685139 | Q8C267 | SETB2_MOUSE | KMT | Chromatin-modifying enzymes / K-methyltransferases | Histone modification write | Histone methylation | 20404330 | # | histone | H3K9 | H3K9me3 | 20404330 | A member of the histone H3K9 methyltransferase family named CLLD8 (or SETDB2 or KMT1F). | # |
SETMAR
(details) |
10762 | SET domain and mariner transposase fusion gene | 6419 (SSTAR profile) |
Q53H47 | SETMR_HUMAN | Pre-SET PF05033 (28-132) SET PF00856 (148-263) HTH_48 PF17906 (346-392) Transposase_1 PF01359 (502-581) |
Setmar | 1921979 | Q80UJ9 | SETMR_MOUSE | # | # | Histone modification write | Histone methylation | 16332963 | # | histone | H3K4, H3K36 | H3K4me, H3K36me | 16332963 | Metnase =SETMAR that has a SET domain and a transposase/nuclease domain. Metnase methylates histone H3 lysines 4 and 36, which are associated with open chromatin. Metnase increases resistance to ionizing radiation and increases nonhomologous end-joining repair of DNA doublestrand breaks. | # |
SF3B1
(details) |
10768 | splicing factor 3b, subunit 1, 155kDa | 23451 (SSTAR profile) |
O75533 | SF3B1_HUMAN | SF3b1 PF08920 (327-453) domain PF22646 (1086-1158) |
Sf3b1 | 1932339 | Q99NB9 | SF3B1_MOUSE | # | # | RNA modification | # | 23568491 | B-WICH | RNA | # | # | 23568491 | Although the causative link between SF3B1 mutation and CLL pathogenesis remains unclear, several lines of evidence suggest SF3B1 mutation might be linked to genomic stability and epigenetic modification. | # |
SF3B3
(details) |
10770 | splicing factor 3b, subunit 3, 130kDa | 23450 (SSTAR profile) |
Q15393 | SF3B3_HUMAN | MMS1_N PF10433 (77-591) CPSF_A PF03178 (863-1180) |
Sf3b3 | 1289341 | Q921M3 | SF3B3_MOUSE | # | # | RNA modification | # | 17643112 | # | RNA | # | # | 17643112 | # | # |
SFMBT1
(details) |
20255 | Scm-like with four mbt domains 1 | 51460 (SSTAR profile) |
Q9UHJ3 | SMBT1_HUMAN | MBT PF02820 (54-121, 166-234, 279-351, 388-454) SLED PF12140 (501-616) SAM_1 PF00536 (793-857) |
Sfmbt1 | 1859609 | Q9JMD1 | SMBT1_MOUSE | # | # | Polycomb group (PcG) protein | # | 21423274 | SCL | histone | H4K20 | # | 21423274 | Table 1 in the reference. | # |
SFMBT2
(details) |
20256 | Scm-like with four mbt domains 2 | 57713 (SSTAR profile) |
Q5VUG0 | SMBT2_HUMAN | MBT PF02820 (78-146, 191-258, 301-375, 411-478) SLED PF12140 (529-642) SAM_1 PF00536 (823-885) |
Sfmbt2 | 2447794 | Q5DTW2 | SMBT2_MOUSE | SAMD | Sterile alpha motif (SAM) domain containing | Histone modification read, Polycomb group (PcG) protein, TF | TF repressor | 23385818 | # | histone, DNA | H3K9me2, H3K9me3, H3K27me3, H4K20me2, H4K20me3 | H3, H4 | 23385818 | SFMBT2 binds preferentially to methylated histone H3 and H4 that are associated with transcriptional repression. Occupancy of SFMBT2 coincide with enrichment of diand tri-methylated H3K9 and H4K20 as well as tri-methylated H3K27 at the HOXB13 gene promoter. | # |
SFPQ
(details) |
10774 | splicing factor proline/glutamine-rich | 6421 (SSTAR profile) |
P23246 | SFPQ_HUMAN | RRM_1 PF00076 (299-363, 374-432) NOPS PF08075 (444-496) |
Sfpq | 1918764 | Q8VIJ6 | SFPQ_MOUSE | RBM | RNA binding motif (RRM) containing | Chromatin remodeling cofactor, RNA modification, TF | TF repressor | 22783022, 10858305, 8449401 | # | DNA, RNA | # | # | 22783022, 10858305, 8449401 | Four components of the Sin3a transcriptional repressor complex: SAP130, SUDS3, SFPQ, and TGIF2. Since the RNA splicing factors do not have an endogenous DNA relaxation activity, topoisomerase I (Chromatin remodeller) gets stimulated by the interaction with the PSF= SFPQ/p54nrb heterodimer. PSF=SFPQ is an essential pre-mRNA splicing factor required early in spliceosome formation. | # |
SFSWAP
(details) |
10790 | Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog) | 6433 (SSTAR profile) |
Q12872 | SFSWA_HUMAN | DRY_EERY PF09750 (34-153) Surp PF01805 (210-255, 458-502) |
Sfswap | 101760 | Q3USH5 | SFSWA_MOUSE | # | # | RNA modification | Alternative splicing | 8940107 | # | RNA | mRNA | # | 8940107 | Regulates its own splicing, and also the splicing of fibronectin and CD45. Represses the splicing of MAPT/Tau exon 10 | New |
SHPRH
(details) |
19336 | SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase | 257218 (SSTAR profile) |
Q149N8 | SHPRH_HUMAN | SNF2-rel_dom PF00176 (307-985) Linker_histone PF00538 (440-512) SHPRH_helical-1st PF21325 (1003-1099) SHPRH_helical-2nd PF21324 (1135-1361) zf-RING_UBOX PF13445 (1432-1478) Helicase_C PF00271 (1514-1622) |
Shprh | 1917581 | Q7TPQ3 | SHPRH_MOUSE | RNF | RING-type (C3HC4) zinc fingers | Histone modification write cofactor | Histone ubiquitination | 17130289 | # | histone | # | # | 17130289 | SHPRH associates with PCNA, RAD18, and the ubiquitin-conjugating enzyme UBC13 (E2) and promotes methyl methanesulfonate (MMS)-induced PCNA polyubiquitination. | # |
SIN3A
(details) |
19353 | SIN3 transcription regulator family member A | 25942 (SSTAR profile) |
Q96ST3 | SIN3A_HUMAN | PAH PF02671 (142-186, 323-380, 478-522) Sin3_corepress PF08295 (551-647) Sin3a_C PF16879 (885-1192) |
Sin3a | 107157 | Q60520 | SIN3A_MOUSE | # | # | Histone modification erase cofactor, TF | Histone acetylation, TF activator, TF repressor | 12670868 | SWI/SNF_Brg1(I), SWI/SNF_Brm, mSin3A, mSin3A-like complex | histone, DNA | DNA motif | # | 12670868 | Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. | # |
SIN3B
(details) |
19354 | SIN3 transcription regulator family member B | 23309 (SSTAR profile) |
O75182 | SIN3B_HUMAN | PAH PF02671 (60-104, 182-235, 322-366) Sin3_corepress PF08295 (394-447, 435-521) Sin3a_C PF16879 (775-1081) |
Sin3b | 107158 | Q62141 | SIN3B_MOUSE | # | # | Histone modification erase cofactor, TF | Histone acetylation, TF repressor | 12670868 | mSin3A | histone, DNA | DNA motif | # | 12670868 | Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. | # |
SIRT1
(details) |
14929 | sirtuin 1 | 23411 (SSTAR profile) |
Q96EB6 | SIR1_HUMAN | SIR2 PF02146 (261-447) | Sirt1 | 2135607 | Q923E4 | SIR1_MOUSE | # | # | Histone modification erase, Histone modification write cofactor | Histone acetylation, Histone methylation | 15469825 | eNoSc | histone | H1K26ac, H3K9ac, H4K16ac | H1K26, H3K9, H4K16 | 15469825 | SirT1 deacetylates histone polypeptides with a preference for histone H4 lysine 16 (H4-K16Ac) and H3 lysine 9 (H3-K9Ac) in vitro. | # |
SIRT2
(details) |
10886 | sirtuin 2 | 22933 (SSTAR profile) |
Q8IXJ6 | SIR2_HUMAN | SIR2 PF02146 (84-268) | Sirt2 | 1927664 | Q8VDQ8 | SIR2_MOUSE | # | # | Histone modification erase, Histone modification write cofactor | Histone acetylation, Histone methylation | 11427894 | # | histone | H3K18ac, H3K56ac, H4K16ac, H4K20me1 | H3K18, H3K56, H4K16, H4K20me2, H4K20me3 | 11427894 | Sir2 =SIRT2 is an NAD-dependent histone deacetylase that mediates transcriptional silencing at mating-type loci, telomeres and ribosomal gene clusters. | # |
SIRT6
(details) |
14934 | sirtuin 6 | 51548 (SSTAR profile) |
Q8N6T7 | SIR6_HUMAN | SIR2 PF02146 (85-221) | Sirt6 | 1354161 | P59941 | SIR6_MOUSE | # | # | Histone modification erase | Histone acetylation | 18337721 | # | histone | H3K9ac, H3K56ac | H3K9, H3K56 | 18337721 | The human SIRT6 protein is an NAD+-dependent, histone H3 lysine 9 (H3K9) deacetylase that modulates telomeric chromatin. SIRT6 associates specifically with telomeres, and SIRT6 depletion leads to telomere dysfunction with end-to-end chromosomal fusions and premature cellular senescence. | # |
SIRT7
(details) |
14935 | sirtuin 7 | 51547 (SSTAR profile) |
Q9NRC8 | SIR7_HUMAN | SIR2 PF02146 (140-273) | Sirt7 | 2385849 | Q8BKJ9 | SIR7_MOUSE | # | # | Histone modification erase | Histone acetylation | 22722849 | B-WICH | histone | H3K18ac | H3K18 | 22722849 | Genome-wide binding studies reveal that SIRT7 binds to promoters of a specific set of gene targets, where it deacetylates H3K18Ac and promotes transcriptional repression. | # |
SKP1
(details) |
10899 | S-phase kinase-associated protein 1 | 6500 (SSTAR profile) |
P63208 | SKP1_HUMAN | Skp1_POZ PF03931 (3-68) Skp1 PF01466 (113-160) |
Akp1a | 103575 | Q9WTX5 | SKP1_MOUSE | # | # | Histone modification write cofactor | Histone ubiquitination | 16943429 | BCOR | histone | # | # | 16943429 | The proteins in the BCOR complex include the PcG and PcG-associated proteins NSPC1, RING1, RNF2, and RYBP as well as components of an SCF ubiquitin ligase, SKP1, and FBXL10. BCOR recruits a unique combination of enzymatic activities to chromatin targets: a PcG E3 ubiquitin ligase for histone H2A, a demethylase for histone H3 K36, and an SCF E3 ubiquitin ligase. | # |
SLU7
(details) |
16939 | Pre-mRNA-splicing factor SLU7 (hSlu7) | 10569 (SSTAR profile) |
O95391 | SLU7_HUMAN | Slu7 PF11708 (160-432) | Slu7 | 2385598 | Q8BHJ9 | SLU7_MOUSE | # | # | RNA modification | Alternative splicing | 12764196 | # | RNA | mRNA | # | 12764196 | Regulates 3` splice site selection | New |
SMARCA1
(details) |
11097 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 | 6594 (SSTAR profile) |
P28370 | SMCA1_HUMAN | SNF2-rel_dom PF00176 (186-465) Helicase_C PF00271 (487-612) HAND PF09110 (758-856) SLIDE PF09111 (911-1028) |
Smarca1 | 1935127 | Q6PGB8 | SMCA1_MOUSE | # | # | Chromatin remodeling, Histone modification erase | Histone acetylation | 15310751 | NuRF, CERF, CERF | chromatin | # | # | 15310751 | Mammalian genomes encode two imitation switch family chromatin remodeling proteins, SNF2H and SNF2L =SMARCA1. | # |
SMARCA2
(details) |
11098 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | 6595 (SSTAR profile) |
P51531 | SMCA2_HUMAN | QLQ PF08880 (174-208) HSA PF07529 (438-508) BRK PF07533 (591-633) SNF2-rel_dom PF00176 (727-1021) Helicase_C PF00271 (1051-1164) SnAC PF14619 (1259-1326) Bromodomain PF00439 (1421-1489) |
Smarca2 | 99603 | Q6DIC0 | SMCA2_MOUSE | # | # | Histone modification read, TF | TF activator | 22464331 | BAF, nBAF, npBAF, WINAC, bBAF, SWI/SNF BRM-BRG1 | histone, DNA | H3, DNA motif | # | 22464331 | Fig. 5 in the reference. | # |
SMARCA4
(details) |
11100 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | 6597 (SSTAR profile) |
P51532 | SMCA4_HUMAN | QLQ PF08880 (172-205) HSA PF07529 (461-532) BRK PF07533 (612-653) SNF2-rel_dom PF00176 (754-1051) Helicase_C PF00271 (1081-1194) SnAC PF14619 (1321-1388) Bromodomain PF00439 (1477-1547) |
Smarca4 | 88192 | Q3TKT4 | SMCA4_MOUSE | # | # | Histone modification read, TF | TF activator | 17582821 | BAF, nBAF, npBAF, PBAF, SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, SWI/SNF-like_EPAFa, WINAC, SWI/SNF-like EPAFB, bBAF, SWI/SNF BRM-BRG1, CREST-BRG1 | histone | H3, H4 | # | 17582821 | The BRG1 =SMARCA4 bromodomain exhibits binding, albeit weak, to acetylated peptides that are derived from histones H3 and H4. | # |
SMARCA5
(details) |
11101 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 8467 (SSTAR profile) |
O60264 | SMCA5_HUMAN | SNF2-rel_dom PF00176 (183-462) Helicase_C PF00271 (484-597) HAND PF09110 (743-841) SLIDE PF09111 (897-1011) |
Smarca5 | 1935129 | Q91ZW3 | SMCA5_MOUSE | # | # | Chromatin remodeling | # | 10880450 | ACF, B-WICH, RSF, CHRAC, NoRC | chromatin | # | # | 10880450 | The DNA-binding properties of the p15–p17 complex are possibly relevant for incorporation of p15–p17 into chromatin, aided by the nucleosome remodeling activity of hSNF2H =SMARCA5 plus hACF1. | # |
SMARCAD1
(details) |
18398 | SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 | 56916 (SSTAR profile) |
Q9H4L7 | SMRCD_HUMAN | SNF2-rel_dom PF00176 (500-786) Helicase_C PF00271 (855-967) |
Smarcad1 | 95453 | Q04692 | SMRCD_MOUSE | # | # | Chromatin remodeling | # | 22960744 | # | chromatin | # | # | 22960744 | The yeast Saccharomyces cerevisiae Fun30 protein and its human counterpart SMARCAD1, two ATP-dependent chromatin remodellers of the Snf2 ATPase family, are directly involved in the DSB response. | # |
SMARCAL1
(details) |
11102 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 | 50485 (SSTAR profile) |
Q9NZC9 | SMAL1_HUMAN | HARP PF07443 (245-304, 344-397) SNF2-rel_dom PF00176 (439-688) Helicase_C PF00271 (714-822) |
Smarcal1 | 1859183 | Q8BJL0 | SMAL1_MOUSE | # | # | Chromatin remodeling | # | 11799392 | # | chromatin | # | # | 11799392 | The unique constellation of findings constituting SIOD indicates that SMARCAL1 regulates the transcriptional activity of a particular subset of genes through chromatin remodeling during both development and later life. | # |
SMARCB1
(details) |
11103 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | 6598 (SSTAR profile) |
Q12824 | SNF5_HUMAN | INI1_DNA-bd PF21459 (12-104) SNF5 PF04855 (180-373) |
Smarcb1 | 1328366 | Q9Z0H3 | SNF5_MOUSE | # | # | Histone modification read | # | 21423274 | BAF, nBAF, npBAF, PBAF, SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, SWI/SNF-like_EPAFa, WINAC, SWI/SNF-like EPAFB, bBAF, SWI/SNF BRM-BRG1 | histone | H3K56 | # | 21423274 | Table 1 in the reference (SMARCB1 =Snf5) | # |
SMARCC1
(details) |
11104 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 6599 (SSTAR profile) |
Q92922 | SMRC1_HUMAN | SWIRM-assoc_2 PF16496 (31-165) SWIRM PF04433 (459-537) Myb_DNA-binding PF00249 (622-664) SWIRM-assoc_3 PF16498 (705-772) SWIRM-assoc_1 PF16495 (872-952) |
Smarcc1 | 1203524 | P97496 | SMRC1_MOUSE | # | # | Chromatin remodeling cofactor | # | 10078207 | BAF, nBAF, npBAF, PBAF, SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, SWI/SNF-like_EPAFa, WINAC, SWI/SNF-like EPAFB, bBAF, SWI/SNF BRM-BRG1 | chromatin | # | # | 10078207 | The addition of INI1, BAF155 =SMARCC1, and BAF170 to BRG1 increases remodeling activity to a level comparable to that of the whole hSWI/SNF complex. | # |
SMARCC2
(details) |
11105 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | 6601 (SSTAR profile) |
Q8TAQ2 | SMRC2_HUMAN | SWIRM-assoc_2 PF16496 (5-137) SWIRM PF04433 (434-512) Myb_DNA-binding PF00249 (600-642) SWIRM-assoc_3 PF16498 (683-748) SWIRM-assoc_1 PF16495 (864-945) |
Smarcc2 | 1915344 | Q6PDG5 | SMRC2_MOUSE | # | # | Chromatin remodeling cofactor | # | 10078207 | BAF, nBAF, npBAF, PBAF, SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, SWI/SNF-like_EPAFa, WINAC, SWI/SNF-like EPAFB, bBAF, SWI/SNF BRM-BRG1 | chromatin | # | # | 10078207 | The addition of INI1, BAF155, and BAF170 =SMARCC2 to BRG1 increases remodeling activity to a level comparable to that of the whole hSWI/SNF complex. | # |
SMARCD1
(details) |
11106 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 | 6602 (SSTAR profile) |
Q96GM5 | SMRD1_HUMAN | SWIB PF02201 (294-364) | Smarcd1 | 1933623 | Q61466 | SMRD1_MOUSE | # | # | Chromatin remodeling | # | 12917342 | BAF, nBAF, npBAF, PBAF, SWI/SNF_Brg1(I), SWI/SNF_Brm, SWI/SNF-like_EPAFa, WINAC, SWI/SNF-like EPAFB, SWI/SNF BRM-BRG1 | chromatin | # | # | 12917342 | BAF60a =SMARCD1 possesses at least two interaction surfaces, one for GR and BRG1 and a second for BAF155 and BAF170. A GR mutant, GR(R488Q), that fails to interact with BAF60a=SMARCD1 in vitro has reduced chromatin-remodeling activity and reduced transcriptional activity from the promoter assembled as chromatin in vivo. | # |
SMARCD2
(details) |
11107 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 6603 (SSTAR profile) |
Q92925 | SMRD2_HUMAN | SWIB PF02201 (310-379) | Smarcd2 | 1933621 | Q99JR8 | SMRD2_MOUSE | # | # | Chromatin remodeling cofactor | # | 20148946 | BAF, PBAF, SWI/SNF_Brg1(I), SWI/SNF_Brm, SWI/SNF-like EPAFB, bBAF, SWI/SNF BRM-BRG1 | chromatin | # | # | 20148946 | The SWI/SNF chromatin remodeling complexes are important regulators of transcription; they consist of large multisubunit assemblies containing either Brm or Brg1 as the catalytic ATPase subunit and a variable subset of approximately 10 Brg/Brm-associated factors (BAF). Among these factors, BAF60 proteins (BAF60a, BAF60b=SMARCD2 or BAF60c), which are found in most complexes, are thought to bridge interactions between transcription factors and SWI/SNF complexes. | # |
SMARCD3
(details) |
11108 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 | 6604 (SSTAR profile) |
Q6STE5 | SMRD3_HUMAN | SWIB PF02201 (262-333) | Smarcd3 | 1914243 | Q6P9Z1 | SMRD3_MOUSE | # | # | Chromatin remodeling cofactor | # | 20148946 | BAF, nBAF, npBAF, PBAF, SWI/SNF_Brg1(I), SWI/SNF_Brm, SWI/SNF BRM-BRG1 | chromatin | # | # | 20148946 | The SWI/SNF chromatin remodeling complexes are important regulators of transcription; they consist of large multisubunit assemblies containing either Brm or Brg1 as the catalytic ATPase subunit and a variable subset of approximately 10 Brg/Brm-associated factors (BAF). Among these factors, BAF60 proteins (BAF60a, BAF60b or BAF60c=SMARCD3), which are found in most complexes, are thought to bridge interactions between transcription factors and SWI/SNF complexes. | # |
SMARCE1
(details) |
11109 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 | 6605 (SSTAR profile) |
Q969G3 | SMCE1_HUMAN | HMG_box PF00505 (66-134) | Smarce1 | 1927347 | O54941 | SMCE1_MOUSE | # | # | Chromatin remodeling cofactor | # | 12672490 | BAF, nBAF, npBAF, PBAF, SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, SWI/SNF-like_EPAFa, WINAC, SWI/SNF-like EPAFB, bBAF | chromatin | # | # | 12672490 | In addition to Swi2/Snf2 proteins, there is evidence that other core components are required for chromatin-remodeling activity. More recently, two additional human Swi/Snf members, BAF57 =SMARCE1 and BAF60a, have been shown to interact directly with regulatory proteins. | # |
SMEK1
(details) |
20219 | SMEK homolog 1, suppressor of mek1 (Dictyostelium) | 55671 (SSTAR profile) |
Q6IN85 | P4R3A_HUMAN | domain PF22972 (5-101) PP4R3 PF04802 (141-645) |
Smek1 | 1915984 | Q6P2K6 | P4R3A_MOUSE | # | # | Histone modification erase cofactor | Histone phosphorylation | 18614045 | PPP4C-PPP4R2-PPP4R3A | histone | H2AFX | # | # | Member of PPP4C-PPP4R2-PPP4R3A PP4 complex which specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX). | # |
SMEK2
(details) |
29267 | SMEK homolog 2, suppressor of mek1 (Dictyostelium) | 57223 (SSTAR profile) |
Q5MIZ7 | P4R3B_HUMAN | domain PF22972 (5-101) PP4R3 PF04802 (144-682) |
Smek2 | 2144474 | Q922R5 | P4R3B_MOUSE | # | # | Histone modification erase cofactor | Histone phosphorylation | 18614045 | # | histone | H2AFX | # | # | Member of PPP4C-PPP4R2-PPP4R3B complex which dephosphorylates H2AFX. | # |
SMYD1
(details) |
20986 | SET and MYND domain containing 1 | 150572 (SSTAR profile) |
Q8NB12 | SMYD1_HUMAN | SET PF00856 (18-252) zf-MYND PF01753 (52-90) |
Smyd1 | 104790 | P97443 | SMYD1_MOUSE | ZMYND, KMT | Zinc fingers, MYND-type, "Chromatin-modifying enzymes / K-methyltransferases" | Histone modification write | Histone methylation | 22498752 | # | histone | H3K4 | H3K4me | # | SMYD1 methylates histone H3 at Lys-4 (H3K4me), according to UniProt. | # |
SMYD2
(details) |
20982 | SET and MYND domain containing 2 | 56950 (SSTAR profile) |
Q9NRG4 | SMYD2_HUMAN | SET PF00856 (18-240) zf-MYND PF01753 (52-90) |
Smyd2 | 1915889 | Q8R5A0 | SMYD2_MOUSE | ZMYND, KMT | Zinc fingers, MYND-type, Chromatin-modifying enzymes / K-methyltransferases | Histone modification write | Histone methylation | 18065756 | # | histone | H3K4, H3K36 | H3K4me, H3K36me2 | 18065756 | Some reports indicate that SMYD2 methylates p53 and histone H3. | # |
SMYD3
(details) |
15513 | SET and MYND domain containing 3 | 64754 (SSTAR profile) |
Q9H7B4 | SMYD3_HUMAN | SET PF00856 (15-239) zf-MYND PF01753 (49-87) |
Smyd3 | 1916976 | Q9CWR2 | SMYD3_MOUSE | ZMYND, KMT | Zinc fingers, MYND-type, Chromatin-modifying enzymes / K-methyltransferases | Histone modification write | Histone methylation | 15235609 | # | histone | H3K4, H3K5 | H3K4me2, H3K4me3, H3K5me2, H3K5me3 | 15235609 | The SET domain of SMYD3 shows histone H3-lysine 4 (H3-K4)-specific methyltransferase activity, which is enhanced in the presence of the heat-shock protein HSP90A. | # |
SMYD4
(details) |
21067 | SET and MYND domain containing 4 | 114826 (SSTAR profile) |
Q8IYR2 | SMYD4_HUMAN | SET PF00856 (244-574) zf-MYND PF01753 (296-335) |
Smyd4 | 2442796 | Q8BTK5 | SMYD4_MOUSE | ZMYND | Zinc fingers, MYND-type | Histone modification erase cofactor | Histone acetylation | 18714374 | # | # | # | # | # | SMYD4 interacts with HDAC1 and HDAC3. | # |
SNAI2
(details) |
11094 | snail family zinc finger 2 | 6591 (SSTAR profile) |
O43623 | SNAI2_HUMAN | zf-C2H2 PF00096 (128-150, 159-181, 185-207, 213-235, 241-260) | Snai2 | 1096393 | P97469 | SNAI2_MOUSE | SNAI, ZNF | Snail homologs, Zinc fingers, C2H2-type | Histone modification erase cofactor | # | 15734731, 22986495 | # | histone | # | # | # | May recruit HDAC1. PHD12 interacts directly with Sin3A/HDAC, which in turn interacts with Snail2. | # |
SP1
(details) |
11205 | Sp1 transcription factor | # | P08047 | SP1_HUMAN | zf-C2H2 PF00096 (656-680, 686-708) | Sp1 | 98372 | O89090 | SP1_MOUSE | SP, ZNF | Specificity protein transcription factors, Zinc fingers, C2H2-type | Chromatin remodeling, TF | TF activator, TF repressor | 17827154, 18850004 | CREST-BRG1 | DNA | DNA motif | # | 17049555 | # | # |
SP100
(details) |
11206 | SP100 nuclear antigen | 6672 (SSTAR profile) |
P23497 | SP100_HUMAN | HSR PF03172 (37-146) SAND PF01342 (600-678) HMG_box_2 PF09011 (697-752) HMG_box PF00505 (769-837) |
Sp100 | 109561 | O35892 | SP100_MOUSE | PHF | Zinc fingers, PHD-type | Chromatin remodeling cofactor | # | 9636146 | # | chromatin | # | # | 9636146 | There is an association between the PML/SP100 NBs and the chromatin nuclear compartment. This supports a model in which the NBs may play a role in certain aspects of chromatin dynamics. | # |
SP140
(details) |
17133 | SP140 nuclear body protein | 11262 (SSTAR profile) |
Q13342 | SP140_HUMAN | HSR PF03172 (38-135) SAND PF01342 (583-661) PHD PF00628 (693-733) Bromodomain PF00439 (779-833) |
Sp140 | 3702467 | # | # | PHF | Zinc fingers, PHD-type | Histone modification read, TF | # | 22464331 | # | histone | H3 | # | 22464331 | Fig. 5 in the reference. | # |
SPEN
(details) |
17575 | spen family transcriptional repressor | 23013 (SSTAR profile) |
Q96T58 | MINT_HUMAN | RRM_1 PF00076 (8-67, 337-407, 439-508, 519-583) MINT_MID PF20809 (2012-3467) MINT_RID PF20810 (2366-2584, 3009-3469) MINT_RAM7 PF20808 (2654-2749) SPOC PF07744 (3506-3662) |
Spen | 1891706 | Q62504 | MINT_MOUSE | RBM | RNA binding motif (RRM) containing | Histone modification erase cofactor, TF | Histone acetylation, TF activator, TF repressor | 11331609 | # | histone | # | # | 11331609 | SHARP =SPEN recruits histone deacetylase activity. SHARP is a potent transcriptional repressor whose repression domain (RD) interacts directly with SMRT and at least five members of the NuRD complex including HDAC1 and HDAC2. | # |
SPOP
(details) |
11254 | speckle-type POZ protein | 8405 (SSTAR profile) |
O43791 | SPOP_HUMAN | domain PF22486 (33-161) BTB PF00651 (191-296) |
Spop | 1343085 | Q6ZWS8 | SPOP_MOUSE | BTBD | BTB/POZ domain containing | Histone modification write | Histone ubiquitination | 15897469 | # | histone | MacroH2A1 | MacroH2A1ub | 15897469 | The E3 ubiquitin ligase consisting of SPOP and CULLIN3 is able to ubiquitinate the Polycomb group protein BMI1 and the variant histone MACROH2A. | # |
SRCAP
(details) |
16974 | Snf2-related CREBBP activator protein | 10847 (SSTAR profile) |
Q6ZRS2 | SRCAP_HUMAN | HSA PF07529 (125-195) SNF2-rel_dom PF00176 (621-906) Helicase_C PF00271 (2044-2156) |
Srcap | 2444036 | # | # | # | # | Chromatin remodeling, Histone modification erase | Histone acetylation | 17617668 | NuA4-related complex, SRCAP | histone | H2A.Z | # | 17617668 | The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters. | # |
SRRM4
(details) |
29389 | Serine/arginine repetitive matrix protein 4 (Medulloblastoma antigen MU-MB-2.76) (Neural-specific serine/arginine repetitive splicing factor of 100 kDa) (Neural-specific SR-related protein of 100 kDa) (nSR100) | 84530 (SSTAR profile) |
A7MD48 | SRRM4_HUMAN | SRRM_C PF15230 (459-521) | Srrm4 | 1916205 | Q8BKA3 | SRRM4_MOUSE | # | # | RNA modification | Alternative splicing | 29961578 | # | RNA | mRNA | # | 29961578 | Regulates alternative splicing events in genes with important neuronal functions | New |
SRSF1
(details) |
10780 | serine/arginine-rich splicing factor 1 | 6426 (SSTAR profile) |
Q07955 | SRSF1_HUMAN | RRM_1 PF00076 (18-85, 123-184) | Srsf1 | 98283 | Q6PDM2 | SRSF1_MOUSE | SRSF, RBM | Serine/arginine-rich splicing factors, RNA binding motif (RRM) containing | RNA modification | # | 24706538 | # | RNA | # | # | 24706538 | H3S10 phosphorylation has been shown to promote the recruitment of per-mRNA-splicing factor SRp20 and alternative-splicing factor (ASF)/per-mRNAsplicing factor 2 (SF2) modular proteins to the chromosomes. | # |
SRSF10
(details) |
16713 | Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein) | 10772 (SSTAR profile) |
O75494 | SRS10_HUMAN | RRM_1 PF00076 (12-81) | Srsf10 | 1333805 | Q9R0U0 | SRS10_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 11684676 | # | RNA | mRNA | # | 11684676 | Regulates alternative splicing sites of E1A | New |
SRSF12
(details) |
21220 | Serine/arginine-rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine-rich 13B) (Splicing factor, arginine/serine-rich 19) | 135295 (SSTAR profile) |
Q8WXF0 | SRS12_HUMAN | RRM_1 PF00076 (12-81) | Srsf12 | 2661424 | Q8C8K3 | SRS12_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 11684676 | # | RNA | mRNA | # | 11684676 | Regulates alternative splicing sites of E1A | New |
SRSF3
(details) |
10785 | serine/arginine-rich splicing factor 3 | 6428 (SSTAR profile) |
P84103 | SRSF3_HUMAN | RRM_1 PF00076 (12-77) | Srsf3 | 98285 | P84104 | SRSF3_MOUSE | SRSF, RBM | Serine/arginine-rich splicing factors, RNA binding motif (RRM) containing | RNA modification | # | 24706538 | # | RNA | # | # | 24706538 | H3S10 phosphorylation has been shown to promote the recruitment of per-mRNA-splicing factor SRp20 and alternative-splicing factor (ASF)/per-mRNAsplicing factor 2 (SF2) modular proteins to the chromosomes. | # |
SRSF6
(details) |
10788 | Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6) | 6431 (SSTAR profile) |
Q13247 | SRSF6_HUMAN | RRM_1 PF00076 (4-64, 112-177) | Srsf6 | 1915246 | Q3TWW8 | SRSF6_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 22767602 | # | RNA | mRNA | # | 22767602 | Promotes Tau exon 10 inclusion | New |
SS18L1
(details) |
15592 | synovial sarcoma translocation gene on chromosome 18-like 1 | 26039 (SSTAR profile) |
O75177 | CREST_HUMAN | SSXT PF05030 (12-73) | Ss18l1 | 2444061 | Q8BW22 | CREST_MOUSE | # | # | Chromatin remodeling | # | 23799466 | CREST-BRG1 | chromatin | # | # | 23799466 | - | # |
SS18L2
(details) |
15593 | synovial sarcoma translocation gene on chromosome 18-like 2 | 51188 (SSTAR profile) |
Q9UHA2 | S18L2_HUMAN | SSXT PF05030 (12-73) | Deb1 | 1349474 | Q9D174 | S18L2_MOUSE | # | # | Chromatin remodeling | # | 19163965, 8666667 | # | chromatin | # | # | 15986999 | # | # |
SSRP1
(details) |
11327 | structure specific recognition protein 1 | 6749 (SSTAR profile) |
Q08945 | SSRP1_HUMAN | POB3_N PF17292 (3-96) SSrecog PF03531 (105-170) PH1_SSRP1-like PF21103 (197-327) Rttp106-like_middle PF08512 (340-427) HMG_box PF00505 (547-615) SSRP1_C PF21092 (663-709) |
Ssrp1 | 107912 | Q08943 | SSRP1_MOUSE | # | # | Chromatin remodeling | # | 12934006 | FACT | histone | H3, H4 | # | 12934006 | Both FACT and Spt16 can bind to nucleosomes and H2A-H2B dimers, whereas SSRP1 can only bind to H3-H4 tetramers but not to intact nucleosomes. Possibly, upon FACT binding to the nucleosome in the transcribed region, Spt16 facilitates the H2A-H2B displacement, which promotes the interaction between SSRP1 and the “altered” nucleosome. | # |
STK4
(details) |
11408 | serine/threonine kinase 4 | 6789 (SSTAR profile) |
Q13043 | STK4_HUMAN | Pkinase PF00069 (31-281) Mst1_SARAH PF11629 (433-480) |
Stk4 | 1929004 | Q9JI11 | STK4_MOUSE | # | # | Histone modification write | Histone phosphorylation | 12757711 | # | histone | H2AS14 | H2BS14ph | 12757711 | Mst1 =STK4 can phosphorylate H2B at S14 in vitro and in vivo, and the onset of H2B S14 phosphorylation is dependent upon cleavage of Mst1 by caspase-3. | # |
SUDS3
(details) |
29545 | suppressor of defective silencing 3 homolog (S. cerevisiae) | 64426 (SSTAR profile) |
Q9H7L9 | SDS3_HUMAN | Sds3 PF08598 (61-186) | Suds3 | 1919204 | Q8BR65 | SDS3_MOUSE | # | # | Histone modification erase cofactor | Histone acetylation | 21239494 | mSin3A | histone | # | # | 21239494 | SDS3 is a key component of the histone deacetylase (HDAC)-dependent Sin3A co-repressor complex, serving to maintain its HDAC activity. | # |
SUPT16H
(details) |
11465 | suppressor of Ty 16 homolog (S. cerevisiae) | 11198 (SSTAR profile) |
Q9Y5B9 | SP16H_HUMAN | FACT-Spt16_Nlob PF14826 (5-167) Peptidase_M24 PF00557 (182-411) SPT16 PF08644 (529-689) Rttp106-like_middle PF08512 (809-895) SPT16_C PF21091 (929-1031) |
Supt16 | 1890948 | Q920B9 | SP16H_MOUSE | # | # | Histone modification read | # | 12934006 | WINAC, FACT | histone | H2A, H2B | # | 12934006 | Both FACT and Spt16=SUPT16H can bind to nucleosomes and H2A-H2B dimers, whereas SSRP1 can only bind to H3-H4 tetramers but not to intact nucleosomes. Possibly, upon FACT binding to the nucleosome in the transcribed region, Spt16 facilitates the H2A-H2B displacement, which promotes the interaction between SSRP1 and the “altered” nucleosome. | # |
SUPT3H
(details) |
11466 | suppressor of Ty 3 homolog (S. cerevisiae) | 8464 (SSTAR profile) |
O75486 | SUPT3_HUMAN | TFIID-18kDa PF02269 (26-115) | # | # | # | # | # | # | Histone modification write cofactor | Histone acetylation | 11564863 | PCAF, SAGA, STAGA | histone | # | # | 11564863 | GCN5 is a histone acetyltransferase (HAT) originally identified in Saccharomyces cerevisiae and required for transcription of specific genes within chromatin as part of the SAGA (SPT-ADA-GCN5 acetylase) coactivator complex. Mammalian cells have two distinct GCN5 homologs (PCAF and GCN5L) that have been found in three different SAGA-like complexes (PCAF complex, TFTC [TATA-binding-protein-free TAFII-containing complex], and STAGA [SPT3-TAFII31-GCN5L acetylase]). | # |
SUPT6H
(details) |
11470 | suppressor of Ty 6 homolog (S. cerevisiae) | 6830 (SSTAR profile) |
Q7KZ85 | SPT6H_HUMAN | SPT6_acidic PF14632 (19-126) HTH_44 PF14641 (309-424) domain PF22706 (565-743) YqgF PF14639 (778-931) HHH_7 PF14635 (935-1038) HHH_9 PF17674 (1050-1139) S1 PF00575 (1227-1282) SH2_2 PF14633 (1297-1515) |
Supt6 | 107726 | Q62383 | SPT6H_MOUSE | SH2D | SH2 domain containing | Histone modification erase cofactor | Histone methylation | 23503590 | # | histone | # | # | # | Coordinates H3K27 demethylation. | # |
SUPT7L
(details) |
30632 | suppressor of Ty 7 (S. cerevisiae)-like | 9913 (SSTAR profile) |
O94864 | ST65G_HUMAN | Bromo_TP PF07524 (151-228) | Supt7l | 1919445 | Q9CZV5 | ST65G_MOUSE | # | # | Histone chaperone | # | 11564863 | TFTC-HAT, STAGA | histone | # | # | 11564863 | STAGA contains homologs of most yeast SAGA components, including two novel human proteins with histone-like folds and sequence relationships to yeast SPT7 and ADA1. STAGA preferentially acetylates histone H3 within nucleosomes. | # |
SUV39H1
(details) |
11479 | suppressor of variegation 3-9 homolog 1 (Drosophila) | 6839 (SSTAR profile) |
O43463 | SUV91_HUMAN | Chromo PF00385 (43-91) Pre-SET PF05033 (141-235) SET PF00856 (255-366) |
Suv39h1 | 1099440 | O54864 | SUV91_MOUSE | KMT | Chromatin-modifying enzymes / K-methyltransferases | Histone modification write, Histone modification write | Histone methylation, Histone phosphorylation | 10949293 | eNoSc | histone | H3S10, H3K9me1, H4 | H3K9me3 | 10949293 | In vivo, deregulated SUV39H1 or disrupted Suv39h activity modulate H3 serine 10 phosphorylation in native chromatin and induce aberrant mitotic divisions. | # |
SUV39H2
(details) |
17287 | suppressor of variegation 3-9 homolog 2 (Drosophila) | 79723 (SSTAR profile) |
Q9H5I1 | SUV92_HUMAN | Chromo PF00385 (47-95) Pre-SET PF05033 (149-242) SET PF00856 (262-373) |
Suv39h2 | 1890396 | Q9EQQ0 | SUV92_MOUSE | KMT | Chromatin-modifying enzymes / K-methyltransferases | Histone modification write | Histone methylation | 15107829 | # | histone | H3K9me1 | H3K9me3 | 15107829 | Suv39h proteins are histone methyltransferases that methylate histone H3 on lysine 9, resulting in transcriptional repression or silencing of target genes. | # |
SUV420H1
(details) |
24283 | suppressor of variegation 4-20 homolog 1 (Drosophila) | 51111 (SSTAR profile) |
Q4FZB7 | SV421_HUMAN | SET PF00856 (209-308) | Suv420h1 | 2444557 | Q3U8K7 | SV421_MOUSE | KMT | Chromatin-modifying enzymes / K-methyltransferases | Histone modification write | Histone methylation | # | # | histone | H4K20 | H4K20me3 | # | Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. (Annotated by similarity.) | # |
SUV420H2
(details) |
28405 | suppressor of variegation 4-20 homolog 2 (Drosophila) | 84787 (SSTAR profile) |
Q86Y97 | SV422_HUMAN | SET PF00856 (120-218) | Suv420h2 | 2385262 | Q6Q783 | SV422_MOUSE | KMT | Chromatin-modifying enzymes / K-methyltransferases | Histone modification write | Histone methylation | # | # | histone | H4K20 | H4K20me3 | # | Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. (Annotated by similarity.) | # |
SUZ12
(details) |
17101 | SUZ12 polycomb repressive complex 2 subunit | 23512 (SSTAR profile) |
Q15022 | SUZ12_HUMAN | VEFS-Box PF09733 (548-680) | Suz12 | 1261758 | Q80U70 | SUZ12_MOUSE | ZNF | Zinc fingers, C2H2-type | Histone modification write cofactor, Histone modification write cofactor, Polycomb group (PcG) protein, TF | Histone methylation, Histone ubiquitination, TF repressor | 15385962 | PRC2 | DNA | DNA motif | # | 15385962 | SUZ12 is a recently identified Polycomb group (PcG) protein, which together with EZH2 and EED forms different Polycomb repressive complexes (PRC2/3). | # |
SYNCRIP
(details) |
16918 | synaptotagmin binding, cytoplasmic RNA interacting protein | 10492 (SSTAR profile) |
O60506 | HNRPQ_HUMAN | hnRNP_Q_AcD PF18360 (34-103) RRM_1 PF00076 (164-229, 245-307, 340-401) |
Syncrip | 1891690 | Q7TMK9 | HNRPQ_MOUSE | RBM | RNA binding motif (RRM) containing | RNA modification | mRNA editing | 11134005, 11352648 | APOB_mRNA_editosome | RNA | mRNA | # | 11134005, 11352648 | GRY-RBP =HNRPQ has been shown to bind to apobec-1, the catalytic component of apoB mRNA editosome, in vivo and in vitro. | # |
TADA1
(details) |
30631 | transcriptional adaptor 1 | 117143 (SSTAR profile) |
Q96BN2 | TADA1_HUMAN | SAGA-Tad1 PF12767 (7-107, 136-193) | Tada1 | 1196415 | Q99LM9 | TADA1_MOUSE | # | # | Histone chaperone | # | 11564863 | STAGA | histone | H2A | # | 11564863 | Within STAGA are two novel histone fold-containing protein subunits: STAF65γ, which is encoded by the KIAA0764 gene of previously unknown function, and STAF42=TADA1, a novel histone H2A-like protein. | # |
TADA2A
(details) |
11531 | transcriptional adaptor 2A | 6871 (SSTAR profile) |
O75478 | TAD2A_HUMAN | Myb_DNA-binding PF00249 (74-118) domain PF22941 (165-240) SWIRM PF04433 (375-440) |
Tada2a | 2144471 | Q8CHV6 | TAD2A_MOUSE | # | # | Histone modification read, TF | TF activator | 19103755 | PCAF, ATAC | histone | H3 | # | 19103755 | The SANT domain of c-Myb has been shown to bind histone H3 tails and position them for acetylation. The SANT domains in ADA2a=TADA2A and ZZZ3/ATAC1 might enable the complex to associate with nucleosome tails in order to potentiate the catalytic activities of GCN5 and ATAC2, similar to what has been shown for the SANT domains in yeast Ada2 and Swi3. | # |
TADA2B
(details) |
30781 | transcriptional adaptor 2B | 93624 (SSTAR profile) |
Q86TJ2 | TAD2B_HUMAN | Myb_DNA-binding PF00249 (68-112) domain PF22941 (164-237) |
Tada2b | 3035274 | # | # | # | # | Histone modification write cofactor | Histone acetylation | 17694077 | TFTC-HAT | histone | # | # | 17694077 | ADA2b =TADA2B is present in human STAGA/TFTC-type complexes. | # |
TADA3
(details) |
19422 | transcriptional adaptor 3 | 10474 (SSTAR profile) |
O75528 | TADA3_HUMAN | Ada3 PF10198 (311-418) | Tada3 | 1915724 | Q8R0L9 | TADA3_MOUSE | # | # | Histone modification write cofactor | Histone acetylation | 11773077 | PCAF, TFTC-HAT, ATAC, STAGA | histone | # | # | 11773077 | Ada2 potentiates the Gcn5 catalytic activity and Ada3 =TADA3 facilitates nucleosomal acetylation and an expanded lysine specificity. | # |
TAF1
(details) |
11535 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | 6872 (SSTAR profile) |
P21675 | TAF1_HUMAN | TBP-binding PF09247 (27-87) DUF3591 PF12157 (589-1050) zf-CCHC_6 PF15288 (1282-1324) Bromodomain PF00439 (1411-1492, 1538-1613) |
Taf1 | 1336878 | Q80UV9 | TAF1_MOUSE | KAT | Chromatin-modifying enzymes / K-acetyltransferases | Histone modification write | Histone acetylation | 11295558 | CHD8, MLL2/3, MLL4/WBP7 | histone | H3, H4 | H3ac, H4ac | 11295558 | TAFII250 has histone acetyltransferase (HAT) activity and can acetylate the tails of the core histones H3 and H4 in vitro. Both the N- and C-terminal kinase domains of TAFII250 are required for efficient transphosphorylation of RAP74 on serine residues. This suggests that the targeted phosphorylation of RAP74 by TAFII250 may provide a mechanism for signaling between components within the initiation complex to regulate transcription. | # |
TAF10
(details) |
11543 | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa | 6881 (SSTAR profile) |
Q12962 | TAF10_HUMAN | TFIID_30kDa PF03540 (128-177) | Taf10 | 1346320 | Q8K0H5 | TAF10_MOUSE | # | # | Histone chaperone, Histone modification write | Histone acetylation | 15099517 | PCAF, TFTC-HAT, SAGA, STAGA | histone | H3, H4 | # | 15099517 | SET9 can monomethylate the TBP-associated factor TAF10 at a single lysine residue located at the loop 2 region within the putative histone-fold domain of the protein. | # |
TAF12
(details) |
11545 | TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa | 6883 (SSTAR profile) |
Q16514 | TAF12_HUMAN | TFIID_20kDa PF03847 (59-126) | Taf12 | 1913714 | Q8VE65 | TAF12_MOUSE | # | # | Histone chaperone, Histone modification write | Histone acetylation | 10594036 | PCAF, STAGA | histone | # | # | 10594036 | Heterodimerization requires the alpha2 and alpha3 helices of the hTAF(II)20 histone fold and is abolished by mutations in the hydrophobic face of the hTAF(II)20 alpha2 helix. Interaction with hTAF(II)20 requires a domain of hTAF(II)135 which shows sequence homology to H2A. | # |
TAF1L
(details) |
18056 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like | 138474 (SSTAR profile) |
Q8IZX4 | TAF1L_HUMAN | TBP-binding PF09247 (26-86) DUF3591 PF12157 (583-1047) zf-CCHC_6 PF15288 (1278-1322) Bromodomain PF00439 (1409-1488, 1536-1612) |
# | # | # | # | # | # | Histone modification read | # | 22464331 | # | histone | H1.4ac, H2Aac, H2Bac, H3ac, H4ac | # | 22464331 | Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro). | # |
TAF2
(details) |
11536 | TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa | 6873 (SSTAR profile) |
Q6P1X5 | TAF2_HUMAN | () | Taf2 | 2443028 | Q8C176 | TAF2_MOUSE | # | # | TF | # | # | TFTC-HAT | DNA | DNA motif | # | # | Added because it is a complex partner | # |
TAF3
(details) |
17303 | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa | 83860 (SSTAR profile) |
Q5VWG9 | TAF3_HUMAN | Bromo_TP PF07524 (4-79) PHD PF00628 (867-912) |
Taf3 | 2388097 | Q5HZG4 | TAF3_MOUSE | PHF | Zinc fingers, PHD-type | Histone modification read | # | 21423274 | # | histone | H3K4me | # | 21423274 | Table 1 in the reference. | # |
TAF4
(details) |
11537 | TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa | 6874 (SSTAR profile) |
O00268 | TAF4_HUMAN | TAFH PF07531 (592-680) TAF4 PF05236 (833-1082) |
# | # | # | # | # | # | Histone chaperone | # | 10594036 | TFTC-HAT, CHD8, MLL2/3, MLL4/WBP7 | histone | # | # | 10594036 | The histone fold region of hTAFII135 is required for coactivator activity in mammalian cells. | # |
TAF5
(details) |
11539 | TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa | 6877 (SSTAR profile) |
Q15542 | TAF5_HUMAN | TFIID_NTD2 PF04494 (210-340) WD40 PF00400 (466-498, 535-571, 577-612, 618-655, 660-697, 703-739) |
Taf5 | 2442144 | Q8C092 | TAF5_MOUSE | WDR | WD repeat domain containing | Histone modification write cofactor | Histone acetylation | 10373431 | TFTC-HAT | histone | # | # | 10373431 | TFTC, similar to other TBP-free TAFII complexes (yeast SAGA, hSTAGA, and hPCAF) contains the acetyltransferase hGCN5 and is able to acetylate histones in both a free and a nucleosomal context. A monoclonal antibody raised against hTAFII100 recognized hTAFII100=TAF5 not only in TFTC, but detected also a weak band in the PCAF complex. | # |
TAF5L
(details) |
17304 | TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa | 27097 (SSTAR profile) |
O75529 | TAF5L_HUMAN | TFIID_NTD2 PF04494 (66-196) WD40 PF00400 (269-296, 334-370, 379-412, 418-454, 459-496, 501-538) |
Taf5l | 1919039 | Q91WQ5 | TAF5L_MOUSE | WDR | WD repeat domain containing | Histone modification write cofactor | Histone acetylation | 10373431 | PCAF, TFTC-HAT, STAGA | histone | # | # | 10373431 | The PCAF complex contains hPAF65β=TAF5L, a WD40 repeat-containing factor having similarity to Htafii100(row=423) (5). Antibodies raised against hPAF65β revealed a band around 65 kDa in both the PCAF and the TFTC complexes. | # |
TAF6
(details) |
11540 | TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa | 6878 (SSTAR profile) |
P49848 | TAF6_HUMAN | TAF PF02969 (12-76) TAF6_C PF07571 (214-399) |
Taf6 | 109129 | Q62311 | TAF6_MOUSE | # | # | Histone chaperone | # | 9611234 | TFTC-HAT, CHD8, MLL2/3, MLL4/WBP7 | DNA | # | # | 9611234 | The N-CoR/Sin3/HDAc complexes have a key role in the regulation of cellular proliferation and differentiation. N-CoR interacts directly with each of the basal factors, TFIIB and TAFII70 (=TAF6). | # |
TAF6L
(details) |
17305 | TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa | 10629 (SSTAR profile) |
Q9Y6J9 | TAF6L_HUMAN | TAF PF02969 (10-73) TAF6_C PF07571 (155-327) |
Taf6l | 2444957 | Q8R2K4 | TAF6L_MOUSE | # | # | Histone chaperone | # | 12601814 | PCAF, TFTC-HAT, STAGA | histone | # | # | 12601814 | Human PAF65-alpha shows a strong sequence homology to TAFII80 and also contains a putative HFD. Thus, PAF65-alpha may also interact with TAFII32 in the TFTC complex. | # |
TAF7
(details) |
11541 | TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa | 6879 (SSTAR profile) |
Q15545 | TAF7_HUMAN | TAFII55_N PF04658 (13-176) | Taf7 | 1346348 | Q9R1C0 | TAF7_MOUSE | # | # | Histone modification write cofactor, Histone modification write cofactor | Histone methylation, Histone acetylation | 22711989 | CHD8, MLL2/3, MLL4/WBP7 | histone | # | # | 22711989 | The largest transcription factor IID (TFIID) subunit, TBP-associated factor 1 (TAF1), possesses protein kinase and histone acetyltransferase (HAT) activities. | # |
TAF8
(details) |
17300 | TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa | 129685 (SSTAR profile) |
Q7Z7C8 | TAF8_HUMAN | Bromo_TP PF07524 (32-105) TAF8_C PF10406 (146-195) |
Taf8 | 1926879 | Q9EQH4 | TAF8_MOUSE | # | # | Histone chaperone | # | 17375202 | # | histone | # | # | 17375202 | Present in a small TAF complex (SMAT), containing TAF8, TAF10 and SPT7L. | # |
TAF9
(details) |
11542 | TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa | 6880 (SSTAR profile) |
Q16594 | TAF9_HUMAN | TFIID-31kDa PF02291 (10-130) | Taf9 | 1888697 | Q8VI33 | TAF9_MOUSE | # | # | Histone chaperone | # | 9674425 | PCAF, STAGA, CHD8, MLL2/3, MLL4/WBP7 | DNA | # | # | 9674425 | Histone-like TAFs, including TAFII31 =TAF9, are found within the PCAF histone acetylase complex. | # |
TAF9B
(details) |
17306 | TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa | 51616 (SSTAR profile) |
Q9HBM6 | TAF9B_HUMAN | TFIID-31kDa PF02291 (10-130) | Taf9b | 3039562 | Q6NZA9 | TAF9B_MOUSE | # | # | Histone chaperone | # | 15899866 | TFTC-HAT | histone | # | # | 15899866 | TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9. | # |
TBL1XR1
(details) |
29529 | transducin (beta)-like 1 X-linked receptor 1 | 79718 (SSTAR profile) |
Q9BZK7 | TBL1R_HUMAN | LisH PF08513 (6-32) WD40 PF00400 (164-197, 226-252, 258-294, 340-377, 382-428, 432-470) |
Tbl1xr1 | 2441730 | Q8BHJ5 | TBL1R_MOUSE | WDR | WD repeat domain containing | # | # | 15601853 | # | histone | # | # | # | Targets Ncor repressive complex to deacethylated histones. | # |
TDG
(details) |
11700 | thymine-DNA glycosylase | 6996 (SSTAR profile) |
Q13569 | TDG_HUMAN | UDG PF03167 (129-288) | Tdg | 108247 | P56581 | TDG_MOUSE | # | # | DNA modification | DNA hydroxymethylation | 22962365 | # | DNA | G:U, G:T, G:hmU | C, 5mC, 5hmC | 22962365 | The mammalian thymine DNA glycosylase (TDG) is implicated in active DNA demethylation via the base excision repair pathway. | # |
TDRD3
(details) |
20612 | tudor domain containing 3 | 81550 (SSTAR profile) |
Q9H7E2 | TDRD3_HUMAN | RMI1_N_C PF08585 (1-72) domain PF22562 (195-233) TUDOR PF00567 (555-611) |
Tdrd3 | 2444023 | Q91W18 | TDRD3_MOUSE | TDRD | Tudor domain containing | Histone modification read | # | 21172665 | # | histone | H3R17me2a, H4R3me2a | # | 21172665 | TDRD3 is an effector molecule for arginine-methylated histone marks. | # |
TDRD7
(details) |
30831 | tudor domain containing 7 | 23424 (SSTAR profile) |
Q8NHU6 | TDRD7_HUMAN | OST-HTH PF12872 (7-72, 236-274) TUDOR PF00567 (462-582, 653-775, 912-1026) |
Tdrd7 | 2140279 | Q8K1H1 | TDRD7_MOUSE | TDRD | Tudor domain containing | Histone modification read | # | 21423274 | # | histone | H3K9 | # | 21423274 | Table 1 in the reference. | # |
TDRKH
(details) |
11713 | tudor and KH domain containing | 11022 (SSTAR profile) |
Q9Y2W6 | TDRKH_HUMAN | KH_1 PF00013 (54-116, 126-190) TUDOR PF00567 (305-423) |
Tdrkh | 1919884 | Q80VL1 | TDRKH_MOUSE | TDRD | Tudor domain containing | RNA modification | # | 23714778 | # | RNA | piRNA | # | 23714778 | Piwi proteins and Piwi-interacting RNAs (piRNAs) repress transposition, regulate translation, and guide epigenetic programming in the germline. The evolutionarily conserved Tudor and KH domain-containing protein, Tdrkh (a.k.a. Tdrd2), is required for spermatogenesis and involved in piRNA biogenesis, the primary piRNA biogenesis pathway involves 3'→5' processing of 31-37 nt intermediates and that Tdrkh promotes this final step of piRNA biogenesis but not the ping-pong cycle. | # |
TET1
(details) |
29484 | tet methylcytosine dioxygenase 1 | 80312 (SSTAR profile) |
Q8NFU7 | TET1_HUMAN | zf-CXXC PF02008 (585-625) Tet_JBP PF12851 (1580-2051) |
Tet1 | 1098693 | Q3URK3 | TET1_MOUSE | # | # | DNA modification | DNA hydroxymethylation | 23222540 | # | DNA | mC | hmC | 23222540 | Ten eleven translocation (TET) enzymes, including TET1, TET2 and TET3, convert 5-methylcytosine to 5-hydroxymethylcytosine and regulate gene transcription. | # |
TET2
(details) |
25941 | tet methylcytosine dioxygenase 2 | 54790 (SSTAR profile) |
Q6N021 | TET2_HUMAN | Tet_JBP PF12851 (1290-1904) | Tet2 | 2443298 | Q4JK59 | TET2_MOUSE | # | # | DNA modification | DNA hydroxymethylation | 23222540 | # | DNA | mC | hmC | 23222540 | Ten eleven translocation (TET) enzymes, including TET1, TET2 and TET3, convert 5-methylcytosine to 5-hydroxymethylcytosine and regulate gene transcription. Downregulation of TET2 reduces the amount of histone 2B Ser 112 GlcNAc marks in vivo, which are associated with gene transcription regulation. | # |
TET3
(details) |
28313 | tet methylcytosine dioxygenase 3 | 200424 (SSTAR profile) |
O43151 | TET3_HUMAN | zf-CXXC PF02008 (52-90) Tet_JBP PF12851 (986-1697) |
Tet3 | 2446229 | Q8BG87 | TET3_MOUSE | # | # | DNA modification | DNA hydroxymethylation | 23222540 | # | DNA | mC | hmC | 23222540 | Ten eleven translocation (TET) enzymes, including TET1, TET2 and TET3, convert 5-methylcytosine to 5-hydroxymethylcytosine and regulate gene transcription. There is a direct interaction of TET2 and TET3 with O-GlcNAc transferase (OGT). | # |
TEX10
(details) |
25988 | testis expressed 10 | 54881 (SSTAR profile) |
Q9NXF1 | TEX10_HUMAN | Ipi1_N PF12333 (134-239) | Tex10 | 1344413 | Q3URQ0 | TEX10_MOUSE | # | # | Histone modification write cofactor, Histone modification write cofactor | Histone methylation, Histone acetylation | # | CHD8, MLL2/3, MLL4/WBP7 | histone | # | # | 22872859 | - | # |
TFDP1
(details) |
11749 | transcription factor Dp-1 | 7027 (SSTAR profile) |
Q14186 | TFDP1_HUMAN | E2F_TDP PF02319 (113-193) DP PF08781 (200-338) |
Tfdp1 | 101934 | Q08639 | TFDP1_MOUSE | # | # | Histone modification | # | 24217316, 22325352 | RING2-L3MBTL2 | histone | # | # | 24217316, 22325352 | Part of a RING2 complex. | # |
TFPT
(details) |
13630 | TCF3 (E2A) fusion partner (in childhood Leukemia) | 29844 (SSTAR profile) |
P0C1Z6 | TFPT_HUMAN | () | Tfpt | 1916964 | Q3U1J1 | TFPT_MOUSE | INO80 | INO80 complex subunits | Chromatin remodeling cofactor, DNA modification | DNA hydroxymethylation | 16230350 | Ino80 | chromatin | # | # | 16230350 | Subunit Composition of the hINO80 Complex: These proteins included the “Pim-1 kinase-associated protein-associated protein 1” (PAPA-1, GI 13775202), Amida (also known as TCF3 =TFPT). | # |
THRAP3
(details) |
22964 | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | 9967 (SSTAR profile) |
Q9Y2W1 | TR150_HUMAN | THRAP3_BCLAF1 PF15440 (107-862) | Tr150 | 2442637 | Q569Z6 | TR150_MOUSE | # | # | RNA modification | RNA degradation | 20123736 | # | RNA | mRNA | # | 20123736 | Mediates nuclear mRNA degradation | New |
TLE1
(details) |
11837 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | 7088 (SSTAR profile) |
Q04724 | TLE1_HUMAN | TLE_N PF03920 (18-132) WD40 PF00400 (477-511, 531-558, 577-602, 607-644, 692-725, 739-766) |
Tle1 | 104636 | Q62440 | TLE1_MOUSE | WDR | WD repeat domain containing | Chromatin remodeling, Histone modification cofactor | # | 9334241, 17041588 | # | histone | H3 | # | 9334241, 17041588 | Native Groucho/TLE proteins interact specifically with histone H3 and not with other core histones. | # |
TLE2
(details) |
11838 | transducin-like enhancer of split 2 | 7089 (SSTAR profile) |
Q04725 | TLE2_HUMAN | TLE_N PF03920 (18-130) WD40 PF00400 (450-484, 504-531, 550-575, 580-617, 665-698, 712-739) |
Tle2 | 104635 | Q9WVB2 | TLE2_MOUSE | WDR | WD repeat domain containing | Histone modification cofactor | # | 17041588 | # | histone | H3 | H3K4, H3K9, H3K27me | 17041588 | CUL4-DDB1 complexes interact with multiple WD40-repeat proteins (WDRs) including TLE1-3, WDR5, L2DTL (also known as CDT2) and the Polycomb-group protein EED (also known as ESC). WDR5 and EED are core components of histone methylation complexes that are essential for histone H3 methylation and epigenetic control at K4 or K9 and K27, respectively. | # |
TLE4
(details) |
11840 | transducin-like enhancer of split 4 | 7091 (SSTAR profile) |
Q04727 | TLE4_HUMAN | TLE_N PF03920 (24-138) WD40 PF00400 (480-514, 534-561, 580-605, 610-647, 695-728, 742-769) |
Tle4 | 104633 | Q62441 | TLE4_MOUSE | WDR | WD repeat domain containing | Histone modification erase cofactor, TF | # | 24190972 | # | histone | H3ac, H4ac | # | 24190972 | Tle4 is the transcriptional repressor responsible for the establishment of the epigenetic repressive marks at the Ifng locus that result in silencing of Ifng gene expression. Tle proteins have been shown to oligomerize, to associate with amino-terminal domains of histone-modifying proteins, and to form higher-order structures as parts of repressive complexes. | # |
TLK1
(details) |
11841 | tousled-like kinase 1 | 9874 (SSTAR profile) |
Q9UKI8 | TLK1_HUMAN | Pkinase PF00069 (458-734) | Tlk1 | 2441683 | Q8C0V0 | TLK1_MOUSE | # | # | Histone modification write | Histone phosphorylation | 11314006 | # | histone | H3S10 | H3S10ph | 11314006 | Purified TLK1B phosphorylates histone H3 at S(10) with high specificity both in a mix of core histones and in isolated chromatin, suggesting that histone H3 is a physiological substrate for TLK1B. | # |
TLK2
(details) |
11842 | tousled-like kinase 2 | 11011 (SSTAR profile) |
Q86UE8 | TLK2_HUMAN | Pkinase PF00069 (464-741) | Tlk2 | 1346023 | O55047 | TLK2_MOUSE | # | # | Histone modification write | Histone phosphorylation | 12660173 | # | chromatin | # | # | 12660173 | There is a functional co-operation between ATM and Chk1 in propagation of a checkpoint response during S phase, suggesting that, through transient inhibition of Tlk kinases, the ATM-Chk1-Tlk pathway may regulate processes involved in chromatin assembly. | # |
TNP1
(details) |
11951 | transition protein 1 (during histone to protamine replacement) | 7141 (SSTAR profile) |
P09430 | STP1_HUMAN | TP1 PF02079 (1-53) | Tnp1 | 98784 | P10856 | STP1_MOUSE | # | # | Chromatin remodeling | # | 12743712 | # | chromatin | # | # | 12743712 | Distinct roles for the two major transition nuclear proteins, TP1 = STP1 and TP2 = STP2, in histone displacement, sperm nuclear shaping, chromatin condensation, and maintenance of DNA integrity have been proposed. | # |
TNP2
(details) |
11952 | transition protein 2 (during histone to protamine replacement) | 7142 (SSTAR profile) |
Q05952 | STP2_HUMAN | TP2 PF01254 (1-136) | Tnp2 | 98785 | P11378 | STP2_MOUSE | # | # | Chromatin remodeling | # | 12743712 | # | chromatin | # | # | 12743712 | Distinct roles for the two major transition nuclear proteins, TP1 = STP1 and TP2 = STP2, in histone displacement, sperm nuclear shaping, chromatin condensation, and maintenance of DNA integrity have been proposed. | # |
TONSL
(details) |
7801 | tonsoku-like, DNA repair protein | 4796 (SSTAR profile) |
Q96HA7 | TONSL_HUMAN | TPR_8 PF13181 (202-235) domain PF13176 (311-344) Ank_2 PF12796 (529-628) LRR_6 PF13516 (1097-1120, 1128-1151, 1248-1271) |
Tonsl | 1919999 | Q6NZL6 | TONSL_MOUSE | ANKRD | Ankyrin repeat domain containing | Chromatin remodeling | # | 21113133 | # | histone | # | # | 21113133 | Mms22L associates with Nfkbil2 =TONSL, which may function as a scaffolding unit to bridge chromatin to multiple protein complexes. | # |
TOP2A
(details) |
11989 | topoisomerase (DNA) II alpha 170kDa | 7153 (SSTAR profile) |
P11388 | TOP2A_HUMAN | HATPase_c PF02518 (80-176) DNA_gyraseB PF00204 (265-425) Toprim PF01751 (456-562) TOPRIM_C PF16898 (574-711) DNA_topoisoIV PF00521 (713-1171) DTHCT PF08070 (1231-1511) |
Top2a | 98790 | Q01320 | TOP2A_MOUSE | # | # | Chromatin remodeling | # | 11062478 | # | DNA | DNA | # | 11062478 | Histone deacetylase interacts directly with DNA topoisomerase II. | # |
TOP2B
(details) |
11990 | topoisomerase (DNA) II beta 180kDa | 7155 (SSTAR profile) |
Q02880 | TOP2B_HUMAN | HATPase_c PF02518 (101-197) DNA_gyraseB PF00204 (286-447) Toprim PF01751 (477-583) TOPRIM_C PF16898 (594-731) DNA_topoisoIV PF00521 (734-1193) DTHCT PF08070 (1447-1626) |
Top2b | 98791 | Q64511 | TOP2B_MOUSE | # | # | Chromatin remodeling | # | 11062478 | WINAC | chromatin | # | # | 11062478 | Histone deacetylase interacts directly with DNA topoisomerase II. | # |
TP53
(details) |
11998 | tumor protein p53 | 7157 (SSTAR profile) |
P04637 | P53_HUMAN | P53_TAD PF08563 (13-33) TAD2 PF18521 (23-55) P53 PF00870 (101-288) P53_tetramer PF07710 (323-357) |
Trp53 | 98834 | P02340 | P53_MOUSE | # | # | Histone modification write cofactor, TF | Histone acetylation, TF activator, TF repressor | 23870121 | # | histone | H3 | # | 23870121 | SET1 complex (SET1C)-mediated H3K4 trimethylation is dependent upon p53- and p300-mediated H3 acetylation. Complementary cell-based assays demonstrate a DNA-damage-induced p53-SET1C interaction, a corresponding enrichment of SET1C and H3K4me3 on a p53 target gene (p21/WAF1), and a corresponding codependency of H3K4 trimethylation and transcription upon p300 and SET1C. | # |
TP53BP1
(details) |
11999 | tumor protein p53 binding protein 1 | 7158 (SSTAR profile) |
Q12888 | TP53B_HUMAN | 53-BP1_Tudor PF09038 (1481-1604) BRCT_3 PF18428 (1866-1968) |
Trp53bp1 | 1351320 | P70399 | TP53B_MOUSE | # | # | Histone modification read | # | 15525939 | # | histone | H4K79me2, H4K20me2 | # | 15525939 | In vitro, the 53BP1 =TP53BP1 tandem tudor domain binds histone H3 methylated on Lys 79 using residues that form the walls of the pocket; these residues are also required for recruitment of 53BP1 to DSBs. | # |
TRA2B
(details) |
10781 | Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B) | 6434 (SSTAR profile) |
P62995 | TRA2B_HUMAN | RRM_1 PF00076 (122-190) | Tra2B | 106016 | P62996 | TRA2B_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 12165565 | # | RNA | mRNA | # | 12165565 | Promotes exon 7 inclusion of SMN | New |
TRIM16
(details) |
17241 | tripartite motif containing 16 | 10626 (SSTAR profile) |
O95361 | TRI16_HUMAN | zf-B_box PF00643 (127-165) PRY PF13765 (375-424) SPRY PF00622 (426-543) |
Trim16 | 2137356 | Q99PP9 | TRI16_MOUSE | TRIM | Tripartite motif containing / Tripartite motif containing | Histone modification write | Histone acetylation | 19147277, 20729920 | # | histone, DNA | # | # | # | Overexpression of this gene increases histone acetylation. TRIM16 has been identified as a DNA-binding protein with histone acetylase activity. | # |
TRIM24
(details) |
11812 | tripartite motif containing 24 | 8805 (SSTAR profile) |
O15164 | TIF1A_HUMAN | zf-B_box PF00643 (221-258) PHD PF00628 (829-870) Bromodomain PF00439 (908-989) |
Trim24 | 109275 | Q64127 | TIF1A_MOUSE | TRIM, RNF, PHF | Tripartite motif containing / Tripartite motif containing, RING-type (C3HC4) zinc fingers, Zinc fingers, PHD-type | Histone modification read | # | 22464331 | # | histone | H3K4, H3K23ac | # | 21164480 | Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac) (UniProt). | # |
TRIM27
(details) |
9975 | tripartite motif containing 27 | 5987 (SSTAR profile) |
P14373 | TRI27_HUMAN | zf-C3HC4_4 PF15227 (16-56) zf-B_box PF00643 (93-132) PRY PF13765 (318-366) SPRY PF00622 (370-482) |
Trim27 | 97904 | Q62158 | TRI27_MOUSE | TRIM, RNF | Tripartite motif containing / Tripartite motif containing, RING-type (C3HC4) zinc fingers | Histone modification erase cofactor | Histone acetylation | 19351825 | # | # | # | # | # | The recruitment of HDAC1 to the TBP-2 promoter is mediated by a protein complex consisting of RET finger protein (RFP; also called TRIM27) and the trimeric transcription factor NF-Y. | # |
TRIM28
(details) |
16384 | tripartite motif containing 28 | 10155 (SSTAR profile) |
Q13263 | TIF1B_HUMAN | zf-RING_5 PF14634 (65-122) zf-B_box PF00643 (149-195, 207-245) PHD PF00628 (628-669) |
Trim28 | 109274 | Q62318 | TIF1B_MOUSE | TRIM, RNF, PHF | Tripartite motif containing / Tripartite motif containing, RING-type (C3HC4) zinc fingers, Zinc fingers, PHD-type | Histone modification read | # | 22464331 | # | histone | H3 | # | 22464331 | Fig. 5 in the reference. | # |
TRIM33
(details) |
16290 | tripartite motif containing 33 | 51592 (SSTAR profile) |
Q9UPN9 | TRI33_HUMAN | zf-B_box PF00643 (274-310) PHD PF00628 (890-931) Bromodomain PF00439 (967-1046) |
Trim33 | 2137357 | Q99PP7 | TRI33_MOUSE | TRIM, PHF, RNF | Tripartite motif containing / Tripartite motif containing, Zinc fingers, PHD-type, RING-type (C3HC4) zinc fingers | Histone modification read | # | 23926104 | # | histone | H3K9me3, H3K18ac | # | 23926104 | TRIM33 helps recruit SMAD2/3 to chromatin via interaction of its PHD and Bromo domains with histone H3 trimethylated at lysine 9 (H3K9me3) and histone H3 acetylated at lysine 18 (H3K18ac), respectively. | # |
TRRAP
(details) |
12347 | transformation/transcription domain-associated protein | 8295 (SSTAR profile) |
Q9Y4A5 | TRRAP_HUMAN | Tra1_central PF20175 (240-895) Tra1_ring PF20206 (1003-2695) FAT PF02259 (2851-3201) PI3_PI4_kinase PF00454 (3531-3782) |
Trrap | 2153272 | Q80YV3 | TRRAP_MOUSE | # | # | Histone modification write cofactor | Histone acetylation | 14966270 | SWR, PCAF, TFTC-HAT, NuA4, SAGA, NuA4-related complex, STAGA | histone | # | # | 14966270 | The complex(es) contain(s) other subunits shared with NuA4, including TRRAP, p400/hDomino, Brd8. | # |
TRUB2
(details) |
17170 | Mitochondrial mRNA pseudouridine synthase TRUB2 (EC 5.4.99.-) | 26995 (SSTAR profile) |
O95900 | TRUB2-HUMAN | TruB_N PF01509 (88-231) | Trub2 | 2442186 | Q91WG3 | TRUB2_MOUSE | Pseudouridine synthases | Pseudouridine synthases | RNA modification | RNA pseudouridinilation | 27974379 | # | RNA | mt--mRNA | U | 27974379 | Pseudouridinilation of mitochondrial mRNA | New |
TSSK6
(details) |
30410 | testis-specific serine kinase 6 | 83983 (SSTAR profile) |
Q9BXA6 | TSSK6_HUMAN | Pkinase PF00069 (12-267) | Tssk6 | 2148775 | Q925K9 | TSSK6_MOUSE | # | # | Histone modification write | Histone phosphorylation | 15870294 | # | histone | H1, H2A, H2AX, H3 | # | # | Phosphorylates histones H1, H2A, H2AX, and H3 but not H2B or H4 in vitro. | # |
TTK
(details) |
12401 | TTK protein kinase | 7272 (SSTAR profile) |
P33981 | TTK_HUMAN | Pkinase PF00069 (525-791) | Ttk | 1194921 | P35761 | TTK_MOUSE | # | # | Histone modification write cofactor | Histone phosphorylation | 22732840 | # | histone | H2AT120 | H2AT120ph | 22732840 | Mps1 = TTK activity enhances H2A‐T120ph and is critical for Sgo1 recruitment to centromeres, thereby promoting Aurora B centromere recruitment in early mitosis. | # |
TYW5
(details) |
26754 | tRNA-yW synthesizing protein 5 | 129450 (SSTAR profile) |
A2RUC4 | TYW5_HUMAN | Cupin_8 PF13621 (17-254) | Tyw5 | 1915986 | A2RSX7 | TYW5_MOUSE | # | # | RNA modification | # | 20972222 | # | RNA | # | # | 20972222 | Functional analyses of structure-based mutants have revealed the essential Arg residues participating in tRNA recognition by TYW5. These findings extend the repertoire of the tRNA modification enzyme into the Fe(II)/2-OG oxygenase superfamily. | # |
U2AF2
(details) |
23156 | Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit) | 11338 (SSTAR profile) |
P26368 | U2AF2_HUMAN | RRM_1 PF00076 (151-225, 261-330, 400-459) | U2Af2 | 98886 | P26369 | U2AF2_MOUSE | RBM | RNA binding motif containing | RNA modification | Alternative splicing | 17579712, 16452196 | # | RNA | mRNA | # | 17579712, 16452196 | Regulates alternative splcing of FIR | New |
UBE2A
(details) |
12472 | ubiquitin-conjugating enzyme E2A | 7319 (SSTAR profile) |
P49459 | UBE2A_HUMAN | UQ_con PF00179 (8-143) | Ube2a | 102959 | Q9Z255 | UBE2A_MOUSE | UBE2 | Ubiquitin-conjugating enzymes E2 | Histone modification write | Histone ubiquitination | 8797826 | # | histone | H2A, H2BK120 | H2BK120ub1 | 8797826 | RAD6 (=UBE2) has been identified as the first ubiquitin-conjugating enzyme, able to mono- and polyubiquitinate histones 2A and 2B in vitro. | # |
UBE2B
(details) |
12473 | ubiquitin-conjugating enzyme E2B | 7320 (SSTAR profile) |
P63146 | UBE2B_HUMAN | UQ_con PF00179 (7-143) | Ube2b | 102944 | P63147 | UBE2B_MOUSE | UBE2 | Ubiquitin-conjugating enzymes E2 | Histone modification write | Histone ubiquitination | 8797826 | # | histone | H2A, H2BK121 | H2BK120ub2 | 8797826 | RAD6 (=UBE2) has been identified as the first ubiquitin-conjugating enzyme, able to mono- and polyubiquitinate histones 2A and 2B in vitro. | # |
UBE2D1
(details) |
12474 | ubiquitin-conjugating enzyme E2D 1 | 7321 (SSTAR profile) |
P51668 | UB2D1_HUMAN | UQ_con PF00179 (5-141) | Ube2d1 | 2384911 | P61080 | UB2D1_MOUSE | UBE2 | Ubiquitin-conjugating enzymes E2 | Histone modification write | Histone ubiquitination | 22438555 | # | histone | H2BK48 | H2BK48ub | 22438555 | Ubiquitination of TP53. | # |
UBE2D3
(details) |
12476 | ubiquitin-conjugating enzyme E2D 3 | 7323 (SSTAR profile) |
P61077 | UB2D3_HUMAN | UQ_con PF00179 (5-141) | Ube2d3 | 1913355 | P61079 | UB2D3_MOUSE | UBE2 | Ubiquitin-conjugating enzymes E2 | Histone modification write | Histone ubiquitination | 21772249 | # | histone | H2AK119 | H2AK119ub | 21772249 | Figure 7 in the reference (UBE2D3 =UbcH5c). | # |
UBE2E1
(details) |
12477 | ubiquitin-conjugating enzyme E2E 1 | 7324 (SSTAR profile) |
P51965 | UB2E1_HUMAN | UQ_con PF00179 (51-187) | Ube2e1 | 107411 | P52482 | UB2E1_MOUSE | UBE2 | Ubiquitin-conjugating enzymes E2 | Histone modification write | Histone ubiquitination | 16307923 | # | histone | H2BK120 | H2BK120ub | 16307923 | The human RNF20/40 complex functions as the E3 ligase and UbcH6 (=UBE2E1) as the ubiquitin E2-conjugating enzyme for histone H2B-K120 monoubiquitination. | # |
UBE2H
(details) |
12484 | ubiquitin-conjugating enzyme E2H | 7328 (SSTAR profile) |
P62256 | UBE2H_HUMAN | UQ_con PF00179 (30-144) | Ube2h | 104632 | P62257 | UBE2H_MOUSE | UBE2 | Ubiquitin-conjugating enzymes E2 | Histone modification write | Histone ubiquitination | 8132613 | # | histone | H2A, H2B | H2Aub, H2Bub | 8132613 | The capacity of the UBC8I UbcH2 enzymes to ubiquitinate histones in vitro raises makes it possible that these enzymes may be involved in this process in vivo. | # |
UBE2N
(details) |
12492 | ubiquitin-conjugating enzyme E2N | 7334 (SSTAR profile) |
P61088 | UBE2N_HUMAN | UQ_con PF00179 (7-143) | Ube2n | 1934835 | P61089 | UBE2N_MOUSE | UBE2 | Ubiquitin-conjugating enzymes E2 | Histone modification write | Histone ubiquitination | 17709392 | # | histone | H2AX | H2AXub | 17709392 | TIP60 regulates the ubiquitination of H2AX via the ubiquitin-conjugating enzyme UBC13 (=UBE2N), which is induced by DNA damage. | # |
UBE2T
(details) |
25009 | ubiquitin-conjugating enzyme E2T (putative) | 29089 (SSTAR profile) |
Q9NPD8 | UBE2T_HUMAN | UQ_con PF00179 (6-146) | Ube2t | 1914446 | Q9CQ37 | UBE2T_MOUSE | UBE2 | Ubiquitin-conjugating enzymes E2 | Histone modification write | Histone ubiquitination | 17938197 | # | histone | # | # | 17938197 | histone | # |
UBN1
(details) |
12506 | ubinuclein 1 | 29855 (SSTAR profile) |
Q9NPG3 | UBN1_HUMAN | HUN PF08729 (118-170) UBN_AB PF14075 (346-567) |
Ubn1 | 1891307 | Q4G0F8 | UBN1_MOUSE | # | # | Histone modification write cofactor | Histone methylation | 19029251, 21807893 | # | histone | # | # | # | Binds to proliferation-promoting genes and associates with histone methyltransferase activity that methylates lysine 9 of histone H3. Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex. | # |
UBR2
(details) |
21289 | ubiquitin protein ligase E3 component n-recognin 2 | 23304 (SSTAR profile) |
Q8IWV8 | UBR2_HUMAN | zf-UBR PF02207 (99-167) ClpS PF02617 (222-301) domain PF22960 (778-872) PRT6_C PF18995 (1309-1729) |
Ubr2 | 1861099 | Q6WKZ8 | UBR2_MOUSE | UBR | Ubiquitin protein ligase E3 component n-recognins | Histone modification write | Histone ubiquitination | # | # | histone | H2A | # | # | Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. (Annotated by similarity.) | # |
UBR5
(details) |
16806 | ubiquitin protein ligase E3 component n-recognin 5 | 51366 (SSTAR profile) |
O95071 | UBR5_HUMAN | E3_UbLigase_EDD PF11547 (183-228) PABP PF00658 (2391-2450) HECT PF00632 (2505-2799) |
Ubr5 | 1918040 | Q80TP3 | UBR5_MOUSE | UBR | Ubiquitin protein ligase E3 component n-recognins | Chromatin remodeling, Histone modification write cofactor | Histone ubiquitination | 22884692 | # | histone | H2A, H2AX | H2Aub, H2AXub | 22884692 | Excessive spreading of a DNA-damage-associated chromatin modification can occur. TRIP12 and UBR5 are two suppressors of such spreading. | # |
UBR7
(details) |
20344 | ubiquitin protein ligase E3 component n-recognin 7 (putative) | 55148 (SSTAR profile) |
Q8N806 | UBR7_HUMAN | zf-UBR PF02207 (46-112) | Ubr7 | 1913872 | Q8BU04 | UBR7_MOUSE | UBR | Ubiquitin protein ligase E3 component n-recognins | DNA modification cofactor | DNA methylation | 21745816 | # | DNA | # | # | 21745816 | Part of the DNMT1/USP7/UHRF1 complex which increases DNA methylation efficiency. | # |
UCHL5
(details) |
19678 | ubiquitin carboxyl-terminal hydrolase L5 | 51377 (SSTAR profile) |
Q9Y5K5 | UCHL5_HUMAN | Peptidase_C12 PF01088 (8-209) UCH_C PF18031 (265-309) |
Uchl5 | 1914848 | Q9WUP7 | UCHL5_MOUSE | INO80 | INO80 complex subunits | Histone modification erase cofactor | Histone ubiquitination | 18922472 | Ino80 | histone | # | # | 18922472 | Deubiquitination by Uch37 is activated by proteasomal binding, which enables Uch37 to process polyubiquitin chains. In the nucleus Uch37 is also associated with the human Ino80 chromatin-remodeling complex (hINO80). In hINO80, Uch37 is held in an inactive state; however, it can be activated by transient interaction of the Ino80 complex with the proteasome. | # |
UHRF1
(details) |
12556 | ubiquitin-like with PHD and ring finger domains 1 | 29128 (SSTAR profile) |
Q96T88 | UHRF1_HUMAN | ubiquitin PF00240 (2-75) TTD PF12148 (133-285) PHD PF00628 (318-363) SAD_SRA PF02182 (417-585) |
Uhrf1 | 1338889 | Q8VDF2 | UHRF1_MOUSE | RNF | RING-type (C3HC4) zinc fingers | Histone modification read, Histone modification write cofactor | Histone ubiquitination | 17967883 | # | histone, DNA | H3K9me3, H3R2, H3, mCG | H3ub | 17967883 | ICBP90 =UHRF1and its murine homologue Np95 are enriched in pericentric heterochromatin of interphase nuclei, and this localization is dependent on H3K9 methylation. | # |
UHRF2
(details) |
12557 | ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase | 115426 (SSTAR profile) |
Q96PU4 | UHRF2_HUMAN | ubiquitin PF00240 (2-74) TTD PF12148 (125-311) PHD PF00628 (347-392) SAD_SRA PF02182 (445-614) |
Uhrf2 | 1923718 | Q7TMI3 | UHRF2_MOUSE | RNF, PHF | RING-type (C3HC4) zinc fingers, Zinc fingers, PHD-type | Histone modification read | # | 15361834 | # | histone, DNA | H3K9me3, mCG | # | 15361834 | The SRA domain of the murine homologue of ICBP90=UHRF2, Np95, has histone H3-binding activity (Citterio et al., 2004). Methylated DNA twisted around histone H3 might be the primary target for Np95 and ICBP90 in vivo. | # |
UIMC1
(details) |
30298 | ubiquitin interaction motif containing 1 | 51720 (SSTAR profile) |
Q96RL1 | UIMC1_HUMAN | RAP80_UIM PF18282 (73-125) | Uimc1 | 103185 | Q5U5Q9 | UIMC1_MOUSE | # | # | Histone modification read | # | 19015238 | BRCA1-A | histone | H2AK63ub, H2AXK63ub, H2BK63ub | # | 19015238 | The interaction between RAP80 =UIMC1 and ubiquitinated histones H2A and H2B is increased following DNA damage. | # |
USP11
(details) |
12609 | ubiquitin specific peptidase 11 | 8237 (SSTAR profile) |
P51784 | UBP11_HUMAN | DUSP PF06337 (86-183) Ubiquitin_3 PF14836 (199-285) UCH PF00443 (309-927) USP7_C2 PF14533 (493-596) |
Usp11 | 2384312 | Q99K46 | UBP11_MOUSE | USP | Ubiquitin-specific peptidases | Histone modification erase cofactor | Histone ubiquitination | 20233726 | # | histone | # | # | 20233726 | USP11 is a chromatin-associated protein and its catalytic activity is required for its genome maintenance activities. USP11 may be a DUB that functions in the DNA damage response to double-strand breaks. | # |
USP12
(details) |
20485 | ubiquitin specific peptidase 12 | 219333 (SSTAR profile) |
O75317 | UBP12_HUMAN | UCH PF00443 (39-366) | Usp12 | 1270128 | Q9D9M2 | UBP12_MOUSE | USP | Ubiquitin-specific peptidases | Histone modification erase | Histone ubiquitination | 22033037 | # | histone | H2Aub | H2A | 22033037 | Involved in H2A deubiquitination. | # |
USP15
(details) |
12613 | ubiquitin specific peptidase 15 | 9958 (SSTAR profile) |
Q9Y4E8 | UBP15_HUMAN | DUSP PF06337 (27-118) Ubiquitin_3 PF14836 (135-221) UCH PF00443 (289-930) USP7_C2 PF14533 (473-601) |
Usp15 | 101857 | Q8R5H1 | UBP15_MOUSE | USP | Ubiquitin-specific peptidases | Histone modification erase | Histone ubiquitination | 24526689 | # | histone | H2BK120ub | H2BK120 | 24526689 | Enhanced Usp15 binding to ubH2B facilitates deubiquitination of ubH2B in free histones but not in nucleosomes. | # |
USP16
(details) |
12614 | ubiquitin specific peptidase 16 | 10600 (SSTAR profile) |
Q9Y5T5 | UBP16_HUMAN | zf-UBP PF02148 (47-124) UCH PF00443 (197-819) |
Usp16 | 1921362 | Q99LG0 | UBP16_MOUSE | USP | Ubiquitin-specific peptidases | Histone modification erase | Histone ubiquitination | 10077596 | # | histone | H2Aub | H2A | 10077596 | Recombinant Ubp-M=USP16 is able to deubiquitinate histone H2A in vitro, and the phosphorylated form is also enzymatically active. | # |
USP17L2
(details) |
34434 | ubiquitin specific peptidase 17-like family member 2 | 377630 (SSTAR profile) |
Q6R6M4 | U17L2_HUMAN | UCH PF00443 (81-372) | Usp17le | 3643640 | Q7M764 | U17PE_MOUSE | # | # | Histone modification erase cofactor | Histone ubiquitination | 21239494 | # | histone | # | # | 21239494 | SDS3 is a key component of the histone deacetylase (HDAC)-dependent Sin3A co-repressor complex, serving to maintain its HDAC activity. Both exogenous and endogenous functional interaction between deubiquitinating enzyme USP17 = USP17L2 and human SDS3 has been reported. | # |
USP21
(details) |
12620 | ubiquitin specific peptidase 21 | 27005 (SSTAR profile) |
Q9UK80 | UBP21_HUMAN | UCH PF00443 (212-555) | Usp21 | 1353665 | Q9QZL6 | UBP21_MOUSE | USP | Ubiquitin-specific peptidases | Histone modification erase | Histone ubiquitination | # | # | histone | H2Aub | H2A | # | Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. (Annotated by similarity.) | # |
USP22
(details) |
12621 | ubiquitin specific peptidase 22 | 23326 (SSTAR profile) |
Q9UPT9 | UBP22_HUMAN | zf-UBP PF02148 (63-123) UCH PF00443 (176-517) |
Usp22 | 2144157 | Q5DU02 | UBP22_MOUSE | USP | Ubiquitin-specific peptidases | Histone modification write cofactor | Histone ubiquitination | 18469533 | SAGA | histone | H2Aub, H2Bub | H2A, H2B | 18469533 | USP22 deubiquitylates histone H2A in addition to H2B. This supports a model in which the H2A ubiquitin hydrolase USP22 is coordinately expressed with Polycomb H2A ubiquitin ligases in order that the transcription of certain critical transforming genes be maintained in the face of the global repression mediated by Polycomb. | # |
USP3
(details) |
12626 | ubiquitin specific peptidase 3 | 9960 (SSTAR profile) |
Q9Y6I4 | UBP3_HUMAN | zf-UBP PF02148 (29-107) UCH PF00443 (160-508) |
Usp3 | 2152450 | Q91W36 | UBP3_MOUSE | USP | Ubiquitin-specific peptidases | Histone modification write | Histone ubiquitination | 17980597 | # | histone | H2Aub, H2Bub | H2A, H2B | 17980597 | The ubiquitin-specific protease 3 USP3 is a deubiquitinating enzyme for uH2A and uH2B. USP3 dynamically associates with chromatin and deubiquitinates H2A/H2B in vivo. | # |
USP36
(details) |
20062 | ubiquitin specific peptidase 36 | 57602 (SSTAR profile) |
Q9P275 | UBP36_HUMAN | UCH PF00443 (122-421) | Usp36 | 1919594 | B1AQJ2 | UBP36_MOUSE | USP | Ubiquitin-specific peptidases | Histone modification write cofactor | Histone ubiquitination | 22622177 | # | histone | H2Bub | H2B | 22622177 | Deubiquitination of histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). | # |
USP44
(details) |
20064 | ubiquitin specific peptidase 44 | 84101 (SSTAR profile) |
Q9H0E7 | UBP44_HUMAN | zf-UBP PF02148 (28-91) UCH PF00443 (273-675) |
Usp44 | 3045318 | Q8C2S0 | UBP44_MOUSE | USP | Ubiquitin-specific peptidases | Histone modification erase | Histone ubiquitination | 22681888 | # | histone | H2Bub1 | H2B | 22681888 | USP44 is most likely an H2Bub1-specific DUB, whose downregulation during ESC differentiation contributes to increased H2Bub1 levels. | # |
USP46
(details) |
20075 | ubiquitin specific peptidase 46 | 64854 (SSTAR profile) |
P62068 | UBP46_HUMAN | UCH PF00443 (35-362) | Usp46 | 1916977 | P62069 | UBP46_MOUSE | USP | Ubiquitin-specific peptidases | Histone modification erase | Histone ubiquitination | 22033037 | # | histone | H2Aub | H2A | 22033037 | Involved in H2A deubiquitination. | # |
USP49
(details) |
20078 | ubiquitin specific peptidase 49 | 25862 (SSTAR profile) |
Q70CQ1 | UBP49_HUMAN | zf-UBP PF02148 (26-87) UCH PF00443 (253-654) |
Usp49 | 2685391 | Q6P9L4 | UBP49_MOUSE | USP | Ubiquitin-specific peptidases | Histone modification erase | Histone ubiquitination | 23824326 | # | histone | H2Bub | H2B | 23824326 | Ubiquitin-specific peptidase 49 (USP49) is a histone H2B-specific deubiquitinase and shows that H2B deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons. | # |
USP7
(details) |
12630 | ubiquitin specific peptidase 7 (herpes virus-associated) | 7874 (SSTAR profile) |
Q93009 | UBP7_HUMAN | domain PF22486 (70-195) UCH PF00443 (214-518) USP7_ICP0_bdg PF12436 (620-867) USP7_C2 PF14533 (877-1086) |
Usp7 | 2182061 | Q6A4J8 | UBP7_MOUSE | USP | Ubiquitin-specific peptidases | Histone modification erase, DNA modification cofactor | Histone ubiquitination, DNA methylation | 15749019 | BCOR | histone, DNA | H2Bub | H2B | 15749019 | GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7 | # |
UTY
(details) |
12638 | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | 7404 (SSTAR profile) |
O14607 | UTY_HUMAN | TPR_8 PF13181 (202-235) JmjC PF02373 (1080-1188) KDM6_C-hel PF21322 (1195-1249) KDM6_GATAL PF21326 (1267-1327) |
Uty | 894810 | P79457 | UTY_MOUSE | TTC | Tetratricopeptide (TTC) repeat domain containing | Histone modification erase | Histone ubiquitination | 24798337 | # | histone | H3K27me | # | 24798337 | The Jumonji C lysine demethylases (KDMs) are 2-oxoglutarate- and Fe(II)-dependent oxygenases. KDM6A (UTX) and KDM6B (JMJD3) are KDM6 subfamily members that catalyze demethylation of Nϵ-methylated histone 3 lysine 27 (H3K27), a mark important for transcriptional repression. Despite reports stating that UTY (KDM6C) is inactive as a KDM, we demonstrate by biochemical studies, employing MS and NMR, that UTY (KDM6C) is an active KDM. Crystallographic analyses reveal that the UTY(KDM6C) active site is highly conserved with those of KDM6B and KDM6A. | # |
VDR
(details) |
12679 | vitamin D (1,25- dihydroxyvitamin D3) receptor | 7421 (SSTAR profile) |
P11473 | VDR_HUMAN | zf-C4 PF00105 (23-91) Hormone_recep PF00104 (227-403) |
Vdr | 103076 | P48281 | VDR_MOUSE | NR | Nuclear hormone receptors | Chromatin remodeling cofactor, TF | # | 16252006 | # | histone | H2BK12ac, H3K14ac, H4K16ac | # | 16252006 | WINAC associates with chromatin through a physical interaction between the WSTF bromodomain and acetylated histones, which appears to be indispensable for VDR/promoter association for ligand-induced transrepression of 1α(OH)ase gene expression. | # |
VIRMA
(details) |
24500 | Protein virilizer homolog | 25962 (SSTAR profile) |
Q69YN4 | VIR_HUMAN | VIR_N PF15912 (5-278) | Virma | 1913435 | A2AIV2 | VIR_MOUSE | ARMH | Armadillo like helical domain containing | RNA modification | RNA methylation | 29507755 | WMM | RNA | A of mRNA | m6A | 29507755 | Mediates methylation in 3'UTR and near stop codon | New |
VPS72
(details) |
11644 | vacuolar protein sorting 72 homolog (S. cerevisiae) | 6944 (SSTAR profile) |
Q15906 | VPS72_HUMAN | YL1 PF05764 (7-212) YL1_C PF08265 (291-319) |
Vps72 | 1202305 | Q62481 | VPS72_MOUSE | # | # | Histone modification write cofactor | Histone acetylation | 14966270 | NuA4, NuA4-related complex | chromatin | # | # | 14966270 | The YL1 =VPS72 protein is a subunit of the TRRAP/TIP60 HAT complex. The YL1 protein is also present in cells as a subunit of the previously uncharacterized mammalian SRCAP complex, which bears a striking similarity to the S. cerevisiae SWR1 chromatin remodeling complex. | # |
VRK1
(details) |
12718 | vaccinia related kinase 1 | 7443 (SSTAR profile) |
Q99986 | VRK1_HUMAN | Pkinase PF00069 (39-271) | Vrk1 | 1261847 | Q80X41 | VRK1_MOUSE | # | # | Histone modification write | Histone phosphorylation | 22194607 | # | histone | H3S10, H3T3 | H3S10ph, H3T3ph | # | Phosphorylates histones H3-S10, H3-T3. | # |
WAC
(details) |
17327 | WW domain containing adaptor with coiled-coil | 51322 (SSTAR profile) |
Q9BTA9 | WAC_HUMAN | WW PF00397 (133-160) | Wac | 2387357 | Q924H7 | WAC_MOUSE | # | # | Histone modification write cofactor | Histone ubiquitination | 21329877 | # | histone | # | # | # | Regulates H2B ubiquitinations. | # |
WDR5
(details) |
12757 | WD repeat domain 5 | 11091 (SSTAR profile) |
P61964 | WDR5_HUMAN | WD40 PF00400 (38-72, 78-115, 119-157, 161-199, 203-242, 246-287, 292-331) | Wdr5 | 2155884 | P61965 | WDR5_MOUSE | WDR | WD repeat domain containing | Histone modification read | # | 16946699 | ATAC, NSL, RING2-L3MBTL2, COMPASS, Menin-associated_HMT, MLL-HCF, CHD8, MLL2/3, COMPASS-like MLL1,2, MLL4/WBP7, COMPASS-like MLL3,4 | histone | H3K4, H3K4me1, H3K4me2, H3K4me3 | # | 16946699 | The WD40 domain of WDR5 represents a new class of histone methyl-lysine recognition domains that is important for recruiting H3K4 methyltransferases to K4-dimethylated histone H3 tail as well as for global and gene-specific K4 trimethylation. Here is given the crystal structures of full-length WDR5, WDR5Delta23 and its complexes with unmodified, mono-, di- and trimethylated histone H3K4 peptides. | # |
WDR77
(details) |
29652 | WD repeat domain 77 | 79084 (SSTAR profile) |
Q9BQA1 | MEP50_HUMAN | WD40 PF00400 (122-153, 160-196) | Wdr77 | 1917715 | Q99J09 | MEP50_MOUSE | WDR | WD repeat domain containing | Histone modification write | Histone methylation | 22009756 | methylosome | histone | H2A, H4 | H2Ame, H4me | # | Methylates histones H2A and H4 in Xenopus. | # |
WDR82
(details) |
28826 | WD repeat domain 82 | 80335 (SSTAR profile) |
Q6UXN9 | WDR82_HUMAN | WD40 PF00400 (15-49, 98-135, 228-267) | Wdr82 | 1924555 | Q8BFQ4 | WDR82_MOUSE | WDR | WD repeat domain containing | Histone modification write cofactor | Histone methylation | 17355966 | COMPASS | histone | # | # | 17355966 | A mammalian Set1A complex analogous to the yeast Set1/COMPASS histone H3-Lys4 methyltransferase complex has previously been identified. WDR82 is a regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. | # |
WHSC1
(details) |
12766 | Wolf-Hirschhorn syndrome candidate 1 | 7468 (SSTAR profile) |
O96028 | NSD2_HUMAN | PWWP PF00855 (221-299, 881-972) HMG_box PF00505 (454-505) domain PF23011 (668-712, 1241-1284) domain PF22908 (716-763) domain PF23004 (764-816) PHD PF00628 (834-872) AWS PF17907 (1022-1060) SET PF00856 (1073-1180) C5HCH PF17982 (1284-1328) |
Whsc1 | 1276574 | Q8BVE8 | NSD2_MOUSE | PHF | Zinc fingers, PHD-type | Histone modification write | Histone methylation | 18172012 | # | histone | H3K27 | H3K27me | 18172012 | Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity. | # |
WHSC1L1
(details) |
12767 | Wolf-Hirschhorn syndrome candidate 1-like 1 | 54904 (SSTAR profile) |
Q9BZ95 | NSD3_HUMAN | PWWP PF00855 (269-348, 962-1050) domain PF23011 (700-746) domain PF22908 (749-798) domain PF23004 (799-851) AWS PF17907 (1104-1142) SET PF00856 (1155-1262) C5HCH PF17982 (1366-1410) |
Whsc1l1 | 2142581 | Q6P2L6 | NSD3_MOUSE | # | # | Chromatin remodeling cofactor, TF | # | 16682010 | # | histone | H3K4, H3K27 | # | 16682010 | WHISTLE =WHSC1L1 di-methylates H3K4 and di-, and tri-methylates H3K27 of histones. | # |
WSB2
(details) |
19222 | WD repeat and SOCS box containing 2 | 55884 (SSTAR profile) |
Q9NYS7 | WSB2_HUMAN | WD40 PF00400 (145-182, 188-225, 231-267, 289-320, 338-360) SOCS_box PF07525 (367-401) |
Wsb2 | 2144041 | O54929 | WSB2_MOUSE | WDR | WD repeat domain containing | Histone modification write | Histone ubiquitination | 21070969 | # | histone | # | # | # | May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including histones. (Annotated by similarity). | # |
WTAP
(details) |
16846 | Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (hFL(2)D) (WT1-associated protein) (Wilms tumor 1-associating protein) | 9589 (SSTAR profile) |
Q15007 | FL2D_HUMAN | Wtap PF17098 (68-223) | Wtap | 1926395 | Q9ER69 | FL2D_MOUSE | # | # | RNA modification | RNA methylation | 24407421 | WMM | RNA | A of mRNA | m6A | 24407421 | Regulates recruitment of the m6A methyltransferase complex to mRNA targets | New |
YAF2
(details) |
17363 | YY1 associated factor 2 | 10138 (SSTAR profile) |
Q8IY57 | YAF2_HUMAN | zf-RanBP PF00641 (20-43) YAF2_RYBP PF17219 (104-133) |
Yaf2 | 1914307 | Q99LW6 | YAF2_MOUSE | # | # | Chromatin remodeling cofactor | # | 11593398 | BCOR, RING2-L3MBTL2, RING2-FBRS | chromatin | # | # | 11593398 | Both Myc and Yaf2 could play a role in chromatin remodeling complexes. | # |
YEATS2
(details) |
25489 | YEATS domain containing 2 | 55689 (SSTAR profile) |
Q9ULM3 | YETS2_HUMAN | YEATS PF03366 (230-310) domain PF22951 (1144-1241) |
Yeats2 | 2447762 | Q3TUF7 | YETS2_MOUSE | # | # | Histone chaperone | # | 18838386, 29057918 | ATAC | histone | H3K27ac | # | 18838386, 29057918 | A YEATS2-NC2beta histone fold module that interacts with the TATA-binding protein (TBP) and negatively regulates transcription when recruited to a promoter. The p38 kinase-interacting protein (p38IP/FAM48A) is a novel component of STAGA with distant similarity to yeast Spt20.YEATS2 as a histone H3K27ac reader that regulates a transcriptional program essential for NSCLC tumorigenesis. | # |
YEATS4
(details) |
24859 | YEATS domain containing 4 | 8089 (SSTAR profile) |
O95619 | YETS4_HUMAN | YEATS PF03366 (42-121) | Yeats4 | 1927224 | Q9CR11 | YETS4_MOUSE | # | # | Histone modification write cofactor | Histone acetylation | 14966270 | NuA4, NuA4-related complex, SRCAP | histone | # | # | 14966270 | The essential GAS41 =YEATS4 protein is a member of the AF9/ENL-related (YEATS) family, and associated to transcription/chromatin-modifying complexes, including yeast NuA4, NuA3, Sas2, SWI/SNF, TFIID/mediator/TFIIF, and human SWI/SNF complexes. | # |
YTHDC1
(details) |
30626 | YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) | 91746 (SSTAR profile) |
Q96MU7 | YTDC1_HUMAN | YTH PF04146 (355-492) | Ythdc1 | 2443713 | E9Q5K9 | YTDC1_MOUSE | # | # | RNA modification | Alternative splicing | 20167602 | # | RNA | mRNA | m6A of mRNA | 20167602 | Regulates splicing site selection of vertabrate-specific exons. | New |
YWHAB
(details) |
12849 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 7529 (SSTAR profile) |
P31946 | 1433B_HUMAN | 14-3-3 PF00244 (11-231) | Ywhab | 1891917 | Q9CQV8 | 1433B_MOUSE | # | # | Histone modification erase cofactor | Histone acetylation | 10869435 | # | histone | # | # | 10869435 | Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent (=YWHAB) cellular localization. | # |
YWHAE
(details) |
12851 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 7531 (SSTAR profile) |
P62258 | 1433E_HUMAN | 14-3-3 PF00244 (10-232) | Ywhae | 894689 | P62259 | 1433E_MOUSE | # | # | Histone modification erase cofactor | Histone acetylation | 10869435 | # | histone | # | # | 10869435 | Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent (=YWHAE) cellular localization. | # |
YWHAZ
(details) |
12855 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 7534 (SSTAR profile) |
P63104 | 1433Z_HUMAN | 14-3-3 PF00244 (9-229) | Ywhaz | 109484 | P63101 | 1433Z_MOUSE | # | # | Histone modification read | # | 16246723 | # | histone | H3 | # | 16246723 | 14-3-3 =YWHAZ isoforms are proteins that bind modified H3 tail peptide tails in a strictly phosphorylation-dependent manner. | # |
YY1
(details) |
12856 | YY1 transcription factor | 7528 (SSTAR profile) |
P25490 | TYY1_HUMAN | zf-C2H2 PF00096 (298-320, 325-347, 353-377, 383-407) | Yy1 | 99150 | Q00899 | TYY1_MOUSE | INO80, ZNF | INO80 complex subunits, Zinc fingers, C2H2-type | Chromatin remodeling cofactor, TF | TF repressor | 11445535 | Ino80 | DNA | DNA motif | # | 11445535 | YY1 is complex comprising components of the evolutionarily conserved INO80 chromatin-remodeling complex. | # |
ZBTB16
(details) |
12930 | zinc finger and BTB domain containing 16 | 7704 (SSTAR profile) |
Q05516 | ZBT16_HUMAN | BTB PF00651 (25-124) zf-C2H2_6 PF13912 (461-483, 518-540) zf-C2H2 PF00096 (490-512, 546-568, 574-596) domain PF12874 (630-652) |
Zbtb16 | 103222 | # | # | ZBTB, ZNF, BTBD | Zinc fingers, C2H2-type, BTB/POZ domain containing | Histone modification erase cofactor | Histone acetylation | 9627120, 15467736 | # | histone | # | # | # | Recruites SMRT-mSin3-HDAC co-repressor complex. The repressive domains of PLZF function by recruiting N-CoR/Sin3A co-repressor complexes which in turn recruit histone deacetylases (HDACs). | # |
ZBTB33
(details) |
16682 | zinc finger and BTB domain containing 33 | 10009 (SSTAR profile) |
Q86T24 | KAISO_HUMAN | BTB PF00651 (22-116) | Zbtb33 | 1927290 | Q8BN78 | KAISO_MOUSE | ZBTB, BTBD, ZNF | BTB/POZ domain containing, Zinc fingers, C2H2-type | Histone modification write cofactor, Histone modification erase cofactor, TF | Histone acetylation, Histone methylation, TF repressor | 14527417 | # | DNA | CG, mCG, DNA motif | # | 14527417 | Kaiso, a methyl CpG binding protein belonging to the BTB/POZ family of transcription factors, is a component of the human N-CoR complex. In vitro, the Kaiso/N-CoR complex binds specific CpG-rich sequences in a methylation-dependent manner. In vivo, Kaiso targets the N-CoR complex to the MTA2 gene promoter in a methylation-dependent manner. This repression also requires a functional N-CoR deacetylase complex, which brings about histone hypoacetylation and methylation of H3 lysine 9 to the MTA2 locus. | # |
ZBTB7A
(details) |
18078 | Zinc finger and BTB domain-containing protein 7A (Factor binding IST protein 1) (FBI-1) (Factor that binds to inducer of short transcripts protein 1) (HIV-1 1st-binding protein 1) (Leukemia/lymphoma-related factor) (POZ and Krueppel erythroid myeloid ontogenic factor) (POK erythroid myeloid ontogenic factor) (Pokemon) (Pokemon 1) (TTF-I-interacting peptide 21) (TIP21) (Zinc finger protein 857A) | 51341 (SSTAR profile) |
O95365 | ZBT7A_HUMAN | BTB PF00651 (24-129) zf-C2H2 PF00096 (410-432, 438-460) |
Zbtb7A | 1335091 | O88939 | ZBT7A_MOUSE | BTBD | BTB domain containing | RNA modification | Alternative splicing | 24514149 | # | RNA | mRNA | # | 24514149 | Regulates alternative splicing of BCL-X and apoptotic factors | New |
ZBTB7C
(details) |
31700 | zinc finger and BTB domain containing 7C | 201501 (SSTAR profile) |
A1YPR0 | ZBT7C_HUMAN | BTB PF00651 (24-128) zf-C2H2 PF00096 (392-414, 448-469) |
Zbtb7c | 2443302 | Q8VCZ7 | ZBT7C_MOUSE | ZBTB, ZNF, BTBD | Zinc fingers, C2H2-type, BTB/POZ domain containing | Histone modification cofactor | # | 21804610 | # | histone | # | # | 21804610 | Kr-pok =ZBTB7C competes with MIZ-1 in binding to these elements and represses transcription by inhibiting MIZ-1/p300 recruitment, which decreases the acetylation of histones H3 and H4. | # |
ZC3H13
(details) |
20368 | Zinc finger CCCH domain-containing protein 13 | 23091 (SSTAR profile) |
Q5T200 | ZC3HD_HUMAN | zf-CCCH PF00642 (40-62) | Zc3h13 | 1914552 | E9Q784 | ZC3HD_MOUSE | ZC3H | Zinc fingers CCCH-type | RNA modification | RNA methylation | 29507755 | WMM | RNA | A of mRNA | m6A | 29507755 | Binds WTAP to RBM15 or RBM15B RNA-binding component | New |
ZCWPW1
(details) |
23486 | zinc finger, CW type with PWWP domain 1 | 55063 (SSTAR profile) |
Q9H0M4 | ZCPW1_HUMAN | zf-CW PF07496 (256-302) PWWP PF00855 (318-412) |
Zcwpw1 | 2685899 | Q6IR42 | ZCPW1_MOUSE | # | # | Histone modification read | # | 21423274 | # | histone | H3K4me | # | 21423274 | Table 1 in the reference. | # |
ZFP57
(details) |
18791 | ZFP57 zinc finger protein | 346171 (SSTAR profile) |
Q9NU63 | ZFP57_HUMAN | KRAB PF01352 (16-56) zf-C2H2 PF00096 (91-113, 119-141, 147-169, 175-197, 300-322, 328-350) |
Zfp57 | 99204 | Q8C6P8 | ZFP57_MOUSE | # | # | TF | TF repressor | # | # | DNA | mC, DNA motif | # | # | Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. (UniProt) | # |
ZGPAT
(details) |
15948 | zinc finger, CCCH-type with G patch domain | 84619 (SSTAR profile) |
Q8N5A5 | ZGPAT_HUMAN | zf-CCCH_4 PF18044 (177-199) G-patch PF01585 (333-376) |
Zgpat | 2449939 | Q8VDM1 | ZGPAT_MOUSE | ZC3H, GPATCH | Zinc fingers, CCCH-type domain containing, "G patch domain containing" | TF | TF repressor | 22498752 | # | DNA | DNA motif | # | # | Recruits the chromatin multiprotein complex NuRD to target promoters. | # |
ZHX1
(details) |
12871 | zinc fingers and homeoboxes 1 | 11244 (SSTAR profile) |
Q9UKY1 | ZHX1_HUMAN | zf_C2H2_ZHX PF18387 (99-151) Homeodomain PF00046 (299-340, 469-521, 575-622, 666-717) Homez PF11569 (784-822) |
Zhx1 | 109271 | P70121 | ZHX1_MOUSE | ZNF, ZFHX | Zinc fingers, C2H2-type, Homeoboxes / ZF class | Chromatin remodeling, Histone modification write cofactor | Histone acetylation, Histone methylation | 17303076 | # | histone | # | # | 17303076 | Presence of a PWWP domain is required for interaction of ZHX1. This domain may function as a site of protein–protein interaction and influence chromatin remodeling, and thereby facilitate the fine tuning of transcriptional processes. | # |
ZMYM2
(details) |
12989 | zinc finger, MYM-type 2 | 7750 (SSTAR profile) |
Q9UBW7 | ZMYM2_HUMAN | zf-FCS PF06467 (328-364, 371-412, 422-457, 465-504, 534-571, 637-674, 681-716, 725-762, 766-803) DUF3504 PF12012 (1190-1359) |
Zmym2 | 1923257 | Q9CU65 | ZMYM2_MOUSE | ZMYM | Zinc fingers, MYM type | Histone modification erase cofactor, TF | Histone acetylation | 12493763 | BHC, LSD-CoREST | DNA | DNA motif | # | 12493763 | A family of HDAC1,2-associated complexes includes proteins with a putative role in DNA binding such as ZNF261/XFIM (=ZMYM3), ZNF198/FIM (=ZMYM2), and ZNF217. | # |
ZMYM3
(details) |
13054 | zinc finger, MYM-type 3 | 9203 (SSTAR profile) |
Q14202 | ZMYM3_HUMAN | zf-FCS PF06467 (353-389, 406-444, 449-490, 497-535, 546-580, 591-624, 632-664, 676-714, 718-754) DUF3504 PF12012 (1184-1354) |
Zmym3 | 1927231 | Q9JLM4 | ZMYM3_MOUSE | ZMYM | Zinc fingers, MYM type | Histone modification erase cofactor | Histone acetylation | 12493763 | BHC | DNA | # | # | 12493763 | A family of HDAC1,2-associated complexes includes proteins with a putative role in DNA binding such as ZNF261/XFIM (=ZMYM3), ZNF198/FIM (=ZMYM2), and ZNF217. | # |
ZMYND11
(details) |
16966 | zinc finger, MYND-type containing 11 | 10771 (SSTAR profile) |
Q15326 | ZMY11_HUMAN | SAMD1_WH PF21524 (18-68) Bromodomain PF00439 (184-241) PWWP PF00855 (281-351) |
Zmynd11 | 1913755 | Q8R5C8 | ZMY11_MOUSE | ZMYND | Zinc fingers, MYND-type | Histone modification read | Histone methylation | 22498752 | # | histone | H3.3K36me3 | # | # | ZMYND11 recognizes and binds histone H3.3 trimethylated at Lys-36 (H3.3K36me3), according to UniProt. | # |
ZMYND8
(details) |
9397 | zinc finger, MYND-type containing 8 | 23613 (SSTAR profile) |
Q9ULU4 | PKCB1_HUMAN | PHD PF00628 (91-130) Bromodomain PF00439 (165-239) PWWP PF00855 (280-348) DUF3544 PF12064 (412-608) |
Zmynd8 | 1918025 | # | # | ZMYND, PHF | Zinc fingers, MYND-type, "Zinc fingers, PHD-type" | Histone modification erase cofactor | Histone acetylation | 25123934 | # | histone | # | # | # | ZMYND8 is part of the NuRD complex. | # |
ZNF217
(details) |
13009 | zinc finger protein 217 | 7764 (SSTAR profile) |
O75362 | ZN217_HUMAN | zf-C2H2 PF00096 (128-150, 156-178, 377-397, 472-493) | # | # | # | # | ZNF | Zinc fingers, C2H2-type | Histone modification erase cofactor, TF | Histone acetylation, TF repressor | 12493763 | BHC, LSD-CoREST | DNA | # | # | 12493763 | A family of HDAC1,2-associated complexes includes proteins with a putative role in DNA binding such as ZNF261/XFIM (=ZMYM3), ZNF198/FIM (=ZMYM2), and ZNF217. | # |
ZNF516
(details) |
28990 | zinc finger protein 516 | 9658 (SSTAR profile) |
Q92618 | ZN516_HUMAN | zf-C2H2 PF00096 (34-56, 62-84, 248-270, 276-298, 1098-1120) | Zfp516 | 2443957 | Q7TSH3 | ZN516_MOUSE | ZNF | Zinc fingers, C2H2-type | Histone modification erase cofactor, TF | Histone acetylation, TF repressor | 23752268 | LSD-CoREST | histone, DNA | # | # | 23752268 | Part of the HDAC interactome, TF annotation from Uniprot. | # |
ZNF532
(details) |
30940 | zinc finger protein 532 | 55205 (SSTAR profile) |
Q9HCE3 | ZN532_HUMAN | zf-C2H2_11 PF16622 (1203-1226) zf-C2H2_6 PF13912 (1264-1286) |
Zfp532 | 3036282 | Q6NXK2 | ZN532_MOUSE | ZNF | Zinc fingers, C2H2-type | Histone modification erase cofactor | Histone acetylation | 25123934 | # | histone | # | # | # | A member of NuRD complex. | # |
ZNF541
(details) |
25294 | zinc finger protein 541 | 84215 (SSTAR profile) |
Q9H0D2 | ZN541_HUMAN | zf-C2H2 PF00096 (140-162) zf-C2H2_6 PF13912 (168-190, 1289-1312) ELM2 PF01448 (1055-1111) |
Zfp541 | 3647699 | Q0GGX2 | ZN541_MOUSE | ZNF | Zinc fingers, C2H2-type | Chromatin remodeling | # | 18849567 | # | chromatin | # | # | # | Forms a complex with chromatin remodeling activity during spermatogenesis. UniProt: Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis (by similarity). | # |
ZNF592
(details) |
28986 | zinc finger protein 592 | 9640 (SSTAR profile) |
Q92610 | ZN592_HUMAN | zf-C2H2_11 PF16622 (1153-1176) | Zfp592 | 2443541 | Q8BHZ4 | ZN592_MOUSE | ZNF | Zinc fingers, C2H2-type | Histone modification erase cofactor | Histone acetylation | 25123934 | # | histone | # | # | # | A member of NuRD complex. | # |
ZNF687
(details) |
29277 | zinc finger protein 687 | 57592 (SSTAR profile) |
Q8N1G0 | ZN687_HUMAN | zf-C2H2 PF00096 (993-1016, 1200-1222) zf-C2H2_11 PF16622 (1135-1158) |
Zfp687 | 1925516 | Q9D2D7 | ZN687_MOUSE | # | # | Histone modification erase cofactor | Histone acetylation | 25123934 | # | histone | # | # | # | A member of NuRD complex. | # |
ZNF711
(details) |
13128 | zinc finger protein 711 | 7552 (SSTAR profile) |
Q9Y462 | ZN711_HUMAN | Zfx_Zfy_act PF04704 (62-356) zf-C2H2 PF00096 (383-405, 505-527, 562-584, 590-613, 619-641, 676-698, 704-727, 733-755) |
Zfp711 | 3045342 | A2ANX9 | ZN711_MOUSE | ZNF | Zinc fingers, C2H2-type | Histone modification erase cofactor | Histone acetylation | 20346720 | # | histone | # | # | 20346720 | The PHD domain of PHF8 binds to H3K4me3 and colocalizes with H3K4me3 at transcription initiation sites. Furthermore, PHF8 interacts with another XMLR protein, ZNF711, which binds to a subset of PHF8 target genes, including the XLMR gene JARID1C. | # |
ZNHIT1
(details) |
21688 | zinc finger, HIT-type containing 1 | 10467 (SSTAR profile) |
O43257 | ZNHI1_HUMAN | zf-HIT PF04438 (113-141) | Znhit1 | 1917353 | Q8R331 | ZNHI1_MOUSE | ZNHIT | Zinc fingers, HIT-type | Chromatin remodeling cofactor, Histone modification erase cofactor | Histone acetylation | 15647280 | SRCAP | histone | # | # | 15647280 | YL1 protein is also present in cells as a subunit of the previously uncharacterized mammalian SRCAP complex, which bears a striking similarity to the recently described S. cerevisiae SWR1 chromatin remodeling complex and is composed of the SNF2-related SRCAP helicase, ARP6, ZnF/HIT1. | # |
ZRANB3
(details) |
25249 | zinc finger, RAN-binding domain containing 3 | 84083 (SSTAR profile) |
Q5FWF4 | ZRAB3_HUMAN | SNF2-rel_dom PF00176 (40-299) Helicase_C PF00271 (329-435) zf-RanBP PF00641 (623-648) HNH PF01844 (1014-1049) |
Zranb3 | 1918362 | Q6NZP1 | ZRAB3_MOUSE | ZRANB | Zinc fingers, RAN-binding domain containing | Chromatin remodeling, Histone modification read cofactor | Histone methylation | 22705370 | # | histone | # | # | 22705370 | All four proteins (HARP, HARP-like domain (HPL), SMARCA1, RAD54L) belong to the SNF2 =ZRANB3 family, whose members participate in a variety of processes including chromatin remodeling, transcription, DNA repair, and recombination. | # |
ZZZ3
(details) |
24523 | zinc finger, ZZ-type containing 3 | 26009 (SSTAR profile) |
Q8IYH5 | ZZZ3_HUMAN | Myb_DNA-binding PF00249 (655-703) ZZ PF00569 (818-865) |
Zzz3 | 1920453 | Q6KAQ7 | ZZZ3_MOUSE | ZZZ | Zinc fingers, ZZ-type | Histone modification read | # | 19103755 | ATAC | histone | # | # | 19103755 | The SANT domain of c-Myb has been shown to bind histone H3 tails and position them for acetylation (35). Moreover, the SANT domains in ADA2a and ZZZ3/ATAC1 might enable the complex to associate with nucleosome tails in order to potentiate the catalytic activities of GCN5 and ATAC2, similar to what has been shown for the SANT domains in yeast Ada2 and Swi3. | # |